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PPP2R5D (protein phosphatase 2 regulatory subunit B'delta)

Identity

Alias_namesprotein phosphatase 2
Alias_symbol (synonym)B56D
Other aliasB56delta
MRD35
HGNC (Hugo) PPP2R5D
LocusID (NCBI) 5528
Atlas_Id 41820
Location 6p21.1  [Link to chromosome band 6p21]
Location_base_pair Starts at 42984499 and ends at 43012345 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ABCC10 (6p21.1) / PPP2R5D (6p21.1)PPP2R5D (6p21.1) / ASCC3 (6q16.3)PPP2R5D (6p21.1) / UBR2 (6p21.1)
ABCC10 6p21.1 / PPP2R5D 6p21.1PPP2R5D 6p21.1 / ASCC3 6q16.3PPP2R5D 6p21.1 / UBR2 6p21.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  ABCC10/PPP2R5D (6p21)
PPP2R5D/UBR2 (6p21)
t(6;6)(p21;q16) PPP2R5D/ASCC3


External links

Nomenclature
HGNC (Hugo)PPP2R5D   9312
Cards
Entrez_Gene (NCBI)PPP2R5D  5528  protein phosphatase 2 regulatory subunit B'delta
AliasesB56D; B56delta; MRD35
GeneCards (Weizmann)PPP2R5D
Ensembl hg19 (Hinxton)ENSG00000112640 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000112640 [Gene_View]  ENSG00000112640 [Sequence]  chr6:42984499-43012345 [Contig_View]  PPP2R5D [Vega]
ICGC DataPortalENSG00000112640
TCGA cBioPortalPPP2R5D
AceView (NCBI)PPP2R5D
Genatlas (Paris)PPP2R5D
WikiGenes5528
SOURCE (Princeton)PPP2R5D
Genetics Home Reference (NIH)PPP2R5D
Genomic and cartography
GoldenPath hg38 (UCSC)PPP2R5D  -     chr6:42984499-43012345 +  6p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPP2R5D  -     6p21.1   [Description]    (hg19-Feb_2009)
EnsemblPPP2R5D - 6p21.1 [CytoView hg19]  PPP2R5D - 6p21.1 [CytoView hg38]
Mapping of homologs : NCBIPPP2R5D [Mapview hg19]  PPP2R5D [Mapview hg38]
OMIM601646   616355   
Gene and transcription
Genbank (Entrez)AB000634 AB000635 AB209861 AB451342 AB451357
RefSeq transcript (Entrez)NM_001270476 NM_006245 NM_180976 NM_180977
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPP2R5D
Cluster EST : UnigeneHs.533308 [ NCBI ]
CGAP (NCI)Hs.533308
Alternative Splicing GalleryENSG00000112640
Gene ExpressionPPP2R5D [ NCBI-GEO ]   PPP2R5D [ EBI - ARRAY_EXPRESS ]   PPP2R5D [ SEEK ]   PPP2R5D [ MEM ]
Gene Expression Viewer (FireBrowse)PPP2R5D [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5528
GTEX Portal (Tissue expression)PPP2R5D
Human Protein AtlasENSG00000112640-PPP2R5D [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14738   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14738  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14738
Splice isoforms : SwissVarQ14738
PhosPhoSitePlusQ14738
Domains : Interpro (EBI)ARM-like    ARM-type_fold    PP2A_B56   
Domain families : Pfam (Sanger)B56 (PF01603)   
Domain families : Pfam (NCBI)pfam01603   
Conserved Domain (NCBI)PPP2R5D
DMDM Disease mutations5528
Blocks (Seattle)PPP2R5D
SuperfamilyQ14738
Human Protein Atlas [tissue]ENSG00000112640-PPP2R5D [tissue]
Peptide AtlasQ14738
HPRD09039
IPIIPI00000030   IPI00219543   IPI00219544   IPI00946763   IPI00946908   IPI00946952   IPI00947369   
Protein Interaction databases
DIP (DOE-UCLA)Q14738
IntAct (EBI)Q14738
FunCoupENSG00000112640
BioGRIDPPP2R5D
STRING (EMBL)PPP2R5D
ZODIACPPP2R5D
Ontologies - Pathways
QuickGOQ14738
Ontology : AmiGOprotein phosphatase type 2A complex  phosphoprotein phosphatase activity  protein serine/threonine phosphatase activity  protein binding  nucleus  nucleoplasm  cytosol  cytosol  protein dephosphorylation  protein dephosphorylation  signal transduction  nervous system development  negative regulation of peptidyl-threonine phosphorylation  protein phosphatase regulator activity  regulation of protein autophosphorylation  positive regulation of protein dephosphorylation  regulation of phosphoprotein phosphatase activity  protein phosphatase activator activity  
Ontology : EGO-EBIprotein phosphatase type 2A complex  phosphoprotein phosphatase activity  protein serine/threonine phosphatase activity  protein binding  nucleus  nucleoplasm  cytosol  cytosol  protein dephosphorylation  protein dephosphorylation  signal transduction  nervous system development  negative regulation of peptidyl-threonine phosphorylation  protein phosphatase regulator activity  regulation of protein autophosphorylation  positive regulation of protein dephosphorylation  regulation of phosphoprotein phosphatase activity  protein phosphatase activator activity  
Pathways : KEGGmRNA surveillance pathway    Oocyte meiosis    PI3K-Akt signaling pathway    Adrenergic signaling in cardiomyocytes    Dopaminergic synapse   
NDEx NetworkPPP2R5D
Atlas of Cancer Signalling NetworkPPP2R5D
Wikipedia pathwaysPPP2R5D
Orthology - Evolution
OrthoDB5528
GeneTree (enSembl)ENSG00000112640
Phylogenetic Trees/Animal Genes : TreeFamPPP2R5D
HOVERGENQ14738
HOGENOMQ14738
Homologs : HomoloGenePPP2R5D
Homology/Alignments : Family Browser (UCSC)PPP2R5D
Gene fusions - Rearrangements
Fusion : MitelmanABCC10/PPP2R5D [6p21.1/6p21.1]  [t(6;6)(p21;p21)]  
Fusion : MitelmanPPP2R5D/ASCC3 [6p21.1/6q16.3]  [t(6;6)(p21;q16)]  
Fusion : MitelmanPPP2R5D/UBR2 [6p21.1/6p21.1]  [t(6;6)(p21;p21)]  
Fusion PortalABCC10 6p21.1 PPP2R5D 6p21.1 BRCA
Fusion PortalPPP2R5D 6p21.1 ASCC3 6q16.3 BRCA
Fusion PortalPPP2R5D 6p21.1 UBR2 6p21.1 BLCA
Fusion : QuiverPPP2R5D
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP2R5D [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP2R5D
dbVarPPP2R5D
ClinVarPPP2R5D
1000_GenomesPPP2R5D 
Exome Variant ServerPPP2R5D
ExAC (Exome Aggregation Consortium)ENSG00000112640
GNOMAD BrowserENSG00000112640
Varsome BrowserPPP2R5D
Genetic variants : HAPMAP5528
Genomic Variants (DGV)PPP2R5D [DGVbeta]
DECIPHERPPP2R5D [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPP2R5D 
Mutations
ICGC Data PortalPPP2R5D 
TCGA Data PortalPPP2R5D 
Broad Tumor PortalPPP2R5D
OASIS PortalPPP2R5D [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP2R5D  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPP2R5D
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPP2R5D
DgiDB (Drug Gene Interaction Database)PPP2R5D
DoCM (Curated mutations)PPP2R5D (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPP2R5D (select a term)
intoGenPPP2R5D
Cancer3DPPP2R5D(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601646    616355   
Orphanet23719   
DisGeNETPPP2R5D
MedgenPPP2R5D
Genetic Testing Registry PPP2R5D
NextProtQ14738 [Medical]
TSGene5528
GENETestsPPP2R5D
Target ValidationPPP2R5D
Huge Navigator PPP2R5D [HugePedia]
snp3D : Map Gene to Disease5528
BioCentury BCIQPPP2R5D
ClinGenPPP2R5D
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5528
Chemical/Pharm GKB GenePA33676
Clinical trialPPP2R5D
Miscellaneous
canSAR (ICR)PPP2R5D (select the gene name)
Probes
Litterature
PubMed63 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPP2R5D
EVEXPPP2R5D
GoPubMedPPP2R5D
iHOPPPP2R5D
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:31:51 CET 2018

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