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PPP2R5E (protein phosphatase 2 regulatory subunit B', epsilon)

Identity

Alias_namesprotein phosphatase 2
Other alias-
HGNC (Hugo) PPP2R5E
LocusID (NCBI) 5529
Atlas_Id 41821
Location 14q23.2  [Link to chromosome band 14q23]
Location_base_pair Starts at 63840610 and ends at 64010079 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
PPP2R5E (14q23.2) / MAP4K4 (2q11.2)PPP2R5E (14q23.2) / PLEKHH1 (14q24.1)PPP2R5E (14q23.2) / PPP2R5E (14q23.2)
PTK2 (8q24.3) / PPP2R5E (14q23.2)SUSD6 (14q24.1) / PPP2R5E (14q23.2)TRIO (5p15.2) / PPP2R5E (14q23.2)
PPP2R5E 14q23.2 / PLEKHH1 14q24.1PTK2 8q24.3 / PPP2R5E 14q23.2TRIO 5p15.2 / PPP2R5E 14q23.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PPP2R5E   9313
Cards
Entrez_Gene (NCBI)PPP2R5E  5529  protein phosphatase 2 regulatory subunit B', epsilon
Aliases
GeneCards (Weizmann)PPP2R5E
Ensembl hg19 (Hinxton)ENSG00000154001 [Gene_View]  chr14:63840610-64010079 [Contig_View]  PPP2R5E [Vega]
Ensembl hg38 (Hinxton)ENSG00000154001 [Gene_View]  chr14:63840610-64010079 [Contig_View]  PPP2R5E [Vega]
ICGC DataPortalENSG00000154001
TCGA cBioPortalPPP2R5E
AceView (NCBI)PPP2R5E
Genatlas (Paris)PPP2R5E
WikiGenes5529
SOURCE (Princeton)PPP2R5E
Genetics Home Reference (NIH)PPP2R5E
Genomic and cartography
GoldenPath hg19 (UCSC)PPP2R5E  -     chr14:63840610-64010079 -  14q23.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PPP2R5E  -     14q23.2   [Description]    (hg38-Dec_2013)
EnsemblPPP2R5E - 14q23.2 [CytoView hg19]  PPP2R5E - 14q23.2 [CytoView hg38]
Mapping of homologs : NCBIPPP2R5E [Mapview hg19]  PPP2R5E [Mapview hg38]
OMIM601647   
Gene and transcription
Genbank (Entrez)AA782601 AB209811 AB451233 AB451358 AK299520
RefSeq transcript (Entrez)NM_001282179 NM_001282180 NM_001282181 NM_001282182 NM_006246
RefSeq genomic (Entrez)NC_000014 NC_018925 NT_026437 NW_004929393
Consensus coding sequences : CCDS (NCBI)PPP2R5E
Cluster EST : UnigeneHs.594347 [ NCBI ]
CGAP (NCI)Hs.594347
Alternative Splicing GalleryENSG00000154001
Gene ExpressionPPP2R5E [ NCBI-GEO ]   PPP2R5E [ EBI - ARRAY_EXPRESS ]   PPP2R5E [ SEEK ]   PPP2R5E [ MEM ]
Gene Expression Viewer (FireBrowse)PPP2R5E [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5529
GTEX Portal (Tissue expression)PPP2R5E
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16537   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16537  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16537
Splice isoforms : SwissVarQ16537
PhosPhoSitePlusQ16537
Domains : Interpro (EBI)ARM-type_fold    PP2A_B56   
Domain families : Pfam (Sanger)B56 (PF01603)   
Domain families : Pfam (NCBI)pfam01603   
Conserved Domain (NCBI)PPP2R5E
DMDM Disease mutations5529
Blocks (Seattle)PPP2R5E
SuperfamilyQ16537
Human Protein AtlasENSG00000154001
Peptide AtlasQ16537
HPRD09040
IPIIPI00002853   IPI01025482   IPI00556528   
Protein Interaction databases
DIP (DOE-UCLA)Q16537
IntAct (EBI)Q16537
FunCoupENSG00000154001
BioGRIDPPP2R5E
STRING (EMBL)PPP2R5E
ZODIACPPP2R5E
Ontologies - Pathways
QuickGOQ16537
Ontology : AmiGOprotein phosphatase type 2A complex  protein binding  cytoplasm  signal transduction  protein phosphatase type 2A regulator activity  regulation of protein phosphatase type 2A activity  regulation of protein phosphatase type 2A activity  
Ontology : EGO-EBIprotein phosphatase type 2A complex  protein binding  cytoplasm  signal transduction  protein phosphatase type 2A regulator activity  regulation of protein phosphatase type 2A activity  regulation of protein phosphatase type 2A activity  
Pathways : KEGGmRNA surveillance pathway    Oocyte meiosis    PI3K-Akt signaling pathway    Adrenergic signaling in cardiomyocytes    Dopaminergic synapse   
NDEx NetworkPPP2R5E
Atlas of Cancer Signalling NetworkPPP2R5E
Wikipedia pathwaysPPP2R5E
Orthology - Evolution
OrthoDB5529
GeneTree (enSembl)ENSG00000154001
Phylogenetic Trees/Animal Genes : TreeFamPPP2R5E
HOVERGENQ16537
HOGENOMQ16537
Homologs : HomoloGenePPP2R5E
Homology/Alignments : Family Browser (UCSC)PPP2R5E
Gene fusions - Rearrangements
Fusion : MitelmanPPP2R5E/PLEKHH1 [14q23.2/14q24.1]  
Fusion : MitelmanPTK2/PPP2R5E [8q24.3/14q23.2]  [t(8;14)(q24;q23)]  
Fusion : MitelmanTRIO/PPP2R5E [5p15.2/14q23.2]  [t(5;14)(p15;q23)]  
Fusion: TCGAPPP2R5E 14q23.2 PLEKHH1 14q24.1 LUSC
Fusion: TCGAPTK2 8q24.3 PPP2R5E 14q23.2 BRCA
Fusion: TCGATRIO 5p15.2 PPP2R5E 14q23.2 HNSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP2R5E [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP2R5E
dbVarPPP2R5E
ClinVarPPP2R5E
1000_GenomesPPP2R5E 
Exome Variant ServerPPP2R5E
ExAC (Exome Aggregation Consortium)PPP2R5E (select the gene name)
Genetic variants : HAPMAP5529
Genomic Variants (DGV)PPP2R5E [DGVbeta]
DECIPHER (Syndromes)14:63840610-64010079  ENSG00000154001
CONAN: Copy Number AnalysisPPP2R5E 
Mutations
ICGC Data PortalPPP2R5E 
TCGA Data PortalPPP2R5E 
Broad Tumor PortalPPP2R5E
OASIS PortalPPP2R5E [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP2R5E  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPP2R5E
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPP2R5E
DgiDB (Drug Gene Interaction Database)PPP2R5E
DoCM (Curated mutations)PPP2R5E (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPP2R5E (select a term)
intoGenPPP2R5E
Cancer3DPPP2R5E(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601647   
Orphanet
MedgenPPP2R5E
Genetic Testing Registry PPP2R5E
NextProtQ16537 [Medical]
TSGene5529
GENETestsPPP2R5E
Huge Navigator PPP2R5E [HugePedia]
snp3D : Map Gene to Disease5529
BioCentury BCIQPPP2R5E
ClinGenPPP2R5E
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5529
Chemical/Pharm GKB GenePA33677
Clinical trialPPP2R5E
Miscellaneous
canSAR (ICR)PPP2R5E (select the gene name)
Probes
Litterature
PubMed51 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPP2R5E
EVEXPPP2R5E
GoPubMedPPP2R5E
iHOPPPP2R5E
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:15:24 CEST 2017

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