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PPP3CA (protein phosphatase 3 catalytic subunit alpha)

Identity

Alias_namesCALN
CALNA
protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha)
protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform
protein phosphatase 3, catalytic subunit, alpha isozyme
Alias_symbol (synonym)CNA1
PPP2B
Other aliasCALNA1
CCN1
HGNC (Hugo) PPP3CA
LocusID (NCBI) 5530
Atlas_Id 41822
Location 4q24  [Link to chromosome band 4q24]
Location_base_pair Starts at 101944587 and ends at 102268628 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ADGRL3 (4q13.1) / PPP3CA (4q24)CANT1 (17q25.3) / PPP3CA (4q24)CD9 (12p13.31) / PPP3CA (4q24)
MSL1 (17q21.1) / PPP3CA (4q24)NOA1 (4q12) / PPP3CA (4q24)PPP3CA (4q24) / ACTL6A (3q26.33)
PPP3CA (4q24) / BRD2 (6p21.32)PPP3CA (4q24) / COL25A1 (4q25)PPP3CA (4q24) / DDX42 (17q23.3)
PPP3CA (4q24) / PPP3CA (4q24)PPP3CA (4q24) / SEPT11 (4q21.1)PPP3CA (4q24) / SPARCL1 (4q22.1)
RASSF3 (12q14.2) / PPP3CA (4q24)C4orf14 PPP3CA 4q24CANT1 17q25.3 / PPP3CA 4q24
CD9 12p13.31 / PPP3CA 4q24LPHN3 PPP3CA 4q24PPP3CA 4q24 / BRD2 6p21.32
PPP3CA 4q24 / COL25A1 4q25PPP3CA 4q24 / SEPT11 4q21.1PPP3CA 4q24 / SPARCL1 4q22.1
RASSF3 12q14.2 / PPP3CA 4q24

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PPP3CA   9314
Cards
Entrez_Gene (NCBI)PPP3CA  5530  protein phosphatase 3 catalytic subunit alpha
AliasesCALN; CALNA; CALNA1; CCN1; 
CNA1; PPP2B
GeneCards (Weizmann)PPP3CA
Ensembl hg19 (Hinxton)ENSG00000138814 [Gene_View]  chr4:101944587-102268628 [Contig_View]  PPP3CA [Vega]
Ensembl hg38 (Hinxton)ENSG00000138814 [Gene_View]  chr4:101944587-102268628 [Contig_View]  PPP3CA [Vega]
ICGC DataPortalENSG00000138814
TCGA cBioPortalPPP3CA
AceView (NCBI)PPP3CA
Genatlas (Paris)PPP3CA
WikiGenes5530
SOURCE (Princeton)PPP3CA
Genetics Home Reference (NIH)PPP3CA
Genomic and cartography
GoldenPath hg19 (UCSC)PPP3CA  -     chr4:101944587-102268628 -  4q24   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PPP3CA  -     4q24   [Description]    (hg38-Dec_2013)
EnsemblPPP3CA - 4q24 [CytoView hg19]  PPP3CA - 4q24 [CytoView hg38]
Mapping of homologs : NCBIPPP3CA [Mapview hg19]  PPP3CA [Mapview hg38]
OMIM114105   
Gene and transcription
Genbank (Entrez)AB451338 AB451487 AK290532 AL353950 AM393486
RefSeq transcript (Entrez)NM_000944 NM_001130691 NM_001130692
RefSeq genomic (Entrez)NC_000004 NC_018915 NT_016354 NW_004929320
Consensus coding sequences : CCDS (NCBI)PPP3CA
Cluster EST : UnigeneHs.435512 [ NCBI ]
CGAP (NCI)Hs.435512
Alternative Splicing GalleryENSG00000138814
Gene ExpressionPPP3CA [ NCBI-GEO ]   PPP3CA [ EBI - ARRAY_EXPRESS ]   PPP3CA [ SEEK ]   PPP3CA [ MEM ]
Gene Expression Viewer (FireBrowse)PPP3CA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5530
GTEX Portal (Tissue expression)PPP3CA
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ08209   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ08209  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ08209
Splice isoforms : SwissVarQ08209
Catalytic activity : Enzyme3.1.3.16 [ Enzyme-Expasy ]   3.1.3.163.1.3.16 [ IntEnz-EBI ]   3.1.3.16 [ BRENDA ]   3.1.3.16 [ KEGG ]   
PhosPhoSitePlusQ08209
Domaine pattern : Prosite (Expaxy)SER_THR_PHOSPHATASE (PS00125)   
Domains : Interpro (EBI)Calcineurin-like_PHP_apaH    Metallo-depent_PP-like    Ser/Thr-sp_prot-phosphatase   
Domain families : Pfam (Sanger)Metallophos (PF00149)   
Domain families : Pfam (NCBI)pfam00149   
Domain families : Smart (EMBL)PP2Ac (SM00156)  
Conserved Domain (NCBI)PPP3CA
DMDM Disease mutations5530
Blocks (Seattle)PPP3CA
PDB (SRS)1AUI    1M63    1MF8    2JOG    2JZI    2P6B    2R28    2W73    3LL8    4F0Z    4Q5U    5C1V   
PDB (PDBSum)1AUI    1M63    1MF8    2JOG    2JZI    2P6B    2R28    2W73    3LL8    4F0Z    4Q5U    5C1V   
PDB (IMB)1AUI    1M63    1MF8    2JOG    2JZI    2P6B    2R28    2W73    3LL8    4F0Z    4Q5U    5C1V   
PDB (RSDB)1AUI    1M63    1MF8    2JOG    2JZI    2P6B    2R28    2W73    3LL8    4F0Z    4Q5U    5C1V   
Structural Biology KnowledgeBase1AUI    1M63    1MF8    2JOG    2JZI    2P6B    2R28    2W73    3LL8    4F0Z    4Q5U    5C1V   
SCOP (Structural Classification of Proteins)1AUI    1M63    1MF8    2JOG    2JZI    2P6B    2R28    2W73    3LL8    4F0Z    4Q5U    5C1V   
CATH (Classification of proteins structures)1AUI    1M63    1MF8    2JOG    2JZI    2P6B    2R28    2W73    3LL8    4F0Z    4Q5U    5C1V   
SuperfamilyQ08209
Human Protein AtlasENSG00000138814
Peptide AtlasQ08209
HPRD00234
IPIIPI00179415   IPI00747748   IPI00966317   IPI00877617   IPI00910825   IPI00967142   IPI00984119   IPI00984843   
Protein Interaction databases
DIP (DOE-UCLA)Q08209
IntAct (EBI)Q08209
FunCoupENSG00000138814
BioGRIDPPP3CA
STRING (EMBL)PPP3CA
ZODIACPPP3CA
Ontologies - Pathways
QuickGOQ08209
Ontology : AmiGOG1/S transition of mitotic cell cycle  response to amphetamine  protein serine/threonine phosphatase activity  calcium ion binding  protein binding  calmodulin binding  calmodulin binding  nucleoplasm  nucleoplasm  cytoplasm  mitochondrion  cytosol  calcineurin complex  calcineurin complex  protein dephosphorylation  protein dephosphorylation  protein import into nucleus  calcium ion transport  Wnt signaling pathway, calcium modulating pathway  drug binding  transition between fast and slow fiber  cardiac muscle hypertrophy in response to stress  dephosphorylation  enzyme binding  Z disc  calcineurin-NFAT signaling cascade  calmodulin-dependent protein phosphatase activity  calmodulin-dependent protein phosphatase activity  multicellular organismal response to stress  negative regulation of chromatin binding  cellular response to drug  Fc-epsilon receptor signaling pathway  T cell activation  sarcolemma  positive regulation of transcription from RNA polymerase II promoter  negative regulation of insulin secretion  protein heterodimerization activity  protein dimerization activity  skeletal muscle fiber development  negative regulation of dendrite morphogenesis  modulation of synaptic transmission  positive regulation of sequence-specific DNA binding transcription factor activity  positive regulation of NFAT protein import into nucleus  response to calcium ion  excitatory postsynaptic potential  cellular response to glucose stimulus  postsynapse  positive regulation of cardiac muscle hypertrophy in response to stress  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  response to amphetamine  protein serine/threonine phosphatase activity  calcium ion binding  protein binding  calmodulin binding  calmodulin binding  nucleoplasm  nucleoplasm  cytoplasm  mitochondrion  cytosol  calcineurin complex  calcineurin complex  protein dephosphorylation  protein dephosphorylation  protein import into nucleus  calcium ion transport  Wnt signaling pathway, calcium modulating pathway  drug binding  transition between fast and slow fiber  cardiac muscle hypertrophy in response to stress  dephosphorylation  enzyme binding  Z disc  calcineurin-NFAT signaling cascade  calmodulin-dependent protein phosphatase activity  calmodulin-dependent protein phosphatase activity  multicellular organismal response to stress  negative regulation of chromatin binding  cellular response to drug  Fc-epsilon receptor signaling pathway  T cell activation  sarcolemma  positive regulation of transcription from RNA polymerase II promoter  negative regulation of insulin secretion  protein heterodimerization activity  protein dimerization activity  skeletal muscle fiber development  negative regulation of dendrite morphogenesis  modulation of synaptic transmission  positive regulation of sequence-specific DNA binding transcription factor activity  positive regulation of NFAT protein import into nucleus  response to calcium ion  excitatory postsynaptic potential  cellular response to glucose stimulus  postsynapse  positive regulation of cardiac muscle hypertrophy in response to stress  
Pathways : BIOCARTASignaling Pathway from G-Protein Families [Genes]    Endocytotic role of NDK, Phosphins and Dynamin [Genes]    Effects of calcineurin in Keratinocyte Differentiation [Genes]    Nitric Oxide Signaling Pathway [Genes]    Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells [Genes]    Fc Epsilon Receptor I Signaling in Mast Cells [Genes]    Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK) [Genes]    Role of MEF2D in T-cell Apoptosis [Genes]    NFAT and Hypertrophy of the heart (Transcription in the broken heart) [Genes]    T Cell Receptor Signaling Pathway [Genes]    BCR Signaling Pathway [Genes]    fMLP induced chemokine gene expression in HMC-1 cells [Genes]    Regulation of PGC-1a [Genes]    Regulation of ck1/cdk5 by type 1 glutamate receptors [Genes]   
Pathways : KEGGMAPK signaling pathway    Calcium signaling pathway    Oocyte meiosis    Apoptosis    Wnt signaling pathway    Axon guidance    VEGF signaling pathway    Osteoclast differentiation    Natural killer cell mediated cytotoxicity    T cell receptor signaling pathway    B cell receptor signaling pathway    Long-term potentiation    Glutamatergic synapse    Dopaminergic synapse    Alzheimer's disease    Amyotrophic lateral sclerosis (ALS)    Amphetamine addiction    Tuberculosis    HTLV-I infection   
NDEx NetworkPPP3CA
Atlas of Cancer Signalling NetworkPPP3CA
Wikipedia pathwaysPPP3CA
Orthology - Evolution
OrthoDB5530
GeneTree (enSembl)ENSG00000138814
Phylogenetic Trees/Animal Genes : TreeFamPPP3CA
HOVERGENQ08209
HOGENOMQ08209
Homologs : HomoloGenePPP3CA
Homology/Alignments : Family Browser (UCSC)PPP3CA
Gene fusions - Rearrangements
Fusion : MitelmanCANT1/PPP3CA [17q25.3/4q24]  [t(4;17)(q24;q25)]  
Fusion : MitelmanCD9/PPP3CA [12p13.31/4q24]  [t(4;12)(q24;p13)]  
Fusion : MitelmanLPHN3/4q24 [PPP3CA/t(4;4)(q13;q24)]  
Fusion : MitelmanPPP3CA/BRD2 [4q24/6p21.32]  [t(4;6)(q24;p21)]  
Fusion : MitelmanPPP3CA/SEPT11 [4q24/4q21.1]  [t(4;4)(q21;q24)]  
Fusion : MitelmanPPP3CA/SPARCL1 [4q24/4q22.1]  [t(4;4)(q22;q24)]  
Fusion : MitelmanRASSF3/PPP3CA [12q14.2/4q24]  [t(4;12)(q24;q14)]  
Fusion: TCGAC4orf14 PPP3CA 4q24 BRCA
Fusion: TCGACANT1 17q25.3 PPP3CA 4q24 PRAD
Fusion: TCGACD9 12p13.31 PPP3CA 4q24 PRAD
Fusion: TCGALPHN3 PPP3CA 4q24 BRCA
Fusion: TCGAPPP3CA 4q24 BRD2 6p21.32 PRAD
Fusion: TCGAPPP3CA 4q24 COL25A1 4q25 BRCA
Fusion: TCGAPPP3CA 4q24 SEPT11 4q21.1 PRAD
Fusion: TCGAPPP3CA 4q24 SPARCL1 4q22.1 BRCA
Fusion: TCGARASSF3 12q14.2 PPP3CA 4q24 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP3CA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP3CA
dbVarPPP3CA
ClinVarPPP3CA
1000_GenomesPPP3CA 
Exome Variant ServerPPP3CA
ExAC (Exome Aggregation Consortium)PPP3CA (select the gene name)
Genetic variants : HAPMAP5530
Genomic Variants (DGV)PPP3CA [DGVbeta]
DECIPHER (Syndromes)4:101944587-102268628  ENSG00000138814
CONAN: Copy Number AnalysisPPP3CA 
Mutations
ICGC Data PortalPPP3CA 
TCGA Data PortalPPP3CA 
Broad Tumor PortalPPP3CA
OASIS PortalPPP3CA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP3CA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPP3CA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPP3CA
DgiDB (Drug Gene Interaction Database)PPP3CA
DoCM (Curated mutations)PPP3CA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPP3CA (select a term)
intoGenPPP3CA
Cancer3DPPP3CA(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM114105   
Orphanet
MedgenPPP3CA
Genetic Testing Registry PPP3CA
NextProtQ08209 [Medical]
TSGene5530
GENETestsPPP3CA
Huge Navigator PPP3CA [HugePedia]
snp3D : Map Gene to Disease5530
BioCentury BCIQPPP3CA
ClinGenPPP3CA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5530
Chemical/Pharm GKB GenePA33678
Clinical trialPPP3CA
Miscellaneous
canSAR (ICR)PPP3CA (select the gene name)
Probes
Litterature
PubMed132 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPP3CA
EVEXPPP3CA
GoPubMedPPP3CA
iHOPPPP3CA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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