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PPP3CA (protein phosphatase 3 catalytic subunit alpha)

Identity

Alias (NCBI)ACCIID
CALN
CALNA
CALNA1
CCN1
CNA1
DEE91
IECEE
IECEE1
PPP2B
HGNC (Hugo) PPP3CA
HGNC Alias symbCNA1
PPP2B
HGNC Alias namecalcineurin A alpha
 protein phosphatase 2B, catalytic subunit, alpha isoform
HGNC Previous nameCALN
 CALNA
HGNC Previous nameprotein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha)
 protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform
 protein phosphatase 3, catalytic subunit, alpha isozyme
LocusID (NCBI) 5530
Atlas_Id 41822
Location 4q24  [Link to chromosome band 4q24]
Location_base_pair Starts at 101023418 and ends at 101347526 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADGRL3 (4q13.1) / PPP3CA (4q24)CANT1 (17q25.3) / PPP3CA (4q24)CD9 (12p13.31) / PPP3CA (4q24)
MSL1 (17q21.1) / PPP3CA (4q24)NOA1 (4q12) / PPP3CA (4q24)PPP3CA (4q24) / ACTL6A (3q26.33)
PPP3CA (4q24) / BRD2 (6p21.32)PPP3CA (4q24) / COL25A1 (4q25)PPP3CA (4q24) / DDX42 (17q23.3)
PPP3CA (4q24) / PPP3CA (4q24)PPP3CA (4q24) / SEPT11 (4q21.1)PPP3CA (4q24) / SPARCL1 (4q22.1)
RASSF3 (12q14.2) / PPP3CA (4q24)C4orf14 PPP3CA 4q24CANT1 17q25.3 / PPP3CA 4q24
CD9 12p13.31 / PPP3CA 4q24LPHN3 PPP3CA 4q24PPP3CA 4q24 / BRD2 6p21.32
PPP3CA 4q24 / COL25A1 4q25PPP3CA 4q24 / SEPT11 4q21.1PPP3CA 4q24 / SPARCL1 4q22.1
RASSF3 12q14.2 / PPP3CA 4q24

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PPP3CA   9314
Cards
Entrez_Gene (NCBI)PPP3CA    protein phosphatase 3 catalytic subunit alpha
AliasesACCIID; CALN; CALNA; CALNA1; 
CCN1; CNA1; DEE91; IECEE; IECEE1; PPP2B
GeneCards (Weizmann)PPP3CA
Ensembl hg19 (Hinxton)ENSG00000138814 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138814 [Gene_View]  ENSG00000138814 [Sequence]  chr4:101023418-101347526 [Contig_View]  PPP3CA [Vega]
ICGC DataPortalENSG00000138814
TCGA cBioPortalPPP3CA
AceView (NCBI)PPP3CA
Genatlas (Paris)PPP3CA
SOURCE (Princeton)PPP3CA
Genetics Home Reference (NIH)PPP3CA
Genomic and cartography
GoldenPath hg38 (UCSC)PPP3CA  -     chr4:101023418-101347526 -  4q24   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPP3CA  -     4q24   [Description]    (hg19-Feb_2009)
GoldenPathPPP3CA - 4q24 [CytoView hg19]  PPP3CA - 4q24 [CytoView hg38]
ImmunoBaseENSG00000138814
Genome Data Viewer NCBIPPP3CA [Mapview hg19]  
OMIM114105   617711   618265   
Gene and transcription
Genbank (Entrez)AB451338 AB451487 AK290532 AL353950 AW973358
RefSeq transcript (Entrez)NM_000944 NM_001130691 NM_001130692
Consensus coding sequences : CCDS (NCBI)PPP3CA
Gene ExpressionPPP3CA [ NCBI-GEO ]   PPP3CA [ EBI - ARRAY_EXPRESS ]   PPP3CA [ SEEK ]   PPP3CA [ MEM ]
Gene Expression Viewer (FireBrowse)PPP3CA [ Firebrowse - Broad ]
GenevisibleExpression of PPP3CA in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5530
GTEX Portal (Tissue expression)PPP3CA
Human Protein AtlasENSG00000138814-PPP3CA [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ08209   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ08209  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ08209
PhosPhoSitePlusQ08209
Domaine pattern : Prosite (Expaxy)SER_THR_PHOSPHATASE (PS00125)   
Domains : Interpro (EBI)Calcineurin-like_PHP_ApaH    Metallo-depent_PP-like    MPP_PP2B    PP2B    Ser/Thr-sp_prot-phosphatase   
Domain families : Pfam (Sanger)Metallophos (PF00149)   
Domain families : Pfam (NCBI)pfam00149   
Domain families : Smart (EMBL)PP2Ac (SM00156)  
Conserved Domain (NCBI)PPP3CA
PDB (RSDB)1AUI    1M63    1MF8    2JOG    2JZI    2P6B    2R28    2W73    3LL8    4F0Z    4Q5U    5C1V    5SVE    6NUC    6NUF    6NUU    6UUQ   
PDB Europe1AUI    1M63    1MF8    2JOG    2JZI    2P6B    2R28    2W73    3LL8    4F0Z    4Q5U    5C1V    5SVE    6NUC    6NUF    6NUU    6UUQ   
PDB (PDBSum)1AUI    1M63    1MF8    2JOG    2JZI    2P6B    2R28    2W73    3LL8    4F0Z    4Q5U    5C1V    5SVE    6NUC    6NUF    6NUU    6UUQ   
PDB (IMB)1AUI    1M63    1MF8    2JOG    2JZI    2P6B    2R28    2W73    3LL8    4F0Z    4Q5U    5C1V    5SVE    6NUC    6NUF    6NUU    6UUQ   
Structural Biology KnowledgeBase1AUI    1M63    1MF8    2JOG    2JZI    2P6B    2R28    2W73    3LL8    4F0Z    4Q5U    5C1V    5SVE    6NUC    6NUF    6NUU    6UUQ   
SCOP (Structural Classification of Proteins)1AUI    1M63    1MF8    2JOG    2JZI    2P6B    2R28    2W73    3LL8    4F0Z    4Q5U    5C1V    5SVE    6NUC    6NUF    6NUU    6UUQ   
CATH (Classification of proteins structures)1AUI    1M63    1MF8    2JOG    2JZI    2P6B    2R28    2W73    3LL8    4F0Z    4Q5U    5C1V    5SVE    6NUC    6NUF    6NUU    6UUQ   
SuperfamilyQ08209
AlphaFold pdb e-kbQ08209   
Human Protein Atlas [tissue]ENSG00000138814-PPP3CA [tissue]
HPRD00234
Protein Interaction databases
DIP (DOE-UCLA)Q08209
IntAct (EBI)Q08209
BioGRIDPPP3CA
STRING (EMBL)PPP3CA
ZODIACPPP3CA
Ontologies - Pathways
QuickGOQ08209
Ontology : AmiGOG1/S transition of mitotic cell cycle  response to amphetamine  protein serine/threonine phosphatase activity  protein serine/threonine phosphatase activity  calcium ion binding  protein binding  calmodulin binding  calmodulin binding  calmodulin binding  nucleoplasm  nucleoplasm  cytoplasm  cytoplasm  mitochondrion  cytosol  cytosol  cytosol  plasma membrane  calcineurin complex  calcineurin complex  calcineurin complex  protein dephosphorylation  protein dephosphorylation  protein dephosphorylation  protein import into nucleus  calcium ion transport  Wnt signaling pathway, calcium modulating pathway  brain development  aging  cytoplasmic side of plasma membrane  transition between fast and slow fiber  cardiac muscle hypertrophy in response to stress  cyclosporin A binding  dephosphorylation  extrinsic component of plasma membrane  enzyme binding  Z disc  positive regulation of cell migration  calcineurin-NFAT signaling cascade  calcineurin-NFAT signaling cascade  calcineurin-NFAT signaling cascade  calmodulin-dependent protein phosphatase activity  calmodulin-dependent protein phosphatase activity  calmodulin-dependent protein phosphatase activity  multicellular organismal response to stress  negative regulation of chromatin binding  slit diaphragm  Fc-epsilon receptor signaling pathway  wound healing  T cell activation  sarcolemma  dendritic spine  skeletal muscle tissue regeneration  protein-containing complex binding  positive regulation of cell adhesion  positive regulation of endocytosis  positive regulation of transcription by RNA polymerase II  negative regulation of insulin secretion  protein dimerization activity  skeletal muscle fiber development  negative regulation of dendrite morphogenesis  positive regulation of DNA-binding transcription factor activity  ATPase binding  response to calcium ion  excitatory postsynaptic potential  peptidyl-serine dephosphorylation  cellular response to glucose stimulus  calcineurin-mediated signaling  calcineurin-mediated signaling  Schaffer collateral - CA1 synapse  glutamatergic synapse  postsynaptic modulation of chemical synaptic transmission  protein serine phosphatase activity  protein threonine phosphatase activity  positive regulation of cardiac muscle hypertrophy in response to stress  negative regulation of production of miRNAs involved in gene silencing by miRNA  positive regulation of connective tissue replacement  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  response to amphetamine  protein serine/threonine phosphatase activity  protein serine/threonine phosphatase activity  calcium ion binding  protein binding  calmodulin binding  calmodulin binding  calmodulin binding  nucleoplasm  nucleoplasm  cytoplasm  cytoplasm  mitochondrion  cytosol  cytosol  cytosol  plasma membrane  calcineurin complex  calcineurin complex  calcineurin complex  protein dephosphorylation  protein dephosphorylation  protein dephosphorylation  protein import into nucleus  calcium ion transport  Wnt signaling pathway, calcium modulating pathway  brain development  aging  cytoplasmic side of plasma membrane  transition between fast and slow fiber  cardiac muscle hypertrophy in response to stress  cyclosporin A binding  dephosphorylation  extrinsic component of plasma membrane  enzyme binding  Z disc  positive regulation of cell migration  calcineurin-NFAT signaling cascade  calcineurin-NFAT signaling cascade  calcineurin-NFAT signaling cascade  calmodulin-dependent protein phosphatase activity  calmodulin-dependent protein phosphatase activity  calmodulin-dependent protein phosphatase activity  multicellular organismal response to stress  negative regulation of chromatin binding  slit diaphragm  Fc-epsilon receptor signaling pathway  wound healing  T cell activation  sarcolemma  dendritic spine  skeletal muscle tissue regeneration  protein-containing complex binding  positive regulation of cell adhesion  positive regulation of endocytosis  positive regulation of transcription by RNA polymerase II  negative regulation of insulin secretion  protein dimerization activity  skeletal muscle fiber development  negative regulation of dendrite morphogenesis  positive regulation of DNA-binding transcription factor activity  ATPase binding  response to calcium ion  excitatory postsynaptic potential  peptidyl-serine dephosphorylation  cellular response to glucose stimulus  calcineurin-mediated signaling  calcineurin-mediated signaling  Schaffer collateral - CA1 synapse  glutamatergic synapse  postsynaptic modulation of chemical synaptic transmission  protein serine phosphatase activity  protein threonine phosphatase activity  positive regulation of cardiac muscle hypertrophy in response to stress  negative regulation of production of miRNAs involved in gene silencing by miRNA  positive regulation of connective tissue replacement  
Pathways : BIOCARTASignaling Pathway from G-Protein Families [Genes]    Endocytotic role of NDK, Phosphins and Dynamin [Genes]    Effects of calcineurin in Keratinocyte Differentiation [Genes]    Nitric Oxide Signaling Pathway [Genes]    Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells [Genes]    Fc Epsilon Receptor I Signaling in Mast Cells [Genes]    Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK) [Genes]    Role of MEF2D in T-cell Apoptosis [Genes]    NFAT and Hypertrophy of the heart (Transcription in the broken heart) [Genes]    T Cell Receptor Signaling Pathway [Genes]    BCR Signaling Pathway [Genes]    fMLP induced chemokine gene expression in HMC-1 cells [Genes]    Regulation of PGC-1a [Genes]    Regulation of ck1/cdk5 by type 1 glutamate receptors [Genes]   
Pathways : KEGGMAPK signaling pathway    Calcium signaling pathway    Oocyte meiosis    Apoptosis    Wnt signaling pathway    Axon guidance    VEGF signaling pathway    Osteoclast differentiation    Natural killer cell mediated cytotoxicity    T cell receptor signaling pathway    B cell receptor signaling pathway    Long-term potentiation    Glutamatergic synapse    Dopaminergic synapse    Alzheimer's disease    Amyotrophic lateral sclerosis (ALS)    Amphetamine addiction    Tuberculosis    HTLV-I infection   
NDEx NetworkPPP3CA
Atlas of Cancer Signalling NetworkPPP3CA
Wikipedia pathwaysPPP3CA
Orthology - Evolution
OrthoDB5530
GeneTree (enSembl)ENSG00000138814
Phylogenetic Trees/Animal Genes : TreeFamPPP3CA
Homologs : HomoloGenePPP3CA
Homology/Alignments : Family Browser (UCSC)PPP3CA
Gene fusions - Rearrangements
Fusion : MitelmanCANT1/PPP3CA [17q25.3/4q24]  
Fusion : MitelmanCD9/PPP3CA [12p13.31/4q24]  
Fusion : MitelmanLPHN3/4q24 [PPP3CA/t(4;4)(q13;q24)]  
Fusion : MitelmanPPP3CA/BRD2 [4q24/6p21.32]  
Fusion : MitelmanPPP3CA/SEPT11 [4q24/4q21.1]  
Fusion : MitelmanPPP3CA/SPARCL1 [4q24/4q22.1]  
Fusion : MitelmanRASSF3/PPP3CA [12q14.2/4q24]  
Fusion : QuiverPPP3CA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP3CA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP3CA
dbVarPPP3CA
ClinVarPPP3CA
MonarchPPP3CA
1000_GenomesPPP3CA 
Exome Variant ServerPPP3CA
GNOMAD BrowserENSG00000138814
Varsome BrowserPPP3CA
ACMGPPP3CA variants
VarityQ08209
Genomic Variants (DGV)PPP3CA [DGVbeta]
DECIPHERPPP3CA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPP3CA 
Mutations
ICGC Data PortalPPP3CA 
TCGA Data PortalPPP3CA 
Broad Tumor PortalPPP3CA
OASIS PortalPPP3CA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP3CA  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPPP3CA
Mutations and Diseases : HGMDPPP3CA
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPPP3CA
DgiDB (Drug Gene Interaction Database)PPP3CA
DoCM (Curated mutations)PPP3CA
CIViC (Clinical Interpretations of Variants in Cancer)PPP3CA
Cancer3DPPP3CA
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM114105    617711    618265   
Orphanet
DisGeNETPPP3CA
MedgenPPP3CA
Genetic Testing Registry PPP3CA
NextProtQ08209 [Medical]
GENETestsPPP3CA
Target ValidationPPP3CA
Huge Navigator PPP3CA [HugePedia]
ClinGenPPP3CA
Clinical trials, drugs, therapy
MyCancerGenomePPP3CA
Protein Interactions : CTDPPP3CA
Pharm GKB GenePA33678
Pharm GKB PathwaysPA165985892   
PharosQ08209
Clinical trialPPP3CA
Miscellaneous
canSAR (ICR)PPP3CA
HarmonizomePPP3CA
DataMed IndexPPP3CA
Probes
Litterature
PubMed181 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPPP3CA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:26:32 CEST 2021

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