Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PPP3CB (protein phosphatase 3 catalytic subunit beta)

Identity

Alias (NCBI)CALNA2
CALNB
CNA2
PP2Bbeta
HGNC (Hugo) PPP3CB
HGNC Alias symbCALNA2
CNA2
PP2Bbeta
HGNC Alias namecalcineurin A beta
 protein phosphatase 2B, catalytic subunit, beta isoform
HGNC Previous nameCALNB
HGNC Previous nameprotein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta)
 protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform
 protein phosphatase 3, catalytic subunit, beta isozyme
LocusID (NCBI) 5532
Atlas_Id 41823
Location 10q22.2  [Link to chromosome band 10q22]
Location_base_pair Starts at 73436433 and ends at 73496024 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PPP3CB (10q22.2) / ODC1 (2p25.1)PPP3CB (10q22.2) / RPLP0 (12q24.23)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PPP3CB   9315
Cards
Entrez_Gene (NCBI)PPP3CB    protein phosphatase 3 catalytic subunit beta
AliasesCALNA2; CALNB; CNA2; PP2Bbeta
GeneCards (Weizmann)PPP3CB
Ensembl hg19 (Hinxton)ENSG00000107758 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000107758 [Gene_View]  ENSG00000107758 [Sequence]  chr10:73436433-73496024 [Contig_View]  PPP3CB [Vega]
ICGC DataPortalENSG00000107758
TCGA cBioPortalPPP3CB
AceView (NCBI)PPP3CB
Genatlas (Paris)PPP3CB
SOURCE (Princeton)PPP3CB
Genetics Home Reference (NIH)PPP3CB
Genomic and cartography
GoldenPath hg38 (UCSC)PPP3CB  -     chr10:73436433-73496024 -  10q22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPP3CB  -     10q22.2   [Description]    (hg19-Feb_2009)
GoldenPathPPP3CB - 10q22.2 [CytoView hg19]  PPP3CB - 10q22.2 [CytoView hg38]
ImmunoBaseENSG00000107758
genome Data Viewer NCBIPPP3CB [Mapview hg19]  
OMIM114106   
Gene and transcription
Genbank (Entrez)AJ488506 AK300701 AK301582 BC028049 BC035464
RefSeq transcript (Entrez)NM_001142353 NM_001142354 NM_001289968 NM_001289969 NM_021132
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPP3CB
Alternative Splicing GalleryENSG00000107758
Gene ExpressionPPP3CB [ NCBI-GEO ]   PPP3CB [ EBI - ARRAY_EXPRESS ]   PPP3CB [ SEEK ]   PPP3CB [ MEM ]
Gene Expression Viewer (FireBrowse)PPP3CB [ Firebrowse - Broad ]
GenevisibleExpression of PPP3CB in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5532
GTEX Portal (Tissue expression)PPP3CB
Human Protein AtlasENSG00000107758-PPP3CB [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP16298   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP16298  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP16298
Splice isoforms : SwissVarP16298
PhosPhoSitePlusP16298
Domaine pattern : Prosite (Expaxy)SER_THR_PHOSPHATASE (PS00125)   
Domains : Interpro (EBI)Calcineurin-like_PHP_ApaH    Metallo-depent_PP-like    MPP_PP2B    Ser/Thr-sp_prot-phosphatase   
Domain families : Pfam (Sanger)Metallophos (PF00149)   
Domain families : Pfam (NCBI)pfam00149   
Domain families : Smart (EMBL)PP2Ac (SM00156)  
Conserved Domain (NCBI)PPP3CB
Blocks (Seattle)PPP3CB
PDB (RSDB)4OR9    4ORA    4ORC   
PDB Europe4OR9    4ORA    4ORC   
PDB (PDBSum)4OR9    4ORA    4ORC   
PDB (IMB)4OR9    4ORA    4ORC   
Structural Biology KnowledgeBase4OR9    4ORA    4ORC   
SCOP (Structural Classification of Proteins)4OR9    4ORA    4ORC   
CATH (Classification of proteins structures)4OR9    4ORA    4ORC   
SuperfamilyP16298
Human Protein Atlas [tissue]ENSG00000107758-PPP3CB [tissue]
Peptide AtlasP16298
HPRD00235
IPIIPI00872930   IPI00218862   IPI01011046   IPI00647432   IPI00027809   IPI00181738   IPI00748557   
Protein Interaction databases
DIP (DOE-UCLA)P16298
IntAct (EBI)P16298
BioGRIDPPP3CB
STRING (EMBL)PPP3CB
ZODIACPPP3CB
Ontologies - Pathways
QuickGOP16298
Ontology : AmiGOnegative regulation of T cell mediated cytotoxicity  lymphangiogenesis  protein serine/threonine phosphatase activity  calcium ion binding  protein binding  calmodulin binding  calmodulin binding  calmodulin binding  nucleoplasm  cytoplasm  cytoplasm  cytosol  plasma membrane  calcineurin complex  calcineurin complex  protein phosphorylation  protein dephosphorylation  protein dephosphorylation  signal transduction  Wnt signaling pathway, calcium modulating pathway  heart development  learning  memory  drug binding  dephosphorylation  calcium ion regulated exocytosis  enzyme binding  Z disc  T cell differentiation  T-tubule  protein phosphatase 2B binding  locomotion involved in locomotory behavior  calcineurin-NFAT signaling cascade  calmodulin-dependent protein phosphatase activity  calmodulin-dependent protein phosphatase activity  calmodulin-dependent protein phosphatase activity  calmodulin-dependent protein phosphatase activity  response to cytokine  cellular response to drug  positive regulation of insulin secretion involved in cellular response to glucose stimulus  Fc-epsilon receptor signaling pathway  T cell proliferation  T cell activation  T cell homeostasis  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  protein dimerization activity  regulation of synaptic plasticity  axon extension  regulation of insulin secretion  calcineurin-mediated signaling  glutamatergic synapse  regulation of synaptic vesicle endocytosis  
Ontology : EGO-EBInegative regulation of T cell mediated cytotoxicity  lymphangiogenesis  protein serine/threonine phosphatase activity  calcium ion binding  protein binding  calmodulin binding  calmodulin binding  calmodulin binding  nucleoplasm  cytoplasm  cytoplasm  cytosol  plasma membrane  calcineurin complex  calcineurin complex  protein phosphorylation  protein dephosphorylation  protein dephosphorylation  signal transduction  Wnt signaling pathway, calcium modulating pathway  heart development  learning  memory  drug binding  dephosphorylation  calcium ion regulated exocytosis  enzyme binding  Z disc  T cell differentiation  T-tubule  protein phosphatase 2B binding  locomotion involved in locomotory behavior  calcineurin-NFAT signaling cascade  calmodulin-dependent protein phosphatase activity  calmodulin-dependent protein phosphatase activity  calmodulin-dependent protein phosphatase activity  calmodulin-dependent protein phosphatase activity  response to cytokine  cellular response to drug  positive regulation of insulin secretion involved in cellular response to glucose stimulus  Fc-epsilon receptor signaling pathway  T cell proliferation  T cell activation  T cell homeostasis  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  protein dimerization activity  regulation of synaptic plasticity  axon extension  regulation of insulin secretion  calcineurin-mediated signaling  glutamatergic synapse  regulation of synaptic vesicle endocytosis  
Pathways : KEGGMAPK signaling pathway    Calcium signaling pathway    Oocyte meiosis    Apoptosis    Wnt signaling pathway    Axon guidance    VEGF signaling pathway    Osteoclast differentiation    Natural killer cell mediated cytotoxicity    T cell receptor signaling pathway    B cell receptor signaling pathway    Long-term potentiation    Glutamatergic synapse    Dopaminergic synapse    Alzheimer's disease    Amyotrophic lateral sclerosis (ALS)    Amphetamine addiction    Tuberculosis    HTLV-I infection   
NDEx NetworkPPP3CB
Atlas of Cancer Signalling NetworkPPP3CB
Wikipedia pathwaysPPP3CB
Orthology - Evolution
OrthoDB5532
GeneTree (enSembl)ENSG00000107758
Phylogenetic Trees/Animal Genes : TreeFamPPP3CB
HOGENOMP16298
Homologs : HomoloGenePPP3CB
Homology/Alignments : Family Browser (UCSC)PPP3CB
Gene fusions - Rearrangements
Fusion : QuiverPPP3CB
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP3CB [hg38]
dbVarPPP3CB
ClinVarPPP3CB
MonarchPPP3CB
1000_GenomesPPP3CB 
Exome Variant ServerPPP3CB
GNOMAD BrowserENSG00000107758
Varsome BrowserPPP3CB
Genomic Variants (DGV)PPP3CB [DGVbeta]
DECIPHERPPP3CB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPP3CB 
Mutations
ICGC Data PortalPPP3CB 
TCGA Data PortalPPP3CB 
Broad Tumor PortalPPP3CB
OASIS PortalPPP3CB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP3CB  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPPP3CB
Mutations and Diseases : HGMDPPP3CB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPP3CB
DgiDB (Drug Gene Interaction Database)PPP3CB
DoCM (Curated mutations)PPP3CB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPP3CB (select a term)
intoGenPPP3CB
Cancer3DPPP3CB(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM114106   
Orphanet
DisGeNETPPP3CB
MedgenPPP3CB
Genetic Testing Registry PPP3CB
NextProtP16298 [Medical]
GENETestsPPP3CB
Target ValidationPPP3CB
Huge Navigator PPP3CB [HugePedia]
ClinGenPPP3CB
Clinical trials, drugs, therapy
MyCancerGenomePPP3CB
Protein Interactions : CTD
Pharm GKB GenePA33679
Pharm GKB PathwaysPA165985892   
PharosP16298
Clinical trialPPP3CB
Miscellaneous
canSAR (ICR)PPP3CB (select the gene name)
HarmonizomePPP3CB
DataMed IndexPPP3CB
Probes
Litterature
PubMed70 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPPP3CB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 1 18:32:40 CET 2021
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