Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PPP3CB (protein phosphatase 3 catalytic subunit beta)

Identity

Alias_namesCALNB
protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta)
protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform
protein phosphatase 3, catalytic subunit, beta isozyme
Alias_symbol (synonym)CALNA2
CNA2
PP2Bbeta
Other alias
HGNC (Hugo) PPP3CB
LocusID (NCBI) 5532
Atlas_Id 41823
Location 10q22.2  [Link to chromosome band 10q22]
Location_base_pair Starts at 73436428 and ends at 73496024 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PPP3CB (10q22.2) / ODC1 (2p25.1)PPP3CB (10q22.2) / RPLP0 (12q24.23)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PPP3CB   9315
Cards
Entrez_Gene (NCBI)PPP3CB  5532  protein phosphatase 3 catalytic subunit beta
AliasesCALNA2; CALNB; CNA2; PP2Bbeta
GeneCards (Weizmann)PPP3CB
Ensembl hg19 (Hinxton)ENSG00000107758 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000107758 [Gene_View]  ENSG00000107758 [Sequence]  chr10:73436428-73496024 [Contig_View]  PPP3CB [Vega]
ICGC DataPortalENSG00000107758
TCGA cBioPortalPPP3CB
AceView (NCBI)PPP3CB
Genatlas (Paris)PPP3CB
WikiGenes5532
SOURCE (Princeton)PPP3CB
Genetics Home Reference (NIH)PPP3CB
Genomic and cartography
GoldenPath hg38 (UCSC)PPP3CB  -     chr10:73436428-73496024 -  10q22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPP3CB  -     10q22.2   [Description]    (hg19-Feb_2009)
EnsemblPPP3CB - 10q22.2 [CytoView hg19]  PPP3CB - 10q22.2 [CytoView hg38]
Mapping of homologs : NCBIPPP3CB [Mapview hg19]  PPP3CB [Mapview hg38]
OMIM114106   
Gene and transcription
Genbank (Entrez)AJ488506 AK300701 AK301582 BC028049 BC035464
RefSeq transcript (Entrez)NM_001142353 NM_001142354 NM_001289968 NM_001289969 NM_021132
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPP3CB
Cluster EST : UnigeneHs.500067 [ NCBI ]
CGAP (NCI)Hs.500067
Alternative Splicing GalleryENSG00000107758
Gene ExpressionPPP3CB [ NCBI-GEO ]   PPP3CB [ EBI - ARRAY_EXPRESS ]   PPP3CB [ SEEK ]   PPP3CB [ MEM ]
Gene Expression Viewer (FireBrowse)PPP3CB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5532
GTEX Portal (Tissue expression)PPP3CB
Human Protein AtlasENSG00000107758-PPP3CB [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP16298   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP16298  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP16298
Splice isoforms : SwissVarP16298
Catalytic activity : Enzyme3.1.3.16 [ Enzyme-Expasy ]   3.1.3.163.1.3.16 [ IntEnz-EBI ]   3.1.3.16 [ BRENDA ]   3.1.3.16 [ KEGG ]   
PhosPhoSitePlusP16298
Domaine pattern : Prosite (Expaxy)SER_THR_PHOSPHATASE (PS00125)   
Domains : Interpro (EBI)Calcineurin-like_PHP_ApaH    Metallo-depent_PP-like    Ser/Thr-sp_prot-phosphatase   
Domain families : Pfam (Sanger)Metallophos (PF00149)   
Domain families : Pfam (NCBI)pfam00149   
Domain families : Smart (EMBL)PP2Ac (SM00156)  
Conserved Domain (NCBI)PPP3CB
DMDM Disease mutations5532
Blocks (Seattle)PPP3CB
PDB (SRS)4OR9    4ORA    4ORC   
PDB (PDBSum)4OR9    4ORA    4ORC   
PDB (IMB)4OR9    4ORA    4ORC   
PDB (RSDB)4OR9    4ORA    4ORC   
Structural Biology KnowledgeBase4OR9    4ORA    4ORC   
SCOP (Structural Classification of Proteins)4OR9    4ORA    4ORC   
CATH (Classification of proteins structures)4OR9    4ORA    4ORC   
SuperfamilyP16298
Human Protein Atlas [tissue]ENSG00000107758-PPP3CB [tissue]
Peptide AtlasP16298
HPRD00235
IPIIPI00872930   IPI00218862   IPI01011046   IPI00647432   IPI00027809   IPI00181738   IPI00748557   
Protein Interaction databases
DIP (DOE-UCLA)P16298
IntAct (EBI)P16298
FunCoupENSG00000107758
BioGRIDPPP3CB
STRING (EMBL)PPP3CB
ZODIACPPP3CB
Ontologies - Pathways
QuickGOP16298
Ontology : AmiGOnegative regulation of T cell mediated cytotoxicity  lymphangiogenesis  protein serine/threonine phosphatase activity  calcium ion binding  protein binding  calmodulin binding  calmodulin binding  nucleoplasm  cytosol  plasma membrane  calcineurin complex  protein phosphorylation  protein dephosphorylation  signal transduction  Wnt signaling pathway, calcium modulating pathway  heart development  learning  memory  drug binding  dephosphorylation  calcium ion regulated exocytosis  enzyme binding  Z disc  T cell differentiation  T-tubule  protein phosphatase 2B binding  locomotion involved in locomotory behavior  calcineurin-NFAT signaling cascade  calmodulin-dependent protein phosphatase activity  calmodulin-dependent protein phosphatase activity  response to cytokine  social behavior  cellular response to drug  positive regulation of insulin secretion involved in cellular response to glucose stimulus  Fc-epsilon receptor signaling pathway  T cell proliferation  T cell activation  T cell homeostasis  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  protein dimerization activity  regulation of synaptic plasticity  axon extension  regulation of insulin secretion  
Ontology : EGO-EBInegative regulation of T cell mediated cytotoxicity  lymphangiogenesis  protein serine/threonine phosphatase activity  calcium ion binding  protein binding  calmodulin binding  calmodulin binding  nucleoplasm  cytosol  plasma membrane  calcineurin complex  protein phosphorylation  protein dephosphorylation  signal transduction  Wnt signaling pathway, calcium modulating pathway  heart development  learning  memory  drug binding  dephosphorylation  calcium ion regulated exocytosis  enzyme binding  Z disc  T cell differentiation  T-tubule  protein phosphatase 2B binding  locomotion involved in locomotory behavior  calcineurin-NFAT signaling cascade  calmodulin-dependent protein phosphatase activity  calmodulin-dependent protein phosphatase activity  response to cytokine  social behavior  cellular response to drug  positive regulation of insulin secretion involved in cellular response to glucose stimulus  Fc-epsilon receptor signaling pathway  T cell proliferation  T cell activation  T cell homeostasis  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  protein dimerization activity  regulation of synaptic plasticity  axon extension  regulation of insulin secretion  
Pathways : BIOCARTAfMLP induced chemokine gene expression in HMC-1 cells [Genes]    Role of MEF2D in T-cell Apoptosis [Genes]    NFAT and Hypertrophy of the heart (Transcription in the broken heart) [Genes]    Endocytotic role of NDK, Phosphins and Dynamin [Genes]    T Cell Receptor Signaling Pathway [Genes]    BCR Signaling Pathway [Genes]    Effects of calcineurin in Keratinocyte Differentiation [Genes]    Regulation of PGC-1a [Genes]    Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK) [Genes]    Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells [Genes]    Fc Epsilon Receptor I Signaling in Mast Cells [Genes]    Signaling Pathway from G-Protein Families [Genes]    Nitric Oxide Signaling Pathway [Genes]   
Pathways : KEGGB cell receptor signaling pathway    VEGF signaling pathway    Long-term potentiation    Wnt signaling pathway    Apoptosis    T cell receptor signaling pathway    Axon guidance    Natural killer cell mediated cytotoxicity    Calcium signaling pathway    MAPK signaling pathway   
NDEx NetworkPPP3CB
Atlas of Cancer Signalling NetworkPPP3CB
Wikipedia pathwaysPPP3CB
Orthology - Evolution
OrthoDB5532
GeneTree (enSembl)ENSG00000107758
Phylogenetic Trees/Animal Genes : TreeFamPPP3CB
HOVERGENP16298
HOGENOMP16298
Homologs : HomoloGenePPP3CB
Homology/Alignments : Family Browser (UCSC)PPP3CB
Gene fusions - Rearrangements
Fusion : QuiverPPP3CB
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP3CB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP3CB
dbVarPPP3CB
ClinVarPPP3CB
1000_GenomesPPP3CB 
Exome Variant ServerPPP3CB
ExAC (Exome Aggregation Consortium)ENSG00000107758
GNOMAD BrowserENSG00000107758
Genetic variants : HAPMAP5532
Genomic Variants (DGV)PPP3CB [DGVbeta]
DECIPHERPPP3CB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPP3CB 
Mutations
ICGC Data PortalPPP3CB 
TCGA Data PortalPPP3CB 
Broad Tumor PortalPPP3CB
OASIS PortalPPP3CB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP3CB  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPP3CB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPP3CB
DgiDB (Drug Gene Interaction Database)PPP3CB
DoCM (Curated mutations)PPP3CB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPP3CB (select a term)
intoGenPPP3CB
Cancer3DPPP3CB(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM114106   
Orphanet
DisGeNETPPP3CB
MedgenPPP3CB
Genetic Testing Registry PPP3CB
NextProtP16298 [Medical]
TSGene5532
GENETestsPPP3CB
Target ValidationPPP3CB
Huge Navigator PPP3CB [HugePedia]
snp3D : Map Gene to Disease5532
BioCentury BCIQPPP3CB
ClinGenPPP3CB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5532
Chemical/Pharm GKB GenePA33679
Clinical trialPPP3CB
Miscellaneous
canSAR (ICR)PPP3CB (select the gene name)
Probes
Litterature
PubMed64 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPP3CB
EVEXPPP3CB
GoPubMedPPP3CB
iHOPPPP3CB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jun 22 16:44:25 CEST 2018
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