Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PPP3CC (protein phosphatase 3 catalytic subunit gamma)

Identity

Alias (NCBI)CALNA3
CNA3
PP2Bgamma
HGNC (Hugo) PPP3CC
HGNC Alias symbCALNA3
PP2Bgamma
HGNC Alias namecalcineurin A gamma
 protein phosphatase 2B, catalytic subunit, gamma isoform
HGNC Previous nameprotein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (calcineurin A gamma)
 protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform
 protein phosphatase 3, catalytic subunit, gamma isozyme
LocusID (NCBI) 5533
Atlas_Id 47268
Location 8p21.3  [Link to chromosome band 8p21]
Location_base_pair Starts at 22440970 and ends at 22541144 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PPP3CC (8p21.3) / DLC1 (8p22)PPP3CC (8p21.3) / PIWIL2 (8p21.3)PPP3CC (8p21.3) / PRKAG2 (7q36.1)
PPP3CC (8p21.3) / PSD3 (8p22)PPP3CC 8p21.3 / PIWIL2 8p21.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  PPP3CC/PIWIL2 (8p21)

External links

Nomenclature
HGNC (Hugo)PPP3CC   9316
Cards
Entrez_Gene (NCBI)PPP3CC    protein phosphatase 3 catalytic subunit gamma
AliasesCALNA3; CNA3; PP2Bgamma
GeneCards (Weizmann)PPP3CC
Ensembl hg19 (Hinxton)ENSG00000120910 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000120910 [Gene_View]  ENSG00000120910 [Sequence]  chr8:22440970-22541144 [Contig_View]  PPP3CC [Vega]
ICGC DataPortalENSG00000120910
TCGA cBioPortalPPP3CC
AceView (NCBI)PPP3CC
Genatlas (Paris)PPP3CC
SOURCE (Princeton)PPP3CC
Genetics Home Reference (NIH)PPP3CC
Genomic and cartography
GoldenPath hg38 (UCSC)PPP3CC  -     chr8:22440970-22541144 +  8p21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPP3CC  -     8p21.3   [Description]    (hg19-Feb_2009)
GoldenPathPPP3CC - 8p21.3 [CytoView hg19]  PPP3CC - 8p21.3 [CytoView hg38]
ImmunoBaseENSG00000120910
genome Data Viewer NCBIPPP3CC [Mapview hg19]  
OMIM114107   
Gene and transcription
Genbank (Entrez)AK055013 AK299415 AY007249 BC004864 DB517138
RefSeq transcript (Entrez)NM_001243974 NM_001243975 NM_005605
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPP3CC
Alternative Splicing GalleryENSG00000120910
Gene ExpressionPPP3CC [ NCBI-GEO ]   PPP3CC [ EBI - ARRAY_EXPRESS ]   PPP3CC [ SEEK ]   PPP3CC [ MEM ]
Gene Expression Viewer (FireBrowse)PPP3CC [ Firebrowse - Broad ]
GenevisibleExpression of PPP3CC in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5533
GTEX Portal (Tissue expression)PPP3CC
Human Protein AtlasENSG00000120910-PPP3CC [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP48454   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP48454  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP48454
Splice isoforms : SwissVarP48454
PhosPhoSitePlusP48454
Domaine pattern : Prosite (Expaxy)SER_THR_PHOSPHATASE (PS00125)   
Domains : Interpro (EBI)Calcineurin-like_PHP_ApaH    Metallo-depent_PP-like    MPP_PP2B    Ser/Thr-sp_prot-phosphatase   
Domain families : Pfam (Sanger)Metallophos (PF00149)   
Domain families : Pfam (NCBI)pfam00149   
Domain families : Smart (EMBL)PP2Ac (SM00156)  
Conserved Domain (NCBI)PPP3CC
Blocks (Seattle)PPP3CC
SuperfamilyP48454
Human Protein Atlas [tissue]ENSG00000120910-PPP3CC [tissue]
Peptide AtlasP48454
HPRD00236
IPIIPI00413731   IPI00305491   IPI00930559   IPI00930518   IPI00975881   IPI00872489   IPI01010201   IPI00976896   IPI00977724   IPI00978786   
Protein Interaction databases
DIP (DOE-UCLA)P48454
IntAct (EBI)P48454
BioGRIDPPP3CC
STRING (EMBL)PPP3CC
ZODIACPPP3CC
Ontologies - Pathways
QuickGOP48454
Ontology : AmiGOprotein binding  calmodulin binding  cytoplasm  cytoplasm  mitochondrion  cytosol  calcineurin complex  protein dephosphorylation  brain development  calcineurin-NFAT signaling cascade  calmodulin-dependent protein phosphatase activity  calmodulin-dependent protein phosphatase activity  metal ion binding  calcineurin-mediated signaling  glutamatergic synapse  presynaptic cytosol  positive regulation of synaptic vesicle endocytosis  positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  
Ontology : EGO-EBIprotein binding  calmodulin binding  cytoplasm  cytoplasm  mitochondrion  cytosol  calcineurin complex  protein dephosphorylation  brain development  calcineurin-NFAT signaling cascade  calmodulin-dependent protein phosphatase activity  calmodulin-dependent protein phosphatase activity  metal ion binding  calcineurin-mediated signaling  glutamatergic synapse  presynaptic cytosol  positive regulation of synaptic vesicle endocytosis  positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  
Pathways : KEGGMAPK signaling pathway    Calcium signaling pathway    Oocyte meiosis    Apoptosis    Wnt signaling pathway    Axon guidance    VEGF signaling pathway    Osteoclast differentiation    Natural killer cell mediated cytotoxicity    T cell receptor signaling pathway    B cell receptor signaling pathway    Long-term potentiation    Glutamatergic synapse    Dopaminergic synapse    Alzheimer's disease    Amyotrophic lateral sclerosis (ALS)    Amphetamine addiction    Tuberculosis    HTLV-I infection   
NDEx NetworkPPP3CC
Atlas of Cancer Signalling NetworkPPP3CC
Wikipedia pathwaysPPP3CC
Orthology - Evolution
OrthoDB5533
GeneTree (enSembl)ENSG00000120910
Phylogenetic Trees/Animal Genes : TreeFamPPP3CC
HOGENOMP48454
Homologs : HomoloGenePPP3CC
Homology/Alignments : Family Browser (UCSC)PPP3CC
Gene fusions - Rearrangements
Fusion : MitelmanPPP3CC/PIWIL2 [8p21.3/8p21.3]  
Fusion PortalPPP3CC 8p21.3 PIWIL2 8p21.3 HNSC
Fusion : QuiverPPP3CC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP3CC [hg38]
dbVarPPP3CC
ClinVarPPP3CC
MonarchPPP3CC
1000_GenomesPPP3CC 
Exome Variant ServerPPP3CC
GNOMAD BrowserENSG00000120910
Varsome BrowserPPP3CC
Genomic Variants (DGV)PPP3CC [DGVbeta]
DECIPHERPPP3CC [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPP3CC 
Mutations
ICGC Data PortalPPP3CC 
TCGA Data PortalPPP3CC 
Broad Tumor PortalPPP3CC
OASIS PortalPPP3CC [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP3CC  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPPP3CC
Mutations and Diseases : HGMDPPP3CC
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPP3CC
DgiDB (Drug Gene Interaction Database)PPP3CC
DoCM (Curated mutations)PPP3CC (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPP3CC (select a term)
intoGenPPP3CC
Cancer3DPPP3CC(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM114107   
Orphanet
DisGeNETPPP3CC
MedgenPPP3CC
Genetic Testing Registry PPP3CC
NextProtP48454 [Medical]
GENETestsPPP3CC
Target ValidationPPP3CC
Huge Navigator PPP3CC [HugePedia]
ClinGenPPP3CC
Clinical trials, drugs, therapy
MyCancerGenomePPP3CC
Protein Interactions : CTD
Pharm GKB GenePA33680
Pharm GKB PathwaysPA165985892   
PharosP48454
Clinical trialPPP3CC
Miscellaneous
canSAR (ICR)PPP3CC (select the gene name)
HarmonizomePPP3CC
DataMed IndexPPP3CC
Probes
Litterature
PubMed52 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPPP3CC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 1 18:32:41 CET 2021
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