PPP3CC (protein phosphatase 3 catalytic subunit gamma)

2007-04-01 Affiliation

Identity

HGNC

PPP3CC

LOCATION

8p21.3

LOCUSID

5533

ALIAS

CALNA3,CNA3,PP2Bgamma

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5533
MIM: 114107
HGNC: 9316
Ensembl: ENSG00000120910

Variants:

dbSNP: 5533
ClinVar: 5533
TCGA: ENSG00000120910
COSMIC: PPP3CC

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000120910	ENST00000240139	P48454
ENSG00000120910	ENST00000289963	P48454
ENSG00000120910	ENST00000397775	P48454
ENSG00000120910	ENST00000518852	G3V111
ENSG00000120910	ENST00000521651	H0YB04
ENSG00000120910	ENST00000522000	H0YB02
ENSG00000120910	ENST00000522034	H0YC26
ENSG00000120910	ENST00000523620	E5RJH4

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
MAPK signaling pathway	KEGG	ko04010
Calcium signaling pathway	KEGG	ko04020
Wnt signaling pathway	KEGG	ko04310
Axon guidance	KEGG	ko04360
VEGF signaling pathway	KEGG	ko04370
Natural killer cell mediated cytotoxicity	KEGG	ko04650
T cell receptor signaling pathway	KEGG	ko04660
B cell receptor signaling pathway	KEGG	ko04662
Long-term potentiation	KEGG	ko04720
Alzheimer's disease	KEGG	ko05010
Amyotrophic lateral sclerosis (ALS)	KEGG	ko05014
MAPK signaling pathway	KEGG	hsa04010
Calcium signaling pathway	KEGG	hsa04020
Wnt signaling pathway	KEGG	hsa04310
Axon guidance	KEGG	hsa04360
VEGF signaling pathway	KEGG	hsa04370
Natural killer cell mediated cytotoxicity	KEGG	hsa04650
T cell receptor signaling pathway	KEGG	hsa04660
B cell receptor signaling pathway	KEGG	hsa04662
Long-term potentiation	KEGG	hsa04720
Alzheimer's disease	KEGG	hsa05010
Amyotrophic lateral sclerosis (ALS)	KEGG	hsa05014
Oocyte meiosis	KEGG	ko04114
Oocyte meiosis	KEGG	hsa04114
Osteoclast differentiation	KEGG	ko04380
Osteoclast differentiation	KEGG	hsa04380
Tuberculosis	KEGG	ko05152
Tuberculosis	KEGG	hsa05152
Glutamatergic synapse	KEGG	ko04724
Glutamatergic synapse	KEGG	hsa04724
HTLV-I infection	KEGG	ko05166
HTLV-I infection	KEGG	hsa05166
Dopaminergic synapse	KEGG	ko04728
Dopaminergic synapse	KEGG	hsa04728
Amphetamine addiction	KEGG	hsa05031
Amphetamine addiction	KEGG	ko05031
Oxytocin signaling pathway	KEGG	hsa04921
Oxytocin signaling pathway	KEGG	ko04921
cGMP-PKG signaling pathway	KEGG	hsa04022
cGMP-PKG signaling pathway	KEGG	ko04022
Glucagon signaling pathway	KEGG	hsa04922
Glucagon signaling pathway	KEGG	ko04922
Renin secretion	KEGG	hsa04924
Renin secretion	KEGG	ko04924
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
Opioid Signalling	REACTOME	R-HSA-111885
DARPP-32 events	REACTOME	R-HSA-180024
Programmed Cell Death	REACTOME	R-HSA-5357801
Apoptosis	REACTOME	R-HSA-109581
Intrinsic Pathway for Apoptosis	REACTOME	R-HSA-109606
Activation of BH3-only proteins	REACTOME	R-HSA-114452
Activation of BAD and translocation to mitochondria	REACTOME	R-HSA-111447
Th1 and Th2 cell differentiation	KEGG	ko04658
Th1 and Th2 cell differentiation	KEGG	hsa04658
Th17 cell differentiation	KEGG	ko04659
Th17 cell differentiation	KEGG	hsa04659

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PMIDs
PA248	NFKB1	Gene	Pathway	associated	23922006
PA296	RELA	Gene	Pathway	associated	23922006
PA31582	NFATC1	Gene	Pathway	associated	23922006
PA31583	NFATC2	Gene	Pathway	associated	23922006
PA31584	NFATC4	Gene	Pathway	associated	23922006
PA31600	NFKB2	Gene	Pathway	associated	23922006
PA34321	REL	Gene	Pathway	associated	23922006
PA34322	RELB	Gene	Pathway	associated	23922006

References

Pubmed ID	Year	Title	Citations
18198266	2008	No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics.	111
12851458	2003	Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit.	66
18715757	2008	Genetic associations with schizophrenia: meta-analyses of 12 candidate genes.	62
20398908	2010	Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients.	32
17339875	2007	More evidence supports the association of PPP3CC with schizophrenia.	22
17339875	2007	More evidence supports the association of PPP3CC with schizophrenia.	22
20379146	2010	Biological pathway-based genome-wide association analysis identified the vasoactive intestinal peptide (VIP) pathway important for obesity.	22
15820226	2005	Decreased hippocampal expression of the susceptibility gene PPP3CC and other calcineurin subunits in schizophrenia.	21
18460741	2008	Protein phosphatase and TRAIL receptor genes as new candidate tumor genes on chromosome 8p in prostate cancer.	18
22360420	2012	Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.	18

Citation

Dessen P

PPP3CC (protein phosphatase 3 catalytic subunit gamma)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47268/ppp3cc