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PPP3CC (protein phosphatase 3 catalytic subunit gamma)

Identity

Alias_namesprotein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (calcineurin A gamma)
protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform
protein phosphatase 3, catalytic subunit, gamma isozyme
Alias_symbol (synonym)CALNA3
PP2Bgamma
Other aliasCNA3
HGNC (Hugo) PPP3CC
LocusID (NCBI) 5533
Atlas_Id 47268
Location 8p21.3  [Link to chromosome band 8p21]
Location_base_pair Starts at 22440970 and ends at 22541144 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PPP3CC (8p21.3) / DLC1 (8p22)PPP3CC (8p21.3) / PIWIL2 (8p21.3)PPP3CC (8p21.3) / PRKAG2 (7q36.1)
PPP3CC (8p21.3) / PSD3 (8p22)PPP3CC 8p21.3 / PIWIL2 8p21.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PPP3CC   9316
Cards
Entrez_Gene (NCBI)PPP3CC  5533  protein phosphatase 3 catalytic subunit gamma
AliasesCALNA3; CNA3; PP2Bgamma
GeneCards (Weizmann)PPP3CC
Ensembl hg19 (Hinxton)ENSG00000120910 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000120910 [Gene_View]  chr8:22440970-22541144 [Contig_View]  PPP3CC [Vega]
ICGC DataPortalENSG00000120910
TCGA cBioPortalPPP3CC
AceView (NCBI)PPP3CC
Genatlas (Paris)PPP3CC
WikiGenes5533
SOURCE (Princeton)PPP3CC
Genetics Home Reference (NIH)PPP3CC
Genomic and cartography
GoldenPath hg38 (UCSC)PPP3CC  -     chr8:22440970-22541144 +  8p21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPP3CC  -     8p21.3   [Description]    (hg19-Feb_2009)
EnsemblPPP3CC - 8p21.3 [CytoView hg19]  PPP3CC - 8p21.3 [CytoView hg38]
Mapping of homologs : NCBIPPP3CC [Mapview hg19]  PPP3CC [Mapview hg38]
OMIM114107   
Gene and transcription
Genbank (Entrez)AK055013 AK299415 AY007249 BC004864 DB517138
RefSeq transcript (Entrez)NM_001243974 NM_001243975 NM_005605
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPP3CC
Cluster EST : UnigeneHs.731683 [ NCBI ]
CGAP (NCI)Hs.731683
Alternative Splicing GalleryENSG00000120910
Gene ExpressionPPP3CC [ NCBI-GEO ]   PPP3CC [ EBI - ARRAY_EXPRESS ]   PPP3CC [ SEEK ]   PPP3CC [ MEM ]
Gene Expression Viewer (FireBrowse)PPP3CC [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5533
GTEX Portal (Tissue expression)PPP3CC
Protein : pattern, domain, 3D structure
UniProt/SwissProtP48454   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP48454  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP48454
Splice isoforms : SwissVarP48454
Catalytic activity : Enzyme3.1.3.16 [ Enzyme-Expasy ]   3.1.3.163.1.3.16 [ IntEnz-EBI ]   3.1.3.16 [ BRENDA ]   3.1.3.16 [ KEGG ]   
PhosPhoSitePlusP48454
Domaine pattern : Prosite (Expaxy)SER_THR_PHOSPHATASE (PS00125)   
Domains : Interpro (EBI)Calcineurin-like_PHP_ApaH    Metallo-depent_PP-like    Ser/Thr-sp_prot-phosphatase   
Domain families : Pfam (Sanger)Metallophos (PF00149)   
Domain families : Pfam (NCBI)pfam00149   
Domain families : Smart (EMBL)PP2Ac (SM00156)  
Conserved Domain (NCBI)PPP3CC
DMDM Disease mutations5533
Blocks (Seattle)PPP3CC
SuperfamilyP48454
Human Protein AtlasENSG00000120910
Peptide AtlasP48454
HPRD00236
IPIIPI00413731   IPI00305491   IPI00930559   IPI00930518   IPI00975881   IPI00872489   IPI01010201   IPI00976896   IPI00977724   IPI00978786   
Protein Interaction databases
DIP (DOE-UCLA)P48454
IntAct (EBI)P48454
FunCoupENSG00000120910
BioGRIDPPP3CC
STRING (EMBL)PPP3CC
ZODIACPPP3CC
Ontologies - Pathways
QuickGOP48454
Ontology : AmiGOphosphoprotein phosphatase activity  protein binding  calmodulin binding  mitochondrion  cytosol  protein dephosphorylation  brain development  metal ion binding  extracellular exosome  positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  
Ontology : EGO-EBIphosphoprotein phosphatase activity  protein binding  calmodulin binding  mitochondrion  cytosol  protein dephosphorylation  brain development  metal ion binding  extracellular exosome  positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  
Pathways : BIOCARTA [Genes]   
Pathways : KEGG   
NDEx NetworkPPP3CC
Atlas of Cancer Signalling NetworkPPP3CC
Wikipedia pathwaysPPP3CC
Orthology - Evolution
OrthoDB5533
GeneTree (enSembl)ENSG00000120910
Phylogenetic Trees/Animal Genes : TreeFamPPP3CC
HOVERGENP48454
HOGENOMP48454
Homologs : HomoloGenePPP3CC
Homology/Alignments : Family Browser (UCSC)PPP3CC
Gene fusions - Rearrangements
Fusion : MitelmanPPP3CC/PIWIL2 [8p21.3/8p21.3]  
Fusion: TCGAPPP3CC 8p21.3 PIWIL2 8p21.3 HNSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP3CC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP3CC
dbVarPPP3CC
ClinVarPPP3CC
1000_GenomesPPP3CC 
Exome Variant ServerPPP3CC
ExAC (Exome Aggregation Consortium)PPP3CC (select the gene name)
Genetic variants : HAPMAP5533
Genomic Variants (DGV)PPP3CC [DGVbeta]
DECIPHERPPP3CC [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPP3CC 
Mutations
ICGC Data PortalPPP3CC 
TCGA Data PortalPPP3CC 
Broad Tumor PortalPPP3CC
OASIS PortalPPP3CC [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP3CC  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPP3CC
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPP3CC
DgiDB (Drug Gene Interaction Database)PPP3CC
DoCM (Curated mutations)PPP3CC (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPP3CC (select a term)
intoGenPPP3CC
Cancer3DPPP3CC(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM114107   
Orphanet
MedgenPPP3CC
Genetic Testing Registry PPP3CC
NextProtP48454 [Medical]
TSGene5533
GENETestsPPP3CC
Target ValidationPPP3CC
Huge Navigator PPP3CC [HugePedia]
snp3D : Map Gene to Disease5533
BioCentury BCIQPPP3CC
ClinGenPPP3CC
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5533
Chemical/Pharm GKB GenePA33680
Clinical trialPPP3CC
Miscellaneous
canSAR (ICR)PPP3CC (select the gene name)
Probes
Litterature
PubMed44 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPP3CC
EVEXPPP3CC
GoPubMedPPP3CC
iHOPPPP3CC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:50:46 CEST 2017

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