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PPP3R1 (protein phosphatase 3 regulatory subunit B, alpha)

Identity

Alias (NCBI)CALNB1
CNB
CNB1
HGNC (Hugo) PPP3R1
HGNC Alias symbCALNB1
CNB
CNB1
HGNC Alias namecalcineurin B, type I (19kDa)
 protein phosphatase 2B regulatory subunit B alpha
HGNC Previous nameprotein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I)
 protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I)
 protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform
 protein phosphatase 3, regulatory subunit B, alpha
LocusID (NCBI) 5534
Atlas_Id 46614
Location 2p14  [Link to chromosome band 2p14]
Location_base_pair Starts at 68178857 and ends at 68252532 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AKT1 (14q32.33) / PPP3R1 (2p14)MORC3 (21q22.12) / PPP3R1 (2p14)PPP3R1 (2p14) / CNRIP1 (2p14)
PPP3R1 (2p14) / SPATS2L (2q33.1)PPP3R1 (2p14) / TTC27 (2p22.3)PPP3R1 (2p14) / WDPCP (2p15)
STAT1 (2q32.2) / PPP3R1 (2p14)PPP3R1 2p14 / CNRIP1 2p14PPP3R1 2p14 / SPATS2L 2q33.1
PPP3R1 2p14 / TTC27 2p22.3PPP3R1 2p14 / WDPCP 2p15

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PPP3R1   9317
Cards
Entrez_Gene (NCBI)PPP3R1    protein phosphatase 3 regulatory subunit B, alpha
AliasesCALNB1; CNB; CNB1
GeneCards (Weizmann)PPP3R1
Ensembl hg19 (Hinxton)ENSG00000221823 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000221823 [Gene_View]  ENSG00000221823 [Sequence]  chr2:68178857-68252532 [Contig_View]  PPP3R1 [Vega]
ICGC DataPortalENSG00000221823
TCGA cBioPortalPPP3R1
AceView (NCBI)PPP3R1
Genatlas (Paris)PPP3R1
SOURCE (Princeton)PPP3R1
Genetics Home Reference (NIH)PPP3R1
Genomic and cartography
GoldenPath hg38 (UCSC)PPP3R1  -     chr2:68178857-68252532 -  2p14   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPP3R1  -     2p14   [Description]    (hg19-Feb_2009)
GoldenPathPPP3R1 - 2p14 [CytoView hg19]  PPP3R1 - 2p14 [CytoView hg38]
ImmunoBaseENSG00000221823
Genome Data Viewer NCBIPPP3R1 [Mapview hg19]  
OMIM601302   
Gene and transcription
Genbank (Entrez)AK307136 AK314893 BC027913 BM468705 BQ228635
RefSeq transcript (Entrez)NM_000945
Consensus coding sequences : CCDS (NCBI)PPP3R1
Gene ExpressionPPP3R1 [ NCBI-GEO ]   PPP3R1 [ EBI - ARRAY_EXPRESS ]   PPP3R1 [ SEEK ]   PPP3R1 [ MEM ]
Gene Expression Viewer (FireBrowse)PPP3R1 [ Firebrowse - Broad ]
GenevisibleExpression of PPP3R1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5534
GTEX Portal (Tissue expression)PPP3R1
Human Protein AtlasENSG00000221823-PPP3R1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP63098   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP63098  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP63098
PhosPhoSitePlusP63098
Domaine pattern : Prosite (Expaxy)EF_HAND_1 (PS00018)    EF_HAND_2 (PS50222)   
Domains : Interpro (EBI)Calcineur_B    EF-hand-dom_pair    EF_Hand_1_Ca_BS    EF_hand_dom   
Domain families : Pfam (Sanger)EF-hand_7 (PF13499)   
Domain families : Pfam (NCBI)pfam13499   
Domain families : Smart (EMBL)EFh (SM00054)  
Conserved Domain (NCBI)PPP3R1
PDB (RSDB)1AUI    1M63    1MF8    2P6B    3LL8    4F0Z    4OR9    4ORA    4ORC    5SVE    6NUC    6NUF    6NUU   
PDB Europe1AUI    1M63    1MF8    2P6B    3LL8    4F0Z    4OR9    4ORA    4ORC    5SVE    6NUC    6NUF    6NUU   
PDB (PDBSum)1AUI    1M63    1MF8    2P6B    3LL8    4F0Z    4OR9    4ORA    4ORC    5SVE    6NUC    6NUF    6NUU   
PDB (IMB)1AUI    1M63    1MF8    2P6B    3LL8    4F0Z    4OR9    4ORA    4ORC    5SVE    6NUC    6NUF    6NUU   
Structural Biology KnowledgeBase1AUI    1M63    1MF8    2P6B    3LL8    4F0Z    4OR9    4ORA    4ORC    5SVE    6NUC    6NUF    6NUU   
SCOP (Structural Classification of Proteins)1AUI    1M63    1MF8    2P6B    3LL8    4F0Z    4OR9    4ORA    4ORC    5SVE    6NUC    6NUF    6NUU   
CATH (Classification of proteins structures)1AUI    1M63    1MF8    2P6B    3LL8    4F0Z    4OR9    4ORA    4ORC    5SVE    6NUC    6NUF    6NUU   
SuperfamilyP63098
AlphaFold pdb e-kbP63098   
Human Protein Atlas [tissue]ENSG00000221823-PPP3R1 [tissue]
HPRD03195
Protein Interaction databases
DIP (DOE-UCLA)P63098
IntAct (EBI)P63098
BioGRIDPPP3R1
STRING (EMBL)PPP3R1
ZODIACPPP3R1
Ontologies - Pathways
QuickGOP63098
Ontology : AmiGObranching involved in blood vessel morphogenesis  epithelial to mesenchymal transition  calcium-dependent protein serine/threonine phosphatase activity  calcium ion binding  protein binding  calmodulin binding  nucleoplasm  mitochondrion  cytosol  calcineurin complex  calcineurin complex  protein dephosphorylation  protein import into nucleus  Wnt signaling pathway, calcium modulating pathway  heart development  calcium-dependent protein serine/threonine phosphatase regulator activity  cyclosporin A binding  phosphatase binding  protein domain specific binding  myelination in peripheral nervous system  calcineurin-NFAT signaling cascade  Fc-epsilon receptor signaling pathway  sarcolemma  regulation of phosphoprotein phosphatase activity  positive regulation of transcription by RNA polymerase II  lung epithelial cell differentiation  Schaffer collateral - CA1 synapse  parallel fiber to Purkinje cell synapse  postsynapse  glutamatergic synapse  regulation of postsynaptic neurotransmitter receptor internalization  postsynaptic modulation of chemical synaptic transmission  positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  
Ontology : EGO-EBIbranching involved in blood vessel morphogenesis  epithelial to mesenchymal transition  calcium-dependent protein serine/threonine phosphatase activity  calcium ion binding  protein binding  calmodulin binding  nucleoplasm  mitochondrion  cytosol  calcineurin complex  calcineurin complex  protein dephosphorylation  protein import into nucleus  Wnt signaling pathway, calcium modulating pathway  heart development  calcium-dependent protein serine/threonine phosphatase regulator activity  cyclosporin A binding  phosphatase binding  protein domain specific binding  myelination in peripheral nervous system  calcineurin-NFAT signaling cascade  Fc-epsilon receptor signaling pathway  sarcolemma  regulation of phosphoprotein phosphatase activity  positive regulation of transcription by RNA polymerase II  lung epithelial cell differentiation  Schaffer collateral - CA1 synapse  parallel fiber to Purkinje cell synapse  postsynapse  glutamatergic synapse  regulation of postsynaptic neurotransmitter receptor internalization  postsynaptic modulation of chemical synaptic transmission  positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  
Pathways : KEGGMAPK signaling pathway    Calcium signaling pathway    Oocyte meiosis    Apoptosis    Wnt signaling pathway    Axon guidance    VEGF signaling pathway    Osteoclast differentiation    Natural killer cell mediated cytotoxicity    T cell receptor signaling pathway    B cell receptor signaling pathway    Long-term potentiation    Glutamatergic synapse    Alzheimer's disease    Amyotrophic lateral sclerosis (ALS)    Amphetamine addiction    Tuberculosis    HTLV-I infection   
NDEx NetworkPPP3R1
Atlas of Cancer Signalling NetworkPPP3R1
Wikipedia pathwaysPPP3R1
Orthology - Evolution
OrthoDB5534
GeneTree (enSembl)ENSG00000221823
Phylogenetic Trees/Animal Genes : TreeFamPPP3R1
Homologs : HomoloGenePPP3R1
Homology/Alignments : Family Browser (UCSC)PPP3R1
Gene fusions - Rearrangements
Fusion : MitelmanPPP3R1/SPATS2L [2p14/2q33.1]  
Fusion : MitelmanPPP3R1/TTC27 [2p14/2p22.3]  
Fusion : QuiverPPP3R1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP3R1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP3R1
dbVarPPP3R1
ClinVarPPP3R1
MonarchPPP3R1
1000_GenomesPPP3R1 
Exome Variant ServerPPP3R1
GNOMAD BrowserENSG00000221823
Varsome BrowserPPP3R1
ACMGPPP3R1 variants
VarityP63098
Genomic Variants (DGV)PPP3R1 [DGVbeta]
DECIPHERPPP3R1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPP3R1 
Mutations
ICGC Data PortalPPP3R1 
TCGA Data PortalPPP3R1 
Broad Tumor PortalPPP3R1
OASIS PortalPPP3R1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP3R1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPPP3R1
Mutations and Diseases : HGMDPPP3R1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPPP3R1
DgiDB (Drug Gene Interaction Database)PPP3R1
DoCM (Curated mutations)PPP3R1
CIViC (Clinical Interpretations of Variants in Cancer)PPP3R1
Cancer3DPPP3R1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601302   
Orphanet
DisGeNETPPP3R1
MedgenPPP3R1
Genetic Testing Registry PPP3R1
NextProtP63098 [Medical]
GENETestsPPP3R1
Target ValidationPPP3R1
Huge Navigator PPP3R1 [HugePedia]
ClinGenPPP3R1
Clinical trials, drugs, therapy
MyCancerGenomePPP3R1
Protein Interactions : CTDPPP3R1
Pharm GKB GenePA33681
Pharm GKB PathwaysPA165985892   
PharosP63098
Clinical trialPPP3R1
Miscellaneous
canSAR (ICR)PPP3R1
HarmonizomePPP3R1
DataMed IndexPPP3R1
Probes
Litterature
PubMed90 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPPP3R1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:26:33 CEST 2021

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