PPP3R2 (protein phosphatase 3 regulatory subunit B, beta)

2007-04-01  

Identity

HGNC
LOCATION
9q31.1
LOCUSID
ALIAS
PPP3RL

Other Information

Locus ID:

NCBI: 5535
MIM: 613821
HGNC: 9318
Ensembl: ENSG00000188386

Variants:

dbSNP: 5535
ClinVar: 5535
TCGA: ENSG00000188386
COSMIC: PPP3R2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000188386ENST00000374806Q96LZ3
ENSG00000188386ENST00000636434A0A1B0GUC7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Calcium signaling pathwayKEGGko04020
Wnt signaling pathwayKEGGko04310
Axon guidanceKEGGko04360
VEGF signaling pathwayKEGGko04370
Natural killer cell mediated cytotoxicityKEGGko04650
T cell receptor signaling pathwayKEGGko04660
B cell receptor signaling pathwayKEGGko04662
Long-term potentiationKEGGko04720
Alzheimer's diseaseKEGGko05010
Amyotrophic lateral sclerosis (ALS)KEGGko05014
MAPK signaling pathwayKEGGhsa04010
Calcium signaling pathwayKEGGhsa04020
Wnt signaling pathwayKEGGhsa04310
Axon guidanceKEGGhsa04360
VEGF signaling pathwayKEGGhsa04370
Natural killer cell mediated cytotoxicityKEGGhsa04650
T cell receptor signaling pathwayKEGGhsa04660
B cell receptor signaling pathwayKEGGhsa04662
Long-term potentiationKEGGhsa04720
Alzheimer's diseaseKEGGhsa05010
Amyotrophic lateral sclerosis (ALS)KEGGhsa05014
Oocyte meiosisKEGGko04114
Oocyte meiosisKEGGhsa04114
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Amphetamine addictionKEGGhsa05031
Amphetamine addictionKEGGko05031
Oxytocin signaling pathwayKEGGhsa04921
Oxytocin signaling pathwayKEGGko04921
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
Glucagon signaling pathwayKEGGhsa04922
Glucagon signaling pathwayKEGGko04922
Renin secretionKEGGhsa04924
Renin secretionKEGGko04924
Th1 and Th2 cell differentiationKEGGko04658
Th1 and Th2 cell differentiationKEGGhsa04658
Th17 cell differentiationKEGGko04659
Th17 cell differentiationKEGGhsa04659

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA248NFKB1GenePathwayassociated23922006
PA296RELAGenePathwayassociated23922006
PA31582NFATC1GenePathwayassociated23922006
PA31583NFATC2GenePathwayassociated23922006
PA31584NFATC4GenePathwayassociated23922006
PA31600NFKB2GenePathwayassociated23922006
PA34321RELGenePathwayassociated23922006
PA34322RELBGenePathwayassociated23922006

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
191561682009Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.46
176845442007Systematic association mapping identifies NELL1 as a novel IBD disease gene.38
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
158652092005Characterization of a human regulatory subunit of protein phosphatase 3 gene (PPP3RL) expressed specifically in testis.7
173249362007Calcineurin potentiates the activation of procaspase-3 by accelerating its proteolytic maturation.7
175312002007A new calcineurin inhibition domain in Cabin1.4
201078312010Are calcineurin genes associated with endurance phenotype traits?2
201078312010Are calcineurin genes associated with endurance phenotype traits?2
205932912010Polymorphisms in the calcineurin genes are associated with the training responsiveness of cardiac phenotypes in Chinese young adults.2

Citation

Dessen P

PPP3R2 (protein phosphatase 3 regulatory subunit B, beta)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47133/ppp3r2