PPP4C (protein phosphatase 4 catalytic subunit)

2003-11-01  

Identity

HGNC
LOCATION
16p11.2
LOCUSID
ALIAS
PP-X,PP4,PP4C,PPH3,PPP4,PPX

Other Information

Locus ID:

NCBI: 5531
MIM: 602035
HGNC: 9319
Ensembl: ENSG00000149923

Variants:

dbSNP: 5531
ClinVar: 5531
TCGA: ENSG00000149923
COSMIC: PPP4C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000149923ENST00000279387P60510
ENSG00000149923ENST00000279387A0A024R625
ENSG00000149923ENST00000561610P60510
ENSG00000149923ENST00000561610A0A024R625
ENSG00000149923ENST00000562222H3BV22
ENSG00000149923ENST00000562664H3BTA2
ENSG00000149923ENST00000563597H3BVE3
ENSG00000149923ENST00000563732H3BPN5
ENSG00000149923ENST00000566749I3L4X0
ENSG00000149923ENST00000627746H3BPN5

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Glucagon signaling pathwayKEGGhsa04922
Glucagon signaling pathwayKEGGko04922
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
Processing of DNA double-strand break endsREACTOMER-HSA-5693607

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
186140452008A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication.100
187584382008PP4 is a gamma H2AX phosphatase required for recovery from the DNA damage checkpoint.94
201547052010A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination.55
224910122012Phosphoproteomic analysis reveals that PP4 dephosphorylates KAP-1 impacting the DNA damage response.46
150731672004Suppression of MEK/ERK signaling pathway enhances cisplatin-induced NF-kappaB activation by protein phosphatase 4-mediated NF-kappaB p65 Thr dephosphorylation.39
183470642008Protein phosphatase 4 catalytic subunit regulates Cdk1 activity and microtubule organization via NDEL1 dephosphorylation.38
187158712008PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4.36
192425452009Association and mutation analyses of 16p11.2 autism candidate genes.35
247114182014Distinct phosphatases antagonize the p53 response in different phases of the cell cycle.33
253203072015Merkel cell polyomavirus small T antigen mediates microtubule destabilization to promote cell motility and migration.30

Citation

Dessen P

PPP4C (protein phosphatase 4 catalytic subunit)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41824/ppp4c