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PPP4C (protein phosphatase 4 catalytic subunit)

Identity

Alias_namescatalytic subunit
Alias_symbol (synonym)PP4
PPX
Other aliasPP-X
PP4C
PPH3
PPP4
HGNC (Hugo) PPP4C
LocusID (NCBI) 5531
Atlas_Id 41824
Location 16p11.2  [Link to chromosome band 16p11]
Location_base_pair Starts at 30087297 and ends at 30096698 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PPP4C   9319
Cards
Entrez_Gene (NCBI)PPP4C  5531  protein phosphatase 4 catalytic subunit
AliasesPP-X; PP4; PP4C; PPH3; 
PPP4; PPX
GeneCards (Weizmann)PPP4C
Ensembl hg19 (Hinxton)ENSG00000149923 [Gene_View]  chr16:30087297-30096698 [Contig_View]  PPP4C [Vega]
Ensembl hg38 (Hinxton)ENSG00000149923 [Gene_View]  chr16:30087297-30096698 [Contig_View]  PPP4C [Vega]
ICGC DataPortalENSG00000149923
TCGA cBioPortalPPP4C
AceView (NCBI)PPP4C
Genatlas (Paris)PPP4C
WikiGenes5531
SOURCE (Princeton)PPP4C
Genetics Home Reference (NIH)PPP4C
Genomic and cartography
GoldenPath hg19 (UCSC)PPP4C  -     chr16:30087297-30096698 +  16p11.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PPP4C  -     16p11.2   [Description]    (hg38-Dec_2013)
EnsemblPPP4C - 16p11.2 [CytoView hg19]  PPP4C - 16p11.2 [CytoView hg38]
Mapping of homologs : NCBIPPP4C [Mapview hg19]  PPP4C [Mapview hg38]
OMIM602035   
Gene and transcription
Genbank (Entrez)AA765831 AF097996 AL519181 BC001416 BG705710
RefSeq transcript (Entrez)NM_001303503 NM_001303504 NM_001303506 NM_001303507 NM_002720
RefSeq genomic (Entrez)NC_000016 NC_018927 NT_187260 NW_004929400
Consensus coding sequences : CCDS (NCBI)PPP4C
Cluster EST : UnigeneHs.534338 [ NCBI ]
CGAP (NCI)Hs.534338
Alternative Splicing GalleryENSG00000149923
Gene ExpressionPPP4C [ NCBI-GEO ]   PPP4C [ EBI - ARRAY_EXPRESS ]   PPP4C [ SEEK ]   PPP4C [ MEM ]
Gene Expression Viewer (FireBrowse)PPP4C [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5531
GTEX Portal (Tissue expression)PPP4C
Protein : pattern, domain, 3D structure
UniProt/SwissProtP60510   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP60510  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP60510
Splice isoforms : SwissVarP60510
Catalytic activity : Enzyme3.1.3.16 [ Enzyme-Expasy ]   3.1.3.163.1.3.16 [ IntEnz-EBI ]   3.1.3.16 [ BRENDA ]   3.1.3.16 [ KEGG ]   
PhosPhoSitePlusP60510
Domaine pattern : Prosite (Expaxy)SER_THR_PHOSPHATASE (PS00125)   
Domains : Interpro (EBI)Calcineurin-like_PHP_apaH    Metallo-depent_PP-like    Ser/Thr-sp_prot-phosphatase   
Domain families : Pfam (Sanger)Metallophos (PF00149)   
Domain families : Pfam (NCBI)pfam00149   
Domain families : Smart (EMBL)PP2Ac (SM00156)  
Conserved Domain (NCBI)PPP4C
DMDM Disease mutations5531
Blocks (Seattle)PPP4C
SuperfamilyP60510
Human Protein AtlasENSG00000149923
Peptide AtlasP60510
HPRD03615
IPIIPI00012833   
Protein Interaction databases
DIP (DOE-UCLA)P60510
IntAct (EBI)P60510
FunCoupENSG00000149923
BioGRIDPPP4C
STRING (EMBL)PPP4C
ZODIACPPP4C
Ontologies - Pathways
QuickGOP60510
Ontology : AmiGONF-kappaB-inducing kinase activity  protein serine/threonine phosphatase activity  protein serine/threonine phosphatase activity  protein binding  lamin binding  nucleus  nucleoplasm  cytoplasm  microtubule organizing center  plasma membrane  protein dephosphorylation  protein dephosphorylation  protein dephosphorylation  regulation of double-strand break repair via homologous recombination  protein complex binding  NIK/NF-kappaB signaling  metal ion binding  cellular response to interleukin-1  
Ontology : EGO-EBINF-kappaB-inducing kinase activity  protein serine/threonine phosphatase activity  protein serine/threonine phosphatase activity  protein binding  lamin binding  nucleus  nucleoplasm  cytoplasm  microtubule organizing center  plasma membrane  protein dephosphorylation  protein dephosphorylation  protein dephosphorylation  regulation of double-strand break repair via homologous recombination  protein complex binding  NIK/NF-kappaB signaling  metal ion binding  cellular response to interleukin-1  
NDEx NetworkPPP4C
Atlas of Cancer Signalling NetworkPPP4C
Wikipedia pathwaysPPP4C
Orthology - Evolution
OrthoDB5531
GeneTree (enSembl)ENSG00000149923
Phylogenetic Trees/Animal Genes : TreeFamPPP4C
HOVERGENP60510
HOGENOMP60510
Homologs : HomoloGenePPP4C
Homology/Alignments : Family Browser (UCSC)PPP4C
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP4C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP4C
dbVarPPP4C
ClinVarPPP4C
1000_GenomesPPP4C 
Exome Variant ServerPPP4C
ExAC (Exome Aggregation Consortium)PPP4C (select the gene name)
Genetic variants : HAPMAP5531
Genomic Variants (DGV)PPP4C [DGVbeta]
DECIPHER (Syndromes)16:30087297-30096698  ENSG00000149923
CONAN: Copy Number AnalysisPPP4C 
Mutations
ICGC Data PortalPPP4C 
TCGA Data PortalPPP4C 
Broad Tumor PortalPPP4C
OASIS PortalPPP4C [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP4C  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPP4C
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPP4C
DgiDB (Drug Gene Interaction Database)PPP4C
DoCM (Curated mutations)PPP4C (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPP4C (select a term)
intoGenPPP4C
Cancer3DPPP4C(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602035   
Orphanet
MedgenPPP4C
Genetic Testing Registry PPP4C
NextProtP60510 [Medical]
TSGene5531
GENETestsPPP4C
Huge Navigator PPP4C [HugePedia]
snp3D : Map Gene to Disease5531
BioCentury BCIQPPP4C
ClinGenPPP4C
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5531
Chemical/Pharm GKB GenePA33683
Clinical trialPPP4C
Miscellaneous
canSAR (ICR)PPP4C (select the gene name)
Probes
Litterature
PubMed58 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPP4C
EVEXPPP4C
GoPubMedPPP4C
iHOPPPP4C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:15:25 CEST 2017

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