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PPP4C (protein phosphatase 4 catalytic subunit)

Identity

Alias (NCBI)PP-X
PP4
PP4C
PPH3
PPP4
PPX
HGNC (Hugo) PPP4C
HGNC Alias symbPP4
PPX
HGNC Alias nameprotein phosphatase X, catalytic subunit
HGNC Previous nameprotein phosphatase 4 (formerly X), catalytic subunit
 protein phosphatase 4, catalytic subunit
LocusID (NCBI) 5531
Atlas_Id 41824
Location 16p11.2  [Link to chromosome band 16p11]
Location_base_pair Starts at 30075994 and ends at 30085376 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PPP4C   9319
Cards
Entrez_Gene (NCBI)PPP4C    protein phosphatase 4 catalytic subunit
AliasesPP-X; PP4; PP4C; PPH3; 
PPP4; PPX
GeneCards (Weizmann)PPP4C
Ensembl hg19 (Hinxton)ENSG00000149923 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000149923 [Gene_View]  ENSG00000149923 [Sequence]  chr16:30075994-30085376 [Contig_View]  PPP4C [Vega]
ICGC DataPortalENSG00000149923
TCGA cBioPortalPPP4C
AceView (NCBI)PPP4C
Genatlas (Paris)PPP4C
SOURCE (Princeton)PPP4C
Genetics Home Reference (NIH)PPP4C
Genomic and cartography
GoldenPath hg38 (UCSC)PPP4C  -     chr16:30075994-30085376 +  16p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPP4C  -     16p11.2   [Description]    (hg19-Feb_2009)
GoldenPathPPP4C - 16p11.2 [CytoView hg19]  PPP4C - 16p11.2 [CytoView hg38]
ImmunoBaseENSG00000149923
Genome Data Viewer NCBIPPP4C [Mapview hg19]  
OMIM602035   
Gene and transcription
Genbank (Entrez)AA765831 AF097996 AL519181 BC001416 BG705710
RefSeq transcript (Entrez)NM_001303503 NM_001303504 NM_001303506 NM_001303507 NM_002720
Consensus coding sequences : CCDS (NCBI)PPP4C
Gene ExpressionPPP4C [ NCBI-GEO ]   PPP4C [ EBI - ARRAY_EXPRESS ]   PPP4C [ SEEK ]   PPP4C [ MEM ]
Gene Expression Viewer (FireBrowse)PPP4C [ Firebrowse - Broad ]
GenevisibleExpression of PPP4C in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5531
GTEX Portal (Tissue expression)PPP4C
Human Protein AtlasENSG00000149923-PPP4C [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP60510   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP60510  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP60510
PhosPhoSitePlusP60510
Domaine pattern : Prosite (Expaxy)SER_THR_PHOSPHATASE (PS00125)   
Domains : Interpro (EBI)Calcineurin-like_PHP_ApaH    Metallo-depent_PP-like    Ser/Thr-sp_prot-phosphatase   
Domain families : Pfam (Sanger)Metallophos (PF00149)   
Domain families : Pfam (NCBI)pfam00149   
Domain families : Smart (EMBL)PP2Ac (SM00156)  
Conserved Domain (NCBI)PPP4C
SuperfamilyP60510
AlphaFold pdb e-kbP60510   
Human Protein Atlas [tissue]ENSG00000149923-PPP4C [tissue]
HPRD03615
Protein Interaction databases
DIP (DOE-UCLA)P60510
IntAct (EBI)P60510
BioGRIDPPP4C
STRING (EMBL)PPP4C
ZODIACPPP4C
Ontologies - Pathways
QuickGOP60510
Ontology : AmiGOchromatin  NF-kappaB-inducing kinase activity  protein serine/threonine phosphatase activity  protein serine/threonine phosphatase activity  protein serine/threonine phosphatase activity  protein binding  nucleoplasm  nucleoplasm  microtubule organizing center  cytosol  plasma membrane  regulation of double-strand break repair via homologous recombination  histone dephosphorylation  protein phosphatase 4 complex  negative regulation of histone phosphorylation  NIK/NF-kappaB signaling  metal ion binding  regulation of double-strand break repair  
Ontology : EGO-EBIchromatin  NF-kappaB-inducing kinase activity  protein serine/threonine phosphatase activity  protein serine/threonine phosphatase activity  protein serine/threonine phosphatase activity  protein binding  nucleoplasm  nucleoplasm  microtubule organizing center  cytosol  plasma membrane  regulation of double-strand break repair via homologous recombination  histone dephosphorylation  protein phosphatase 4 complex  negative regulation of histone phosphorylation  NIK/NF-kappaB signaling  metal ion binding  regulation of double-strand break repair  
NDEx NetworkPPP4C
Atlas of Cancer Signalling NetworkPPP4C
Wikipedia pathwaysPPP4C
Orthology - Evolution
OrthoDB5531
GeneTree (enSembl)ENSG00000149923
Phylogenetic Trees/Animal Genes : TreeFamPPP4C
Homologs : HomoloGenePPP4C
Homology/Alignments : Family Browser (UCSC)PPP4C
Gene fusions - Rearrangements
Fusion : QuiverPPP4C
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP4C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP4C
dbVarPPP4C
ClinVarPPP4C
MonarchPPP4C
1000_GenomesPPP4C 
Exome Variant ServerPPP4C
GNOMAD BrowserENSG00000149923
Varsome BrowserPPP4C
ACMGPPP4C variants
VarityP60510
Genomic Variants (DGV)PPP4C [DGVbeta]
DECIPHERPPP4C [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPP4C 
Mutations
ICGC Data PortalPPP4C 
TCGA Data PortalPPP4C 
Broad Tumor PortalPPP4C
OASIS PortalPPP4C [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP4C  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPPP4C
Mutations and Diseases : HGMDPPP4C
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPPP4C
DgiDB (Drug Gene Interaction Database)PPP4C
DoCM (Curated mutations)PPP4C
CIViC (Clinical Interpretations of Variants in Cancer)PPP4C
Cancer3DPPP4C
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602035   
Orphanet
DisGeNETPPP4C
MedgenPPP4C
Genetic Testing Registry PPP4C
NextProtP60510 [Medical]
GENETestsPPP4C
Target ValidationPPP4C
Huge Navigator PPP4C [HugePedia]
ClinGenPPP4C
Clinical trials, drugs, therapy
MyCancerGenomePPP4C
Protein Interactions : CTDPPP4C
Pharm GKB GenePA33683
PharosP60510
Clinical trialPPP4C
Miscellaneous
canSAR (ICR)PPP4C
HarmonizomePPP4C
ARCHS4PPP4C
DataMed IndexPPP4C
Probes
Litterature
PubMed86 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPPP4C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 12:53:34 CET 2022

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