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PPP4R1 (protein phosphatase 4 regulatory subunit 1)

Identity

Alias_namesprotein phosphatase 4
Alias_symbol (synonym)PP4R1
Other aliasMEG1
PP4(Rmeg)
HGNC (Hugo) PPP4R1
LocusID (NCBI) 9989
Atlas_Id 47190
Location 18p11.22  [Link to chromosome band 18p11]
Location_base_pair Starts at 9546789 and ends at 9614605 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
KDM5C (Xp11.22) / PPP4R1 (18p11.22)PPP4R1 (18p11.22) / CCNB3 (Xp11.22)PPP4R1 (18p11.22) / PPP4R1 (18p11.22)
TLR6 (4p14) / PPP4R1 (18p11.22)KDM5C Xp11.22 / PPP4R1 18p11.22PPP4R1 18p11.22 / CCNB3 Xp11.22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PPP4R1   9320
Cards
Entrez_Gene (NCBI)PPP4R1  9989  protein phosphatase 4 regulatory subunit 1
AliasesMEG1; PP4(Rmeg); PP4R1
GeneCards (Weizmann)PPP4R1
Ensembl hg19 (Hinxton)ENSG00000154845 [Gene_View]  chr18:9546789-9614605 [Contig_View]  PPP4R1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000154845 [Gene_View]  chr18:9546789-9614605 [Contig_View]  PPP4R1 [Vega]
ICGC DataPortalENSG00000154845
TCGA cBioPortalPPP4R1
AceView (NCBI)PPP4R1
Genatlas (Paris)PPP4R1
WikiGenes9989
SOURCE (Princeton)PPP4R1
Genetics Home Reference (NIH)PPP4R1
Genomic and cartography
GoldenPath hg19 (UCSC)PPP4R1  -     chr18:9546789-9614605 -  18p11.22   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PPP4R1  -     18p11.22   [Description]    (hg38-Dec_2013)
EnsemblPPP4R1 - 18p11.22 [CytoView hg19]  PPP4R1 - 18p11.22 [CytoView hg38]
Mapping of homologs : NCBIPPP4R1 [Mapview hg19]  PPP4R1 [Mapview hg38]
OMIM604908   
Gene and transcription
Genbank (Entrez)AF100744 AF111106 AF200478 AI621152 AK025509
RefSeq transcript (Entrez)NM_001042388 NM_005134
RefSeq genomic (Entrez)NC_000018 NC_018929 NT_010859 NW_004929409
Consensus coding sequences : CCDS (NCBI)PPP4R1
Cluster EST : UnigeneHs.743236 [ NCBI ]
CGAP (NCI)Hs.743236
Alternative Splicing GalleryENSG00000154845
Gene ExpressionPPP4R1 [ NCBI-GEO ]   PPP4R1 [ EBI - ARRAY_EXPRESS ]   PPP4R1 [ SEEK ]   PPP4R1 [ MEM ]
Gene Expression Viewer (FireBrowse)PPP4R1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9989
GTEX Portal (Tissue expression)PPP4R1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TF05   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TF05  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TF05
Splice isoforms : SwissVarQ8TF05
PhosPhoSitePlusQ8TF05
Domaine pattern : Prosite (Expaxy)HEAT_REPEAT (PS50077)   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    HEAT    HEAT_type_2    PP4R1   
Domain families : Pfam (Sanger)HEAT (PF02985)   
Domain families : Pfam (NCBI)pfam02985   
Conserved Domain (NCBI)PPP4R1
DMDM Disease mutations9989
Blocks (Seattle)PPP4R1
SuperfamilyQ8TF05
Human Protein AtlasENSG00000154845
Peptide AtlasQ8TF05
IPIIPI00411730   IPI00478255   IPI01015964   
Protein Interaction databases
DIP (DOE-UCLA)Q8TF05
IntAct (EBI)Q8TF05
FunCoupENSG00000154845
BioGRIDPPP4R1
STRING (EMBL)PPP4R1
ZODIACPPP4R1
Ontologies - Pathways
QuickGOQ8TF05
Ontology : AmiGOphosphoprotein phosphatase activity  protein binding  protein phosphorylation  protein dephosphorylation  signal transduction  protein phosphatase 4 complex  protein phosphatase type 4 regulator activity  regulation of catalytic activity  
Ontology : EGO-EBIphosphoprotein phosphatase activity  protein binding  protein phosphorylation  protein dephosphorylation  signal transduction  protein phosphatase 4 complex  protein phosphatase type 4 regulator activity  regulation of catalytic activity  
NDEx NetworkPPP4R1
Atlas of Cancer Signalling NetworkPPP4R1
Wikipedia pathwaysPPP4R1
Orthology - Evolution
OrthoDB9989
GeneTree (enSembl)ENSG00000154845
Phylogenetic Trees/Animal Genes : TreeFamPPP4R1
HOVERGENQ8TF05
HOGENOMQ8TF05
Homologs : HomoloGenePPP4R1
Homology/Alignments : Family Browser (UCSC)PPP4R1
Gene fusions - Rearrangements
Fusion : MitelmanKDM5C/PPP4R1 [Xp11.22/18p11.22]  [t(X;18)(p11;p11)]  
Fusion : MitelmanPPP4R1/CCNB3 [18p11.22/Xp11.22]  [t(X;18)(p11;p11)]  
Fusion: TCGAKDM5C Xp11.22 PPP4R1 18p11.22 LUAD
Fusion: TCGAPPP4R1 18p11.22 CCNB3 Xp11.22 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP4R1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP4R1
dbVarPPP4R1
ClinVarPPP4R1
1000_GenomesPPP4R1 
Exome Variant ServerPPP4R1
ExAC (Exome Aggregation Consortium)PPP4R1 (select the gene name)
Genetic variants : HAPMAP9989
Genomic Variants (DGV)PPP4R1 [DGVbeta]
DECIPHER (Syndromes)18:9546789-9614605  ENSG00000154845
CONAN: Copy Number AnalysisPPP4R1 
Mutations
ICGC Data PortalPPP4R1 
TCGA Data PortalPPP4R1 
Broad Tumor PortalPPP4R1
OASIS PortalPPP4R1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP4R1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPP4R1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPP4R1
DgiDB (Drug Gene Interaction Database)PPP4R1
DoCM (Curated mutations)PPP4R1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPP4R1 (select a term)
intoGenPPP4R1
Cancer3DPPP4R1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604908   
Orphanet
MedgenPPP4R1
Genetic Testing Registry PPP4R1
NextProtQ8TF05 [Medical]
TSGene9989
GENETestsPPP4R1
Huge Navigator PPP4R1 [HugePedia]
snp3D : Map Gene to Disease9989
BioCentury BCIQPPP4R1
ClinGenPPP4R1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9989
Chemical/Pharm GKB GenePA33684
Clinical trialPPP4R1
Miscellaneous
canSAR (ICR)PPP4R1 (select the gene name)
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPP4R1
EVEXPPP4R1
GoPubMedPPP4R1
iHOPPPP4R1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:15:25 CEST 2017

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