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PPP4R3A (protein phosphatase 4 regulatory subunit 3A)

Identity

Alias_namesKIAA2010
SMEK1
KIAA2010
SMEK homolog 1, suppressor of mek1 (Dictyostelium)
protein phosphatase 4, regulatory subunit 3A
Alias_symbol (synonym)FLJ20707
MSTP033
FLFL1
smk-1
smk1
PP4R3
Other aliasPP4R3A
HGNC (Hugo) PPP4R3A
LocusID (NCBI) 55671
Atlas_Id 55942
Location 14q32.12  [Link to chromosome band 14q32]
Location_base_pair Starts at 91457481 and ends at 91510480 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CDC42BPB (14q32.32) / PPP4R3A (14q32.12)LOC728012 () / PPP4R3A (14q32.12)PPP4R3A (14q32.12) / FBLN5 (14q32.12)
PPP4R3A (14q32.12) / FBXO34 (14q22.3)PPP4R3A (14q32.12) / HEATR3 (16q12.1)PSMB7 (9q33.3) / PPP4R3A (14q32.12)
SRM (1p36.22) / PPP4R3A (14q32.12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PPP4R3A   20219
Cards
Entrez_Gene (NCBI)PPP4R3A  55671  protein phosphatase 4 regulatory subunit 3A
AliasesFLFL1; KIAA2010; MSTP033; PP4R3; 
PP4R3A; SMEK1; smk-1; smk1
GeneCards (Weizmann)PPP4R3A
Ensembl hg19 (Hinxton)ENSG00000100796 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100796 [Gene_View]  chr14:91457481-91510480 [Contig_View]  PPP4R3A [Vega]
ICGC DataPortalENSG00000100796
TCGA cBioPortalPPP4R3A
AceView (NCBI)PPP4R3A
Genatlas (Paris)PPP4R3A
WikiGenes55671
SOURCE (Princeton)PPP4R3A
Genetics Home Reference (NIH)PPP4R3A
Genomic and cartography
GoldenPath hg38 (UCSC)PPP4R3A  -     chr14:91457481-91510480 -  14q32.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPP4R3A  -     14q32.12   [Description]    (hg19-Feb_2009)
EnsemblPPP4R3A - 14q32.12 [CytoView hg19]  PPP4R3A - 14q32.12 [CytoView hg38]
Mapping of homologs : NCBIPPP4R3A [Mapview hg19]  PPP4R3A [Mapview hg38]
OMIM610351   
Gene and transcription
Genbank (Entrez)AB095930 AF113213 AI608781 AK000714 AK001885
RefSeq transcript (Entrez)NM_001284280 NM_001284281 NM_017936 NM_032560
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPP4R3A
Cluster EST : UnigeneHs.533887 [ NCBI ]
CGAP (NCI)Hs.533887
Alternative Splicing GalleryENSG00000100796
Gene ExpressionPPP4R3A [ NCBI-GEO ]   PPP4R3A [ EBI - ARRAY_EXPRESS ]   PPP4R3A [ SEEK ]   PPP4R3A [ MEM ]
Gene Expression Viewer (FireBrowse)PPP4R3A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55671
GTEX Portal (Tissue expression)PPP4R3A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6IN85   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6IN85  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6IN85
Splice isoforms : SwissVarQ6IN85
PhosPhoSitePlusQ6IN85
Domains : Interpro (EBI)ARM-type_fold    DUF625    PH_dom-like   
Domain families : Pfam (Sanger)SMK-1 (PF04802)   
Domain families : Pfam (NCBI)pfam04802   
Conserved Domain (NCBI)PPP4R3A
DMDM Disease mutations55671
Blocks (Seattle)PPP4R3A
SuperfamilyQ6IN85
Human Protein AtlasENSG00000100796
Peptide AtlasQ6IN85
HPRD11176
IPIIPI00217013   IPI00479778   IPI00384714   IPI00017290   IPI00942526   IPI00384531   IPI01026164   IPI01025804   IPI01025451   IPI01025294   IPI01025404   IPI00793513   
Protein Interaction databases
DIP (DOE-UCLA)Q6IN85
IntAct (EBI)Q6IN85
FunCoupENSG00000100796
BioGRIDPPP4R3A
STRING (EMBL)PPP4R3A
ZODIACPPP4R3A
Ontologies - Pathways
QuickGOQ6IN85
Ontology : AmiGOnucleoplasm  cytoplasm  microtubule organizing center  
Ontology : EGO-EBInucleoplasm  cytoplasm  microtubule organizing center  
NDEx NetworkPPP4R3A
Atlas of Cancer Signalling NetworkPPP4R3A
Wikipedia pathwaysPPP4R3A
Orthology - Evolution
OrthoDB55671
GeneTree (enSembl)ENSG00000100796
Phylogenetic Trees/Animal Genes : TreeFamPPP4R3A
HOVERGENQ6IN85
HOGENOMQ6IN85
Homologs : HomoloGenePPP4R3A
Homology/Alignments : Family Browser (UCSC)PPP4R3A
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP4R3A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP4R3A
dbVarPPP4R3A
ClinVarPPP4R3A
1000_GenomesPPP4R3A 
Exome Variant ServerPPP4R3A
ExAC (Exome Aggregation Consortium)PPP4R3A (select the gene name)
Genetic variants : HAPMAP55671
Genomic Variants (DGV)PPP4R3A [DGVbeta]
DECIPHERPPP4R3A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPP4R3A 
Mutations
ICGC Data PortalPPP4R3A 
TCGA Data PortalPPP4R3A 
Broad Tumor PortalPPP4R3A
OASIS PortalPPP4R3A [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDPPP4R3A
BioMutasearch PPP4R3A
DgiDB (Drug Gene Interaction Database)PPP4R3A
DoCM (Curated mutations)PPP4R3A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPP4R3A (select a term)
intoGenPPP4R3A
Cancer3DPPP4R3A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610351   
Orphanet
MedgenPPP4R3A
Genetic Testing Registry PPP4R3A
NextProtQ6IN85 [Medical]
TSGene55671
GENETestsPPP4R3A
Target ValidationPPP4R3A
Huge Navigator PPP4R3A [HugePedia]
snp3D : Map Gene to Disease55671
BioCentury BCIQPPP4R3A
ClinGenPPP4R3A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55671
Chemical/Pharm GKB GenePA162403940
Clinical trialPPP4R3A
Miscellaneous
canSAR (ICR)PPP4R3A (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPP4R3A
EVEXPPP4R3A
GoPubMedPPP4R3A
iHOPPPP4R3A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:50:48 CEST 2017

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