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PPP4R3B (protein phosphatase 4 regulatory subunit 3B)

Identity

Alias_namesSMEK2
SMEK homolog 2, suppressor of mek1 (Dictyostelium)
protein phosphatase 4, regulatory subunit 3B
Alias_symbol (synonym)PSY2
FLFL2
KIAA1387
FLJ31474
Other aliasPP4R3B
smk1
HGNC (Hugo) PPP4R3B
LocusID (NCBI) 57223
Atlas_Id 77776
Location 2p16.1  [Link to chromosome band 2p16]
Location_base_pair Starts at 55547292 and ends at 55617725 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PPP4R3B (2p16.1) / ALK (2p23.2)PPP4R3B (2p16.1) / AMY2B (1p21.1)PPP4R3B (2p16.1) / CHMP1A (16q24.3)
PPP4R3B (2p16.1) / PSME4 (2p16.2)PPP4R3B (2p16.1) / TAGLN2 (1q23.2)PPP4R3B (2p16.1) / UBC (12q24.31)
TMEM38B (9q31.2) / PPP4R3B (2p16.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PPP4R3B   29267
Cards
Entrez_Gene (NCBI)PPP4R3B  57223  protein phosphatase 4 regulatory subunit 3B
AliasesFLFL2; PP4R3B; PSY2; SMEK2; 
smk1
GeneCards (Weizmann)PPP4R3B
Ensembl hg19 (Hinxton)ENSG00000275052 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000275052 [Gene_View]  chr2:55547292-55617725 [Contig_View]  PPP4R3B [Vega]
ICGC DataPortalENSG00000275052
TCGA cBioPortalPPP4R3B
AceView (NCBI)PPP4R3B
Genatlas (Paris)PPP4R3B
WikiGenes57223
SOURCE (Princeton)PPP4R3B
Genetics Home Reference (NIH)PPP4R3B
Genomic and cartography
GoldenPath hg38 (UCSC)PPP4R3B  -     chr2:55547292-55617725 -  2p16.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPP4R3B  -     2p16.1   [Description]    (hg19-Feb_2009)
EnsemblPPP4R3B - 2p16.1 [CytoView hg19]  PPP4R3B - 2p16.1 [CytoView hg38]
Mapping of homologs : NCBIPPP4R3B [Mapview hg19]  PPP4R3B [Mapview hg38]
OMIM610352   
Gene and transcription
Genbank (Entrez)AB037808 AK023148 AK026437 AK056036 AK056503
RefSeq transcript (Entrez)NM_001122964 NM_001282850 NM_020463
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPP4R3B
Cluster EST : UnigeneHs.654969 [ NCBI ]
CGAP (NCI)Hs.654969
Alternative Splicing GalleryENSG00000275052
Gene ExpressionPPP4R3B [ NCBI-GEO ]   PPP4R3B [ EBI - ARRAY_EXPRESS ]   PPP4R3B [ SEEK ]   PPP4R3B [ MEM ]
Gene Expression Viewer (FireBrowse)PPP4R3B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57223
GTEX Portal (Tissue expression)PPP4R3B
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5MIZ7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5MIZ7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5MIZ7
Splice isoforms : SwissVarQ5MIZ7
PhosPhoSitePlusQ5MIZ7
Domains : Interpro (EBI)ARM-type_fold    DUF625    PH_dom-like   
Domain families : Pfam (Sanger)SMK-1 (PF04802)   
Domain families : Pfam (NCBI)pfam04802   
Conserved Domain (NCBI)PPP4R3B
DMDM Disease mutations57223
Blocks (Seattle)PPP4R3B
SuperfamilyQ5MIZ7
Human Protein AtlasENSG00000275052
Peptide AtlasQ5MIZ7
HPRD13854
IPIIPI00414323   IPI00551045   IPI00746325   IPI00793981   IPI00795848   
Protein Interaction databases
DIP (DOE-UCLA)Q5MIZ7
IntAct (EBI)Q5MIZ7
FunCoupENSG00000275052
BioGRIDPPP4R3B
STRING (EMBL)PPP4R3B
ZODIACPPP4R3B
Ontologies - Pathways
QuickGOQ5MIZ7
Ontology : AmiGOnucleoplasm  cytoplasm  centrosome  protein dephosphorylation  nuclear speck  regulation of lipid metabolic process  protein phosphatase 4 complex  positive regulation of gluconeogenesis  
Ontology : EGO-EBInucleoplasm  cytoplasm  centrosome  protein dephosphorylation  nuclear speck  regulation of lipid metabolic process  protein phosphatase 4 complex  positive regulation of gluconeogenesis  
NDEx NetworkPPP4R3B
Atlas of Cancer Signalling NetworkPPP4R3B
Wikipedia pathwaysPPP4R3B
Orthology - Evolution
OrthoDB57223
GeneTree (enSembl)ENSG00000275052
Phylogenetic Trees/Animal Genes : TreeFamPPP4R3B
HOVERGENQ5MIZ7
HOGENOMQ5MIZ7
Homologs : HomoloGenePPP4R3B
Homology/Alignments : Family Browser (UCSC)PPP4R3B
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP4R3B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP4R3B
dbVarPPP4R3B
ClinVarPPP4R3B
1000_GenomesPPP4R3B 
Exome Variant ServerPPP4R3B
ExAC (Exome Aggregation Consortium)PPP4R3B (select the gene name)
Genetic variants : HAPMAP57223
Genomic Variants (DGV)PPP4R3B [DGVbeta]
DECIPHERPPP4R3B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPP4R3B 
Mutations
ICGC Data PortalPPP4R3B 
TCGA Data PortalPPP4R3B 
Broad Tumor PortalPPP4R3B
OASIS PortalPPP4R3B [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDPPP4R3B
BioMutasearch PPP4R3B
DgiDB (Drug Gene Interaction Database)PPP4R3B
DoCM (Curated mutations)PPP4R3B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPP4R3B (select a term)
intoGenPPP4R3B
Cancer3DPPP4R3B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610352   
Orphanet
MedgenPPP4R3B
Genetic Testing Registry PPP4R3B
NextProtQ5MIZ7 [Medical]
TSGene57223
GENETestsPPP4R3B
Target ValidationPPP4R3B
Huge Navigator PPP4R3B [HugePedia]
snp3D : Map Gene to Disease57223
BioCentury BCIQPPP4R3B
ClinGenPPP4R3B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57223
Chemical/Pharm GKB GenePA162403977
Clinical trialPPP4R3B
Miscellaneous
canSAR (ICR)PPP4R3B (select the gene name)
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPP4R3B
EVEXPPP4R3B
GoPubMedPPP4R3B
iHOPPPP4R3B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:35:08 CEST 2017

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