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PPP4R3B (protein phosphatase 4 regulatory subunit 3B)

Identity

Alias (NCBI)FLFL2
PP4R3B
PSY2
SMEK2
smk1
HGNC (Hugo) PPP4R3B
HGNC Alias symbPSY2
FLFL2
KIAA1387
FLJ31474
HGNC Previous nameSMEK2
HGNC Previous nameSMEK homolog 2, suppressor of mek1 (Dictyostelium)
 protein phosphatase 4, regulatory subunit 3B
LocusID (NCBI) 57223
Atlas_Id 77776
Location 2p16.1  [Link to chromosome band 2p16]
Location_base_pair Starts at 55547292 and ends at 55617622 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PPP4R3B (2p16.1) / ALK (2p23.2)PPP4R3B (2p16.1) / AMY2B (1p21.1)PPP4R3B (2p16.1) / CHMP1A (16q24.3)
PPP4R3B (2p16.1) / PSME4 (2p16.2)PPP4R3B (2p16.1) / TAGLN2 (1q23.2)PPP4R3B (2p16.1) / UBC (12q24.31)
TMEM38B (9q31.2) / PPP4R3B (2p16.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PPP4R3B   29267
Cards
Entrez_Gene (NCBI)PPP4R3B    protein phosphatase 4 regulatory subunit 3B
AliasesFLFL2; PP4R3B; PSY2; SMEK2; 
smk1
GeneCards (Weizmann)PPP4R3B
Ensembl hg19 (Hinxton)ENSG00000275052 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000275052 [Gene_View]  ENSG00000275052 [Sequence]  chr2:55547292-55617622 [Contig_View]  PPP4R3B [Vega]
ICGC DataPortalENSG00000275052
TCGA cBioPortalPPP4R3B
AceView (NCBI)PPP4R3B
Genatlas (Paris)PPP4R3B
SOURCE (Princeton)PPP4R3B
Genetics Home Reference (NIH)PPP4R3B
Genomic and cartography
GoldenPath hg38 (UCSC)PPP4R3B  -     chr2:55547292-55617622 -  2p16.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPP4R3B  -     2p16.1   [Description]    (hg19-Feb_2009)
GoldenPathPPP4R3B - 2p16.1 [CytoView hg19]  PPP4R3B - 2p16.1 [CytoView hg38]
ImmunoBaseENSG00000275052
Genome Data Viewer NCBIPPP4R3B [Mapview hg19]  
OMIM610352   
Gene and transcription
Genbank (Entrez)AB037808 AK023148 AK026437 AK056036 AK056503
RefSeq transcript (Entrez)NM_001122964 NM_001282850 NM_020463
Consensus coding sequences : CCDS (NCBI)PPP4R3B
Gene ExpressionPPP4R3B [ NCBI-GEO ]   PPP4R3B [ EBI - ARRAY_EXPRESS ]   PPP4R3B [ SEEK ]   PPP4R3B [ MEM ]
Gene Expression Viewer (FireBrowse)PPP4R3B [ Firebrowse - Broad ]
GenevisibleExpression of PPP4R3B in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57223
GTEX Portal (Tissue expression)PPP4R3B
Human Protein AtlasENSG00000275052-PPP4R3B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5MIZ7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5MIZ7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5MIZ7
PhosPhoSitePlusQ5MIZ7
Domains : Interpro (EBI)ARM-type_fold    DUF625    PH-like_dom_sf   
Domain families : Pfam (Sanger)SMK-1 (PF04802)   
Domain families : Pfam (NCBI)pfam04802   
Conserved Domain (NCBI)PPP4R3B
SuperfamilyQ5MIZ7
AlphaFold pdb e-kbQ5MIZ7   
Human Protein Atlas [tissue]ENSG00000275052-PPP4R3B [tissue]
HPRD13854
Protein Interaction databases
DIP (DOE-UCLA)Q5MIZ7
IntAct (EBI)Q5MIZ7
BioGRIDPPP4R3B
STRING (EMBL)PPP4R3B
ZODIACPPP4R3B
Ontologies - Pathways
QuickGOQ5MIZ7
Ontology : AmiGOnucleoplasm  cytoplasm  centrosome  protein dephosphorylation  nuclear speck  protein phosphatase 4 complex  positive regulation of gluconeogenesis  
Ontology : EGO-EBInucleoplasm  cytoplasm  centrosome  protein dephosphorylation  nuclear speck  protein phosphatase 4 complex  positive regulation of gluconeogenesis  
NDEx NetworkPPP4R3B
Atlas of Cancer Signalling NetworkPPP4R3B
Wikipedia pathwaysPPP4R3B
Orthology - Evolution
OrthoDB57223
GeneTree (enSembl)ENSG00000275052
Phylogenetic Trees/Animal Genes : TreeFamPPP4R3B
Homologs : HomoloGenePPP4R3B
Homology/Alignments : Family Browser (UCSC)PPP4R3B
Gene fusions - Rearrangements
Fusion : QuiverPPP4R3B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP4R3B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP4R3B
dbVarPPP4R3B
ClinVarPPP4R3B
MonarchPPP4R3B
1000_GenomesPPP4R3B 
Exome Variant ServerPPP4R3B
GNOMAD BrowserENSG00000275052
Varsome BrowserPPP4R3B
ACMGPPP4R3B variants
VarityQ5MIZ7
Genomic Variants (DGV)PPP4R3B [DGVbeta]
DECIPHERPPP4R3B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPP4R3B 
Mutations
ICGC Data PortalPPP4R3B 
TCGA Data PortalPPP4R3B 
Broad Tumor PortalPPP4R3B
OASIS PortalPPP4R3B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP4R3B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPPP4R3B
Mutations and Diseases : HGMDPPP4R3B
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPPP4R3B
DgiDB (Drug Gene Interaction Database)PPP4R3B
DoCM (Curated mutations)PPP4R3B
CIViC (Clinical Interpretations of Variants in Cancer)PPP4R3B
Cancer3DPPP4R3B
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610352   
Orphanet
DisGeNETPPP4R3B
MedgenPPP4R3B
Genetic Testing Registry PPP4R3B
NextProtQ5MIZ7 [Medical]
GENETestsPPP4R3B
Target ValidationPPP4R3B
Huge Navigator PPP4R3B [HugePedia]
ClinGenPPP4R3B
Clinical trials, drugs, therapy
MyCancerGenomePPP4R3B
Protein Interactions : CTDPPP4R3B
Pharm GKB GenePA162403977
PharosQ5MIZ7
Clinical trialPPP4R3B
Miscellaneous
canSAR (ICR)PPP4R3B
HarmonizomePPP4R3B
DataMed IndexPPP4R3B
Probes
Litterature
PubMed37 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPPP4R3B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:17:00 CEST 2021

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