Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

PPP5C (protein phosphatase 5 catalytic subunit)

Identity

Alias_namesPPP5
protein phosphatase 5
Alias_symbol (synonym)PP5
Other aliasPPT
HGNC (Hugo) PPP5C
LocusID (NCBI) 5536
Atlas_Id 41825
Location 19q13.32  [Link to chromosome band 19q13]
Location_base_pair Starts at 46850251 and ends at 46894232 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
PPP5C (19q13.32) / DCP1B (12p13.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PPP5C   9322
Cards
Entrez_Gene (NCBI)PPP5C  5536  protein phosphatase 5 catalytic subunit
AliasesPP5; PPP5; PPT
GeneCards (Weizmann)PPP5C
Ensembl hg19 (Hinxton)ENSG00000011485 [Gene_View]  chr19:46850251-46894232 [Contig_View]  PPP5C [Vega]
Ensembl hg38 (Hinxton)ENSG00000011485 [Gene_View]  chr19:46850251-46894232 [Contig_View]  PPP5C [Vega]
ICGC DataPortalENSG00000011485
TCGA cBioPortalPPP5C
AceView (NCBI)PPP5C
Genatlas (Paris)PPP5C
WikiGenes5536
SOURCE (Princeton)PPP5C
Genetics Home Reference (NIH)PPP5C
Genomic and cartography
GoldenPath hg19 (UCSC)PPP5C  -     chr19:46850251-46894232 +  19q13.32   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PPP5C  -     19q13.32   [Description]    (hg38-Dec_2013)
EnsemblPPP5C - 19q13.32 [CytoView hg19]  PPP5C - 19q13.32 [CytoView hg38]
Mapping of homologs : NCBIPPP5C [Mapview hg19]  PPP5C [Mapview hg38]
OMIM600658   
Gene and transcription
Genbank (Entrez)AB209615 AK094241 AK223222 AK293402 AK293475
RefSeq transcript (Entrez)NM_001204284 NM_006247
RefSeq genomic (Entrez)NC_000019 NC_018930 NG_028163 NT_011109 NW_004929415
Consensus coding sequences : CCDS (NCBI)PPP5C
Cluster EST : UnigeneHs.654604 [ NCBI ]
CGAP (NCI)Hs.654604
Alternative Splicing GalleryENSG00000011485
Gene ExpressionPPP5C [ NCBI-GEO ]   PPP5C [ EBI - ARRAY_EXPRESS ]   PPP5C [ SEEK ]   PPP5C [ MEM ]
Gene Expression Viewer (FireBrowse)PPP5C [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5536
GTEX Portal (Tissue expression)PPP5C
Protein : pattern, domain, 3D structure
UniProt/SwissProtP53041   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP53041  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP53041
Splice isoforms : SwissVarP53041
Catalytic activity : Enzyme3.1.3.16 [ Enzyme-Expasy ]   3.1.3.163.1.3.16 [ IntEnz-EBI ]   3.1.3.16 [ BRENDA ]   3.1.3.16 [ KEGG ]   
PhosPhoSitePlusP53041
Domaine pattern : Prosite (Expaxy)SER_THR_PHOSPHATASE (PS00125)    TPR (PS50005)    TPR_REGION (PS50293)   
Domains : Interpro (EBI)Calcineurin-like_PHP_apaH    Metallo-depent_PP-like    PPP_dom    Ser/Thr-sp_prot-phosphatase    Ser/Thr_PPase_5    TPR-contain_dom    TPR-like_helical_dom    TPR_1    TPR_repeat   
Domain families : Pfam (Sanger)Metallophos (PF00149)    PPP5 (PF08321)    TPR_1 (PF00515)    TPR_11 (PF13414)   
Domain families : Pfam (NCBI)pfam00149    pfam08321    pfam00515    pfam13414   
Domain families : Smart (EMBL)PP2Ac (SM00156)  TPR (SM00028)  
Conserved Domain (NCBI)PPP5C
DMDM Disease mutations5536
Blocks (Seattle)PPP5C
PDB (SRS)1A17    1S95    1WAO    2BUG    3H60    3H61    3H62    3H63    3H64    3H66    3H67    3H68    3H69   
PDB (PDBSum)1A17    1S95    1WAO    2BUG    3H60    3H61    3H62    3H63    3H64    3H66    3H67    3H68    3H69   
PDB (IMB)1A17    1S95    1WAO    2BUG    3H60    3H61    3H62    3H63    3H64    3H66    3H67    3H68    3H69   
PDB (RSDB)1A17    1S95    1WAO    2BUG    3H60    3H61    3H62    3H63    3H64    3H66    3H67    3H68    3H69   
Structural Biology KnowledgeBase1A17    1S95    1WAO    2BUG    3H60    3H61    3H62    3H63    3H64    3H66    3H67    3H68    3H69   
SCOP (Structural Classification of Proteins)1A17    1S95    1WAO    2BUG    3H60    3H61    3H62    3H63    3H64    3H66    3H67    3H68    3H69   
CATH (Classification of proteins structures)1A17    1S95    1WAO    2BUG    3H60    3H61    3H62    3H63    3H64    3H66    3H67    3H68    3H69   
SuperfamilyP53041
Human Protein AtlasENSG00000011485
Peptide AtlasP53041
HPRD02805
IPIIPI00019812   IPI00984299   IPI00556455   IPI01014578   IPI00793942   
Protein Interaction databases
DIP (DOE-UCLA)P53041
IntAct (EBI)P53041
FunCoupENSG00000011485
BioGRIDPPP5C
STRING (EMBL)PPP5C
ZODIACPPP5C
Ontologies - Pathways
QuickGOP53041
Ontology : AmiGOMAPK cascade  negative regulation of protein phosphorylation  G-protein alpha-subunit binding  RNA binding  phosphoprotein phosphatase activity  protein serine/threonine phosphatase activity  signal transducer activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  plasma membrane  DNA repair  transcription, DNA-templated  protein dephosphorylation  mitotic nuclear division  microtubule binding  lipid binding  response to lead ion  histone dephosphorylation  heat shock protein binding  identical protein binding  positive regulation of I-kappaB kinase/NF-kappaB signaling  perikaryon  intracellular membrane-bounded organelle  protein complex  response to morphine  ADP binding  metal ion binding  protein heterooligomerization  cellular response to hydrogen peroxide  cellular response to cadmium ion  negative regulation of neuron death  proximal dendrite  positive regulation of glucocorticoid receptor signaling pathway  
Ontology : EGO-EBIMAPK cascade  negative regulation of protein phosphorylation  G-protein alpha-subunit binding  RNA binding  phosphoprotein phosphatase activity  protein serine/threonine phosphatase activity  signal transducer activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  plasma membrane  DNA repair  transcription, DNA-templated  protein dephosphorylation  mitotic nuclear division  microtubule binding  lipid binding  response to lead ion  histone dephosphorylation  heat shock protein binding  identical protein binding  positive regulation of I-kappaB kinase/NF-kappaB signaling  perikaryon  intracellular membrane-bounded organelle  protein complex  response to morphine  ADP binding  metal ion binding  protein heterooligomerization  cellular response to hydrogen peroxide  cellular response to cadmium ion  negative regulation of neuron death  proximal dendrite  positive regulation of glucocorticoid receptor signaling pathway  
Pathways : KEGGMAPK signaling pathway   
NDEx NetworkPPP5C
Atlas of Cancer Signalling NetworkPPP5C
Wikipedia pathwaysPPP5C
Orthology - Evolution
OrthoDB5536
GeneTree (enSembl)ENSG00000011485
Phylogenetic Trees/Animal Genes : TreeFamPPP5C
HOVERGENP53041
HOGENOMP53041
Homologs : HomoloGenePPP5C
Homology/Alignments : Family Browser (UCSC)PPP5C
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP5C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP5C
dbVarPPP5C
ClinVarPPP5C
1000_GenomesPPP5C 
Exome Variant ServerPPP5C
ExAC (Exome Aggregation Consortium)PPP5C (select the gene name)
Genetic variants : HAPMAP5536
Genomic Variants (DGV)PPP5C [DGVbeta]
DECIPHER (Syndromes)19:46850251-46894232  ENSG00000011485
CONAN: Copy Number AnalysisPPP5C 
Mutations
ICGC Data PortalPPP5C 
TCGA Data PortalPPP5C 
Broad Tumor PortalPPP5C
OASIS PortalPPP5C [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP5C  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPP5C
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPP5C
DgiDB (Drug Gene Interaction Database)PPP5C
DoCM (Curated mutations)PPP5C (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPP5C (select a term)
intoGenPPP5C
Cancer3DPPP5C(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600658   
Orphanet
MedgenPPP5C
Genetic Testing Registry PPP5C
NextProtP53041 [Medical]
TSGene5536
GENETestsPPP5C
Huge Navigator PPP5C [HugePedia]
snp3D : Map Gene to Disease5536
BioCentury BCIQPPP5C
ClinGenPPP5C
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5536
Chemical/Pharm GKB GenePA33686
Clinical trialPPP5C
Miscellaneous
canSAR (ICR)PPP5C (select the gene name)
Probes
Litterature
PubMed80 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPP5C
EVEXPPP5C
GoPubMedPPP5C
iHOPPPP5C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:15:26 CEST 2017

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.