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PPP6R3 (protein phosphatase 6 regulatory subunit 3)

Identity

Alias_namesC11orf23
SAPS3
chromosome 11 open reading frame 23
SAPS domain family, member 3
protein phosphatase 6, regulatory subunit 3
Alias_symbol (synonym)SAPLa
DKFZp781E2374
DKFZp781O2362
DKFZp781E17107
SAP190
SAPL
PP6R3
FLJ11058
FLJ43065
KIAA1558
MGC125711
MGC125712
Other alias
HGNC (Hugo) PPP6R3
LocusID (NCBI) 55291
Atlas_Id 54550
Location 11q13.2  [Link to chromosome band 11q13]
Location_base_pair Starts at 68228186 and ends at 68382801 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CSHL1 (17q23.3) / PPP6R3 (11q13.2)EEF1G (11q12.3) / PPP6R3 (11q13.2)ITGB5 (3q21.2) / PPP6R3 (11q13.2)
KDM2A (11q13.2) / PPP6R3 (11q13.2)KRT5 (12q13.13) / PPP6R3 (11q13.2)MKL2 (16p13.12) / PPP6R3 (11q13.2)
PC (11q13.2) / PPP6R3 (11q13.2)PPP6R3 (11q13.2) / ARHGAP1 (11p11.2)PPP6R3 (11q13.2) / CNTN5 (11q22.1)
PPP6R3 (11q13.2) / DPP3 (11q13.2)PPP6R3 (11q13.2) / FADD (11q13.3)PPP6R3 (11q13.2) / LRP5 (11q13.2)
PPP6R3 (11q13.2) / MTL5 (11q13.3)PPP6R3 (11q13.2) / POLD3 (11q13.4)PPP6R3 (11q13.2) / PREPL (2p21)
PPP6R3 (11q13.2) / SPTBN2 (11q13.2)PPP6R3 (11q13.2) / SSH2 (17q11.2)PPP6R3 (11q13.2) / YAP1 (11q22.1)
RNF121 (11q13.4) / PPP6R3 (11q13.2)SH3RF1 (4q32.3) / PPP6R3 (11q13.2)SMAD2 (18q21.1) / PPP6R3 (11q13.2)
STRN3 (14q12) / PPP6R3 (11q13.2)VPS50 (7q21.3) / PPP6R3 (11q13.2)CCDC132 PPP6R3 11q13.2
KDM2A 11q13.2 / PPP6R3 11q13.2PC 11q13.2 / PPP6R3 11q13.2PPP6R3 11q13.2 / ARHGAP1 11p11.2
PPP6R3 11q13.2 / FADD 11q13.3PPP6R3 11q13.2 / LRP5 11q13.2PPP6R3 11q13.2 / MTL5 11q13.3
PPP6R3 11q13.2 / POLD3 11q13.4PPP6R3 11q13.2 / SPTBN2 11q13.2PPP6R3 11q13.2 / SSH2 17q11.2
PPP6R3 11q13.2 / YAP1 11q22.1RNF121 11q13.4 / PPP6R3 11q13.2STRN3 14q12 / PPP6R3 11q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)PPP6R3   1173
Cards
Entrez_Gene (NCBI)PPP6R3  55291  protein phosphatase 6 regulatory subunit 3
AliasesC11orf23; PP6R3; SAP190; SAPL; 
SAPLa; SAPS3
GeneCards (Weizmann)PPP6R3
Ensembl hg19 (Hinxton)ENSG00000110075 [Gene_View]  chr11:68228186-68382801 [Contig_View]  PPP6R3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000110075 [Gene_View]  chr11:68228186-68382801 [Contig_View]  PPP6R3 [Vega]
ICGC DataPortalENSG00000110075
TCGA cBioPortalPPP6R3
AceView (NCBI)PPP6R3
Genatlas (Paris)PPP6R3
WikiGenes55291
SOURCE (Princeton)PPP6R3
Genetics Home Reference (NIH)PPP6R3
Genomic and cartography
GoldenPath hg19 (UCSC)PPP6R3  -     chr11:68228186-68382801 +  11q13.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PPP6R3  -     11q13.2   [Description]    (hg38-Dec_2013)
EnsemblPPP6R3 - 11q13.2 [CytoView hg19]  PPP6R3 - 11q13.2 [CytoView hg38]
Mapping of homologs : NCBIPPP6R3 [Mapview hg19]  PPP6R3 [Mapview hg38]
OMIM610879   
Gene and transcription
Genbank (Entrez)AB046778 AF264779 AF264780 AK001920 AK023950
RefSeq transcript (Entrez)NM_001164160 NM_001164161 NM_001164162 NM_001164163 NM_001164164 NM_018312
RefSeq genomic (Entrez)NC_000011 NC_018922 NT_167190 NW_004929380
Consensus coding sequences : CCDS (NCBI)PPP6R3
Cluster EST : UnigeneHs.503022 [ NCBI ]
CGAP (NCI)Hs.503022
Alternative Splicing GalleryENSG00000110075
Gene ExpressionPPP6R3 [ NCBI-GEO ]   PPP6R3 [ EBI - ARRAY_EXPRESS ]   PPP6R3 [ SEEK ]   PPP6R3 [ MEM ]
Gene Expression Viewer (FireBrowse)PPP6R3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55291
GTEX Portal (Tissue expression)PPP6R3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5H9R7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5H9R7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5H9R7
Splice isoforms : SwissVarQ5H9R7
PhosPhoSitePlusQ5H9R7
Domains : Interpro (EBI)ARM-type_fold    SAPS   
Domain families : Pfam (Sanger)SAPS (PF04499)   
Domain families : Pfam (NCBI)pfam04499   
Conserved Domain (NCBI)PPP6R3
DMDM Disease mutations55291
Blocks (Seattle)PPP6R3
SuperfamilyQ5H9R7
Human Protein AtlasENSG00000110075
Peptide AtlasQ5H9R7
HPRD10703
IPIIPI00719821   IPI00719553   IPI00719345   IPI00019540   IPI00719725   IPI00030624   IPI00909546   IPI00975695   IPI01015850   IPI00985268   IPI00976160   IPI00984704   IPI00985128   IPI00983215   IPI00977455   IPI00983893   IPI00983242   IPI00976813   IPI00985067   
Protein Interaction databases
DIP (DOE-UCLA)Q5H9R7
IntAct (EBI)Q5H9R7
FunCoupENSG00000110075
BioGRIDPPP6R3
STRING (EMBL)PPP6R3
ZODIACPPP6R3
Ontologies - Pathways
QuickGOQ5H9R7
Ontology : AmiGOGolgi membrane  protein binding  nucleoplasm  cytoplasm  cytosol  plasma membrane  protein phosphatase binding  regulation of phosphoprotein phosphatase activity  COPII vesicle coating  
Ontology : EGO-EBIGolgi membrane  protein binding  nucleoplasm  cytoplasm  cytosol  plasma membrane  protein phosphatase binding  regulation of phosphoprotein phosphatase activity  COPII vesicle coating  
NDEx NetworkPPP6R3
Atlas of Cancer Signalling NetworkPPP6R3
Wikipedia pathwaysPPP6R3
Orthology - Evolution
OrthoDB55291
GeneTree (enSembl)ENSG00000110075
Phylogenetic Trees/Animal Genes : TreeFamPPP6R3
HOVERGENQ5H9R7
HOGENOMQ5H9R7
Homologs : HomoloGenePPP6R3
Homology/Alignments : Family Browser (UCSC)PPP6R3
Gene fusions - Rearrangements
Fusion : MitelmanCCDC132/11q13.2 [PPP6R3/t(7;11)(q21;q13)]  
Fusion : MitelmanEEF1G/PPP6R3 [11q12.3/11q13.2]  [t(11;11)(q12;q13)]  
Fusion : MitelmanKDM2A/PPP6R3 [11q13.2/11q13.2]  [t(11;11)(q13;q13)]  
Fusion : MitelmanPC/PPP6R3 [11q13.2/11q13.2]  [t(11;11)(q13;q13)]  
Fusion : MitelmanPPP6R3/ARHGAP1 [11q13.2/11p11.2]  [t(11;11)(p11;q13)]  
Fusion : MitelmanPPP6R3/CNTN5 [11q13.2/11q22.1]  [t(11;11)(q13;q22)]  
Fusion : MitelmanPPP6R3/FADD [11q13.2/11q13.3]  [t(11;11)(q13;q13)]  
Fusion : MitelmanPPP6R3/LRP5 [11q13.2/11q13.2]  [t(11;11)(q13;q13)]  
Fusion : MitelmanPPP6R3/MTL5 [11q13.2/11q13.3]  [t(11;11)(q13;q13)]  
Fusion : MitelmanPPP6R3/POLD3 [11q13.2/11q13.4]  [t(11;11)(q13;q13)]  
Fusion : MitelmanPPP6R3/SPTBN2 [11q13.2/11q13.2]  [t(11;11)(q13;q13)]  
Fusion : MitelmanPPP6R3/SSH2 [11q13.2/17q11.2]  [t(11;17)(q13;q11)]  
Fusion : MitelmanPPP6R3/YAP1 [11q13.2/11q22.1]  [t(11;11)(q13;q22)]  
Fusion : MitelmanRNF121/PPP6R3 [11q13.4/11q13.2]  [t(11;11)(q13;q13)]  
Fusion : MitelmanSTRN3/PPP6R3 [14q12/11q13.2]  [t(11;14)(q13;q12)]  
Fusion: TCGACCDC132 PPP6R3 11q13.2 LUAD
Fusion: TCGAKDM2A 11q13.2 PPP6R3 11q13.2 BRCA
Fusion: TCGAPC 11q13.2 PPP6R3 11q13.2 BRCA
Fusion: TCGAPPP6R3 11q13.2 ARHGAP1 11p11.2 LUSC
Fusion: TCGAPPP6R3 11q13.2 FADD 11q13.3 BRCA
Fusion: TCGAPPP6R3 11q13.2 LRP5 11q13.2 LUSC
Fusion: TCGAPPP6R3 11q13.2 MTL5 11q13.3 BRCA
Fusion: TCGAPPP6R3 11q13.2 POLD3 11q13.4 BRCA
Fusion: TCGAPPP6R3 11q13.2 SPTBN2 11q13.2 BRCA
Fusion: TCGAPPP6R3 11q13.2 SSH2 17q11.2 BRCA
Fusion: TCGAPPP6R3 11q13.2 YAP1 11q22.1 BLCA
Fusion: TCGARNF121 11q13.4 PPP6R3 11q13.2 BRCA
Fusion: TCGASTRN3 14q12 PPP6R3 11q13.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPP6R3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPP6R3
dbVarPPP6R3
ClinVarPPP6R3
1000_GenomesPPP6R3 
Exome Variant ServerPPP6R3
ExAC (Exome Aggregation Consortium)PPP6R3 (select the gene name)
Genetic variants : HAPMAP55291
Genomic Variants (DGV)PPP6R3 [DGVbeta]
DECIPHER (Syndromes)11:68228186-68382801  ENSG00000110075
CONAN: Copy Number AnalysisPPP6R3 
Mutations
ICGC Data PortalPPP6R3 
TCGA Data PortalPPP6R3 
Broad Tumor PortalPPP6R3
OASIS PortalPPP6R3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPP6R3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPP6R3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPP6R3
DgiDB (Drug Gene Interaction Database)PPP6R3
DoCM (Curated mutations)PPP6R3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPP6R3 (select a term)
intoGenPPP6R3
Cancer3DPPP6R3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610879   
Orphanet
MedgenPPP6R3
Genetic Testing Registry PPP6R3
NextProtQ5H9R7 [Medical]
TSGene55291
GENETestsPPP6R3
Huge Navigator PPP6R3 [HugePedia]
snp3D : Map Gene to Disease55291
BioCentury BCIQPPP6R3
ClinGenPPP6R3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55291
Chemical/Pharm GKB GenePA25487
Clinical trialPPP6R3
Miscellaneous
canSAR (ICR)PPP6R3 (select the gene name)
Probes
Litterature
PubMed49 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPP6R3
EVEXPPP6R3
GoPubMedPPP6R3
iHOPPPP6R3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:15:26 CEST 2017

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