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PPT2 (palmitoyl-protein thioesterase 2)

Identity

Other aliasC6orf8
G14
PPT-2
HGNC (Hugo) PPT2
LocusID (NCBI) 9374
Atlas_Id 72160
Location 6p21.32  [Link to chromosome band 6p21]
Location_base_pair Starts at 32153999 and ends at 32163681 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PPT2 (6p21.32) / CLIC1 (6p21.33)PPT2 (6p21.32) / EGFL8 (6p21.32)PPT2 (6p21.32) / PPT2 (6p21.32)
PPT2 (6p21.32) / TUBB4A (19p13.3)PPT2 (6p21.32) / ZMIZ1 (10q22.3)RBM10 (Xp11.23) / PPT2 (6p21.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PPT2   9326
Cards
Entrez_Gene (NCBI)PPT2  9374  palmitoyl-protein thioesterase 2
AliasesC6orf8; G14; PPT-2
GeneCards (Weizmann)PPT2
Ensembl hg19 (Hinxton)ENSG00000221988 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000221988 [Gene_View]  chr6:32153999-32163681 [Contig_View]  PPT2 [Vega]
ICGC DataPortalENSG00000221988
TCGA cBioPortalPPT2
AceView (NCBI)PPT2
Genatlas (Paris)PPT2
WikiGenes9374
SOURCE (Princeton)PPT2
Genetics Home Reference (NIH)PPT2
Genomic and cartography
GoldenPath hg38 (UCSC)PPT2  -     chr6:32153999-32163681 +  6p21.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPT2  -     6p21.32   [Description]    (hg19-Feb_2009)
EnsemblPPT2 - 6p21.32 [CytoView hg19]  PPT2 - 6p21.32 [CytoView hg38]
Mapping of homologs : NCBIPPT2 [Mapview hg19]  PPT2 [Mapview hg38]
OMIM603298   
Gene and transcription
Genbank (Entrez)AF020543 AI472281 AL110128 AM392834 BC000955
RefSeq transcript (Entrez)NM_001204103 NM_005155 NM_138717 NM_138934
RefSeq genomic (Entrez)NC_000006 NC_018917 NG_042283 NT_113891 NT_167244 NT_167245 NT_167246 NT_167247 NT_167248 NT_167249
Consensus coding sequences : CCDS (NCBI)PPT2
Cluster EST : UnigeneHs.332138 [ NCBI ]
CGAP (NCI)Hs.332138
Alternative Splicing GalleryENSG00000221988
Gene ExpressionPPT2 [ NCBI-GEO ]   PPT2 [ EBI - ARRAY_EXPRESS ]   PPT2 [ SEEK ]   PPT2 [ MEM ]
Gene Expression Viewer (FireBrowse)PPT2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9374
GTEX Portal (Tissue expression)PPT2
Human Protein AtlasENSG00000221988-PPT2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UMR5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UMR5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UMR5
Splice isoforms : SwissVarQ9UMR5
Catalytic activity : Enzyme3.1.2.- [ Enzyme-Expasy ]   3.1.2.-3.1.2.- [ IntEnz-EBI ]   3.1.2.- [ BRENDA ]   3.1.2.- [ KEGG ]   
PhosPhoSitePlusQ9UMR5
Domains : Interpro (EBI)AB_hydrolase    Palm_thioest    PPT2   
Domain families : Pfam (Sanger)Palm_thioest (PF02089)   
Domain families : Pfam (NCBI)pfam02089   
Conserved Domain (NCBI)PPT2
DMDM Disease mutations9374
Blocks (Seattle)PPT2
PDB (SRS)1PJA   
PDB (PDBSum)1PJA   
PDB (IMB)1PJA   
PDB (RSDB)1PJA   
Structural Biology KnowledgeBase1PJA   
SCOP (Structural Classification of Proteins)1PJA   
CATH (Classification of proteins structures)1PJA   
SuperfamilyQ9UMR5
Human Protein Atlas [tissue]ENSG00000221988-PPT2 [tissue]
Peptide AtlasQ9UMR5
HPRD04486
IPI###############################################################################################################################################################################################################################################################   
Protein Interaction databases
DIP (DOE-UCLA)Q9UMR5
IntAct (EBI)Q9UMR5
FunCoupENSG00000221988
BioGRIDPPT2
STRING (EMBL)PPT2
ZODIACPPT2
Ontologies - Pathways
QuickGOQ9UMR5
Ontology : AmiGOlysosome  palmitoyl-(protein) hydrolase activity  thiolester hydrolase activity  long-chain fatty-acyl-CoA biosynthetic process  lysosomal lumen  extracellular exosome  palmitoyl hydrolase activity  palmitoyl hydrolase activity  macromolecule depalmitoylation  
Ontology : EGO-EBIlysosome  palmitoyl-(protein) hydrolase activity  thiolester hydrolase activity  long-chain fatty-acyl-CoA biosynthetic process  lysosomal lumen  extracellular exosome  palmitoyl hydrolase activity  palmitoyl hydrolase activity  macromolecule depalmitoylation  
Pathways : KEGGFatty acid elongation in mitochondria   
NDEx NetworkPPT2
Atlas of Cancer Signalling NetworkPPT2
Wikipedia pathwaysPPT2
Orthology - Evolution
OrthoDB9374
GeneTree (enSembl)ENSG00000221988
Phylogenetic Trees/Animal Genes : TreeFamPPT2
HOVERGENQ9UMR5
HOGENOMQ9UMR5
Homologs : HomoloGenePPT2
Homology/Alignments : Family Browser (UCSC)PPT2
Gene fusions - Rearrangements
Fusion : QuiverPPT2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPT2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPT2
dbVarPPT2
ClinVarPPT2
1000_GenomesPPT2 
Exome Variant ServerPPT2
ExAC (Exome Aggregation Consortium)ENSG00000221988
GNOMAD BrowserENSG00000221988
Genetic variants : HAPMAP9374
Genomic Variants (DGV)PPT2 [DGVbeta]
DECIPHERPPT2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPT2 
Mutations
ICGC Data PortalPPT2 
TCGA Data PortalPPT2 
Broad Tumor PortalPPT2
OASIS PortalPPT2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPT2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPPT2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPT2
DgiDB (Drug Gene Interaction Database)PPT2
DoCM (Curated mutations)PPT2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPT2 (select a term)
intoGenPPT2
Cancer3DPPT2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603298   
Orphanet
DisGeNETPPT2
MedgenPPT2
Genetic Testing Registry PPT2
NextProtQ9UMR5 [Medical]
TSGene9374
GENETestsPPT2
Target ValidationPPT2
Huge Navigator PPT2 [HugePedia]
snp3D : Map Gene to Disease9374
BioCentury BCIQPPT2
ClinGenPPT2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9374
Chemical/Pharm GKB GenePA33689
Clinical trialPPT2
Miscellaneous
canSAR (ICR)PPT2 (select the gene name)
Probes
Litterature
PubMed1 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePPT2
EVEXPPT2
GoPubMedPPT2
iHOPPPT2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Feb 23 18:48:13 CET 2018

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