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PPTC7 (protein phosphatase targeting COQ7)

Identity

Alias (NCBI)TA-PP2C
TAPP2C
HGNC (Hugo) PPTC7
HGNC Alias symbTA-PP2C
HGNC Alias nameT cell activation protein phosphatase 2C
HGNC Previous namePTC7 protein phosphatase homolog (S. cerevisiae)
LocusID (NCBI) 160760
Atlas_Id 72162
Location 12q24.11  [Link to chromosome band 12q24]
Location_base_pair Starts at 110533245 and ends at 110583318 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PPTC7 (12q24.11) / ALS2CR12 (2q33.1)PPTC7 (12q24.11) / HVCN1 (12q24.11)PPTC7 (12q24.11) / RP11-24B21.1 ()
PPTC7 ALS2CR12PPTC7 RP11-24B21.1PPTC7 HVCN1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PPTC7   30695
Cards
Entrez_Gene (NCBI)PPTC7    protein phosphatase targeting COQ7
AliasesTA-PP2C; TAPP2C
GeneCards (Weizmann)PPTC7
Ensembl hg19 (Hinxton)ENSG00000196850 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000196850 [Gene_View]  ENSG00000196850 [Sequence]  chr12:110533245-110583318 [Contig_View]  PPTC7 [Vega]
ICGC DataPortalENSG00000196850
TCGA cBioPortalPPTC7
AceView (NCBI)PPTC7
Genatlas (Paris)PPTC7
SOURCE (Princeton)PPTC7
Genetics Home Reference (NIH)PPTC7
Genomic and cartography
GoldenPath hg38 (UCSC)PPTC7  -     chr12:110533245-110583318 -  12q24.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPTC7  -     12q24.11   [Description]    (hg19-Feb_2009)
GoldenPathPPTC7 - 12q24.11 [CytoView hg19]  PPTC7 - 12q24.11 [CytoView hg38]
ImmunoBaseENSG00000196850
Genome Data Viewer NCBIPPTC7 [Mapview hg19]  
OMIM609668   
Gene and transcription
Genbank (Entrez)AF385435 AK098051 AK124744 AY357944 BC031339
RefSeq transcript (Entrez)NM_139283
Consensus coding sequences : CCDS (NCBI)PPTC7
Gene ExpressionPPTC7 [ NCBI-GEO ]   PPTC7 [ EBI - ARRAY_EXPRESS ]   PPTC7 [ SEEK ]   PPTC7 [ MEM ]
Gene Expression Viewer (FireBrowse)PPTC7 [ Firebrowse - Broad ]
GenevisibleExpression of PPTC7 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)160760
GTEX Portal (Tissue expression)PPTC7
Human Protein AtlasENSG00000196850-PPTC7 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NI37   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NI37  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NI37
PhosPhoSitePlusQ8NI37
Domaine pattern : Prosite (Expaxy)PPM_2 (PS51746)   
Domains : Interpro (EBI)PPM-type_dom_sf    PPM-type_phosphatase_dom    PPTC7   
Domain families : Pfam (Sanger)SpoIIE (PF07228)   
Domain families : Pfam (NCBI)pfam07228   
Domain families : Smart (EMBL)PP2C_SIG (SM00331)  PP2Cc (SM00332)  
Conserved Domain (NCBI)PPTC7
SuperfamilyQ8NI37
AlphaFold pdb e-kbQ8NI37   
Human Protein Atlas [tissue]ENSG00000196850-PPTC7 [tissue]
HPRD18141
Protein Interaction databases
DIP (DOE-UCLA)Q8NI37
IntAct (EBI)Q8NI37
BioGRIDPPTC7
STRING (EMBL)PPTC7
ZODIACPPTC7
Ontologies - Pathways
QuickGOQ8NI37
Ontology : AmiGOprotein serine/threonine phosphatase activity  protein binding  mitochondrion  mitochondrial matrix  regulation of ubiquinone biosynthetic process  metal ion binding  peptidyl-serine dephosphorylation  protein serine phosphatase activity  protein threonine phosphatase activity  
Ontology : EGO-EBIprotein serine/threonine phosphatase activity  protein binding  mitochondrion  mitochondrial matrix  regulation of ubiquinone biosynthetic process  metal ion binding  peptidyl-serine dephosphorylation  protein serine phosphatase activity  protein threonine phosphatase activity  
NDEx NetworkPPTC7
Atlas of Cancer Signalling NetworkPPTC7
Wikipedia pathwaysPPTC7
Orthology - Evolution
OrthoDB160760
GeneTree (enSembl)ENSG00000196850
Phylogenetic Trees/Animal Genes : TreeFamPPTC7
Homologs : HomoloGenePPTC7
Homology/Alignments : Family Browser (UCSC)PPTC7
Gene fusions - Rearrangements
Fusion : QuiverPPTC7
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPTC7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PPTC7
dbVarPPTC7
ClinVarPPTC7
MonarchPPTC7
1000_GenomesPPTC7 
Exome Variant ServerPPTC7
GNOMAD BrowserENSG00000196850
Varsome BrowserPPTC7
ACMGPPTC7 variants
VarityQ8NI37
Genomic Variants (DGV)PPTC7 [DGVbeta]
DECIPHERPPTC7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPTC7 
Mutations
ICGC Data PortalPPTC7 
TCGA Data PortalPPTC7 
Broad Tumor PortalPPTC7
OASIS PortalPPTC7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPTC7  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPPTC7
Mutations and Diseases : HGMDPPTC7
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPPTC7
DgiDB (Drug Gene Interaction Database)PPTC7
DoCM (Curated mutations)PPTC7
CIViC (Clinical Interpretations of Variants in Cancer)PPTC7
Cancer3DPPTC7
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609668   
Orphanet
DisGeNETPPTC7
MedgenPPTC7
Genetic Testing Registry PPTC7
NextProtQ8NI37 [Medical]
GENETestsPPTC7
Target ValidationPPTC7
Huge Navigator PPTC7 [HugePedia]
ClinGenPPTC7
Clinical trials, drugs, therapy
MyCancerGenomePPTC7
Protein Interactions : CTDPPTC7
Pharm GKB GenePA143485580
PharosQ8NI37
Clinical trialPPTC7
Miscellaneous
canSAR (ICR)PPTC7
HarmonizomePPTC7
DataMed IndexPPTC7
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPPTC7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 16:17:01 CEST 2021

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