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PPY (pancreatic polypeptide)

Identity

Alias (NCBI)PNP
PP
HGNC (Hugo) PPY
HGNC Alias symbPNP
HGNC Alias namepancreatic polypeptide Y
 prepro-PP (prepropancreatic polypeptide)
LocusID (NCBI) 5539
Atlas_Id 45756
Location 17q21.31  [Link to chromosome band 17q21]
Location_base_pair Starts at 43940804 and ends at 43942476 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DDX39B (6p21.33) / PPY (17q21.31)MPP2 (17q21.31) / PPY (17q21.31)PPY (17q21.31) / HBA2 (16p13.3)
PPY (17q21.31) / LARP6 (15q23)SLCO1A2 (12p12.1) / PPY (17q21.31)TEAD2 (19q13.33) / PPY (17q21.31)
TRIM41 (5q35.3) / PPY (17q21.31)MPP2 17q21.31 / PPY 17q21.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PPY   9327
Cards
Entrez_Gene (NCBI)PPY    pancreatic polypeptide
AliasesPNP; PP
GeneCards (Weizmann)PPY
Ensembl hg19 (Hinxton)ENSG00000108849 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000108849 [Gene_View]  ENSG00000108849 [Sequence]  chr17:43940804-43942476 [Contig_View]  PPY [Vega]
ICGC DataPortalENSG00000108849
TCGA cBioPortalPPY
AceView (NCBI)PPY
Genatlas (Paris)PPY
SOURCE (Princeton)PPY
Genetics Home Reference (NIH)PPY
Genomic and cartography
GoldenPath hg38 (UCSC)PPY  -     chr17:43940804-43942476 -  17q21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PPY  -     17q21.31   [Description]    (hg19-Feb_2009)
GoldenPathPPY - 17q21.31 [CytoView hg19]  PPY - 17q21.31 [CytoView hg38]
ImmunoBaseENSG00000108849
genome Data Viewer NCBIPPY [Mapview hg19]  
OMIM167780   
Gene and transcription
Genbank (Entrez)BC032225 BC040033 BI838025 BP384893 BP388331
RefSeq transcript (Entrez)NM_001319209 NM_002722
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PPY
Alternative Splicing GalleryENSG00000108849
Gene ExpressionPPY [ NCBI-GEO ]   PPY [ EBI - ARRAY_EXPRESS ]   PPY [ SEEK ]   PPY [ MEM ]
Gene Expression Viewer (FireBrowse)PPY [ Firebrowse - Broad ]
GenevisibleExpression of PPY in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5539
GTEX Portal (Tissue expression)PPY
Human Protein AtlasENSG00000108849-PPY [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01298   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP01298  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP01298
Splice isoforms : SwissVarP01298
PhosPhoSitePlusP01298
Domaine pattern : Prosite (Expaxy)PANCREATIC_HORMONE_1 (PS00265)    PANCREATIC_HORMONE_2 (PS50276)   
Domains : Interpro (EBI)Pancreatic_hormone    Pancreatic_hormone-like    Pancreatic_hormone-like_CS   
Domain families : Pfam (Sanger)Hormone_3 (PF00159)   
Domain families : Pfam (NCBI)pfam00159   
Domain families : Smart (EMBL)PAH (SM00309)  
Conserved Domain (NCBI)PPY
Blocks (Seattle)PPY
PDB (RSDB)1TZ4    1TZ5   
PDB Europe1TZ4    1TZ5   
PDB (PDBSum)1TZ4    1TZ5   
PDB (IMB)1TZ4    1TZ5   
Structural Biology KnowledgeBase1TZ4    1TZ5   
SCOP (Structural Classification of Proteins)1TZ4    1TZ5   
CATH (Classification of proteins structures)1TZ4    1TZ5   
SuperfamilyP01298
Human Protein Atlas [tissue]ENSG00000108849-PPY [tissue]
Peptide AtlasP01298
HPRD01340
IPIIPI00000982   
Protein Interaction databases
DIP (DOE-UCLA)P01298
IntAct (EBI)P01298
BioGRIDPPY
STRING (EMBL)PPY
ZODIACPPY
Ontologies - Pathways
QuickGOP01298
Ontology : AmiGOG protein-coupled receptor binding  G protein-coupled receptor binding  hormone activity  neuropeptide hormone activity  protein binding  extracellular region  extracellular space  G protein-coupled receptor signaling pathway  neuropeptide signaling pathway  feeding behavior  protein secretion  neuropeptide Y receptor binding  
Ontology : EGO-EBIG protein-coupled receptor binding  G protein-coupled receptor binding  hormone activity  neuropeptide hormone activity  protein binding  extracellular region  extracellular space  G protein-coupled receptor signaling pathway  neuropeptide signaling pathway  feeding behavior  protein secretion  neuropeptide Y receptor binding  
NDEx NetworkPPY
Atlas of Cancer Signalling NetworkPPY
Wikipedia pathwaysPPY
Orthology - Evolution
OrthoDB5539
GeneTree (enSembl)ENSG00000108849
Phylogenetic Trees/Animal Genes : TreeFamPPY
HOGENOMP01298
Homologs : HomoloGenePPY
Homology/Alignments : Family Browser (UCSC)PPY
Gene fusions - Rearrangements
Fusion : MitelmanMPP2/PPY [17q21.31/17q21.31]  
Fusion PortalMPP2 17q21.31 PPY 17q21.31 BRCA
Fusion : QuiverPPY
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPPY [hg38]
dbVarPPY
ClinVarPPY
MonarchPPY
1000_GenomesPPY 
Exome Variant ServerPPY
GNOMAD BrowserENSG00000108849
Varsome BrowserPPY
Genomic Variants (DGV)PPY [DGVbeta]
DECIPHERPPY [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPPY 
Mutations
ICGC Data PortalPPY 
TCGA Data PortalPPY 
Broad Tumor PortalPPY
OASIS PortalPPY [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPPY  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPPY
Mutations and Diseases : HGMDPPY
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PPY
DgiDB (Drug Gene Interaction Database)PPY
DoCM (Curated mutations)PPY (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PPY (select a term)
intoGenPPY
Cancer3DPPY(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM167780   
Orphanet
DisGeNETPPY
MedgenPPY
Genetic Testing Registry PPY
NextProtP01298 [Medical]
GENETestsPPY
Target ValidationPPY
Huge Navigator PPY [HugePedia]
ClinGenPPY
Clinical trials, drugs, therapy
MyCancerGenomePPY
Protein Interactions : CTD
Pharm GKB GenePA33690
PharosP01298
Clinical trialPPY
Miscellaneous
canSAR (ICR)PPY (select the gene name)
HarmonizomePPY
DataMed IndexPPY
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPPY
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 25 19:40:46 CET 2021
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