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PRAM1 (PML-RARA regulated adaptor molecule 1)

Identity

Alias_symbol (synonym)PML-RAR
Other aliasPRAM-1
HGNC (Hugo) PRAM1
LocusID (NCBI) 84106
Atlas_Id 41827
Location 19p13.2  [Link to chromosome band 19p13]
Location_base_pair Starts at 8490056 and ends at 8502654 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PTPRC (1q31.3) / PRAM1 (19p13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PRAM1   30091
Cards
Entrez_Gene (NCBI)PRAM1  84106  PML-RARA regulated adaptor molecule 1
AliasesPML-RAR; PRAM-1
GeneCards (Weizmann)PRAM1
Ensembl hg19 (Hinxton)ENSG00000133246 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000133246 [Gene_View]  chr19:8490056-8502654 [Contig_View]  PRAM1 [Vega]
ICGC DataPortalENSG00000133246
TCGA cBioPortalPRAM1
AceView (NCBI)PRAM1
Genatlas (Paris)PRAM1
WikiGenes84106
SOURCE (Princeton)PRAM1
Genetics Home Reference (NIH)PRAM1
Genomic and cartography
GoldenPath hg38 (UCSC)PRAM1  -     chr19:8490056-8502654 -  19p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRAM1  -     19p13.2   [Description]    (hg19-Feb_2009)
EnsemblPRAM1 - 19p13.2 [CytoView hg19]  PRAM1 - 19p13.2 [CytoView hg38]
Mapping of homologs : NCBIPRAM1 [Mapview hg19]  PRAM1 [Mapview hg38]
OMIM606466   
Gene and transcription
Genbank (Entrez)AJ272324 AK308227 BC028012 BI907455 DA350460
RefSeq transcript (Entrez)NM_032152
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PRAM1
Cluster EST : UnigeneHs.465812 [ NCBI ]
CGAP (NCI)Hs.465812
Alternative Splicing GalleryENSG00000133246
Gene ExpressionPRAM1 [ NCBI-GEO ]   PRAM1 [ EBI - ARRAY_EXPRESS ]   PRAM1 [ SEEK ]   PRAM1 [ MEM ]
Gene Expression Viewer (FireBrowse)PRAM1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84106
GTEX Portal (Tissue expression)PRAM1
Human Protein AtlasENSG00000133246-PRAM1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96QH2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96QH2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96QH2
Splice isoforms : SwissVarQ96QH2
PhosPhoSitePlusQ96QH2
Domains : Interpro (EBI)hSH3    SH3_domain   
Domain families : Pfam (Sanger)hSH3 (PF14603)   
Domain families : Pfam (NCBI)pfam14603   
Conserved Domain (NCBI)PRAM1
DMDM Disease mutations84106
Blocks (Seattle)PRAM1
SuperfamilyQ96QH2
Human Protein Atlas [tissue]ENSG00000133246-PRAM1 [tissue]
Peptide AtlasQ96QH2
HPRD05926
IPIIPI00816773   IPI00335147   IPI00942353   IPI01012942   
Protein Interaction databases
DIP (DOE-UCLA)Q96QH2
IntAct (EBI)Q96QH2
FunCoupENSG00000133246
BioGRIDPRAM1
STRING (EMBL)PRAM1
ZODIACPRAM1
Ontologies - Pathways
QuickGOQ96QH2
Ontology : AmiGOprotein binding  signal transduction  integrin-mediated signaling pathway  lipid binding  regulation of neutrophil degranulation  
Ontology : EGO-EBIprotein binding  signal transduction  integrin-mediated signaling pathway  lipid binding  regulation of neutrophil degranulation  
Pathways : BIOCARTARegulation of transcriptional activity by PML [Genes]   
NDEx NetworkPRAM1
Atlas of Cancer Signalling NetworkPRAM1
Wikipedia pathwaysPRAM1
Orthology - Evolution
OrthoDB84106
GeneTree (enSembl)ENSG00000133246
Phylogenetic Trees/Animal Genes : TreeFamPRAM1
HOVERGENQ96QH2
HOGENOMQ96QH2
Homologs : HomoloGenePRAM1
Homology/Alignments : Family Browser (UCSC)PRAM1
Gene fusions - Rearrangements
Tumor Fusion PortalPRAM1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRAM1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRAM1
dbVarPRAM1
ClinVarPRAM1
1000_GenomesPRAM1 
Exome Variant ServerPRAM1
ExAC (Exome Aggregation Consortium)ENSG00000133246
GNOMAD BrowserENSG00000133246
Genetic variants : HAPMAP84106
Genomic Variants (DGV)PRAM1 [DGVbeta]
DECIPHERPRAM1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRAM1 
Mutations
ICGC Data PortalPRAM1 
TCGA Data PortalPRAM1 
Broad Tumor PortalPRAM1
OASIS PortalPRAM1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRAM1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRAM1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRAM1
DgiDB (Drug Gene Interaction Database)PRAM1
DoCM (Curated mutations)PRAM1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRAM1 (select a term)
intoGenPRAM1
Cancer3DPRAM1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606466   
Orphanet
DisGeNETPRAM1
MedgenPRAM1
Genetic Testing Registry PRAM1
NextProtQ96QH2 [Medical]
TSGene84106
GENETestsPRAM1
Target ValidationPRAM1
Huge Navigator PRAM1 [HugePedia]
snp3D : Map Gene to Disease84106
BioCentury BCIQPRAM1
ClinGenPRAM1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84106
Chemical/Pharm GKB GenePA142671137
Clinical trialPRAM1
Miscellaneous
canSAR (ICR)PRAM1 (select the gene name)
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRAM1
EVEXPRAM1
GoPubMedPRAM1
iHOPPRAM1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:30:06 CET 2017

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