Identity
HGNC
LOCATION
19p13.2
LOCUSID
ALIAS
PML-RAR,PRAM-1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 84106
MIM: 606466
HGNC: 30091
Ensembl: ENSG00000133246
Variants:
dbSNP: 84106
ClinVar: 84106
TCGA: ENSG00000133246
COSMIC: PRAM1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000133246 | ENST00000423345 | Q96QH2 |
| ENSG00000133246 | ENST00000600262 | M0R149 |
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 34047481 | 2021 | NRF2 activation induced by PML-RARα promotes microRNA 125b-1 expression and confers resistance to chemotherapy in acute promyelocytic leukemia. | 6 |
| 34448811 | 2021 | KDM5A suppresses PML-RARα target gene expression and APL differentiation through repressing H3K4me2. | 10 |
| 34047481 | 2021 | NRF2 activation induced by PML-RARα promotes microRNA 125b-1 expression and confers resistance to chemotherapy in acute promyelocytic leukemia. | 6 |
| 34448811 | 2021 | KDM5A suppresses PML-RARα target gene expression and APL differentiation through repressing H3K4me2. | 10 |
| 28431836 | 2018 | Spinal promyelocytic sarcoma as the initial manifestation of acute promyelocytic leukaemia. | 0 |
| 28431836 | 2018 | Spinal promyelocytic sarcoma as the initial manifestation of acute promyelocytic leukaemia. | 0 |
| 28317833 | 2017 | Regulation of NF-κB by PML and PML-RARα. | 7 |
| 28317833 | 2017 | Regulation of NF-κB by PML and PML-RARα. | 7 |
| 25815789 | 2015 | Development and validation of a 3-Plex RT-qPCR assay for the simultaneous detection and quantitation of the three PML-RARa fusion transcripts in acute promyelocytic leukemia. | 3 |
| 25944686 | 2015 | Absolute quantification of the pretreatment PML-RARA transcript defines the relapse risk in acute promyelocytic leukemia. | 14 |
| 25815789 | 2015 | Development and validation of a 3-Plex RT-qPCR assay for the simultaneous detection and quantitation of the three PML-RARa fusion transcripts in acute promyelocytic leukemia. | 3 |
| 25944686 | 2015 | Absolute quantification of the pretreatment PML-RARA transcript defines the relapse risk in acute promyelocytic leukemia. | 14 |
| 25126724 | 2014 | MIR125B1 represses the degradation of the PML-RARA oncoprotein by an autophagy-lysosomal pathway in acute promyelocytic leukemia. | 24 |
| 25126724 | 2014 | MIR125B1 represses the degradation of the PML-RARA oncoprotein by an autophagy-lysosomal pathway in acute promyelocytic leukemia. | 24 |
| 21673516 | 2011 | PML-RARα enhances constitutive autophagic activity through inhibiting the Akt/mTOR pathway. | 19 |
Citation
Dessen P
PRAM1 (PML-RARA regulated adaptor molecule 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/41827/pram1
