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PRDM10 (PR/SET domain 10)

Identity

Alias_namesPR domain containing 10
PR domain 10
Alias_symbol (synonym)KIAA1231
PFM7
MGC131802
Other alias
HGNC (Hugo) PRDM10
LocusID (NCBI) 56980
Atlas_Id 41832
Location 11q24.3  [Link to chromosome band 11q24]
Location_base_pair Starts at 129899706 and ends at 129947622 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CITED2 (6q24.1) / PRDM10 (11q24.3)MED12 (Xq13.1) / PRDM10 (11q24.3)PRDM10 (11q24.3) / COL12A1 (6q13)
PRDM10 (11q24.3) / FABP1 (2p11.2)PRDM10 (11q24.3) / PPM1B (2p21)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(6;11)(q24;q24) CITED2/PRDM10
t(X;11)(q13;q24) MED12/PRDM10

External links

Nomenclature
HGNC (Hugo)PRDM10   13995
Cards
Entrez_Gene (NCBI)PRDM10  56980  PR/SET domain 10
AliasesPFM7
GeneCards (Weizmann)PRDM10
Ensembl hg19 (Hinxton)ENSG00000170325 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000170325 [Gene_View]  ENSG00000170325 [Sequence]  chr11:129899706-129947622 [Contig_View]  PRDM10 [Vega]
ICGC DataPortalENSG00000170325
TCGA cBioPortalPRDM10
AceView (NCBI)PRDM10
Genatlas (Paris)PRDM10
WikiGenes56980
SOURCE (Princeton)PRDM10
Genetics Home Reference (NIH)PRDM10
Genomic and cartography
GoldenPath hg38 (UCSC)PRDM10  -     chr11:129899706-129947622 -  11q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRDM10  -     11q24.3   [Description]    (hg19-Feb_2009)
EnsemblPRDM10 - 11q24.3 [CytoView hg19]  PRDM10 - 11q24.3 [CytoView hg38]
Mapping of homologs : NCBIPRDM10 [Mapview hg19]  PRDM10 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AB033057 AF275817 AF503171 AK000234 AK310354
RefSeq transcript (Entrez)NM_020228 NM_199437 NM_199438 NM_199439
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PRDM10
Cluster EST : UnigeneHs.275086 [ NCBI ]
CGAP (NCI)Hs.275086
Alternative Splicing GalleryENSG00000170325
Gene ExpressionPRDM10 [ NCBI-GEO ]   PRDM10 [ EBI - ARRAY_EXPRESS ]   PRDM10 [ SEEK ]   PRDM10 [ MEM ]
Gene Expression Viewer (FireBrowse)PRDM10 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)56980
GTEX Portal (Tissue expression)PRDM10
Human Protein AtlasENSG00000170325-PRDM10 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NQV6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NQV6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NQV6
Splice isoforms : SwissVarQ9NQV6
Catalytic activity : Enzyme2.1.1.- [ Enzyme-Expasy ]   2.1.1.-2.1.1.- [ IntEnz-EBI ]   2.1.1.- [ BRENDA ]   2.1.1.- [ KEGG ]   
PhosPhoSitePlusQ9NQV6
Domaine pattern : Prosite (Expaxy)SET (PS50280)    ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)SET_dom    Znf_C2H2_jaz    Znf_C2H2_sf    Znf_C2H2_type   
Domain families : Pfam (Sanger)zf-C2H2_jaz (PF12171)   
Domain families : Pfam (NCBI)pfam12171   
Domain families : Smart (EMBL)ZnF_C2H2 (SM00355)  
Conserved Domain (NCBI)PRDM10
DMDM Disease mutations56980
Blocks (Seattle)PRDM10
PDB (RSDB)3IHX   
PDB Europe3IHX   
PDB (PDBSum)3IHX   
PDB (IMB)3IHX   
Structural Biology KnowledgeBase3IHX   
SCOP (Structural Classification of Proteins)3IHX   
CATH (Classification of proteins structures)3IHX   
SuperfamilyQ9NQV6
Human Protein Atlas [tissue]ENSG00000170325-PRDM10 [tissue]
Peptide AtlasQ9NQV6
HPRD11455
IPIIPI00299681   IPI00399316   IPI00921092   IPI00411675   IPI00921029   IPI00398772   IPI00979182   IPI00981143   IPI00982272   IPI00981732   
Protein Interaction databases
DIP (DOE-UCLA)Q9NQV6
IntAct (EBI)Q9NQV6
FunCoupENSG00000170325
BioGRIDPRDM10
STRING (EMBL)PRDM10
ZODIACPRDM10
Ontologies - Pathways
QuickGOQ9NQV6
Ontology : AmiGORNA polymerase II core promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA binding  protein binding  nucleus  regulation of transcription by RNA polymerase II  methyltransferase activity  regulation of gene expression  methylation  histone methyltransferase complex  metal ion binding  
Ontology : EGO-EBIRNA polymerase II core promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA binding  protein binding  nucleus  regulation of transcription by RNA polymerase II  methyltransferase activity  regulation of gene expression  methylation  histone methyltransferase complex  metal ion binding  
NDEx NetworkPRDM10
Atlas of Cancer Signalling NetworkPRDM10
Wikipedia pathwaysPRDM10
Orthology - Evolution
OrthoDB56980
GeneTree (enSembl)ENSG00000170325
Phylogenetic Trees/Animal Genes : TreeFamPRDM10
HOGENOMQ9NQV6
Homologs : HomoloGenePRDM10
Homology/Alignments : Family Browser (UCSC)PRDM10
Gene fusions - Rearrangements
Fusion : QuiverPRDM10
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRDM10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRDM10
dbVarPRDM10
ClinVarPRDM10
1000_GenomesPRDM10 
Exome Variant ServerPRDM10
ExAC (Exome Aggregation Consortium)ENSG00000170325
GNOMAD BrowserENSG00000170325
Varsome BrowserPRDM10
Genetic variants : HAPMAP56980
Genomic Variants (DGV)PRDM10 [DGVbeta]
DECIPHERPRDM10 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRDM10 
Mutations
ICGC Data PortalPRDM10 
TCGA Data PortalPRDM10 
Broad Tumor PortalPRDM10
OASIS PortalPRDM10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRDM10  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRDM10
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRDM10
DgiDB (Drug Gene Interaction Database)PRDM10
DoCM (Curated mutations)PRDM10 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRDM10 (select a term)
intoGenPRDM10
Cancer3DPRDM10(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETPRDM10
MedgenPRDM10
Genetic Testing Registry PRDM10
NextProtQ9NQV6 [Medical]
TSGene56980
GENETestsPRDM10
Target ValidationPRDM10
Huge Navigator PRDM10 [HugePedia]
snp3D : Map Gene to Disease56980
BioCentury BCIQPRDM10
ClinGenPRDM10
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD56980
Chemical/Pharm GKB GenePA33708
Clinical trialPRDM10
Miscellaneous
canSAR (ICR)PRDM10 (select the gene name)
DataMed IndexPRDM10
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRDM10
EVEXPRDM10
GoPubMedPRDM10
iHOPPRDM10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Feb 14 16:51:27 CET 2019
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