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PRDM14 (PR/SET domain 14)

Identity

Alias_namesPR domain containing 14
PR domain 14
Other aliasPFM11
HGNC (Hugo) PRDM14
LocusID (NCBI) 63978
Atlas_Id 49924
Location 8q13.3  [Link to chromosome band 8q13]
Location_base_pair Starts at 70051651 and ends at 70071327 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PRDM14   14001
Cards
Entrez_Gene (NCBI)PRDM14  63978  PR/SET domain 14
AliasesPFM11
GeneCards (Weizmann)PRDM14
Ensembl hg19 (Hinxton)ENSG00000147596 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000147596 [Gene_View]  chr8:70051651-70071327 [Contig_View]  PRDM14 [Vega]
ICGC DataPortalENSG00000147596
TCGA cBioPortalPRDM14
AceView (NCBI)PRDM14
Genatlas (Paris)PRDM14
WikiGenes63978
SOURCE (Princeton)PRDM14
Genetics Home Reference (NIH)PRDM14
Genomic and cartography
GoldenPath hg38 (UCSC)PRDM14  -     chr8:70051651-70071327 -  8q13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRDM14  -     8q13.3   [Description]    (hg19-Feb_2009)
EnsemblPRDM14 - 8q13.3 [CytoView hg19]  PRDM14 - 8q13.3 [CytoView hg38]
Mapping of homologs : NCBIPRDM14 [Mapview hg19]  PRDM14 [Mapview hg38]
OMIM611781   
Gene and transcription
Genbank (Entrez)AF319458 AK022595 BC052311 BF770200 CX166395
RefSeq transcript (Entrez)NM_024504
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PRDM14
Cluster EST : UnigeneHs.736037 [ NCBI ]
CGAP (NCI)Hs.736037
Alternative Splicing GalleryENSG00000147596
Gene ExpressionPRDM14 [ NCBI-GEO ]   PRDM14 [ EBI - ARRAY_EXPRESS ]   PRDM14 [ SEEK ]   PRDM14 [ MEM ]
Gene Expression Viewer (FireBrowse)PRDM14 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)63978
GTEX Portal (Tissue expression)PRDM14
Human Protein AtlasENSG00000147596-PRDM14 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9GZV8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9GZV8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9GZV8
Splice isoforms : SwissVarQ9GZV8
Catalytic activity : Enzyme2.1.1.- [ Enzyme-Expasy ]   2.1.1.-2.1.1.- [ IntEnz-EBI ]   2.1.1.- [ BRENDA ]   2.1.1.- [ KEGG ]   
PhosPhoSitePlusQ9GZV8
Domaine pattern : Prosite (Expaxy)SET (PS50280)    ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)SET_dom    Znf_C2H2    Znf_C2H2-like    Znf_C2H2/integrase_DNA-bd   
Domain families : Pfam (Sanger)zf-C2H2 (PF00096)   
Domain families : Pfam (NCBI)pfam00096   
Domain families : Smart (EMBL)SET (SM00317)  ZnF_C2H2 (SM00355)  
Conserved Domain (NCBI)PRDM14
DMDM Disease mutations63978
Blocks (Seattle)PRDM14
SuperfamilyQ9GZV8
Human Protein Atlas [tissue]ENSG00000147596-PRDM14 [tissue]
Peptide AtlasQ9GZV8
HPRD11457
IPIIPI00001567   IPI00878514   
Protein Interaction databases
DIP (DOE-UCLA)Q9GZV8
IntAct (EBI)Q9GZV8
FunCoupENSG00000147596
BioGRIDPRDM14
STRING (EMBL)PRDM14
ZODIACPRDM14
Ontologies - Pathways
QuickGOQ9GZV8
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  cell morphogenesis  cell fate specification  inner cell mass cell fate commitment  RNA binding  protein binding  nucleoplasm  nucleoplasm  transcription, DNA-templated  germ cell development  embryo implantation  methyltransferase activity  fertilization  germ-line stem cell population maintenance  chromatin DNA binding  histone H3-R26 methylation  somatic stem cell population maintenance  negative regulation of fibroblast growth factor receptor signaling pathway  regulation of DNA methylation  metal ion binding  homeostasis of number of cells within a tissue  inactivation of paternal X chromosome  positive regulation of flagellated sperm motility  positive regulation of stem cell population maintenance  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  cell morphogenesis  cell fate specification  inner cell mass cell fate commitment  RNA binding  protein binding  nucleoplasm  nucleoplasm  transcription, DNA-templated  germ cell development  embryo implantation  methyltransferase activity  fertilization  germ-line stem cell population maintenance  chromatin DNA binding  histone H3-R26 methylation  somatic stem cell population maintenance  negative regulation of fibroblast growth factor receptor signaling pathway  regulation of DNA methylation  metal ion binding  homeostasis of number of cells within a tissue  inactivation of paternal X chromosome  positive regulation of flagellated sperm motility  positive regulation of stem cell population maintenance  
NDEx NetworkPRDM14
Atlas of Cancer Signalling NetworkPRDM14
Wikipedia pathwaysPRDM14
Orthology - Evolution
OrthoDB63978
GeneTree (enSembl)ENSG00000147596
Phylogenetic Trees/Animal Genes : TreeFamPRDM14
HOVERGENQ9GZV8
HOGENOMQ9GZV8
Homologs : HomoloGenePRDM14
Homology/Alignments : Family Browser (UCSC)PRDM14
Gene fusions - Rearrangements
Tumor Fusion PortalPRDM14
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRDM14 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRDM14
dbVarPRDM14
ClinVarPRDM14
1000_GenomesPRDM14 
Exome Variant ServerPRDM14
ExAC (Exome Aggregation Consortium)ENSG00000147596
GNOMAD BrowserENSG00000147596
Genetic variants : HAPMAP63978
Genomic Variants (DGV)PRDM14 [DGVbeta]
DECIPHERPRDM14 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRDM14 
Mutations
ICGC Data PortalPRDM14 
TCGA Data PortalPRDM14 
Broad Tumor PortalPRDM14
OASIS PortalPRDM14 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRDM14  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRDM14
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRDM14
DgiDB (Drug Gene Interaction Database)PRDM14
DoCM (Curated mutations)PRDM14 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRDM14 (select a term)
intoGenPRDM14
Cancer3DPRDM14(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611781   
Orphanet
DisGeNETPRDM14
MedgenPRDM14
Genetic Testing Registry PRDM14
NextProtQ9GZV8 [Medical]
TSGene63978
GENETestsPRDM14
Target ValidationPRDM14
Huge Navigator PRDM14 [HugePedia]
snp3D : Map Gene to Disease63978
BioCentury BCIQPRDM14
ClinGenPRDM14
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD63978
Chemical/Pharm GKB GenePA33712
Clinical trialPRDM14
Miscellaneous
canSAR (ICR)PRDM14 (select the gene name)
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRDM14
EVEXPRDM14
GoPubMedPRDM14
iHOPPRDM14
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:30:12 CET 2017

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