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PRDM8 (PR/SET domain 8)

Identity

Alias_namesPR domain containing 8
PR domain 8
Other aliasEPM10
KMT8D
PFM5
HGNC (Hugo) PRDM8
LocusID (NCBI) 56978
Atlas_Id 72197
Location 4q21.21  [Link to chromosome band 4q21]
Location_base_pair Starts at 80197503 and ends at 80204328 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PCAT4 (4q21.21) / PRDM8 (4q21.21)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PRDM8   13993
Cards
Entrez_Gene (NCBI)PRDM8  56978  PR/SET domain 8
AliasesEPM10; KMT8D; PFM5
GeneCards (Weizmann)PRDM8
Ensembl hg19 (Hinxton)ENSG00000152784 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000152784 [Gene_View]  chr4:80197503-80204328 [Contig_View]  PRDM8 [Vega]
ICGC DataPortalENSG00000152784
TCGA cBioPortalPRDM8
AceView (NCBI)PRDM8
Genatlas (Paris)PRDM8
WikiGenes56978
SOURCE (Princeton)PRDM8
Genetics Home Reference (NIH)PRDM8
Genomic and cartography
GoldenPath hg38 (UCSC)PRDM8  -     chr4:80197503-80204328 +  4q21.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRDM8  -     4q21.21   [Description]    (hg19-Feb_2009)
EnsemblPRDM8 - 4q21.21 [CytoView hg19]  PRDM8 - 4q21.21 [CytoView hg38]
Mapping of homologs : NCBIPRDM8 [Mapview hg19]  PRDM8 [Mapview hg38]
OMIM616639   616640   
Gene and transcription
Genbank (Entrez)AF275815 AI077328 AK292137 BC027929 BC058908
RefSeq transcript (Entrez)NM_001099403 NM_020226
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PRDM8
Cluster EST : UnigeneHs.373642 [ NCBI ]
CGAP (NCI)Hs.373642
Alternative Splicing GalleryENSG00000152784
Gene ExpressionPRDM8 [ NCBI-GEO ]   PRDM8 [ EBI - ARRAY_EXPRESS ]   PRDM8 [ SEEK ]   PRDM8 [ MEM ]
Gene Expression Viewer (FireBrowse)PRDM8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)56978
GTEX Portal (Tissue expression)PRDM8
Human Protein AtlasENSG00000152784-PRDM8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NQV8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NQV8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NQV8
Splice isoforms : SwissVarQ9NQV8
Catalytic activity : Enzyme2.1.1.- [ Enzyme-Expasy ]   2.1.1.-2.1.1.- [ IntEnz-EBI ]   2.1.1.- [ BRENDA ]   2.1.1.- [ KEGG ]   
PhosPhoSitePlusQ9NQV8
Domaine pattern : Prosite (Expaxy)SET (PS50280)    ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)SET_dom    Znf_C2H2    Znf_C2H2-like    Znf_C2H2/integrase_DNA-bd   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)ZnF_C2H2 (SM00355)  
Conserved Domain (NCBI)PRDM8
DMDM Disease mutations56978
Blocks (Seattle)PRDM8
SuperfamilyQ9NQV8
Human Protein Atlas [tissue]ENSG00000152784-PRDM8 [tissue]
Peptide AtlasQ9NQV8
HPRD17904
IPIIPI00876899   IPI00414031   IPI00914570   
Protein Interaction databases
DIP (DOE-UCLA)Q9NQV8
IntAct (EBI)Q9NQV8
FunCoupENSG00000152784
BioGRIDPRDM8
STRING (EMBL)PRDM8
ZODIACPRDM8
Ontologies - Pathways
QuickGOQ9NQV8
Ontology : AmiGODNA binding  protein binding  nucleus  transcription, DNA-templated  regulation of transcription, DNA-templated  methyltransferase activity  oligodendrocyte development  methylation  metal ion binding  
Ontology : EGO-EBIDNA binding  protein binding  nucleus  transcription, DNA-templated  regulation of transcription, DNA-templated  methyltransferase activity  oligodendrocyte development  methylation  metal ion binding  
NDEx NetworkPRDM8
Atlas of Cancer Signalling NetworkPRDM8
Wikipedia pathwaysPRDM8
Orthology - Evolution
OrthoDB56978
GeneTree (enSembl)ENSG00000152784
Phylogenetic Trees/Animal Genes : TreeFamPRDM8
HOVERGENQ9NQV8
HOGENOMQ9NQV8
Homologs : HomoloGenePRDM8
Homology/Alignments : Family Browser (UCSC)PRDM8
Gene fusions - Rearrangements
Tumor Fusion PortalPRDM8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRDM8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRDM8
dbVarPRDM8
ClinVarPRDM8
1000_GenomesPRDM8 
Exome Variant ServerPRDM8
ExAC (Exome Aggregation Consortium)ENSG00000152784
GNOMAD BrowserENSG00000152784
Genetic variants : HAPMAP56978
Genomic Variants (DGV)PRDM8 [DGVbeta]
DECIPHERPRDM8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRDM8 
Mutations
ICGC Data PortalPRDM8 
TCGA Data PortalPRDM8 
Broad Tumor PortalPRDM8
OASIS PortalPRDM8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRDM8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRDM8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRDM8
DgiDB (Drug Gene Interaction Database)PRDM8
DoCM (Curated mutations)PRDM8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRDM8 (select a term)
intoGenPRDM8
Cancer3DPRDM8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616639    616640   
Orphanet21760   
DisGeNETPRDM8
MedgenPRDM8
Genetic Testing Registry PRDM8
NextProtQ9NQV8 [Medical]
TSGene56978
GENETestsPRDM8
Target ValidationPRDM8
Huge Navigator PRDM8 [HugePedia]
snp3D : Map Gene to Disease56978
BioCentury BCIQPRDM8
ClinGenPRDM8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD56978
Chemical/Pharm GKB GenePA33720
Clinical trialPRDM8
Miscellaneous
canSAR (ICR)PRDM8 (select the gene name)
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRDM8
EVEXPRDM8
GoPubMedPRDM8
iHOPPRDM8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 13:10:45 CET 2017

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