PRDX2 (peroxiredoxin 2)

2003-10-01  

Identity

HGNC
LOCATION
19p13.13
LOCUSID
ALIAS
HEL-S-2a,NKEF-B,NKEFB,PRP,PRX2,PRXII,PTX1,TDPX1,TPX1,TSA
FUSION GENES

Other Information

Locus ID:

NCBI: 7001
MIM: 600538
HGNC: 9353
Ensembl: ENSG00000167815

Variants:

dbSNP: 7001
ClinVar: 7001
TCGA: ENSG00000167815
COSMIC: PRDX2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167815ENST00000301522P32119
ENSG00000167815ENST00000301522V9HW12
ENSG00000167815ENST00000334482A6NIW5

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Metabolic GenesREACTOMER-HSA-5628897
Cellular responses to stressREACTOMER-HSA-2262752
Detoxification of Reactive Oxygen SpeciesREACTOMER-HSA-3299685
Neurodegenerative DiseasesREACTOMER-HSA-8863678
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease modelsREACTOMER-HSA-8862803

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA37091TXNGenePathwayassociated23913015

References

Pubmed IDYearTitleCitations
151055032004Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD.264
173292582007The high reactivity of peroxiredoxin 2 with H(2)O(2) is not reflected in its reaction with other oxidants and thiol reagents.127
186069872008HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation.103
180039202007S-nitrosylation of peroxiredoxin 2 promotes oxidative stress-induced neuronal cell death in Parkinson's disease.92
250972612014Linkage of inflammation and oxidative stress via release of glutathionylated peroxiredoxin-2, which acts as a danger signal.89
119042902002Proteomics analysis of cellular response to oxidative stress. Evidence for in vivo overoxidation of peroxiredoxins at their active site.88
171058102007Peroxiredoxin 2 functions as a noncatalytic scavenger of low-level hydrogen peroxide in the erythrocyte.82
229026302012Peroxiredoxin 1 functions as a signal peroxidase to receive, transduce, and transmit peroxide signals in mammalian cells.80
126509762003Aberrant expression of peroxiredoxin subtypes in neurodegenerative disorders.77
190618542009The peroxidase and peroxynitrite reductase activity of human erythrocyte peroxiredoxin 2.61

Citation

Dessen P

PRDX2 (peroxiredoxin 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-10-01

Online version: http://atlasgeneticsoncology.org/gene/41838/prdx2