Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PRDX2 (peroxiredoxin 2)

Identity

Alias_namesTDPX1
Alias_symbol (synonym)PRP
NKEFB
TSA
PRXII
PRX2
MGC4104
Other aliasHEL-S-2a
NKEF-B
PTX1
TPX1
HGNC (Hugo) PRDX2
LocusID (NCBI) 7001
Atlas_Id 41838
Location 19p13.13  [Link to chromosome band 19p13]
Location_base_pair Starts at 12796820 and ends at 12801910 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PRDX2 (19p13.2) / LOC100507412 (-)PRDX2 (19p13.2) / ZNF462 (9q31.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(X;21)(p22;q22) RUNX1/PRDX4


External links

Nomenclature
HGNC (Hugo)PRDX2   9353
Cards
Entrez_Gene (NCBI)PRDX2  7001  peroxiredoxin 2
AliasesHEL-S-2a; NKEF-B; NKEFB; PRP; 
PRX2; PRXII; PTX1; TDPX1; TPX1; TSA
GeneCards (Weizmann)PRDX2
Ensembl hg19 (Hinxton)ENSG00000167815 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000167815 [Gene_View]  chr19:12796820-12801910 [Contig_View]  PRDX2 [Vega]
ICGC DataPortalENSG00000167815
TCGA cBioPortalPRDX2
AceView (NCBI)PRDX2
Genatlas (Paris)PRDX2
WikiGenes7001
SOURCE (Princeton)PRDX2
Genetics Home Reference (NIH)PRDX2
Genomic and cartography
GoldenPath hg38 (UCSC)PRDX2  -     chr19:12796820-12801910 -  19p13.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRDX2  -     19p13.13   [Description]    (hg19-Feb_2009)
EnsemblPRDX2 - 19p13.13 [CytoView hg19]  PRDX2 - 19p13.13 [CytoView hg38]
Mapping of homologs : NCBIPRDX2 [Mapview hg19]  PRDX2 [Mapview hg38]
OMIM600538   
Gene and transcription
Genbank (Entrez)AK022395 AK289485 AK293957 AL600939 BC000452
RefSeq transcript (Entrez)NM_005809 NM_181737 NM_181738
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PRDX2
Cluster EST : UnigeneHs.432121 [ NCBI ]
CGAP (NCI)Hs.432121
Alternative Splicing GalleryENSG00000167815
Gene ExpressionPRDX2 [ NCBI-GEO ]   PRDX2 [ EBI - ARRAY_EXPRESS ]   PRDX2 [ SEEK ]   PRDX2 [ MEM ]
Gene Expression Viewer (FireBrowse)PRDX2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7001
GTEX Portal (Tissue expression)PRDX2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP32119   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP32119  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP32119
Splice isoforms : SwissVarP32119
Catalytic activity : Enzyme1.11.1.15 [ Enzyme-Expasy ]   1.11.1.151.11.1.15 [ IntEnz-EBI ]   1.11.1.15 [ BRENDA ]   1.11.1.15 [ KEGG ]   
PhosPhoSitePlusP32119
Domaine pattern : Prosite (Expaxy)THIOREDOXIN_2 (PS51352)   
Domains : Interpro (EBI)AhpC/TSA    Peroxiredoxin_AhpC-typ    Peroxiredoxin_C    PRDX2    Thioredoxin-like_fold    Thioredoxin_domain   
Domain families : Pfam (Sanger)1-cysPrx_C (PF10417)    AhpC-TSA (PF00578)   
Domain families : Pfam (NCBI)pfam10417    pfam00578   
Conserved Domain (NCBI)PRDX2
DMDM Disease mutations7001
Blocks (Seattle)PRDX2
PDB (SRS)1QMV    5B8A    5B8B   
PDB (PDBSum)1QMV    5B8A    5B8B   
PDB (IMB)1QMV    5B8A    5B8B   
PDB (RSDB)1QMV    5B8A    5B8B   
Structural Biology KnowledgeBase1QMV    5B8A    5B8B   
SCOP (Structural Classification of Proteins)1QMV    5B8A    5B8B   
CATH (Classification of proteins structures)1QMV    5B8A    5B8B   
SuperfamilyP32119
Human Protein AtlasENSG00000167815
Peptide AtlasP32119
HPRD02763
IPIIPI00027350   IPI00909207   IPI00375401   IPI00794777   
Protein Interaction databases
DIP (DOE-UCLA)P32119
IntAct (EBI)P32119
FunCoupENSG00000167815
BioGRIDPRDX2
STRING (EMBL)PRDX2
ZODIACPRDX2
Ontologies - Pathways
QuickGOP32119
Ontology : AmiGOresponse to reactive oxygen species  cytoplasm  cytosol  response to oxidative stress  response to oxidative stress  thioredoxin peroxidase activity  thioredoxin peroxidase activity  thioredoxin peroxidase activity  antioxidant activity  antioxidant activity  removal of superoxide radicals  cellular response to oxidative stress  hydrogen peroxide catabolic process  regulation of apoptotic process  negative regulation of apoptotic process  cell redox homeostasis  oxidation-reduction process  extracellular exosome  
Ontology : EGO-EBIresponse to reactive oxygen species  cytoplasm  cytosol  response to oxidative stress  response to oxidative stress  thioredoxin peroxidase activity  thioredoxin peroxidase activity  thioredoxin peroxidase activity  antioxidant activity  antioxidant activity  removal of superoxide radicals  cellular response to oxidative stress  hydrogen peroxide catabolic process  regulation of apoptotic process  negative regulation of apoptotic process  cell redox homeostasis  oxidation-reduction process  extracellular exosome  
NDEx NetworkPRDX2
Atlas of Cancer Signalling NetworkPRDX2
Wikipedia pathwaysPRDX2
Orthology - Evolution
OrthoDB7001
GeneTree (enSembl)ENSG00000167815
Phylogenetic Trees/Animal Genes : TreeFamPRDX2
HOVERGENP32119
HOGENOMP32119
Homologs : HomoloGenePRDX2
Homology/Alignments : Family Browser (UCSC)PRDX2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRDX2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRDX2
dbVarPRDX2
ClinVarPRDX2
1000_GenomesPRDX2 
Exome Variant ServerPRDX2
ExAC (Exome Aggregation Consortium)PRDX2 (select the gene name)
Genetic variants : HAPMAP7001
Genomic Variants (DGV)PRDX2 [DGVbeta]
DECIPHERPRDX2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRDX2 
Mutations
ICGC Data PortalPRDX2 
TCGA Data PortalPRDX2 
Broad Tumor PortalPRDX2
OASIS PortalPRDX2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRDX2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRDX2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch PRDX2
DgiDB (Drug Gene Interaction Database)PRDX2
DoCM (Curated mutations)PRDX2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRDX2 (select a term)
intoGenPRDX2
Cancer3DPRDX2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600538   
Orphanet
MedgenPRDX2
Genetic Testing Registry PRDX2
NextProtP32119 [Medical]
TSGene7001
GENETestsPRDX2
Target ValidationPRDX2
Huge Navigator PRDX2 [HugePedia]
snp3D : Map Gene to Disease7001
BioCentury BCIQPRDX2
ClinGenPRDX2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7001
Chemical/Pharm GKB GenePA33723
Clinical trialPRDX2
Miscellaneous
canSAR (ICR)PRDX2 (select the gene name)
Probes
Litterature
PubMed149 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRDX2
EVEXPRDX2
GoPubMedPRDX2
iHOPPRDX2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Sep 25 19:26:22 CEST 2017

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