Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

PRDX3 (peroxiredoxin 3)

Identity

Alias_namesAOP1
antioxidant protein 1
Alias_symbol (synonym)MER5
AOP-1
SP-22
Other aliasHBC189
PRO1748
prx-III
HGNC (Hugo) PRDX3
LocusID (NCBI) 10935
Atlas_Id 45771
Location 10q26.11  [Link to chromosome band 10q26]
Location_base_pair Starts at 119167699 and ends at 119178865 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ALYREF (17q25.3) / PRDX3 (10q26.11)CPS1 (2q34) / PRDX3 (10q26.11)EIF3A (10q26.11) / PRDX3 (10q26.11)
PRDX3 (10q26.11) / CCDC57 (17q25.3)PRDX3 (10q26.11) / TIAL1 (10q26.11)PTEN (10q23.31) / PRDX3 (10q26.11)
SHTN1 (10q25.3) / PRDX3 (10q26.11)KIAA1598 PRDX3 10q26.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PRDX3   9354
Cards
Entrez_Gene (NCBI)PRDX3  10935  peroxiredoxin 3
AliasesAOP-1; AOP1; HBC189; MER5; 
PRO1748; SP-22; prx-III
GeneCards (Weizmann)PRDX3
Ensembl hg19 (Hinxton)ENSG00000165672 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000165672 [Gene_View]  chr10:119167699-119178865 [Contig_View]  PRDX3 [Vega]
ICGC DataPortalENSG00000165672
TCGA cBioPortalPRDX3
AceView (NCBI)PRDX3
Genatlas (Paris)PRDX3
WikiGenes10935
SOURCE (Princeton)PRDX3
Genetics Home Reference (NIH)PRDX3
Genomic and cartography
GoldenPath hg38 (UCSC)PRDX3  -     chr10:119167699-119178865 -  10q26.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRDX3  -     10q26.11   [Description]    (hg19-Feb_2009)
EnsemblPRDX3 - 10q26.11 [CytoView hg19]  PRDX3 - 10q26.11 [CytoView hg38]
Mapping of homologs : NCBIPRDX3 [Mapview hg19]  PRDX3 [Mapview hg38]
OMIM604769   
Gene and transcription
Genbank (Entrez)AF118073 AK130897 AK222659 AK313169 AV718278
RefSeq transcript (Entrez)NM_001302272 NM_006793 NM_014098
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PRDX3
Cluster EST : UnigeneHs.523302 [ NCBI ]
CGAP (NCI)Hs.523302
Alternative Splicing GalleryENSG00000165672
Gene ExpressionPRDX3 [ NCBI-GEO ]   PRDX3 [ EBI - ARRAY_EXPRESS ]   PRDX3 [ SEEK ]   PRDX3 [ MEM ]
Gene Expression Viewer (FireBrowse)PRDX3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10935
GTEX Portal (Tissue expression)PRDX3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP30048   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP30048  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP30048
Splice isoforms : SwissVarP30048
Catalytic activity : Enzyme1.11.1.15 [ Enzyme-Expasy ]   1.11.1.151.11.1.15 [ IntEnz-EBI ]   1.11.1.15 [ BRENDA ]   1.11.1.15 [ KEGG ]   
PhosPhoSitePlusP30048
Domaine pattern : Prosite (Expaxy)THIOREDOXIN_2 (PS51352)   
Domains : Interpro (EBI)AhpC/TSA    Peroxiredoxin_C    Thioredoxin-like_fold    Thioredoxin_domain   
Domain families : Pfam (Sanger)1-cysPrx_C (PF10417)    AhpC-TSA (PF00578)   
Domain families : Pfam (NCBI)pfam10417    pfam00578   
Conserved Domain (NCBI)PRDX3
DMDM Disease mutations10935
Blocks (Seattle)PRDX3
PDB (SRS)5JCG   
PDB (PDBSum)5JCG   
PDB (IMB)5JCG   
PDB (RSDB)5JCG   
Structural Biology KnowledgeBase5JCG   
SCOP (Structural Classification of Proteins)5JCG   
CATH (Classification of proteins structures)5JCG   
SuperfamilyP30048
Human Protein AtlasENSG00000165672
Peptide AtlasP30048
HPRD05305
IPIIPI00024919   IPI00384054   IPI00374151   IPI00746746   
Protein Interaction databases
DIP (DOE-UCLA)P30048
IntAct (EBI)P30048
FunCoupENSG00000165672
BioGRIDPRDX3
STRING (EMBL)PRDX3
ZODIACPRDX3
Ontologies - Pathways
QuickGOP30048
Ontology : AmiGOresponse to reactive oxygen species  maternal placenta development  protein binding  cytoplasm  mitochondrion  mitochondrial matrix  early endosome  cytosol  apoptotic process  response to oxidative stress  mitochondrion organization  protein C-terminus binding  positive regulation of cell proliferation  thioredoxin peroxidase activity  thioredoxin peroxidase activity  IkappaB kinase complex  alkyl hydroperoxide reductase activity  peptidyl-cysteine oxidation  kinase binding  protein kinase binding  myeloid cell differentiation  response to lipopolysaccharide  negative regulation of kinase activity  cellular response to oxidative stress  cellular response to reactive oxygen species  response to hydrogen peroxide  hydrogen peroxide catabolic process  hydrogen peroxide catabolic process  identical protein binding  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  negative regulation of apoptotic process  negative regulation of apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  myelin sheath  cell redox homeostasis  positive regulation of NF-kappaB transcription factor activity  regulation of mitochondrial membrane potential  extracellular exosome  cellular oxidant detoxification  
Ontology : EGO-EBIresponse to reactive oxygen species  maternal placenta development  protein binding  cytoplasm  mitochondrion  mitochondrial matrix  early endosome  cytosol  apoptotic process  response to oxidative stress  mitochondrion organization  protein C-terminus binding  positive regulation of cell proliferation  thioredoxin peroxidase activity  thioredoxin peroxidase activity  IkappaB kinase complex  alkyl hydroperoxide reductase activity  peptidyl-cysteine oxidation  kinase binding  protein kinase binding  myeloid cell differentiation  response to lipopolysaccharide  negative regulation of kinase activity  cellular response to oxidative stress  cellular response to reactive oxygen species  response to hydrogen peroxide  hydrogen peroxide catabolic process  hydrogen peroxide catabolic process  identical protein binding  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  negative regulation of apoptotic process  negative regulation of apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  myelin sheath  cell redox homeostasis  positive regulation of NF-kappaB transcription factor activity  regulation of mitochondrial membrane potential  extracellular exosome  cellular oxidant detoxification  
NDEx NetworkPRDX3
Atlas of Cancer Signalling NetworkPRDX3
Wikipedia pathwaysPRDX3
Orthology - Evolution
OrthoDB10935
GeneTree (enSembl)ENSG00000165672
Phylogenetic Trees/Animal Genes : TreeFamPRDX3
HOVERGENP30048
HOGENOMP30048
Homologs : HomoloGenePRDX3
Homology/Alignments : Family Browser (UCSC)PRDX3
Gene fusions - Rearrangements
Fusion : MitelmanSHTN1/PRDX3 [10q25.3/10q26.11]  [t(10;10)(q25;q26)]  
Fusion: TCGAKIAA1598 PRDX3 10q26.11 BLCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRDX3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRDX3
dbVarPRDX3
ClinVarPRDX3
1000_GenomesPRDX3 
Exome Variant ServerPRDX3
ExAC (Exome Aggregation Consortium)PRDX3 (select the gene name)
Genetic variants : HAPMAP10935
Genomic Variants (DGV)PRDX3 [DGVbeta]
DECIPHERPRDX3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRDX3 
Mutations
ICGC Data PortalPRDX3 
TCGA Data PortalPRDX3 
Broad Tumor PortalPRDX3
OASIS PortalPRDX3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRDX3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRDX3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch PRDX3
DgiDB (Drug Gene Interaction Database)PRDX3
DoCM (Curated mutations)PRDX3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRDX3 (select a term)
intoGenPRDX3
Cancer3DPRDX3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604769   
Orphanet
MedgenPRDX3
Genetic Testing Registry PRDX3
NextProtP30048 [Medical]
TSGene10935
GENETestsPRDX3
Target ValidationPRDX3
Huge Navigator PRDX3 [HugePedia]
snp3D : Map Gene to Disease10935
BioCentury BCIQPRDX3
ClinGenPRDX3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10935
Chemical/Pharm GKB GenePA33724
Clinical trialPRDX3
Miscellaneous
canSAR (ICR)PRDX3 (select the gene name)
Probes
Litterature
PubMed113 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRDX3
EVEXPRDX3
GoPubMedPRDX3
iHOPPRDX3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 17:11:35 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.