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PRDX3 (peroxiredoxin 3)

Identity

Alias (NCBI)AOP-1
AOP1
HBC189
MER5
PRO1748
SP-22
prx-III
HGNC (Hugo) PRDX3
HGNC Alias symbMER5
AOP-1
SP-22
HGNC Previous nameAOP1
HGNC Previous nameantioxidant protein 1
LocusID (NCBI) 10935
Atlas_Id 45771
Location 10q26.11  [Link to chromosome band 10q26]
Location_base_pair Starts at 119167720 and ends at 119178812 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ALYREF (17q25.3) / PRDX3 (10q26.11)CPS1 (2q34) / PRDX3 (10q26.11)EIF3A (10q26.11) / PRDX3 (10q26.11)
PRDX3 (10q26.11) / CCDC57 (17q25.3)PRDX3 (10q26.11) / TIAL1 (10q26.11)PTEN (10q23.31) / PRDX3 (10q26.11)
SHTN1 (10q25.3) / PRDX3 (10q26.11)KIAA1598 PRDX3 10q26.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PRDX3   9354
Cards
Entrez_Gene (NCBI)PRDX3    peroxiredoxin 3
AliasesAOP-1; AOP1; HBC189; MER5; 
PRO1748; SP-22; prx-III
GeneCards (Weizmann)PRDX3
Ensembl hg19 (Hinxton)ENSG00000165672 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000165672 [Gene_View]  ENSG00000165672 [Sequence]  chr10:119167720-119178812 [Contig_View]  PRDX3 [Vega]
ICGC DataPortalENSG00000165672
TCGA cBioPortalPRDX3
AceView (NCBI)PRDX3
Genatlas (Paris)PRDX3
SOURCE (Princeton)PRDX3
Genetics Home Reference (NIH)PRDX3
Genomic and cartography
GoldenPath hg38 (UCSC)PRDX3  -     chr10:119167720-119178812 -  10q26.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRDX3  -     10q26.11   [Description]    (hg19-Feb_2009)
GoldenPathPRDX3 - 10q26.11 [CytoView hg19]  PRDX3 - 10q26.11 [CytoView hg38]
ImmunoBaseENSG00000165672
Genome Data Viewer NCBIPRDX3 [Mapview hg19]  
OMIM604769   
Gene and transcription
Genbank (Entrez)AF118073 AK130897 AK222659 AK313169 AV718278
RefSeq transcript (Entrez)NM_001302272 NM_006793 NM_014098
Consensus coding sequences : CCDS (NCBI)PRDX3
Gene ExpressionPRDX3 [ NCBI-GEO ]   PRDX3 [ EBI - ARRAY_EXPRESS ]   PRDX3 [ SEEK ]   PRDX3 [ MEM ]
Gene Expression Viewer (FireBrowse)PRDX3 [ Firebrowse - Broad ]
GenevisibleExpression of PRDX3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10935
GTEX Portal (Tissue expression)PRDX3
Human Protein AtlasENSG00000165672-PRDX3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP30048   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP30048  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP30048
PhosPhoSitePlusP30048
Domaine pattern : Prosite (Expaxy)THIOREDOXIN_2 (PS51352)   
Domains : Interpro (EBI)AhpC/TSA    Peroxiredoxin_C    Thioredoxin-like_sf    Thioredoxin_domain   
Domain families : Pfam (Sanger)1-cysPrx_C (PF10417)    AhpC-TSA (PF00578)   
Domain families : Pfam (NCBI)pfam10417    pfam00578   
Conserved Domain (NCBI)PRDX3
PDB (RSDB)5JCG    5UCX   
PDB Europe5JCG    5UCX   
PDB (PDBSum)5JCG    5UCX   
PDB (IMB)5JCG    5UCX   
Structural Biology KnowledgeBase5JCG    5UCX   
SCOP (Structural Classification of Proteins)5JCG    5UCX   
CATH (Classification of proteins structures)5JCG    5UCX   
SuperfamilyP30048
AlphaFold pdb e-kbP30048   
Human Protein Atlas [tissue]ENSG00000165672-PRDX3 [tissue]
HPRD05305
Protein Interaction databases
DIP (DOE-UCLA)P30048
IntAct (EBI)P30048
BioGRIDPRDX3
STRING (EMBL)PRDX3
ZODIACPRDX3
Ontologies - Pathways
QuickGOP30048
Ontology : AmiGOmaternal placenta development  protein binding  cytoplasm  cytoplasm  mitochondrion  mitochondrion  mitochondrial matrix  early endosome  cytosol  apoptotic process  response to oxidative stress  mitochondrion organization  protein C-terminus binding  positive regulation of cell population proliferation  thioredoxin peroxidase activity  thioredoxin peroxidase activity  alkyl hydroperoxide reductase activity  peptidyl-cysteine oxidation  kinase binding  protein kinase binding  myeloid cell differentiation  response to lipopolysaccharide  protein-containing complex  negative regulation of kinase activity  cellular response to oxidative stress  cellular response to oxidative stress  cellular response to oxidative stress  cellular response to reactive oxygen species  response to hydrogen peroxide  hydrogen peroxide catabolic process  hydrogen peroxide catabolic process  identical protein binding  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  negative regulation of apoptotic process  negative regulation of apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  cell redox homeostasis  positive regulation of NF-kappaB transcription factor activity  regulation of mitochondrial membrane potential  cellular oxidant detoxification  
Ontology : EGO-EBImaternal placenta development  protein binding  cytoplasm  cytoplasm  mitochondrion  mitochondrion  mitochondrial matrix  early endosome  cytosol  apoptotic process  response to oxidative stress  mitochondrion organization  protein C-terminus binding  positive regulation of cell population proliferation  thioredoxin peroxidase activity  thioredoxin peroxidase activity  alkyl hydroperoxide reductase activity  peptidyl-cysteine oxidation  kinase binding  protein kinase binding  myeloid cell differentiation  response to lipopolysaccharide  protein-containing complex  negative regulation of kinase activity  cellular response to oxidative stress  cellular response to oxidative stress  cellular response to oxidative stress  cellular response to reactive oxygen species  response to hydrogen peroxide  hydrogen peroxide catabolic process  hydrogen peroxide catabolic process  identical protein binding  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  negative regulation of apoptotic process  negative regulation of apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  cell redox homeostasis  positive regulation of NF-kappaB transcription factor activity  regulation of mitochondrial membrane potential  cellular oxidant detoxification  
NDEx NetworkPRDX3
Atlas of Cancer Signalling NetworkPRDX3
Wikipedia pathwaysPRDX3
Orthology - Evolution
OrthoDB10935
GeneTree (enSembl)ENSG00000165672
Phylogenetic Trees/Animal Genes : TreeFamPRDX3
Homologs : HomoloGenePRDX3
Homology/Alignments : Family Browser (UCSC)PRDX3
Gene fusions - Rearrangements
Fusion : MitelmanSHTN1/PRDX3 [10q25.3/10q26.11]  
Fusion : QuiverPRDX3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRDX3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRDX3
dbVarPRDX3
ClinVarPRDX3
MonarchPRDX3
1000_GenomesPRDX3 
Exome Variant ServerPRDX3
GNOMAD BrowserENSG00000165672
Varsome BrowserPRDX3
ACMGPRDX3 variants
VarityP30048
Genomic Variants (DGV)PRDX3 [DGVbeta]
DECIPHERPRDX3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRDX3 
Mutations
ICGC Data PortalPRDX3 
TCGA Data PortalPRDX3 
Broad Tumor PortalPRDX3
OASIS PortalPRDX3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRDX3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPRDX3
Mutations and Diseases : HGMDPRDX3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPRDX3
DgiDB (Drug Gene Interaction Database)PRDX3
DoCM (Curated mutations)PRDX3
CIViC (Clinical Interpretations of Variants in Cancer)PRDX3
Cancer3DPRDX3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604769   
Orphanet
DisGeNETPRDX3
MedgenPRDX3
Genetic Testing Registry PRDX3
NextProtP30048 [Medical]
GENETestsPRDX3
Target ValidationPRDX3
Huge Navigator PRDX3 [HugePedia]
ClinGenPRDX3
Clinical trials, drugs, therapy
MyCancerGenomePRDX3
Protein Interactions : CTDPRDX3
Pharm GKB GenePA33724
PharosP30048
Clinical trialPRDX3
Miscellaneous
canSAR (ICR)PRDX3
HarmonizomePRDX3
DataMed IndexPRDX3
Probes
Litterature
PubMed178 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPRDX3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:26:44 CEST 2021

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