Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PRDX5 (peroxiredoxin 5)

Identity

Alias (NCBI)ACR1
AOEB166
B166
HEL-S-55
PLP
PMP20
PRDX6
PRXV
SBBI10
prx-V
HGNC (Hugo) PRDX5
HGNC Alias symbACR1
AOEB166
MGC142285
PRXV
PMP20
B166
PRDX6
PLP
SBBI10
MGC117264
MGC142283
HGNC Alias nameantioxidant enzyme B166
 thioredoxin peroxidase PMP20
 peroxisomal antioxidant enzyme
 TPx type VI
 liver tissue 2D-page spot 71B
 Alu co-repressor 1
LocusID (NCBI) 25824
Atlas_Id 46272
Location 11q13.1  [Link to chromosome band 11q13]
Location_base_pair Starts at 64318121 and ends at 64321811 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
KDM5D (Yq11.222) / PRDX5 (11q13.1)PRDX5 (11q13.1) / MLC1 (22q13.33)PRDX5 (11q13.1) / SNCAIP (5q23.2)
TRMT112 (11q13.1) / PRDX5 (11q13.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PRDX5   9355
Cards
Entrez_Gene (NCBI)PRDX5    peroxiredoxin 5
AliasesACR1; AOEB166; B166; HEL-S-55; 
PLP; PMP20; PRDX6; PRXV; SBBI10; prx-V
GeneCards (Weizmann)PRDX5
Ensembl hg19 (Hinxton)ENSG00000126432 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000126432 [Gene_View]  ENSG00000126432 [Sequence]  chr11:64318121-64321811 [Contig_View]  PRDX5 [Vega]
ICGC DataPortalENSG00000126432
TCGA cBioPortalPRDX5
AceView (NCBI)PRDX5
Genatlas (Paris)PRDX5
SOURCE (Princeton)PRDX5
Genetics Home Reference (NIH)PRDX5
Genomic and cartography
GoldenPath hg38 (UCSC)PRDX5  -     chr11:64318121-64321811 +  11q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRDX5  -     11q13.1   [Description]    (hg19-Feb_2009)
GoldenPathPRDX5 - 11q13.1 [CytoView hg19]  PRDX5 - 11q13.1 [CytoView hg38]
ImmunoBaseENSG00000126432
genome Data Viewer NCBIPRDX5 [Mapview hg19]  
OMIM606583   
Gene and transcription
Genbank (Entrez)AA187737 AF110731 AF112212 AF124993 AF197952
RefSeq transcript (Entrez)NM_001358511 NM_001358516 NM_012094 NM_181651 NM_181652
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PRDX5
Alternative Splicing GalleryENSG00000126432
Gene ExpressionPRDX5 [ NCBI-GEO ]   PRDX5 [ EBI - ARRAY_EXPRESS ]   PRDX5 [ SEEK ]   PRDX5 [ MEM ]
Gene Expression Viewer (FireBrowse)PRDX5 [ Firebrowse - Broad ]
GenevisibleExpression of PRDX5 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)25824
GTEX Portal (Tissue expression)PRDX5
Human Protein AtlasENSG00000126432-PRDX5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP30044   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP30044  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP30044
Splice isoforms : SwissVarP30044
PhosPhoSitePlusP30044
Domaine pattern : Prosite (Expaxy)THIOREDOXIN_2 (PS51352)   
Domains : Interpro (EBI)PRX5-like    Redoxin    Thioredoxin-like_sf    Thioredoxin_domain   
Domain families : Pfam (Sanger)Redoxin (PF08534)   
Domain families : Pfam (NCBI)pfam08534   
Conserved Domain (NCBI)PRDX5
Blocks (Seattle)PRDX5
PDB (RSDB)1H4O    1HD2    1OC3    1URM    2VL2    2VL3    2VL9    3MNG    4K7I    4K7N    4K7O    4MMM   
PDB Europe1H4O    1HD2    1OC3    1URM    2VL2    2VL3    2VL9    3MNG    4K7I    4K7N    4K7O    4MMM   
PDB (PDBSum)1H4O    1HD2    1OC3    1URM    2VL2    2VL3    2VL9    3MNG    4K7I    4K7N    4K7O    4MMM   
PDB (IMB)1H4O    1HD2    1OC3    1URM    2VL2    2VL3    2VL9    3MNG    4K7I    4K7N    4K7O    4MMM   
Structural Biology KnowledgeBase1H4O    1HD2    1OC3    1URM    2VL2    2VL3    2VL9    3MNG    4K7I    4K7N    4K7O    4MMM   
SCOP (Structural Classification of Proteins)1H4O    1HD2    1OC3    1URM    2VL2    2VL3    2VL9    3MNG    4K7I    4K7N    4K7O    4MMM   
CATH (Classification of proteins structures)1H4O    1HD2    1OC3    1URM    2VL2    2VL3    2VL9    3MNG    4K7I    4K7N    4K7O    4MMM   
SuperfamilyP30044
Human Protein Atlas [tissue]ENSG00000126432-PRDX5 [tissue]
Peptide AtlasP30044
HPRD05958
IPIIPI00024915   IPI00759663   IPI00375306   IPI00375307   
Protein Interaction databases
DIP (DOE-UCLA)P30044
IntAct (EBI)P30044
BioGRIDPRDX5
STRING (EMBL)PRDX5
ZODIACPRDX5
Ontologies - Pathways
QuickGOP30044
Ontology : AmiGORNA polymerase III regulatory region DNA binding  peroxidase activity  protein binding  extracellular space  nucleus  cytoplasm  cytoplasm  mitochondrion  mitochondrion  mitochondrial matrix  peroxisome  peroxisome  peroxisomal matrix  cytosol  cytosol  apoptotic process  inflammatory response  response to oxidative stress  thioredoxin peroxidase activity  thioredoxin peroxidase activity  negative regulation of transcription by RNA polymerase III  cytoplasmic vesicle  cellular response to oxidative stress  cellular response to oxidative stress  cellular response to reactive oxygen species  hydrogen peroxide catabolic process  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  negative regulation of apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  intracellular membrane-bounded organelle  cell redox homeostasis  perinuclear region of cytoplasm  oxidation-reduction process  extracellular exosome  cellular oxidant detoxification  
Ontology : EGO-EBIRNA polymerase III regulatory region DNA binding  peroxidase activity  protein binding  extracellular space  nucleus  cytoplasm  cytoplasm  mitochondrion  mitochondrion  mitochondrial matrix  peroxisome  peroxisome  peroxisomal matrix  cytosol  cytosol  apoptotic process  inflammatory response  response to oxidative stress  thioredoxin peroxidase activity  thioredoxin peroxidase activity  negative regulation of transcription by RNA polymerase III  cytoplasmic vesicle  cellular response to oxidative stress  cellular response to oxidative stress  cellular response to reactive oxygen species  hydrogen peroxide catabolic process  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  negative regulation of apoptotic process  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  intracellular membrane-bounded organelle  cell redox homeostasis  perinuclear region of cytoplasm  oxidation-reduction process  extracellular exosome  cellular oxidant detoxification  
Pathways : KEGGPeroxisome   
NDEx NetworkPRDX5
Atlas of Cancer Signalling NetworkPRDX5
Wikipedia pathwaysPRDX5
Orthology - Evolution
OrthoDB25824
GeneTree (enSembl)ENSG00000126432
Phylogenetic Trees/Animal Genes : TreeFamPRDX5
HOGENOMP30044
Homologs : HomoloGenePRDX5
Homology/Alignments : Family Browser (UCSC)PRDX5
Gene fusions - Rearrangements
Fusion : QuiverPRDX5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRDX5 [hg38]
dbVarPRDX5
ClinVarPRDX5
MonarchPRDX5
1000_GenomesPRDX5 
Exome Variant ServerPRDX5
GNOMAD BrowserENSG00000126432
Varsome BrowserPRDX5
Genomic Variants (DGV)PRDX5 [DGVbeta]
DECIPHERPRDX5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRDX5 
Mutations
ICGC Data PortalPRDX5 
TCGA Data PortalPRDX5 
Broad Tumor PortalPRDX5
OASIS PortalPRDX5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRDX5  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPRDX5
Mutations and Diseases : HGMDPRDX5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch PRDX5
DgiDB (Drug Gene Interaction Database)PRDX5
DoCM (Curated mutations)PRDX5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRDX5 (select a term)
intoGenPRDX5
Cancer3DPRDX5(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606583   
Orphanet
DisGeNETPRDX5
MedgenPRDX5
Genetic Testing Registry PRDX5
NextProtP30044 [Medical]
GENETestsPRDX5
Target ValidationPRDX5
Huge Navigator PRDX5 [HugePedia]
ClinGenPRDX5
Clinical trials, drugs, therapy
MyCancerGenomePRDX5
Protein Interactions : CTD
Pharm GKB GenePA33726
PharosP30044
Clinical trialPRDX5
Miscellaneous
canSAR (ICR)PRDX5 (select the gene name)
HarmonizomePRDX5
DataMed IndexPRDX5
Probes
Litterature
PubMed98 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPRDX5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jan 1 18:32:51 CET 2021
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