PRDX6 (peroxiredoxin 6)

2008-03-01  

Identity

HGNC
LOCATION
1q25.1
LOCUSID
ALIAS
1-Cys,AOP2,HEL-S-128m,LPCAT-5,NSGPx,PRX,aiPLA2,p29
FUSION GENES

Other Information

Locus ID:

NCBI: 9588
MIM: 602316
HGNC: 16753
Ensembl: ENSG00000117592

Variants:

dbSNP: 9588
ClinVar: 9588
TCGA: ENSG00000117592
COSMIC: PRDX6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000117592ENST00000340385P30041
ENSG00000117592ENST00000340385V9HWC7

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450

Pathways

PathwaySourceExternal ID
Metabolic pathwaysKEGGhsa01100
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Cellular responses to stressREACTOMER-HSA-2262752
Detoxification of Reactive Oxygen SpeciesREACTOMER-HSA-3299685
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
385063482024Expression and clinical role of PRDX6 in lung adenocarcinoma.0
385063482024Expression and clinical role of PRDX6 in lung adenocarcinoma.0
373292382023Effect of PRDX6 gene polymorphism on susceptibility to chronic obstructive pulmonary disease in the Chinese Han population.1
373867202023An Aboriginal-led consortium approach to chronic disease action for health equity and holistic wellbeing.0
380034662023Prdx6 Regulates Nlrp3 Inflammasome Activation-Driven Inflammatory Response in Lens Epithelial Cells.1
373292382023Effect of PRDX6 gene polymorphism on susceptibility to chronic obstructive pulmonary disease in the Chinese Han population.1
373867202023An Aboriginal-led consortium approach to chronic disease action for health equity and holistic wellbeing.0
380034662023Prdx6 Regulates Nlrp3 Inflammasome Activation-Driven Inflammatory Response in Lens Epithelial Cells.1
352404532022Circular RNA hsa_circ_0011385 contributes to cervical cancer progression through sequestering miR-149-5p and increasing PRDX6 expression.2
356451082022Effect of lentivirus-mediated peroxiredoxins 6 gene silencing on the phenotype of human gastric cancer BGC-823 cells.2
357050352022Human peroxiredoxin 6 is essential for malaria parasites and provides a host-based drug target.4
357230292022PRDX6 alleviates lipopolysaccharide-induced inflammation and ferroptosis in periodontitis.3
359290622022Activation of the JAK1/STAT1 signaling pathway is associated with peroxiredoxin 6 expression levels in human epididymis epithelial cells.0
360089422022Selenocysteine Machinery Primarily Supports TXNRD1 and GPX4 Functions and Together They Are Functionally Linked with SCD and PRDX6.5
362093442022PRDX6 knockout restrains the malignant progression of intrahepatic cholangiocarcinoma.0

Citation

Dessen P

PRDX6 (peroxiredoxin 6)

Atlas Genet Cytogenet Oncol Haematol. 2008-03-01

Online version: http://atlasgeneticsoncology.org/gene/50067/prdx6