Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

PRDX6 (peroxiredoxin 6)

Identity

Alias_symbol (synonym)AOP2
KIAA0106
1-Cys
NSGPx
PRX
aiPLA2
MGC46173
p29
Other aliasHEL-S-128m
HGNC (Hugo) PRDX6
LocusID (NCBI) 9588
Atlas_Id 50067
Location 1q25.1  [Link to chromosome band 1q25]
Location_base_pair Starts at 173477347 and ends at 173488807 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GRID2 (4q22.1) / PRDX6 (1q25.1)MGST2 (4q31.1) / PRDX6 (1q25.1)PRDX6 (1q25.1) / PPP1R8 (1p35.3)
PRDX6 (1q25.1) / PRDX6 (1q25.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PRDX6   16753
Cards
Entrez_Gene (NCBI)PRDX6  9588  peroxiredoxin 6
Aliases1-Cys; AOP2; HEL-S-128m; NSGPx; 
PRX; aiPLA2; p29
GeneCards (Weizmann)PRDX6
Ensembl hg19 (Hinxton)ENSG00000117592 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000117592 [Gene_View]  chr1:173477347-173488807 [Contig_View]  PRDX6 [Vega]
ICGC DataPortalENSG00000117592
TCGA cBioPortalPRDX6
AceView (NCBI)PRDX6
Genatlas (Paris)PRDX6
WikiGenes9588
SOURCE (Princeton)PRDX6
Genetics Home Reference (NIH)PRDX6
Genomic and cartography
GoldenPath hg38 (UCSC)PRDX6  -     chr1:173477347-173488807 +  1q25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRDX6  -     1q25.1   [Description]    (hg19-Feb_2009)
EnsemblPRDX6 - 1q25.1 [CytoView hg19]  PRDX6 - 1q25.1 [CytoView hg38]
Mapping of homologs : NCBIPRDX6 [Mapview hg19]  PRDX6 [Mapview hg38]
OMIM602316   
Gene and transcription
Genbank (Entrez)AJ844621 AJ844622 AK095940 AK289352 AK300680
RefSeq transcript (Entrez)NM_004905
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PRDX6
Cluster EST : UnigeneHs.731505 [ NCBI ]
CGAP (NCI)Hs.731505
Alternative Splicing GalleryENSG00000117592
Gene ExpressionPRDX6 [ NCBI-GEO ]   PRDX6 [ EBI - ARRAY_EXPRESS ]   PRDX6 [ SEEK ]   PRDX6 [ MEM ]
Gene Expression Viewer (FireBrowse)PRDX6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9588
GTEX Portal (Tissue expression)PRDX6
Human Protein AtlasENSG00000117592-PRDX6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP30041   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP30041  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP30041
Splice isoforms : SwissVarP30041
Catalytic activity : Enzyme1.11.1.15 [ Enzyme-Expasy ]   1.11.1.151.11.1.15 [ IntEnz-EBI ]   1.11.1.15 [ BRENDA ]   1.11.1.15 [ KEGG ]   
PhosPhoSitePlusP30041
Domaine pattern : Prosite (Expaxy)THIOREDOXIN_2 (PS51352)   
Domains : Interpro (EBI)AhpC/TSA    Peroxiredoxin_AhpC-typ    Peroxiredoxin_C    Thioredoxin-like_fold    Thioredoxin_domain   
Domain families : Pfam (Sanger)1-cysPrx_C (PF10417)    AhpC-TSA (PF00578)   
Domain families : Pfam (NCBI)pfam10417    pfam00578   
Conserved Domain (NCBI)PRDX6
DMDM Disease mutations9588
Blocks (Seattle)PRDX6
PDB (SRS)1PRX    5B6M    5B6N   
PDB (PDBSum)1PRX    5B6M    5B6N   
PDB (IMB)1PRX    5B6M    5B6N   
PDB (RSDB)1PRX    5B6M    5B6N   
Structural Biology KnowledgeBase1PRX    5B6M    5B6N   
SCOP (Structural Classification of Proteins)1PRX    5B6M    5B6N   
CATH (Classification of proteins structures)1PRX    5B6M    5B6N   
SuperfamilyP30041
Human Protein Atlas [tissue]ENSG00000117592-PRDX6 [tissue]
Peptide AtlasP30041
HPRD03817
IPIIPI00220301   IPI00910553   
Protein Interaction databases
DIP (DOE-UCLA)P30041
IntAct (EBI)P30041
FunCoupENSG00000117592
BioGRIDPRDX6
STRING (EMBL)PRDX6
ZODIACPRDX6
Ontologies - Pathways
QuickGOP30041
Ontology : AmiGOresponse to reactive oxygen species  glutathione peroxidase activity  protein binding  extracellular region  extracellular space  cytoplasm  cytosol  cytosol  response to oxidative stress  membrane  ubiquitin protein ligase binding  azurophil granule lumen  hydrogen peroxide catabolic process  protein homodimerization activity  neutrophil degranulation  cadherin binding  cell redox homeostasis  glycerophospholipid catabolic process  calcium-independent phospholipase A2 activity  peroxiredoxin activity  oxidation-reduction process  extracellular exosome  cellular oxidant detoxification  
Ontology : EGO-EBIresponse to reactive oxygen species  glutathione peroxidase activity  protein binding  extracellular region  extracellular space  cytoplasm  cytosol  cytosol  response to oxidative stress  membrane  ubiquitin protein ligase binding  azurophil granule lumen  hydrogen peroxide catabolic process  protein homodimerization activity  neutrophil degranulation  cadherin binding  cell redox homeostasis  glycerophospholipid catabolic process  calcium-independent phospholipase A2 activity  peroxiredoxin activity  oxidation-reduction process  extracellular exosome  cellular oxidant detoxification  
Pathways : KEGGPhenylalanine metabolism   
NDEx NetworkPRDX6
Atlas of Cancer Signalling NetworkPRDX6
Wikipedia pathwaysPRDX6
Orthology - Evolution
OrthoDB9588
GeneTree (enSembl)ENSG00000117592
Phylogenetic Trees/Animal Genes : TreeFamPRDX6
HOVERGENP30041
HOGENOMP30041
Homologs : HomoloGenePRDX6
Homology/Alignments : Family Browser (UCSC)PRDX6
Gene fusions - Rearrangements
Tumor Fusion PortalPRDX6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRDX6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRDX6
dbVarPRDX6
ClinVarPRDX6
1000_GenomesPRDX6 
Exome Variant ServerPRDX6
ExAC (Exome Aggregation Consortium)ENSG00000117592
GNOMAD BrowserENSG00000117592
Genetic variants : HAPMAP9588
Genomic Variants (DGV)PRDX6 [DGVbeta]
DECIPHERPRDX6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRDX6 
Mutations
ICGC Data PortalPRDX6 
TCGA Data PortalPRDX6 
Broad Tumor PortalPRDX6
OASIS PortalPRDX6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRDX6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRDX6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch PRDX6
DgiDB (Drug Gene Interaction Database)PRDX6
DoCM (Curated mutations)PRDX6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRDX6 (select a term)
intoGenPRDX6
Cancer3DPRDX6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602316   
Orphanet
DisGeNETPRDX6
MedgenPRDX6
Genetic Testing Registry PRDX6
NextProtP30041 [Medical]
TSGene9588
GENETestsPRDX6
Target ValidationPRDX6
Huge Navigator PRDX6 [HugePedia]
snp3D : Map Gene to Disease9588
BioCentury BCIQPRDX6
ClinGenPRDX6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9588
Chemical/Pharm GKB GenePA134992760
Clinical trialPRDX6
Miscellaneous
canSAR (ICR)PRDX6 (select the gene name)
Probes
Litterature
PubMed120 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRDX6
EVEXPRDX6
GoPubMedPRDX6
iHOPPRDX6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:30:13 CET 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.