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PREB (prolactin regulatory element binding)

Identity

Alias_symbol (synonym)SEC12
Other alias
HGNC (Hugo) PREB
LocusID (NCBI) 10113
Atlas_Id 72198
Location 2p23.3  [Link to chromosome band 2p23]
Location_base_pair Starts at 27353625 and ends at 27357542 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ORC5 (7q22.1) / PREB (2p23.3)PREB (2p23.3) / PREB (2p23.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PREB   9356
Cards
Entrez_Gene (NCBI)PREB  10113  prolactin regulatory element binding
AliasesSEC12
GeneCards (Weizmann)PREB
Ensembl hg19 (Hinxton)ENSG00000138073 [Gene_View]  chr2:27353625-27357542 [Contig_View]  PREB [Vega]
Ensembl hg38 (Hinxton)ENSG00000138073 [Gene_View]  chr2:27353625-27357542 [Contig_View]  PREB [Vega]
ICGC DataPortalENSG00000138073
TCGA cBioPortalPREB
AceView (NCBI)PREB
Genatlas (Paris)PREB
WikiGenes10113
SOURCE (Princeton)PREB
Genetics Home Reference (NIH)PREB
Genomic and cartography
GoldenPath hg19 (UCSC)PREB  -     chr2:27353625-27357542 -  2p23.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PREB  -     2p23.3   [Description]    (hg38-Dec_2013)
EnsemblPREB - 2p23.3 [CytoView hg19]  PREB - 2p23.3 [CytoView hg38]
Mapping of homologs : NCBIPREB [Mapview hg19]  PREB [Mapview hg38]
OMIM606395   
Gene and transcription
Genbank (Entrez)AA629936 AF203687 AF226684 AK001976 AK023064
RefSeq transcript (Entrez)NM_013388
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_022184 NW_004929300
Consensus coding sequences : CCDS (NCBI)PREB
Cluster EST : UnigeneHs.279784 [ NCBI ]
CGAP (NCI)Hs.279784
Alternative Splicing GalleryENSG00000138073
Gene ExpressionPREB [ NCBI-GEO ]   PREB [ EBI - ARRAY_EXPRESS ]   PREB [ SEEK ]   PREB [ MEM ]
Gene Expression Viewer (FireBrowse)PREB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10113
GTEX Portal (Tissue expression)PREB
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HCU5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HCU5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HCU5
Splice isoforms : SwissVarQ9HCU5
PhosPhoSitePlusQ9HCU5
Domaine pattern : Prosite (Expaxy)WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)Quinonprotein_ADH-like_supfam    WD40/YVTN_repeat-like_dom    WD40_repeat    WD40_repeat_dom   
Domain families : Pfam (Sanger)WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)PREB
DMDM Disease mutations10113
Blocks (Seattle)PREB
SuperfamilyQ9HCU5
Human Protein AtlasENSG00000138073
Peptide AtlasQ9HCU5
HPRD16216
IPIIPI00033349   IPI00894237   IPI00892567   IPI00892937   IPI00893307   IPI00892685   
Protein Interaction databases
DIP (DOE-UCLA)Q9HCU5
IntAct (EBI)Q9HCU5
FunCoupENSG00000138073
BioGRIDPREB
STRING (EMBL)PREB
ZODIACPREB
Ontologies - Pathways
QuickGOQ9HCU5
Ontology : AmiGOGolgi membrane  DNA binding  nucleus  endoplasmic reticulum membrane  transcription, DNA-templated  regulation of transcription, DNA-templated  ER to Golgi vesicle-mediated transport  protein transport  membrane  integral component of membrane  protein N-linked glycosylation via asparagine  endoplasmic reticulum unfolded protein response  IRE1-mediated unfolded protein response  post-translational protein modification  cellular protein metabolic process  COPII vesicle coating  membrane organization  
Ontology : EGO-EBIGolgi membrane  DNA binding  nucleus  endoplasmic reticulum membrane  transcription, DNA-templated  regulation of transcription, DNA-templated  ER to Golgi vesicle-mediated transport  protein transport  membrane  integral component of membrane  protein N-linked glycosylation via asparagine  endoplasmic reticulum unfolded protein response  IRE1-mediated unfolded protein response  post-translational protein modification  cellular protein metabolic process  COPII vesicle coating  membrane organization  
Pathways : KEGGProtein processing in endoplasmic reticulum   
NDEx NetworkPREB
Atlas of Cancer Signalling NetworkPREB
Wikipedia pathwaysPREB
Orthology - Evolution
OrthoDB10113
GeneTree (enSembl)ENSG00000138073
Phylogenetic Trees/Animal Genes : TreeFamPREB
HOVERGENQ9HCU5
HOGENOMQ9HCU5
Homologs : HomoloGenePREB
Homology/Alignments : Family Browser (UCSC)PREB
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPREB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PREB
dbVarPREB
ClinVarPREB
1000_GenomesPREB 
Exome Variant ServerPREB
ExAC (Exome Aggregation Consortium)PREB (select the gene name)
Genetic variants : HAPMAP10113
Genomic Variants (DGV)PREB [DGVbeta]
DECIPHER (Syndromes)2:27353625-27357542  ENSG00000138073
CONAN: Copy Number AnalysisPREB 
Mutations
ICGC Data PortalPREB 
TCGA Data PortalPREB 
Broad Tumor PortalPREB
OASIS PortalPREB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPREB  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPREB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PREB
DgiDB (Drug Gene Interaction Database)PREB
DoCM (Curated mutations)PREB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PREB (select a term)
intoGenPREB
Cancer3DPREB(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606395   
Orphanet
MedgenPREB
Genetic Testing Registry PREB
NextProtQ9HCU5 [Medical]
TSGene10113
GENETestsPREB
Huge Navigator PREB [HugePedia]
snp3D : Map Gene to Disease10113
BioCentury BCIQPREB
ClinGenPREB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10113
Chemical/Pharm GKB GenePA33727
Clinical trialPREB
Miscellaneous
canSAR (ICR)PREB (select the gene name)
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePREB
EVEXPREB
GoPubMedPREB
iHOPPREB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:39:35 CET 2017

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