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PREPL (prolyl endopeptidase-like)

Identity

Alias_symbol (synonym)KIAA0436
Other aliasCMS22
HGNC (Hugo) PREPL
LocusID (NCBI) 9581
Atlas_Id 46598
Location 2p21  [Link to chromosome band 2p21]
Location_base_pair Starts at 44317609 and ends at 44359749 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PPP6R3 (11q13.2) / PREPL (2p21)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PREPL   30228
Cards
Entrez_Gene (NCBI)PREPL  9581  prolyl endopeptidase-like
AliasesCMS22
GeneCards (Weizmann)PREPL
Ensembl hg19 (Hinxton)ENSG00000138078 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138078 [Gene_View]  chr2:44317609-44359749 [Contig_View]  PREPL [Vega]
ICGC DataPortalENSG00000138078
TCGA cBioPortalPREPL
AceView (NCBI)PREPL
Genatlas (Paris)PREPL
WikiGenes9581
SOURCE (Princeton)PREPL
Genetics Home Reference (NIH)PREPL
Genomic and cartography
GoldenPath hg38 (UCSC)PREPL  -     chr2:44317609-44359749 -  2p21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PREPL  -     2p21   [Description]    (hg19-Feb_2009)
EnsemblPREPL - 2p21 [CytoView hg19]  PREPL - 2p21 [CytoView hg38]
Mapping of homologs : NCBIPREPL [Mapview hg19]  PREPL [Mapview hg38]
OMIM609557   616224   
Gene and transcription
Genbank (Entrez)AB007896 AK025649 AK131463 AW020480 BC013193
RefSeq transcript (Entrez)NM_001042385 NM_001042386 NM_001171603 NM_001171606 NM_001171613 NM_001171617 NM_006036
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PREPL
Cluster EST : UnigeneHs.444349 [ NCBI ]
CGAP (NCI)Hs.444349
Alternative Splicing GalleryENSG00000138078
Gene ExpressionPREPL [ NCBI-GEO ]   PREPL [ EBI - ARRAY_EXPRESS ]   PREPL [ SEEK ]   PREPL [ MEM ]
Gene Expression Viewer (FireBrowse)PREPL [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9581
GTEX Portal (Tissue expression)PREPL
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ4J6C6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ4J6C6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ4J6C6
Splice isoforms : SwissVarQ4J6C6
Catalytic activity : Enzyme3.4.21.- [ Enzyme-Expasy ]   3.4.21.-3.4.21.- [ IntEnz-EBI ]   3.4.21.- [ BRENDA ]   3.4.21.- [ KEGG ]   
PhosPhoSitePlusQ4J6C6
Domains : Interpro (EBI)AB_hydrolase    Pept_S9A_N    Peptidase_S9    Peptidase_S9A   
Domain families : Pfam (Sanger)Peptidase_S9 (PF00326)    Peptidase_S9_N (PF02897)   
Domain families : Pfam (NCBI)pfam00326    pfam02897   
Conserved Domain (NCBI)PREPL
DMDM Disease mutations9581
Blocks (Seattle)PREPL
SuperfamilyQ4J6C6
Human Protein AtlasENSG00000138078
Peptide AtlasQ4J6C6
HPRD17189
IPIIPI00442171   IPI00760871   IPI00619908   IPI00880064   IPI00915800   IPI00917679   IPI00916107   
Protein Interaction databases
DIP (DOE-UCLA)Q4J6C6
IntAct (EBI)Q4J6C6
FunCoupENSG00000138078
BioGRIDPREPL
STRING (EMBL)PREPL
ZODIACPREPL
Ontologies - Pathways
QuickGOQ4J6C6
Ontology : AmiGOserine-type endopeptidase activity  Golgi apparatus  cytosol  cytoskeleton  proteolysis  serine-type exopeptidase activity  
Ontology : EGO-EBIserine-type endopeptidase activity  Golgi apparatus  cytosol  cytoskeleton  proteolysis  serine-type exopeptidase activity  
NDEx NetworkPREPL
Atlas of Cancer Signalling NetworkPREPL
Wikipedia pathwaysPREPL
Orthology - Evolution
OrthoDB9581
GeneTree (enSembl)ENSG00000138078
Phylogenetic Trees/Animal Genes : TreeFamPREPL
HOVERGENQ4J6C6
HOGENOMQ4J6C6
Homologs : HomoloGenePREPL
Homology/Alignments : Family Browser (UCSC)PREPL
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPREPL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PREPL
dbVarPREPL
ClinVarPREPL
1000_GenomesPREPL 
Exome Variant ServerPREPL
ExAC (Exome Aggregation Consortium)PREPL (select the gene name)
Genetic variants : HAPMAP9581
Genomic Variants (DGV)PREPL [DGVbeta]
DECIPHERPREPL [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPREPL 
Mutations
ICGC Data PortalPREPL 
TCGA Data PortalPREPL 
Broad Tumor PortalPREPL
OASIS PortalPREPL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPREPL  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPREPL
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch PREPL
DgiDB (Drug Gene Interaction Database)PREPL
DoCM (Curated mutations)PREPL (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PREPL (select a term)
intoGenPREPL
Cancer3DPREPL(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609557    616224   
Orphanet17525    17524    19272    22441   
MedgenPREPL
Genetic Testing Registry PREPL
NextProtQ4J6C6 [Medical]
TSGene9581
GENETestsPREPL
Target ValidationPREPL
Huge Navigator PREPL [HugePedia]
snp3D : Map Gene to Disease9581
BioCentury BCIQPREPL
ClinGenPREPL (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9581
Chemical/Pharm GKB GenePA142671134
Clinical trialPREPL
Miscellaneous
canSAR (ICR)PREPL (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePREPL
EVEXPREPL
GoPubMedPREPL
iHOPPREPL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:26:24 CEST 2017

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