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PREX1 (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1)

Identity

Alias_namesphosphatidylinositol-3
Alias_symbol (synonym)KIAA1415
P-REX1
Other alias
HGNC (Hugo) PREX1
LocusID (NCBI) 57580
Atlas_Id 43426
Location 20q13.13  [Link to chromosome band 20q13]
Location_base_pair Starts at 47240793 and ends at 47444420 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ATP11C (Xq27.1) / PREX1 (20q13.13)PREX1 (20q13.13) / ARFGEF2 (20q13.13)PREX1 (20q13.13) / EHBP1 (2p15)
PREX1 (20q13.13) / MFN1 (3q26.33)PREX1 (20q13.13) / SUGT1 (13q14.3)RP11-123B3.6 () / PREX1 (20q13.13)
STAU1 (20q13.13) / PREX1 (20q13.13)ATP11C Xq27.1 / PREX1 20q13.13PREX1 20q13.13 / EHBP1 2p15
PREX1 20q13.13 / MFN1 3q26.33RP11-123B3.6 PREX1 20q13.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PREX1   32594
Cards
Entrez_Gene (NCBI)PREX1  57580  phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1
AliasesP-REX1
GeneCards (Weizmann)PREX1
Ensembl hg19 (Hinxton)ENSG00000124126 [Gene_View]  chr20:47240793-47444420 [Contig_View]  PREX1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000124126 [Gene_View]  chr20:47240793-47444420 [Contig_View]  PREX1 [Vega]
ICGC DataPortalENSG00000124126
TCGA cBioPortalPREX1
AceView (NCBI)PREX1
Genatlas (Paris)PREX1
WikiGenes57580
SOURCE (Princeton)PREX1
Genetics Home Reference (NIH)PREX1
Genomic and cartography
GoldenPath hg19 (UCSC)PREX1  -     chr20:47240793-47444420 -  20q13.13   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PREX1  -     20q13.13   [Description]    (hg38-Dec_2013)
EnsemblPREX1 - 20q13.13 [CytoView hg19]  PREX1 - 20q13.13 [CytoView hg38]
Mapping of homologs : NCBIPREX1 [Mapview hg19]  PREX1 [Mapview hg38]
OMIM606905   
Gene and transcription
Genbank (Entrez)AB037836 AJ320261 AK090860 AL136579 AL832913
RefSeq transcript (Entrez)NM_020820
RefSeq genomic (Entrez)NC_000020 NC_018931 NT_011362 NW_004929418
Consensus coding sequences : CCDS (NCBI)PREX1
Cluster EST : UnigeneHs.153310 [ NCBI ]
CGAP (NCI)Hs.153310
Alternative Splicing GalleryENSG00000124126
Gene ExpressionPREX1 [ NCBI-GEO ]   PREX1 [ EBI - ARRAY_EXPRESS ]   PREX1 [ SEEK ]   PREX1 [ MEM ]
Gene Expression Viewer (FireBrowse)PREX1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57580
GTEX Portal (Tissue expression)PREX1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TCU6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TCU6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TCU6
Splice isoforms : SwissVarQ8TCU6
PhosPhoSitePlusQ8TCU6
Domaine pattern : Prosite (Expaxy)DEP (PS50186)    DH_1 (PS00741)    DH_2 (PS50010)    PDZ (PS50106)    PH_DOMAIN (PS50003)   
Domains : Interpro (EBI)DEP_dom    DH-domain    GDS_CDC24_CS    PDZ    PH_dom-like    PH_domain    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)DEP (PF00610)    RhoGEF (PF00621)   
Domain families : Pfam (NCBI)pfam00610    pfam00621   
Domain families : Smart (EMBL)DEP (SM00049)  PDZ (SM00228)  PH (SM00233)  RhoGEF (SM00325)  
Conserved Domain (NCBI)PREX1
DMDM Disease mutations57580
Blocks (Seattle)PREX1
PDB (SRS)3QIK    4YON   
PDB (PDBSum)3QIK    4YON   
PDB (IMB)3QIK    4YON   
PDB (RSDB)3QIK    4YON   
Structural Biology KnowledgeBase3QIK    4YON   
SCOP (Structural Classification of Proteins)3QIK    4YON   
CATH (Classification of proteins structures)3QIK    4YON   
SuperfamilyQ8TCU6
Human Protein AtlasENSG00000124126
Peptide AtlasQ8TCU6
HPRD06066
IPIIPI00295252   IPI00218429   IPI00552692   
Protein Interaction databases
DIP (DOE-UCLA)Q8TCU6
IntAct (EBI)Q8TCU6
FunCoupENSG00000124126
BioGRIDPREX1
STRING (EMBL)PREX1
ZODIACPREX1
Ontologies - Pathways
QuickGOQ8TCU6
Ontology : AmiGORho guanyl-nucleotide exchange factor activity  GTPase activator activity  protein binding  phospholipid binding  cytoplasm  cytosol  plasma membrane  superoxide metabolic process  G-protein coupled receptor signaling pathway  enzyme binding  actin filament polymerization  T cell differentiation  growth cone  neutrophil chemotaxis  regulation of actin filament polymerization  regulation of Rho protein signal transduction  intracellular signal transduction  neutrophil activation  dendritic shaft  intracellular membrane-bounded organelle  positive regulation of GTPase activity  perinuclear region of cytoplasm  regulation of dendrite development  positive regulation of substrate adhesion-dependent cell spreading  
Ontology : EGO-EBIRho guanyl-nucleotide exchange factor activity  GTPase activator activity  protein binding  phospholipid binding  cytoplasm  cytosol  plasma membrane  superoxide metabolic process  G-protein coupled receptor signaling pathway  enzyme binding  actin filament polymerization  T cell differentiation  growth cone  neutrophil chemotaxis  regulation of actin filament polymerization  regulation of Rho protein signal transduction  intracellular signal transduction  neutrophil activation  dendritic shaft  intracellular membrane-bounded organelle  positive regulation of GTPase activity  perinuclear region of cytoplasm  regulation of dendrite development  positive regulation of substrate adhesion-dependent cell spreading  
Pathways : KEGGChemokine signaling pathway   
NDEx NetworkPREX1
Atlas of Cancer Signalling NetworkPREX1
Wikipedia pathwaysPREX1
Orthology - Evolution
OrthoDB57580
GeneTree (enSembl)ENSG00000124126
Phylogenetic Trees/Animal Genes : TreeFamPREX1
HOVERGENQ8TCU6
HOGENOMQ8TCU6
Homologs : HomoloGenePREX1
Homology/Alignments : Family Browser (UCSC)PREX1
Gene fusions - Rearrangements
Fusion : MitelmanATP11C/PREX1 [Xq27.1/20q13.13]  [t(X;20)(q27;q13)]  
Fusion : MitelmanPREX1/EHBP1 [20q13.13/2p15]  [t(2;20)(p15;q13)]  
Fusion : MitelmanPREX1/MFN1 [20q13.13/3q26.33]  [t(3;20)(q26;q13)]  
Fusion: TCGAATP11C Xq27.1 PREX1 20q13.13 BRCA
Fusion: TCGAPREX1 20q13.13 EHBP1 2p15 BRCA
Fusion: TCGAPREX1 20q13.13 MFN1 3q26.33 BRCA
Fusion: TCGARP11-123B3.6 PREX1 20q13.13 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPREX1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PREX1
dbVarPREX1
ClinVarPREX1
1000_GenomesPREX1 
Exome Variant ServerPREX1
ExAC (Exome Aggregation Consortium)PREX1 (select the gene name)
Genetic variants : HAPMAP57580
Genomic Variants (DGV)PREX1 [DGVbeta]
DECIPHER (Syndromes)20:47240793-47444420  ENSG00000124126
CONAN: Copy Number AnalysisPREX1 
Mutations
ICGC Data PortalPREX1 
TCGA Data PortalPREX1 
Broad Tumor PortalPREX1
OASIS PortalPREX1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPREX1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPREX1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PREX1
DgiDB (Drug Gene Interaction Database)PREX1
DoCM (Curated mutations)PREX1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PREX1 (select a term)
intoGenPREX1
Cancer3DPREX1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606905   
Orphanet
MedgenPREX1
Genetic Testing Registry PREX1
NextProtQ8TCU6 [Medical]
TSGene57580
GENETestsPREX1
Huge Navigator PREX1 [HugePedia]
snp3D : Map Gene to Disease57580
BioCentury BCIQPREX1
ClinGenPREX1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57580
Chemical/Pharm GKB GenePA164725018
Clinical trialPREX1
Miscellaneous
canSAR (ICR)PREX1 (select the gene name)
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePREX1
EVEXPREX1
GoPubMedPREX1
iHOPPREX1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:15:35 CEST 2017

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