PREX2 (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2)

2006-10-01  

Identity

HGNC
PREX2
LOCATION
8q13.2
LOCUSID
80243
ALIAS
DEP.2,DEPDC2,P-REX2,PPP1R129
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 80243
MIM: 612139
HGNC: 22950
Ensembl: ENSG00000046889

Variants:

dbSNP: 80243
ClinVar: 80243
TCGA: ENSG00000046889
COSMIC: PREX2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000046889ENST00000288368Q70Z35

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
226225782012Melanoma genome sequencing reveals frequent PREX2 mutations.295
197296582009Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P-REX2a.96
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
153043432004P-Rex2, a new guanine-nucleotide exchange factor for Rac.41
241403442013miR-338-3p suppresses neuroblastoma proliferation, invasion and migration through targeting PREX2a.38
243756442014miR-338-3p suppresses gastric cancer progression through a PTEN-AKT axis by targeting P-REX2a.34
230335352012Rho GEFs and cancer: linking gene expression and metastatic dissemination.31
153043422004P-REX2, a novel PI-3-kinase sensitive Rac exchange factor.30
258294462015PTEN inhibits PREX2-catalyzed activation of RAC1 to restrain tumor cell invasion.26
243670902014Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis.25

Citation

Dessen P

PREX2 (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43227/prex2