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PREX2 (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2)

Identity

Alias_namesregulatory subunit 129
DEPDC2
Alias_symbol (synonym)DEP.2
FLJ12987
P-REX2
PPP1R129
Other alias
HGNC (Hugo) PREX2
LocusID (NCBI) 80243
Atlas_Id 43227
Location 8q13.2  [Link to chromosome band 8q13]
Location_base_pair Starts at 67952115 and ends at 68237033 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FAM49B (8q24.21) / PREX2 (8q13.2)PDE7A (8q13.1) / PREX2 (8q13.2)FAM49B 8q24.21 / PREX2 8q13.2
PDE7A 8q13.1 / PREX2 8q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PREX2   22950
Cards
Entrez_Gene (NCBI)PREX2  80243  phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2
AliasesDEP.2; DEPDC2; P-REX2; PPP1R129
GeneCards (Weizmann)PREX2
Ensembl hg19 (Hinxton)ENSG00000046889 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000046889 [Gene_View]  chr8:67952115-68237033 [Contig_View]  PREX2 [Vega]
ICGC DataPortalENSG00000046889
TCGA cBioPortalPREX2
AceView (NCBI)PREX2
Genatlas (Paris)PREX2
WikiGenes80243
SOURCE (Princeton)PREX2
Genetics Home Reference (NIH)PREX2
Genomic and cartography
GoldenPath hg38 (UCSC)PREX2  -     chr8:67952115-68237033 +  8q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PREX2  -     8q13.2   [Description]    (hg19-Feb_2009)
EnsemblPREX2 - 8q13.2 [CytoView hg19]  PREX2 - 8q13.2 [CytoView hg38]
Mapping of homologs : NCBIPREX2 [Mapview hg19]  PREX2 [Mapview hg38]
OMIM612139   
Gene and transcription
Genbank (Entrez)AJ437636 AK023049 AK023631 AK024079 AK123390
RefSeq transcript (Entrez)NM_024870 NM_025170
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PREX2
Cluster EST : UnigeneHs.732080 [ NCBI ]
CGAP (NCI)Hs.732080
Alternative Splicing GalleryENSG00000046889
Gene ExpressionPREX2 [ NCBI-GEO ]   PREX2 [ EBI - ARRAY_EXPRESS ]   PREX2 [ SEEK ]   PREX2 [ MEM ]
Gene Expression Viewer (FireBrowse)PREX2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)80243
GTEX Portal (Tissue expression)PREX2
Human Protein AtlasENSG00000046889-PREX2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ70Z35   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ70Z35  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ70Z35
Splice isoforms : SwissVarQ70Z35
PhosPhoSitePlusQ70Z35
Domaine pattern : Prosite (Expaxy)DEP (PS50186)    DH_1 (PS00741)    DH_2 (PS50010)    PDZ (PS50106)    PH_DOMAIN (PS50003)   
Domains : Interpro (EBI)DEP_dom    DH-domain    GDS_CDC24_CS    PDZ    PH_dom-like    PH_domain    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)DEP (PF00610)    PH (PF00169)    RhoGEF (PF00621)   
Domain families : Pfam (NCBI)pfam00610    pfam00169    pfam00621   
Domain families : Smart (EMBL)DEP (SM00049)  PDZ (SM00228)  PH (SM00233)  RhoGEF (SM00325)  
Conserved Domain (NCBI)PREX2
DMDM Disease mutations80243
Blocks (Seattle)PREX2
SuperfamilyQ70Z35
Human Protein Atlas [tissue]ENSG00000046889-PREX2 [tissue]
Peptide AtlasQ70Z35
HPRD13135
IPIIPI00418876   IPI00845229   IPI00418875   IPI00873980   
Protein Interaction databases
DIP (DOE-UCLA)Q70Z35
IntAct (EBI)Q70Z35
FunCoupENSG00000046889
BioGRIDPREX2
STRING (EMBL)PREX2
ZODIACPREX2
Ontologies - Pathways
QuickGOQ70Z35
Ontology : AmiGOGTPase activator activity  cytoplasm  plasma membrane  negative regulation of protein kinase activity  G-protein coupled receptor signaling pathway  adult locomotory behavior  phosphatidylinositol 3-kinase signaling  Rac guanyl-nucleotide exchange factor activity  negative regulation of TOR signaling  regulation of Rho protein signal transduction  positive regulation of GTPase activity  dendrite morphogenesis  
Ontology : EGO-EBIGTPase activator activity  cytoplasm  plasma membrane  negative regulation of protein kinase activity  G-protein coupled receptor signaling pathway  adult locomotory behavior  phosphatidylinositol 3-kinase signaling  Rac guanyl-nucleotide exchange factor activity  negative regulation of TOR signaling  regulation of Rho protein signal transduction  positive regulation of GTPase activity  dendrite morphogenesis  
NDEx NetworkPREX2
Atlas of Cancer Signalling NetworkPREX2
Wikipedia pathwaysPREX2
Orthology - Evolution
OrthoDB80243
GeneTree (enSembl)ENSG00000046889
Phylogenetic Trees/Animal Genes : TreeFamPREX2
HOVERGENQ70Z35
HOGENOMQ70Z35
Homologs : HomoloGenePREX2
Homology/Alignments : Family Browser (UCSC)PREX2
Gene fusions - Rearrangements
Fusion : MitelmanFAM49B/PREX2 [8q24.21/8q13.2]  [t(8;8)(q13;q24)]  
Fusion : MitelmanPDE7A/PREX2 [8q13.1/8q13.2]  [t(8;8)(q13;q13)]  
Fusion: TCGA_MDACCFAM49B 8q24.21 PREX2 8q13.2 LUAD
Fusion: TCGA_MDACCPDE7A 8q13.1 PREX2 8q13.2 BRCA
Tumor Fusion PortalPREX2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPREX2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PREX2
dbVarPREX2
ClinVarPREX2
1000_GenomesPREX2 
Exome Variant ServerPREX2
ExAC (Exome Aggregation Consortium)ENSG00000046889
GNOMAD BrowserENSG00000046889
Genetic variants : HAPMAP80243
Genomic Variants (DGV)PREX2 [DGVbeta]
DECIPHERPREX2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPREX2 
Mutations
ICGC Data PortalPREX2 
TCGA Data PortalPREX2 
Broad Tumor PortalPREX2
OASIS PortalPREX2 [ Somatic mutations - Copy number]
Cancer Gene: CensusPREX2 
Somatic Mutations in Cancer : COSMICPREX2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPREX2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PREX2
DgiDB (Drug Gene Interaction Database)PREX2
DoCM (Curated mutations)PREX2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PREX2 (select a term)
intoGenPREX2
Cancer3DPREX2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612139   
Orphanet
DisGeNETPREX2
MedgenPREX2
Genetic Testing Registry PREX2
NextProtQ70Z35 [Medical]
TSGene80243
GENETestsPREX2
Target ValidationPREX2
Huge Navigator PREX2 [HugePedia]
snp3D : Map Gene to Disease80243
BioCentury BCIQPREX2
ClinGenPREX2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD80243
Chemical/Pharm GKB GenePA164725103
Clinical trialPREX2
Miscellaneous
canSAR (ICR)PREX2 (select the gene name)
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePREX2
EVEXPREX2
GoPubMedPREX2
iHOPPREX2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:30:14 CET 2017

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