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PRG2 (proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein))

Identity

Alias_namesproteoglycan 2
Alias_symbol (synonym)MBP
BMPG
proMBP
Other aliasMBP1
HGNC (Hugo) PRG2
LocusID (NCBI) 5553
Atlas_Id 41841
Location 11q12.1  [Link to chromosome band 11q12]
Location_base_pair Starts at 57154260 and ends at 57158130 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CGA (6q14.3) / PRG2 (11q12.1)EPB41 (1p35.3) / PRG2 (11q12.1)PDGFRA (4q12) / PRG2 (11q12.1)
PRG2 (11q12.1) / F11R (1q23.3)PRG2 (11q12.1) / FLNA (Xq28)PRG2 (11q12.1) / LOC100507412 (-)
PRG2 (11q12.1) / MACROD2 (20p12.1)PRG2 (11q12.1) / NTPCR (1q42.2)PRG2 (11q12.1) / SERINC3 (20q13.12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PRG2   9362
Cards
Entrez_Gene (NCBI)PRG2  5553  proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
AliasesBMPG; MBP; MBP1
GeneCards (Weizmann)PRG2
Ensembl hg19 (Hinxton)ENSG00000186652 [Gene_View]  chr11:57154260-57158130 [Contig_View]  PRG2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000186652 [Gene_View]  chr11:57154260-57158130 [Contig_View]  PRG2 [Vega]
ICGC DataPortalENSG00000186652
TCGA cBioPortalPRG2
AceView (NCBI)PRG2
Genatlas (Paris)PRG2
WikiGenes5553
SOURCE (Princeton)PRG2
Genetics Home Reference (NIH)PRG2
Genomic and cartography
GoldenPath hg19 (UCSC)PRG2  -     chr11:57154260-57158130 -  11q12.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PRG2  -     11q12.1   [Description]    (hg38-Dec_2013)
EnsemblPRG2 - 11q12.1 [CytoView hg19]  PRG2 - 11q12.1 [CytoView hg38]
Mapping of homologs : NCBIPRG2 [Mapview hg19]  PRG2 [Mapview hg38]
OMIM605601   
Gene and transcription
Genbank (Entrez)AK312195 AU135652 BC005929 BQ445845 BX395670
RefSeq transcript (Entrez)NM_001243245 NM_001302926 NM_001302927 NM_002728
RefSeq genomic (Entrez)NC_000011 NC_018922 NT_167190 NW_004929380
Consensus coding sequences : CCDS (NCBI)PRG2
Cluster EST : UnigeneHs.512633 [ NCBI ]
CGAP (NCI)Hs.512633
Alternative Splicing GalleryENSG00000186652
Gene ExpressionPRG2 [ NCBI-GEO ]   PRG2 [ EBI - ARRAY_EXPRESS ]   PRG2 [ SEEK ]   PRG2 [ MEM ]
Gene Expression Viewer (FireBrowse)PRG2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5553
GTEX Portal (Tissue expression)PRG2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP13727   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP13727  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP13727
Splice isoforms : SwissVarP13727
PhosPhoSitePlusP13727
Domaine pattern : Prosite (Expaxy)C_TYPE_LECTIN_1 (PS00615)    C_TYPE_LECTIN_2 (PS50041)   
Domains : Interpro (EBI)C-type_lectin    C-type_lectin-like    C-type_lectin_CS    C-type_lectin_fold    Eosinophil_major_basic   
Domain families : Pfam (Sanger)Lectin_C (PF00059)   
Domain families : Pfam (NCBI)pfam00059   
Domain families : Smart (EMBL)CLECT (SM00034)  
Conserved Domain (NCBI)PRG2
DMDM Disease mutations5553
Blocks (Seattle)PRG2
PDB (SRS)1H8U    2BRS    4QXX   
PDB (PDBSum)1H8U    2BRS    4QXX   
PDB (IMB)1H8U    2BRS    4QXX   
PDB (RSDB)1H8U    2BRS    4QXX   
Structural Biology KnowledgeBase1H8U    2BRS    4QXX   
SCOP (Structural Classification of Proteins)1H8U    2BRS    4QXX   
CATH (Classification of proteins structures)1H8U    2BRS    4QXX   
SuperfamilyP13727
Human Protein AtlasENSG00000186652
Peptide AtlasP13727
HPRD09283
IPIIPI00010341   IPI00847535   IPI00981634   
Protein Interaction databases
DIP (DOE-UCLA)P13727
IntAct (EBI)P13727
FunCoupENSG00000186652
BioGRIDPRG2
STRING (EMBL)PRG2
ZODIACPRG2
Ontologies - Pathways
QuickGOP13727
Ontology : AmiGOdefense response to nematode  extracellular region  immune response  heparin binding  transport vesicle  carbohydrate binding  negative regulation of interleukin-10 production  positive regulation of interleukin-4 production  regulation of cytokine biosynthetic process  defense response to bacterium  extracellular exosome  
Ontology : EGO-EBIdefense response to nematode  extracellular region  immune response  heparin binding  transport vesicle  carbohydrate binding  negative regulation of interleukin-10 production  positive regulation of interleukin-4 production  regulation of cytokine biosynthetic process  defense response to bacterium  extracellular exosome  
Pathways : KEGGAsthma   
NDEx NetworkPRG2
Atlas of Cancer Signalling NetworkPRG2
Wikipedia pathwaysPRG2
Orthology - Evolution
OrthoDB5553
GeneTree (enSembl)ENSG00000186652
Phylogenetic Trees/Animal Genes : TreeFamPRG2
HOVERGENP13727
HOGENOMP13727
Homologs : HomoloGenePRG2
Homology/Alignments : Family Browser (UCSC)PRG2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRG2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRG2
dbVarPRG2
ClinVarPRG2
1000_GenomesPRG2 
Exome Variant ServerPRG2
ExAC (Exome Aggregation Consortium)PRG2 (select the gene name)
Genetic variants : HAPMAP5553
Genomic Variants (DGV)PRG2 [DGVbeta]
DECIPHER (Syndromes)11:57154260-57158130  ENSG00000186652
CONAN: Copy Number AnalysisPRG2 
Mutations
ICGC Data PortalPRG2 
TCGA Data PortalPRG2 
Broad Tumor PortalPRG2
OASIS PortalPRG2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRG2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRG2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRG2
DgiDB (Drug Gene Interaction Database)PRG2
DoCM (Curated mutations)PRG2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRG2 (select a term)
intoGenPRG2
Cancer3DPRG2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605601   
Orphanet
MedgenPRG2
Genetic Testing Registry PRG2
NextProtP13727 [Medical]
TSGene5553
GENETestsPRG2
Huge Navigator PRG2 [HugePedia]
snp3D : Map Gene to Disease5553
BioCentury BCIQPRG2
ClinGenPRG2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5553
Chemical/Pharm GKB GenePA33734
Clinical trialPRG2
Miscellaneous
canSAR (ICR)PRG2 (select the gene name)
Probes
Litterature
PubMed68 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRG2
EVEXPRG2
GoPubMedPRG2
iHOPPRG2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:22:51 CET 2017

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