PRG2 (proteoglycan 2, pro eosinophil major basic protein)

2003-02-01  

Identity

HGNC
LOCATION
11q12.1
LOCUSID
ALIAS
BMPG,MBP,MBP1,proMBP
FUSION GENES

Other Information

Locus ID:

NCBI: 5553
MIM: 605601
HGNC: 9362
Ensembl: ENSG00000186652

Variants:

dbSNP: 5553
ClinVar: 5553
TCGA: ENSG00000186652
COSMIC: PRG2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186652ENST00000311862P13727
ENSG00000186652ENST00000525955P13727
ENSG00000186652ENST00000533605P13727

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10

Pathways

PathwaySourceExternal ID
AsthmaKEGGko05310
AsthmaKEGGhsa05310
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
122024802002Novel combinatorial interactions of GATA-1, PU.1, and C/EBPepsilon isoforms regulate transcription of the gene encoding eosinophil granule major basic protein.41
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
193989582009Vesicle-mediated secretion of human eosinophil granule-derived major basic protein.26
123701762002Cell surface targeting of pregnancy-associated plasma protein A proteolytic activity. Reversible adhesion is mediated by two neighboring short consensus repeats.24
257287692015Toxicity of eosinophil MBP is repressed by intracellular crystallization and promoted by extracellular aggregation.24
124218322003Complex of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein. Disulfide structure and carbohydrate attachment.17
145006732003Eosinophil major basic protein stimulates neutrophil superoxide production by a class IA phosphoinositide 3-kinase and protein kinase C-zeta-dependent pathway.12
208494152010MBP-1 is efficiently encoded by an alternative transcript of the ENO1 gene but post-translationally regulated by proteasome-dependent protein turnover.12
170826532006Major basic protein homolog (MBP2): a specific human eosinophil marker.10
209774312011Effects of respiratory syncytial virus infection and major basic protein derived from eosinophils in pulmonary alveolar epithelial cells (A549).10

Citation

Dessen P

PRG2 (proteoglycan 2, pro eosinophil major basic protein)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41841/prg2