PRG4 (proteoglycan 4)

2003-02-01  

Identity

HGNC
PRG4
LOCATION
1q31.1
LOCUSID
10216
ALIAS
CACP,HAPO,JCAP,MSF,SZP

Other Information

Locus ID:

NCBI: 10216
MIM: 604283
HGNC: 9364
Ensembl: ENSG00000116690

Variants:

dbSNP: 10216
ClinVar: 10216
TCGA: ENSG00000116690
COSMIC: PRG4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116690ENST00000367482J3KP74
ENSG00000116690ENST00000367483Q92954
ENSG00000116690ENST00000367485Q92954
ENSG00000116690ENST00000445192Q92954
ENSG00000116690ENST00000533951E9PLR3
ENSG00000116690ENST00000635041Q92954

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
185127762008Decreased lubricin concentrations and markers of joint inflammation in the synovial fluid of patients with anterior cruciate ligament injury.92
174042412007The role of lubricin in the mechanical behavior of synovial fluid.60
251728282014The biology of lubricin: near frictionless joint motion.40
257080252015Lubricin/Proteoglycan 4 Binding to CD44 Receptor: A Mechanism of the Suppression of Proinflammatory Cytokine-Induced Synoviocyte Proliferation by Lubricin.29
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
124756432002Immunolocalisation and expression of proteoglycan 4 (cartilage superficial zone proteoglycan) in tendon.26
266431052015The interaction of lubricin/proteoglycan 4 (PRG4) with toll-like receptors 2 and 4: an anti-inflammatory role of PRG4 in synovial fluid.26
294449762018FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis.26
190581832009Boundary mode lubrication of articular cartilage by recombinant human lubricin.24
204437802010The glycosylation of human synovial lubricin: implications for its role in inflammation.23

Citation

Dessen P

PRG4 (proteoglycan 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41843/prg4