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PRICKLE2 (prickle planar cell polarity protein 2)

Identity

Alias (NCBI)EPM5
HGNC (Hugo) PRICKLE2
HGNC Alias symbDKFZp686D143
HGNC Previous nameprickle-like 2 (Drosophila)
 prickle homolog 2 (Drosophila)
LocusID (NCBI) 166336
Atlas_Id 54552
Location 3p14.1  [Link to chromosome band 3p14]
Location_base_pair Starts at 64092236 and ends at 64225466 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PRICKLE2 (3p14.1) / TCEA3 (1p36.12)SULF2 (20q13.12) / PRICKLE2 (3p14.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PRICKLE2   20340
Cards
Entrez_Gene (NCBI)PRICKLE2    prickle planar cell polarity protein 2
AliasesEPM5
GeneCards (Weizmann)PRICKLE2
Ensembl hg19 (Hinxton)ENSG00000163637 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163637 [Gene_View]  ENSG00000163637 [Sequence]  chr3:64092236-64225466 [Contig_View]  PRICKLE2 [Vega]
ICGC DataPortalENSG00000163637
TCGA cBioPortalPRICKLE2
AceView (NCBI)PRICKLE2
Genatlas (Paris)PRICKLE2
SOURCE (Princeton)PRICKLE2
Genetics Home Reference (NIH)PRICKLE2
Genomic and cartography
GoldenPath hg38 (UCSC)PRICKLE2  -     chr3:64092236-64225466 -  3p14.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRICKLE2  -     3p14.1   [Description]    (hg19-Feb_2009)
GoldenPathPRICKLE2 - 3p14.1 [CytoView hg19]  PRICKLE2 - 3p14.1 [CytoView hg38]
ImmunoBaseENSG00000163637
Genome Data Viewer NCBIPRICKLE2 [Mapview hg19]  
OMIM608501   
Gene and transcription
Genbank (Entrez)AK055479 AK093899 AK127113 AK127839 AL833539
RefSeq transcript (Entrez)NM_001370528 NM_198859
Consensus coding sequences : CCDS (NCBI)PRICKLE2
Gene ExpressionPRICKLE2 [ NCBI-GEO ]   PRICKLE2 [ EBI - ARRAY_EXPRESS ]   PRICKLE2 [ SEEK ]   PRICKLE2 [ MEM ]
Gene Expression Viewer (FireBrowse)PRICKLE2 [ Firebrowse - Broad ]
GenevisibleExpression of PRICKLE2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)166336
GTEX Portal (Tissue expression)PRICKLE2
Human Protein AtlasENSG00000163637-PRICKLE2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z3G6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z3G6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z3G6
PhosPhoSitePlusQ7Z3G6
Domaine pattern : Prosite (Expaxy)LIM_DOMAIN_1 (PS00478)    LIM_DOMAIN_2 (PS50023)    PET (PS51303)   
Domains : Interpro (EBI)LIM1_prickle    LIM2_prickle    LIM3_prickle    PET_domain    PET_prickle    Znf_LIM   
Domain families : Pfam (Sanger)LIM (PF00412)    PET (PF06297)   
Domain families : Pfam (NCBI)pfam00412    pfam06297   
Domain families : Smart (EMBL)LIM (SM00132)  
Conserved Domain (NCBI)PRICKLE2
SuperfamilyQ7Z3G6
AlphaFold pdb e-kbQ7Z3G6   
Human Protein Atlas [tissue]ENSG00000163637-PRICKLE2 [tissue]
HPRD16342
Protein Interaction databases
DIP (DOE-UCLA)Q7Z3G6
IntAct (EBI)Q7Z3G6
BioGRIDPRICKLE2
STRING (EMBL)PRICKLE2
ZODIACPRICKLE2
Ontologies - Pathways
QuickGOQ7Z3G6
Ontology : AmiGOcytoplasm  zinc ion binding  nuclear membrane  Wnt signaling pathway, planar cell polarity pathway  
Ontology : EGO-EBIcytoplasm  zinc ion binding  nuclear membrane  Wnt signaling pathway, planar cell polarity pathway  
Pathways : KEGGWnt signaling pathway   
NDEx NetworkPRICKLE2
Atlas of Cancer Signalling NetworkPRICKLE2
Wikipedia pathwaysPRICKLE2
Orthology - Evolution
OrthoDB166336
GeneTree (enSembl)ENSG00000163637
Phylogenetic Trees/Animal Genes : TreeFamPRICKLE2
Homologs : HomoloGenePRICKLE2
Homology/Alignments : Family Browser (UCSC)PRICKLE2
Gene fusions - Rearrangements
Fusion : MitelmanSULF2/PRICKLE2 [20q13.12/3p14.1]  
Fusion : QuiverPRICKLE2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRICKLE2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRICKLE2
dbVarPRICKLE2
ClinVarPRICKLE2
MonarchPRICKLE2
1000_GenomesPRICKLE2 
Exome Variant ServerPRICKLE2
GNOMAD BrowserENSG00000163637
Varsome BrowserPRICKLE2
ACMGPRICKLE2 variants
VarityQ7Z3G6
Genomic Variants (DGV)PRICKLE2 [DGVbeta]
DECIPHERPRICKLE2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRICKLE2 
Mutations
ICGC Data PortalPRICKLE2 
TCGA Data PortalPRICKLE2 
Broad Tumor PortalPRICKLE2
OASIS PortalPRICKLE2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRICKLE2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPRICKLE2
Mutations and Diseases : HGMDPRICKLE2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPRICKLE2
DgiDB (Drug Gene Interaction Database)PRICKLE2
DoCM (Curated mutations)PRICKLE2
CIViC (Clinical Interpretations of Variants in Cancer)PRICKLE2
Cancer3DPRICKLE2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608501   
Orphanet22878   
DisGeNETPRICKLE2
MedgenPRICKLE2
Genetic Testing Registry PRICKLE2
NextProtQ7Z3G6 [Medical]
GENETestsPRICKLE2
Target ValidationPRICKLE2
Huge Navigator PRICKLE2 [HugePedia]
ClinGenPRICKLE2
Clinical trials, drugs, therapy
MyCancerGenomePRICKLE2
Protein Interactions : CTDPRICKLE2
Pharm GKB GenePA134883144
PharosQ7Z3G6
Clinical trialPRICKLE2
Miscellaneous
canSAR (ICR)PRICKLE2
HarmonizomePRICKLE2
DataMed IndexPRICKLE2
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPRICKLE2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:26:47 CEST 2021

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