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PRICKLE2 (prickle planar cell polarity protein 2)

Identity

Alias_namesprickle-like 2 (Drosophila)
prickle homolog 2 (Drosophila)
Alias_symbol (synonym)DKFZp686D143
Other aliasEPM5
HGNC (Hugo) PRICKLE2
LocusID (NCBI) 166336
Atlas_Id 54552
Location 3p14.1  [Link to chromosome band 3p14]
Location_base_pair Starts at 64079526 and ends at 64211131 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
PRICKLE2 (3p14.1) / TCEA3 (1p36.12)SULF2 (20q13.12) / PRICKLE2 (3p14.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PRICKLE2   20340
Cards
Entrez_Gene (NCBI)PRICKLE2  166336  prickle planar cell polarity protein 2
AliasesEPM5
GeneCards (Weizmann)PRICKLE2
Ensembl hg19 (Hinxton)ENSG00000163637 [Gene_View]  chr3:64079526-64211131 [Contig_View]  PRICKLE2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000163637 [Gene_View]  chr3:64079526-64211131 [Contig_View]  PRICKLE2 [Vega]
ICGC DataPortalENSG00000163637
TCGA cBioPortalPRICKLE2
AceView (NCBI)PRICKLE2
Genatlas (Paris)PRICKLE2
WikiGenes166336
SOURCE (Princeton)PRICKLE2
Genetics Home Reference (NIH)PRICKLE2
Genomic and cartography
GoldenPath hg19 (UCSC)PRICKLE2  -     chr3:64079526-64211131 -  3p14.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PRICKLE2  -     3p14.1   [Description]    (hg38-Dec_2013)
EnsemblPRICKLE2 - 3p14.1 [CytoView hg19]  PRICKLE2 - 3p14.1 [CytoView hg38]
Mapping of homologs : NCBIPRICKLE2 [Mapview hg19]  PRICKLE2 [Mapview hg38]
OMIM608501   613832   
Gene and transcription
Genbank (Entrez)AK055479 AK093899 AK127113 AK127839 AL833539
RefSeq transcript (Entrez)NM_198859
RefSeq genomic (Entrez)NC_000003 NC_018914 NG_031930 NT_022517 NW_004929309
Consensus coding sequences : CCDS (NCBI)PRICKLE2
Cluster EST : UnigeneHs.148105 [ NCBI ]
CGAP (NCI)Hs.148105
Alternative Splicing GalleryENSG00000163637
Gene ExpressionPRICKLE2 [ NCBI-GEO ]   PRICKLE2 [ EBI - ARRAY_EXPRESS ]   PRICKLE2 [ SEEK ]   PRICKLE2 [ MEM ]
Gene Expression Viewer (FireBrowse)PRICKLE2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)166336
GTEX Portal (Tissue expression)PRICKLE2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z3G6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z3G6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z3G6
Splice isoforms : SwissVarQ7Z3G6
PhosPhoSitePlusQ7Z3G6
Domaine pattern : Prosite (Expaxy)LIM_DOMAIN_1 (PS00478)    LIM_DOMAIN_2 (PS50023)    PET (PS51303)   
Domains : Interpro (EBI)PET_domain    Znf_LIM   
Domain families : Pfam (Sanger)LIM (PF00412)    PET (PF06297)   
Domain families : Pfam (NCBI)pfam00412    pfam06297   
Domain families : Smart (EMBL)LIM (SM00132)  
Conserved Domain (NCBI)PRICKLE2
DMDM Disease mutations166336
Blocks (Seattle)PRICKLE2
SuperfamilyQ7Z3G6
Human Protein AtlasENSG00000163637
Peptide AtlasQ7Z3G6
HPRD16342
IPIIPI00085314   IPI00795985   
Protein Interaction databases
DIP (DOE-UCLA)Q7Z3G6
IntAct (EBI)Q7Z3G6
FunCoupENSG00000163637
BioGRIDPRICKLE2
STRING (EMBL)PRICKLE2
ZODIACPRICKLE2
Ontologies - Pathways
QuickGOQ7Z3G6
Ontology : AmiGOcytoplasm  zinc ion binding  nuclear membrane  Wnt signaling pathway, planar cell polarity pathway  
Ontology : EGO-EBIcytoplasm  zinc ion binding  nuclear membrane  Wnt signaling pathway, planar cell polarity pathway  
Pathways : KEGGWnt signaling pathway   
NDEx NetworkPRICKLE2
Atlas of Cancer Signalling NetworkPRICKLE2
Wikipedia pathwaysPRICKLE2
Orthology - Evolution
OrthoDB166336
GeneTree (enSembl)ENSG00000163637
Phylogenetic Trees/Animal Genes : TreeFamPRICKLE2
HOVERGENQ7Z3G6
HOGENOMQ7Z3G6
Homologs : HomoloGenePRICKLE2
Homology/Alignments : Family Browser (UCSC)PRICKLE2
Gene fusions - Rearrangements
Fusion : MitelmanSULF2/PRICKLE2 [20q13.12/3p14.1]  [t(3;20)(p14;q13)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRICKLE2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRICKLE2
dbVarPRICKLE2
ClinVarPRICKLE2
1000_GenomesPRICKLE2 
Exome Variant ServerPRICKLE2
ExAC (Exome Aggregation Consortium)PRICKLE2 (select the gene name)
Genetic variants : HAPMAP166336
Genomic Variants (DGV)PRICKLE2 [DGVbeta]
DECIPHER (Syndromes)3:64079526-64211131  ENSG00000163637
CONAN: Copy Number AnalysisPRICKLE2 
Mutations
ICGC Data PortalPRICKLE2 
TCGA Data PortalPRICKLE2 
Broad Tumor PortalPRICKLE2
OASIS PortalPRICKLE2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRICKLE2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRICKLE2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRICKLE2
DgiDB (Drug Gene Interaction Database)PRICKLE2
DoCM (Curated mutations)PRICKLE2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRICKLE2 (select a term)
intoGenPRICKLE2
Cancer3DPRICKLE2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608501    613832   
Orphanet22878   
MedgenPRICKLE2
Genetic Testing Registry PRICKLE2
NextProtQ7Z3G6 [Medical]
TSGene166336
GENETestsPRICKLE2
Huge Navigator PRICKLE2 [HugePedia]
snp3D : Map Gene to Disease166336
BioCentury BCIQPRICKLE2
ClinGenPRICKLE2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD166336
Chemical/Pharm GKB GenePA134883144
Clinical trialPRICKLE2
Miscellaneous
canSAR (ICR)PRICKLE2 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRICKLE2
EVEXPRICKLE2
GoPubMedPRICKLE2
iHOPPRICKLE2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:15:36 CEST 2017

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