PRICKLE2 (prickle planar cell polarity protein 2)

2014-08-01  

Identity

HGNC
PRICKLE2
LOCATION
3p14.1
LOCUSID
166336
ALIAS
EPM5
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 166336
MIM: 608501
HGNC: 20340
Ensembl: ENSG00000163637

Variants:

dbSNP: 166336
ClinVar: 166336
TCGA: ENSG00000163637
COSMIC: PRICKLE2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163637ENST00000295902A0A1X7SBR1
ENSG00000163637ENST00000498162C9JY03
ENSG00000163637ENST00000564377Q7Z3G6
ENSG00000163637ENST00000564377A0A024R368
ENSG00000163637ENST00000638394Q7Z3G6
ENSG00000163637ENST00000638394A0A024R368

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Wnt signaling pathwayKEGGko04310
Wnt signaling pathwayKEGGhsa04310

References

Pubmed IDYearTitleCitations
237119812013Disruption of the non-canonical Wnt gene PRICKLE2 leads to autism-like behaviors with evidence for hippocampal synaptic dysfunction.30
125258872003Identification and characterization of human PRICKLE1 and PRICKLE2 genes as well as mouse Prickle1 and Prickle2 genes homologous to Drosophila tissue polarity gene prickle.17
220377662012Mink1 regulates β-catenin-independent Wnt signaling via Prickle phosphorylation.13

Citation

Dessen P

PRICKLE2 (prickle planar cell polarity protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54552/prickle2