PRIM1 (DNA primase subunit 1)

2003-02-01  

Identity

HGNC
LOCATION
12q13.3
LOCUSID
ALIAS
p49
FUSION GENES

Other Information

Locus ID:

NCBI: 5557
MIM: 176635
HGNC: 9369
Ensembl: ENSG00000198056

Variants:

dbSNP: 5557
ClinVar: 5557
TCGA: ENSG00000198056
COSMIC: PRIM1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198056ENST00000338193P49642
ENSG00000198056ENST00000549549H0YIP2
ENSG00000198056ENST00000550770F8VNY2
ENSG00000198056ENST00000552590F8VSB2

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Pyrimidine metabolismKEGGko00240
DNA replicationKEGGko03030
Purine metabolismKEGGhsa00230
Pyrimidine metabolismKEGGhsa00240
DNA replicationKEGGhsa03030
Metabolic pathwaysKEGGhsa01100
DNA polymerase alpha / primase complexKEGGhsa_M00261
DNA polymerase alpha / primase complexKEGGM00261
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G1/S TransitionREACTOMER-HSA-69206
Activation of the pre-replicative complexREACTOMER-HSA-68962
E2F mediated regulation of DNA replicationREACTOMER-HSA-113510
Inhibition of replication initiation of damaged DNA by RB1/E2F1REACTOMER-HSA-113501
S PhaseREACTOMER-HSA-69242
Synthesis of DNAREACTOMER-HSA-69239
DNA replication initiationREACTOMER-HSA-68952
DNA strand elongationREACTOMER-HSA-69190
Leading Strand SynthesisREACTOMER-HSA-69109
Polymerase switchingREACTOMER-HSA-69091
Lagging Strand SynthesisREACTOMER-HSA-69186
Processive synthesis on the lagging strandREACTOMER-HSA-69183
Removal of the Flap IntermediateREACTOMER-HSA-69166
M/G1 TransitionREACTOMER-HSA-68874
DNA Replication Pre-InitiationREACTOMER-HSA-69002
Chromosome MaintenanceREACTOMER-HSA-73886
Telomere MaintenanceREACTOMER-HSA-157579
Extension of TelomeresREACTOMER-HSA-180786
Telomere C-strand (Lagging Strand) SynthesisREACTOMER-HSA-174417
Telomere C-strand synthesis initiationREACTOMER-HSA-174430
Polymerase switching on the C-strand of the telomereREACTOMER-HSA-174411
DNA ReplicationREACTOMER-HSA-69306

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
255501592015Crystal structure of the human primase.20
225935762012A conserved motif in the C-terminal tail of DNA polymerase α tethers primase to the eukaryotic replisome.16
267108482016Insight into the Human DNA Primase Interaction with Template-Primer.16
200304002010Mechanisms by which human DNA primase chooses to polymerize a nucleoside triphosphate.6
300979992019DNA primase polypeptide 1 (PRIM1) involves in estrogen-induced breast cancer formation through activation of the G2/M cell cycle checkpoint.4
302572222018Inactivation of PRIM1 Function Sensitizes Cancer Cells to ATR and CHK1 Inhibitors.2
275997562016Variation analysis of PRIM1 gene in Chinese patients with primary ovarian insufficiency.0
304462202018Structural and biochemical insights into inhibition of human primase by citrate.0

Citation

Dessen P

PRIM1 (DNA primase subunit 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41844/prim1