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PRIM2 (DNA primase subunit 2)

Identity

Alias (NCBI)PRIM2A
p58
HGNC (Hugo) PRIM2
HGNC Previous namePRIM2A
HGNC Previous nameprimase, polypeptide 2A (58kD)
 primase, polypeptide 2A, 58kDa
 primase, DNA, polypeptide 2 (58kDa)
 primase (DNA) subunit 2
LocusID (NCBI) 5558
Atlas_Id 43427
Location 6p11.2  [Link to chromosome band 6p11]
Location_base_pair Starts at 57314805 and ends at 57326363 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ACP6 (1q21.2) / PRIM2 (6p11.2)PRIM2 (6p11.2) / CRYAB (11q23.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

Nomenclature
HGNC (Hugo)PRIM2   9370
Cards
Entrez_Gene (NCBI)PRIM2  5558  DNA primase subunit 2
AliasesPRIM2A; p58
GeneCards (Weizmann)PRIM2
Ensembl hg19 (Hinxton)ENSG00000146143 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000146143 [Gene_View]  ENSG00000146143 [Sequence]  chr6:57314805-57326363 [Contig_View]  PRIM2 [Vega]
ICGC DataPortalENSG00000146143
TCGA cBioPortalPRIM2
AceView (NCBI)PRIM2
Genatlas (Paris)PRIM2
WikiGenes5558
SOURCE (Princeton)PRIM2
Genetics Home Reference (NIH)PRIM2
Genomic and cartography
GoldenPath hg38 (UCSC)PRIM2  -     chr6:57314805-57326363 +  6p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRIM2  -     6p11.2   [Description]    (hg19-Feb_2009)
GoldenPathPRIM2 - 6p11.2 [CytoView hg19]  PRIM2 - 6p11.2 [CytoView hg38]
ImmunoBaseENSG00000146143
genome Data Viewer NCBIPRIM2 [Mapview hg19]  
OMIM176636   
Gene and transcription
Genbank (Entrez)AK223287 AK291915 BC017833 BC064931 BI547222
RefSeq transcript (Entrez)NM_000947 NM_001282487 NM_001282488
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PRIM2
Alternative Splicing GalleryENSG00000146143
Gene ExpressionPRIM2 [ NCBI-GEO ]   PRIM2 [ EBI - ARRAY_EXPRESS ]   PRIM2 [ SEEK ]   PRIM2 [ MEM ]
Gene Expression Viewer (FireBrowse)PRIM2 [ Firebrowse - Broad ]
GenevisibleExpression of PRIM2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5558
GTEX Portal (Tissue expression)PRIM2
Human Protein AtlasENSG00000146143-PRIM2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49643   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49643  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49643
Splice isoforms : SwissVarP49643
PhosPhoSitePlusP49643
Domains : Interpro (EBI)DNA_primase_lsu_euk    DNA_primase_lsu_euk/arc   
Domain families : Pfam (Sanger)DNA_primase_lrg (PF04104)   
Domain families : Pfam (NCBI)pfam04104   
Conserved Domain (NCBI)PRIM2
DMDM Disease mutations5558
Blocks (Seattle)PRIM2
PDB (RSDB)3L9Q    3Q36    4BPU    4BPW    4BPX    4RR2    5DQO    5EXR    5F0Q    5F0S    5I7M    6DHW   
PDB Europe3L9Q    3Q36    4BPU    4BPW    4BPX    4RR2    5DQO    5EXR    5F0Q    5F0S    5I7M    6DHW   
PDB (PDBSum)3L9Q    3Q36    4BPU    4BPW    4BPX    4RR2    5DQO    5EXR    5F0Q    5F0S    5I7M    6DHW   
PDB (IMB)3L9Q    3Q36    4BPU    4BPW    4BPX    4RR2    5DQO    5EXR    5F0Q    5F0S    5I7M    6DHW   
Structural Biology KnowledgeBase3L9Q    3Q36    4BPU    4BPW    4BPX    4RR2    5DQO    5EXR    5F0Q    5F0S    5I7M    6DHW   
SCOP (Structural Classification of Proteins)3L9Q    3Q36    4BPU    4BPW    4BPX    4RR2    5DQO    5EXR    5F0Q    5F0S    5I7M    6DHW   
CATH (Classification of proteins structures)3L9Q    3Q36    4BPU    4BPW    4BPX    4RR2    5DQO    5EXR    5F0Q    5F0S    5I7M    6DHW   
SuperfamilyP49643
Human Protein Atlas [tissue]ENSG00000146143-PRIM2 [tissue]
Peptide AtlasP49643
HPRD08900
IPIIPI00027705   IPI00644817   
Protein Interaction databases
DIP (DOE-UCLA)P49643
IntAct (EBI)P49643
FunCoupENSG00000146143
BioGRIDPRIM2
STRING (EMBL)PRIM2
ZODIACPRIM2
Ontologies - Pathways
QuickGOP49643
Ontology : AmiGOG1/S transition of mitotic cell cycle  DNA binding  DNA primase activity  protein binding  nucleoplasm  alpha DNA polymerase:primase complex  DNA replication, synthesis of RNA primer  DNA replication initiation  telomere maintenance via semi-conservative replication  metal ion binding  4 iron, 4 sulfur cluster binding  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  DNA binding  DNA primase activity  protein binding  nucleoplasm  alpha DNA polymerase:primase complex  DNA replication, synthesis of RNA primer  DNA replication initiation  telomere maintenance via semi-conservative replication  metal ion binding  4 iron, 4 sulfur cluster binding  
Pathways : KEGGPurine metabolism    Pyrimidine metabolism    DNA replication   
NDEx NetworkPRIM2
Atlas of Cancer Signalling NetworkPRIM2
Wikipedia pathwaysPRIM2
Orthology - Evolution
OrthoDB5558
GeneTree (enSembl)ENSG00000146143
Phylogenetic Trees/Animal Genes : TreeFamPRIM2
HOGENOMP49643
Homologs : HomoloGenePRIM2
Homology/Alignments : Family Browser (UCSC)PRIM2
Gene fusions - Rearrangements
Fusion : QuiverPRIM2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRIM2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRIM2
dbVarPRIM2
ClinVarPRIM2
MonarchPRIM2
1000_GenomesPRIM2 
Exome Variant ServerPRIM2
GNOMAD BrowserENSG00000146143
Varsome BrowserPRIM2
Genetic variants : HAPMAP5558
Genomic Variants (DGV)PRIM2 [DGVbeta]
DECIPHERPRIM2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRIM2 
Mutations
ICGC Data PortalPRIM2 
TCGA Data PortalPRIM2 
Broad Tumor PortalPRIM2
OASIS PortalPRIM2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRIM2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPRIM2
Mutations and Diseases : HGMDPRIM2
BioMutasearch PRIM2
DgiDB (Drug Gene Interaction Database)PRIM2
DoCM (Curated mutations)PRIM2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRIM2 (select a term)
intoGenPRIM2
Cancer3DPRIM2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176636   
Orphanet
DisGeNETPRIM2
MedgenPRIM2
Genetic Testing Registry PRIM2
NextProtP49643 [Medical]
TSGene5558
GENETestsPRIM2
Target ValidationPRIM2
Huge Navigator PRIM2 [HugePedia]
snp3D : Map Gene to Disease5558
BioCentury BCIQPRIM2
ClinGenPRIM2
Clinical trials, drugs, therapy
Protein Interactions : CTD5558
Pharm GKB GenePA162400108
Clinical trialPRIM2
Miscellaneous
canSAR (ICR)PRIM2 (select the gene name)
HarmonizomePRIM2
DataMed IndexPRIM2
Probes
Litterature
PubMed60 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRIM2
EVEXPRIM2
GoPubMedPRIM2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 14 14:28:12 CEST 2020

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