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PRKAB2 (protein kinase AMP-activated non-catalytic subunit beta 2)

Identity

HGNC (Hugo) PRKAB2
LocusID (NCBI) 5565
Atlas_Id 47316
Location 1q21.1
Location_base_pair Starts at 146626685 and ends at 146644168 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ANO6 (12q12) / PRKAB2 (1q21.1)GATAD2B (1q21.3) / PRKAB2 (1q21.1)PRKAB2 (1q21.1) / ERG (21q22.2)
PRKAB2 (1q21.1) / FBP2 (9q22.32)PRKAB2 (1q21.1) / HNRNPLL (2p22.1)PRKAB2 (1q21.1) / RFWD2 (1q25.1)
RAB5A (3p24.3) / PRKAB2 (1q21.1)PRKAB2 1q21.1 / FBP2 9q22.32

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 0 ]
  Lung: Translocations in Squamous Cell Carcinoma

External links

Nomenclature
HGNC (Hugo)PRKAB2   9379
Cards
Entrez_Gene (NCBI)PRKAB2  5565  protein kinase AMP-activated non-catalytic subunit beta 2
GeneCards (Weizmann)PRKAB2
Ensembl hg19 (Hinxton)ENSG00000131791 [Gene_View]  chr1:146626685-146644168 [Contig_View]  PRKAB2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000131791 [Gene_View]  chr1:146626685-146644168 [Contig_View]  PRKAB2 [Vega]
ICGC DataPortalENSG00000131791
TCGA cBioPortalPRKAB2
AceView (NCBI)PRKAB2
Genatlas (Paris)PRKAB2
WikiGenes5565
SOURCE (Princeton)PRKAB2
Genomic and cartography
GoldenPath hg19 (UCSC)PRKAB2  -     chr1:146626685-146644168 -  1q21.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PRKAB2  -     1q21.1   [Description]    (hg38-Dec_2013)
EnsemblPRKAB2 - 1q21.1 [CytoView hg19]  PRKAB2 - 1q21.1 [CytoView hg38]
Mapping of homologs : NCBIPRKAB2 [Mapview hg19]  PRKAB2 [Mapview hg38]
OMIM602741   
Gene and transcription
Genbank (Entrez)AI026131 AI638769 AJ224538 AK023717 AK292820
RefSeq transcript (Entrez)NM_005399
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_004487 NW_004929293
Consensus coding sequences : CCDS (NCBI)PRKAB2
Cluster EST : UnigeneHs.50732 [ NCBI ]
CGAP (NCI)Hs.50732
Alternative Splicing : Fast-db (Paris)GSHG0002451
Alternative Splicing GalleryENSG00000131791
Gene ExpressionPRKAB2 [ NCBI-GEO ]   PRKAB2 [ EBI - ARRAY_EXPRESS ]   PRKAB2 [ SEEK ]   PRKAB2 [ MEM ]
Gene Expression Viewer (FireBrowse)PRKAB2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)5565
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43741 (Uniprot)
NextProtO43741  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43741
Splice isoforms : SwissVarO43741 (Swissvar)
PhosPhoSitePlusO43741
Domains : Interpro (EBI)AMPK1_CBM    AMPK_beta-2    ASC_dom    Ig_E-set   
Domain families : Pfam (Sanger)AMPK1_CBM (PF16561)    AMPKBI (PF04739)   
Domain families : Pfam (NCBI)pfam16561    pfam04739   
Domain families : Smart (EMBL)AMPKBI (SM01010)  
DMDM Disease mutations5565
Blocks (Seattle)PRKAB2
PDB (SRS)2F15    2V8Q    2V92    2V9J    2Y8L    2Y8Q    2YA3    4CFH    4EAI    4EAJ    4RER    4REW   
PDB (PDBSum)2F15    2V8Q    2V92    2V9J    2Y8L    2Y8Q    2YA3    4CFH    4EAI    4EAJ    4RER    4REW   
PDB (IMB)2F15    2V8Q    2V92    2V9J    2Y8L    2Y8Q    2YA3    4CFH    4EAI    4EAJ    4RER    4REW   
PDB (RSDB)2F15    2V8Q    2V92    2V9J    2Y8L    2Y8Q    2YA3    4CFH    4EAI    4EAJ    4RER    4REW   
Structural Biology KnowledgeBase2F15    2V8Q    2V92    2V9J    2Y8L    2Y8Q    2YA3    4CFH    4EAI    4EAJ    4RER    4REW   
SCOP (Structural Classification of Proteins)2F15    2V8Q    2V92    2V9J    2Y8L    2Y8Q    2YA3    4CFH    4EAI    4EAJ    4RER    4REW   
CATH (Classification of proteins structures)2F15    2V8Q    2V92    2V9J    2Y8L    2Y8Q    2YA3    4CFH    4EAI    4EAJ    4RER    4REW   
SuperfamilyO43741
Human Protein AtlasENSG00000131791
Peptide AtlasO43741
HPRD04117
IPIIPI00013905   IPI00909830   IPI00909353   
Protein Interaction databases
DIP (DOE-UCLA)O43741
IntAct (EBI)O43741
FunCoupENSG00000131791
BioGRIDPRKAB2
STRING (EMBL)PRKAB2
ZODIACPRKAB2
Ontologies - Pathways
QuickGOO43741
Ontology : AmiGOAMP-activated protein kinase activity  protein binding  nucleoplasm  cytosol  cAMP-dependent protein kinase complex  protein phosphorylation  fatty acid biosynthetic process  carnitine shuttle  cell cycle arrest  signal transduction  macroautophagy  protein kinase binding  nucleotide-activated protein kinase complex  regulation of fatty acid biosynthetic process  identical protein binding  regulation of protein kinase activity  regulation of signal transduction by p53 class mediator  
Ontology : EGO-EBIAMP-activated protein kinase activity  protein binding  nucleoplasm  cytosol  cAMP-dependent protein kinase complex  protein phosphorylation  fatty acid biosynthetic process  carnitine shuttle  cell cycle arrest  signal transduction  macroautophagy  protein kinase binding  nucleotide-activated protein kinase complex  regulation of fatty acid biosynthetic process  identical protein binding  regulation of protein kinase activity  regulation of signal transduction by p53 class mediator  
Pathways : BIOCARTAChREBP regulation by carbohydrates and cAMP [Genes]    Reversal of Insulin Resistance by Leptin [Genes]   
Pathways : KEGGFoxO signaling pathway    Circadian rhythm    Insulin signaling pathway    Adipocytokine signaling pathway    Non-alcoholic fatty liver disease (NAFLD)    Hypertrophic cardiomyopathy (HCM)   
NDEx Network
Atlas of Cancer Signalling NetworkPRKAB2
Wikipedia pathwaysPRKAB2
Orthology - Evolution
OrthoDB5565
GeneTree (enSembl)ENSG00000131791
Phylogenetic Trees/Animal Genes : TreeFamPRKAB2
Homologs : HomoloGenePRKAB2
Homology/Alignments : Family Browser (UCSC)PRKAB2
Gene fusions - Rearrangements
Fusion: TCGAPRKAB2 1q21.1 FBP2 9q22.32 KIRC
Polymorphisms : SNP, variants
NCBI Variation ViewerPRKAB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRKAB2
dbVarPRKAB2
ClinVarPRKAB2
1000_GenomesPRKAB2 
Exome Variant ServerPRKAB2
ExAC (Exome Aggregation Consortium)PRKAB2 (select the gene name)
SNP (GeneSNP Utah)PRKAB2
SNP : HGBasePRKAB2
Genetic variants : HAPMAPPRKAB2
Genomic Variants (DGV)PRKAB2 [DGVbeta]
Mutations
ICGC Data PortalPRKAB2 
TCGA Data PortalPRKAB2 
Broad Tumor PortalPRKAB2
OASIS PortalPRKAB2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRKAB2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRKAB2
DgiDB (Drug Gene Interaction Database)PRKAB2
DoCM (Curated mutations)PRKAB2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRKAB2 (select a term)
intoGenPRKAB2
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)1:146626685-146644168
CONAN: Copy Number AnalysisPRKAB2 
Mutations and Diseases : HGMDPRKAB2
OMIM602741   
MedgenPRKAB2
Genetic Testing Registry PRKAB2
NextProtO43741 [Medical]
TSGene5565
GENETestsPRKAB2
Huge Navigator PRKAB2 [HugePedia]  PRKAB2 [HugeCancerGEM]
snp3D : Map Gene to Disease5565
BioCentury BCIQPRKAB2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5565
Chemical/Pharm GKB GenePA33747
Clinical trialPRKAB2
Miscellaneous
canSAR (ICR)PRKAB2 (select the gene name)
Probes
Litterature
PubMed56 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRKAB2
GoPubMedPRKAB2
iHOPPRKAB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Apr 16 18:00:09 CEST 2016

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