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PRKAB2 (protein kinase, AMP-activated, beta 2 non-catalytic subunit)

Identity

Other names-
HGNC (Hugo) PRKAB2
LocusID (NCBI) 5565
Atlas_Id 47316
Location 1q21.1
Location_base_pair Starts at 146626685 and ends at 146644168 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas)

Solid Tumors AmeloblastomID5945

External links

Nomenclature
HGNC (Hugo)PRKAB2   9379
Cards
Entrez_Gene (NCBI)PRKAB2  5565  protein kinase, AMP-activated, beta 2 non-catalytic subunit
GeneCards (Weizmann)PRKAB2
Ensembl hg19 (Hinxton)ENSG00000131791 [Gene_View]  chr1:146626685-146644168 [Contig_View]  PRKAB2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000131791 [Gene_View]  chr1:146626685-146644168 [Contig_View]  PRKAB2 [Vega]
ICGC DataPortalENSG00000131791
TCGA cBioPortalPRKAB2
AceView (NCBI)PRKAB2
Genatlas (Paris)PRKAB2
WikiGenes5565
SOURCE (Princeton)PRKAB2
Genomic and cartography
GoldenPath hg19 (UCSC)PRKAB2  -     chr1:146626685-146644168 -  1q21.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PRKAB2  -     1q21.1   [Description]    (hg38-Dec_2013)
EnsemblPRKAB2 - 1q21.1 [CytoView hg19]  PRKAB2 - 1q21.1 [CytoView hg38]
Mapping of homologs : NCBIPRKAB2 [Mapview hg19]  PRKAB2 [Mapview hg38]
OMIM602741   
Gene and transcription
Genbank (Entrez)AI026131 AI638769 AJ224538 AK023717 AK292820
RefSeq transcript (Entrez)NM_005399
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_004487 NW_004929293
Consensus coding sequences : CCDS (NCBI)PRKAB2
Cluster EST : UnigeneHs.50732 [ NCBI ]
CGAP (NCI)Hs.50732
Alternative Splicing : Fast-db (Paris)GSHG0002451
Alternative Splicing GalleryENSG00000131791
Gene ExpressionPRKAB2 [ NCBI-GEO ]     PRKAB2 [ SEEK ]   PRKAB2 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43741 (Uniprot)
NextProtO43741  [Medical]
With graphics : InterProO43741
Splice isoforms : SwissVarO43741 (Swissvar)
Domains : Interpro (EBI)AMPK_beta-2    ASC_dom    Ig_E-set   
Related proteins : CluSTrO43741
Domain families : Pfam (Sanger)AMPKBI (PF04739)   
Domain families : Pfam (NCBI)pfam04739   
Domain families : Smart (EMBL)AMPKBI (SM01010)  
DMDM Disease mutations5565
Blocks (Seattle)O43741
PDB (SRS)2F15    2V8Q    2V92    2V9J    2Y8L    2Y8Q    2YA3    4CFH    4EAI    4EAJ    4RER    4REW   
PDB (PDBSum)2F15    2V8Q    2V92    2V9J    2Y8L    2Y8Q    2YA3    4CFH    4EAI    4EAJ    4RER    4REW   
PDB (IMB)2F15    2V8Q    2V92    2V9J    2Y8L    2Y8Q    2YA3    4CFH    4EAI    4EAJ    4RER    4REW   
PDB (RSDB)2F15    2V8Q    2V92    2V9J    2Y8L    2Y8Q    2YA3    4CFH    4EAI    4EAJ    4RER    4REW   
Human Protein AtlasENSG00000131791
Peptide AtlasO43741
HPRD04117
IPIIPI00013905   IPI00909830   IPI00909353   
Protein Interaction databases
DIP (DOE-UCLA)O43741
IntAct (EBI)O43741
FunCoupENSG00000131791
BioGRIDPRKAB2
IntegromeDBPRKAB2
STRING (EMBL)PRKAB2
Ontologies - Pathways
QuickGOO43741
Ontology : AmiGOAMP-activated protein kinase activity  protein binding  nucleoplasm  cytosol  energy reserve metabolic process  protein phosphorylation  fatty acid biosynthetic process  carnitine shuttle  organelle organization  mitochondrion organization  cell cycle arrest  signal transduction  insulin receptor signaling pathway  AMP-activated protein kinase complex  regulation of fatty acid biosynthetic process  identical protein binding  cellular lipid metabolic process  small molecule metabolic process  regulation of protein kinase activity  membrane organization  
Ontology : EGO-EBIAMP-activated protein kinase activity  protein binding  nucleoplasm  cytosol  energy reserve metabolic process  protein phosphorylation  fatty acid biosynthetic process  carnitine shuttle  organelle organization  mitochondrion organization  cell cycle arrest  signal transduction  insulin receptor signaling pathway  AMP-activated protein kinase complex  regulation of fatty acid biosynthetic process  identical protein binding  cellular lipid metabolic process  small molecule metabolic process  regulation of protein kinase activity  membrane organization  
Pathways : BIOCARTAChREBP regulation by carbohydrates and cAMP [Genes]    Reversal of Insulin Resistance by Leptin [Genes]   
Pathways : KEGGFoxO signaling pathway    Circadian rhythm    Insulin signaling pathway    Adipocytokine signaling pathway    Non-alcoholic fatty liver disease (NAFLD)    Hypertrophic cardiomyopathy (HCM)   
Protein Interaction DatabasePRKAB2
DoCM (Curated mutations)PRKAB2
Wikipedia pathwaysPRKAB2
Gene fusion - Rearrangements
Gene fusion: TCGA
Polymorphisms : SNP, variants
NCBI Variation ViewerPRKAB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRKAB2
dbVarPRKAB2
ClinVarPRKAB2
1000_GenomesPRKAB2 
Exome Variant ServerPRKAB2
SNP (GeneSNP Utah)PRKAB2
SNP : HGBasePRKAB2
Genetic variants : HAPMAPPRKAB2
Genomic Variants (DGV)PRKAB2 [DGVbeta]
Mutations
ICGC Data PortalPRKAB2 
TCGA Data PortalPRKAB2 
Tumor PortalPRKAB2
Somatic Mutations in Cancer : COSMICPRKAB2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)1:146626685-146644168
CONAN: Copy Number AnalysisPRKAB2 
Mutations and Diseases : HGMDPRKAB2
OMIM602741   
MedgenPRKAB2
NextProtO43741 [Medical]
GENETestsPRKAB2
Disease Genetic AssociationPRKAB2
Huge Navigator PRKAB2 [HugePedia]  PRKAB2 [HugeCancerGEM]
snp3D : Map Gene to Disease5565
DGIdb (Drug Gene Interaction db)PRKAB2
General knowledge
Homologs : HomoloGenePRKAB2
Homology/Alignments : Family Browser (UCSC)PRKAB2
Phylogenetic Trees/Animal Genes : TreeFamPRKAB2
Chemical/Protein Interactions : CTD5565
Chemical/Pharm GKB GenePA33747
Clinical trialPRKAB2
Cancer Resource (Charite)ENSG00000131791
Other databases
Probes
Litterature
PubMed52 Pubmed reference(s) in Entrez
CoreMinePRKAB2
GoPubMedPRKAB2
iHOPPRKAB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 20 19:54:23 CEST 2015

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