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PRKAB2 (protein kinase, AMP-activated, beta 2 non-catalytic subunit)

Identity

Other names-
HGNC (Hugo) PRKAB2
LocusID (NCBI) 5565
Location 1q21.1
Location_base_pair Starts at 146626685 and ends at 146644168 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PRKAB2   9379
Cards
Entrez_Gene (NCBI)PRKAB2  5565  protein kinase, AMP-activated, beta 2 non-catalytic subunit
GeneCards (Weizmann)PRKAB2
Ensembl (Hinxton)ENSG00000131791 [Gene_View]  chr1:146626685-146644168 [Contig_View]  PRKAB2 [Vega]
ICGC DataPortalENSG00000131791
cBioPortalPRKAB2
AceView (NCBI)PRKAB2
Genatlas (Paris)PRKAB2
WikiGenes5565
SOURCE (Princeton)NM_005399
Genomic and cartography
GoldenPath (UCSC)PRKAB2  -  1q21.1   chr1:146626685-146644168 -  1q21.1   [Description]    (hg19-Feb_2009)
EnsemblPRKAB2 - 1q21.1 [CytoView]
Mapping of homologs : NCBIPRKAB2 [Mapview]
OMIM602741   
Gene and transcription
Genbank (Entrez)AI026131 AI638769 AJ224538 AK023717 AK292820
RefSeq transcript (Entrez)NM_005399
RefSeq genomic (Entrez)AC_000133 NC_000001 NC_018912 NT_004487 NW_001838511 NW_004929293
Consensus coding sequences : CCDS (NCBI)PRKAB2
Cluster EST : UnigeneHs.50732 [ NCBI ]
CGAP (NCI)Hs.50732
Alternative Splicing : Fast-db (Paris)GSHG0002451
Alternative Splicing GalleryENSG00000131791
Gene ExpressionPRKAB2 [ NCBI-GEO ]     PRKAB2 [ SEEK ]   PRKAB2 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43741 (Uniprot)
NextProtO43741  [Medical]
With graphics : InterProO43741
Splice isoforms : SwissVarO43741 (Swissvar)
Domains : Interpro (EBI)AMP_prot_kin_bsu_interact-dom [organisation]   Ig_E-set [organisation]  
Related proteins : CluSTrO43741
Domain families : Pfam (Sanger)AMPKBI (PF04739)   
Domain families : Pfam (NCBI)pfam04739   
Domain families : Smart (EMBL)AMPKBI (SM01010)  
DMDM Disease mutations5565
Blocks (Seattle)O43741
PDB (SRS)2F15    2V8Q    2V92    2V9J    2Y8L    2Y8Q    2YA3    4CFH    4EAI    4EAJ   
PDB (PDBSum)2F15    2V8Q    2V92    2V9J    2Y8L    2Y8Q    2YA3    4CFH    4EAI    4EAJ   
PDB (IMB)2F15    2V8Q    2V92    2V9J    2Y8L    2Y8Q    2YA3    4CFH    4EAI    4EAJ   
PDB (RSDB)2F15    2V8Q    2V92    2V9J    2Y8L    2Y8Q    2YA3    4CFH    4EAI    4EAJ   
Human Protein AtlasENSG00000131791 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasO43741
HPRD04117
IPIIPI00013905   IPI00909830   IPI00909353   
Protein Interaction databases
DIP (DOE-UCLA)O43741
IntAct (EBI)O43741
FunCoupENSG00000131791
BioGRIDPRKAB2
InParanoidO43741
Interologous Interaction database O43741
IntegromeDBPRKAB2
STRING (EMBL)PRKAB2
Ontologies - Pathways
Ontology : AmiGOAMP-activated protein kinase activity  protein binding  nucleoplasm  cytosol  energy reserve metabolic process  protein phosphorylation  fatty acid biosynthetic process  carnitine shuttle  cell cycle arrest  signal transduction  insulin receptor signaling pathway  AMP-activated protein kinase complex  regulation of fatty acid biosynthetic process  identical protein binding  cellular lipid metabolic process  small molecule metabolic process  membrane organization  
Ontology : EGO-EBIAMP-activated protein kinase activity  protein binding  nucleoplasm  cytosol  energy reserve metabolic process  protein phosphorylation  fatty acid biosynthetic process  carnitine shuttle  cell cycle arrest  signal transduction  insulin receptor signaling pathway  AMP-activated protein kinase complex  regulation of fatty acid biosynthetic process  identical protein binding  cellular lipid metabolic process  small molecule metabolic process  membrane organization  
Pathways : BIOCARTAChREBP regulation by carbohydrates and cAMP [Genes]    Reversal of Insulin Resistance by Leptin [Genes]   
Pathways : KEGGFoxO signaling pathway    Circadian rhythm    Insulin signaling pathway    Adipocytokine signaling pathway    Non-alcoholic fatty liver disease (NAFLD)    Hypertrophic cardiomyopathy (HCM)   
Protein Interaction DatabasePRKAB2
Wikipedia pathwaysPRKAB2
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PRKAB2
snp3D : Map Gene to Disease5565
SNP (GeneSNP Utah)PRKAB2
SNP : HGBasePRKAB2
Genetic variants : HAPMAPPRKAB2
Exome VariantPRKAB2
1000_GenomesPRKAB2 
ICGC programENSG00000131791 
Somatic Mutations in Cancer : COSMICPRKAB2 
CONAN: Copy Number AnalysisPRKAB2 
Mutations and Diseases : HGMDPRKAB2
Genomic VariantsPRKAB2  PRKAB2 [DGVbeta]
dbVarPRKAB2
ClinVarPRKAB2
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM602741   
MedgenPRKAB2
GENETestsPRKAB2
Disease Genetic AssociationPRKAB2
Huge Navigator PRKAB2 [HugePedia]  PRKAB2 [HugeCancerGEM]
General knowledge
Homologs : HomoloGenePRKAB2
Homology/Alignments : Family Browser (UCSC)PRKAB2
Phylogenetic Trees/Animal Genes : TreeFamPRKAB2
Chemical/Protein Interactions : CTD5565
Chemical/Pharm GKB GenePA33747
Clinical trialPRKAB2
Cancer Resource (Charite)ENSG00000131791
Other databases
Probes
Litterature
PubMed50 Pubmed reference(s) in Entrez
CoreMinePRKAB2
iHOPPRKAB2
OncoSearchPRKAB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jul 26 14:44:19 CEST 2014

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