Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PRKACA (protein kinase cAMP-activated catalytic subunit alpha)

Identity

Other namesPKACA
PPNAD4
HGNC (Hugo) PRKACA
LocusID (NCBI) 5566
Atlas_Id 41846
Location 19p13.12  [Link to chromosome band 19p13]
Location_base_pair Starts at 14202507 and ends at 14219202 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
DNAJB1 (19p13.12) / PRKACA (19p13.12)GATAD2A (19p13.11) / PRKACA (19p13.12)PRKACA (19p13.12) / ENTPD1 (10q24.1)
PRKACA (19p13.12) / NDOR1 (9q34.3)TPGS1 (19p13.3) / PRKACA (19p13.12)DNAJB1 19p13.12 / PRKACA 19p13.12
C19orf20 PRKACA 19p13.12GATAD2A 19p13.11 / PRKACA 19p13.12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(17;17)(q21;q24) PRKAR1A/RARA;del(17)(q21q24) PRKAR1A/RARA

External links

Nomenclature
HGNC (Hugo)PRKACA   9380
Cards
Entrez_Gene (NCBI)PRKACA  5566  protein kinase cAMP-activated catalytic subunit alpha
AliasesPKACA; PPNAD4
GeneCards (Weizmann)PRKACA
Ensembl hg19 (Hinxton)ENSG00000072062 [Gene_View]  chr19:14202507-14219202 [Contig_View]  PRKACA [Vega]
Ensembl hg38 (Hinxton)ENSG00000072062 [Gene_View]  chr19:14202507-14219202 [Contig_View]  PRKACA [Vega]
ICGC DataPortalENSG00000072062
TCGA cBioPortalPRKACA
AceView (NCBI)PRKACA
Genatlas (Paris)PRKACA
WikiGenes5566
SOURCE (Princeton)PRKACA
Genomic and cartography
GoldenPath hg19 (UCSC)PRKACA  -     chr19:14202507-14219202 -  19p13.12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PRKACA  -     19p13.12   [Description]    (hg38-Dec_2013)
EnsemblPRKACA - 19p13.12 [CytoView hg19]  PRKACA - 19p13.12 [CytoView hg38]
Mapping of homologs : NCBIPRKACA [Mapview hg19]  PRKACA [Mapview hg38]
OMIM601639   615830   
Gene and transcription
Genbank (Entrez)AF208004 AF224718 AF239744 AK093803 AK131561
RefSeq transcript (Entrez)NM_001304349 NM_002730 NM_207518
RefSeq genomic (Entrez)NC_000019 NC_018930 NG_029699 NT_011295 NW_004929414
Consensus coding sequences : CCDS (NCBI)PRKACA
Cluster EST : UnigeneHs.631630 [ NCBI ]
CGAP (NCI)Hs.631630
Alternative Splicing GalleryENSG00000072062
Gene ExpressionPRKACA [ NCBI-GEO ]   PRKACA [ EBI - ARRAY_EXPRESS ]   PRKACA [ SEEK ]   PRKACA [ MEM ]
Gene Expression Viewer (FireBrowse)PRKACA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5566
GTEX Portal (Tissue expression)PRKACA
Protein : pattern, domain, 3D structure
UniProt/SwissProtP17612 (Uniprot)
NextProtP17612  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP17612
Splice isoforms : SwissVarP17612 (Swissvar)
PhosPhoSitePlusP17612
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)AGC-kinase_C    Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TK_X (SM00133)  S_TKc (SM00220)  
DMDM Disease mutations5566
Blocks (Seattle)PRKACA
PDB (SRS)2GU8    3AGL    3AGM    3AMA    3AMB    3L9L    3L9M    3L9N    3MVJ    3NX8    3OOG    3OVV    3OWP    3OXT    3P0M    3POO    3VQH    4AE6    4AE9    4WB5    4WB6    4WB7    4WB8   
PDB (PDBSum)2GU8    3AGL    3AGM    3AMA    3AMB    3L9L    3L9M    3L9N    3MVJ    3NX8    3OOG    3OVV    3OWP    3OXT    3P0M    3POO    3VQH    4AE6    4AE9    4WB5    4WB6    4WB7    4WB8   
PDB (IMB)2GU8    3AGL    3AGM    3AMA    3AMB    3L9L    3L9M    3L9N    3MVJ    3NX8    3OOG    3OVV    3OWP    3OXT    3P0M    3POO    3VQH    4AE6    4AE9    4WB5    4WB6    4WB7    4WB8   
PDB (RSDB)2GU8    3AGL    3AGM    3AMA    3AMB    3L9L    3L9M    3L9N    3MVJ    3NX8    3OOG    3OVV    3OWP    3OXT    3P0M    3POO    3VQH    4AE6    4AE9    4WB5    4WB6    4WB7    4WB8   
Structural Biology KnowledgeBase2GU8    3AGL    3AGM    3AMA    3AMB    3L9L    3L9M    3L9N    3MVJ    3NX8    3OOG    3OVV    3OWP    3OXT    3P0M    3POO    3VQH    4AE6    4AE9    4WB5    4WB6    4WB7    4WB8   
SCOP (Structural Classification of Proteins)2GU8    3AGL    3AGM    3AMA    3AMB    3L9L    3L9M    3L9N    3MVJ    3NX8    3OOG    3OVV    3OWP    3OXT    3P0M    3POO    3VQH    4AE6    4AE9    4WB5    4WB6    4WB7    4WB8   
CATH (Classification of proteins structures)2GU8    3AGL    3AGM    3AMA    3AMB    3L9L    3L9M    3L9N    3MVJ    3NX8    3OOG    3OVV    3OWP    3OXT    3P0M    3POO    3VQH    4AE6    4AE9    4WB5    4WB6    4WB7    4WB8   
SuperfamilyP17612
Human Protein AtlasENSG00000072062
Peptide AtlasP17612
HPRD03382
IPIIPI00396630   IPI00217960   IPI00922246   
Protein Interaction databases
DIP (DOE-UCLA)P17612
IntAct (EBI)P17612
FunCoupENSG00000072062
BioGRIDPRKACA
STRING (EMBL)PRKACA
ZODIACPRKACA
Ontologies - Pathways
QuickGOP17612
Ontology : AmiGOG2/M transition of mitotic cell cycle  mesoderm formation  neural tube closure  regulation of heart rate  stimulatory C-type lectin receptor signaling pathway  renal water homeostasis  protein serine/threonine kinase activity  protein serine/threonine kinase activity  cAMP-dependent protein kinase activity  cAMP-dependent protein kinase activity  cAMP-dependent protein kinase activity  cAMP-dependent protein kinase activity  protein serine/threonine/tyrosine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  mitochondrion  Golgi apparatus  centrosome  cytosol  cAMP-dependent protein kinase complex  mRNA processing  protein phosphorylation  blood coagulation  positive regulation of cell proliferation  regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  membrane  nuclear speck  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  protein kinase binding  motile cilium  nucleotide-activated protein kinase complex  neuromuscular junction  ubiquitin protein ligase binding  protein complex binding  activation of protein kinase A activity  protein kinase A regulatory subunit binding  calcium channel complex  calcium-mediated signaling using intracellular calcium source  lipoprotein metabolic process  neuron projection  regulation of protein binding  regulation of cellular respiration  plasma membrane raft  regulation of osteoblast differentiation  protein autophosphorylation  positive regulation of protein export from nucleus  sperm capacitation  perinuclear region of cytoplasm  negative regulation of meiotic cell cycle  regulation of cytosolic calcium ion concentration  regulation of synaptic transmission, glutamatergic  regulation of cardiac muscle contraction  regulation of ryanodine-sensitive calcium-release channel activity  regulation of proteasomal protein catabolic process  extracellular exosome  regulation of protein processing  positive regulation of cell cycle arrest  cellular response to glucose stimulus  cellular response to parathyroid hormone stimulus  cellular response to glucagon stimulus  cellular response to epinephrine stimulus  cell communication by electrical coupling involved in cardiac conduction  sperm midpiece  ciliary base  negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning  regulation of cardiac conduction  regulation of bicellular tight junction assembly  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  mesoderm formation  neural tube closure  regulation of heart rate  stimulatory C-type lectin receptor signaling pathway  renal water homeostasis  protein serine/threonine kinase activity  protein serine/threonine kinase activity  cAMP-dependent protein kinase activity  cAMP-dependent protein kinase activity  cAMP-dependent protein kinase activity  cAMP-dependent protein kinase activity  protein serine/threonine/tyrosine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  mitochondrion  Golgi apparatus  centrosome  cytosol  cAMP-dependent protein kinase complex  mRNA processing  protein phosphorylation  blood coagulation  positive regulation of cell proliferation  regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  membrane  nuclear speck  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  protein kinase binding  motile cilium  nucleotide-activated protein kinase complex  neuromuscular junction  ubiquitin protein ligase binding  protein complex binding  activation of protein kinase A activity  protein kinase A regulatory subunit binding  calcium channel complex  calcium-mediated signaling using intracellular calcium source  lipoprotein metabolic process  neuron projection  regulation of protein binding  regulation of cellular respiration  plasma membrane raft  regulation of osteoblast differentiation  protein autophosphorylation  positive regulation of protein export from nucleus  sperm capacitation  perinuclear region of cytoplasm  negative regulation of meiotic cell cycle  regulation of cytosolic calcium ion concentration  regulation of synaptic transmission, glutamatergic  regulation of cardiac muscle contraction  regulation of ryanodine-sensitive calcium-release channel activity  regulation of proteasomal protein catabolic process  extracellular exosome  regulation of protein processing  positive regulation of cell cycle arrest  cellular response to glucose stimulus  cellular response to parathyroid hormone stimulus  cellular response to glucagon stimulus  cellular response to epinephrine stimulus  cell communication by electrical coupling involved in cardiac conduction  sperm midpiece  ciliary base  negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning  regulation of cardiac conduction  regulation of bicellular tight junction assembly  
Pathways : BIOCARTAActivation of cAMP-dependent protein kinase, PKA [Genes]   
Pathways : KEGGMAPK signaling pathway    Ras signaling pathway    Calcium signaling pathway    Chemokine signaling pathway    Oocyte meiosis    Apoptosis    Adrenergic signaling in cardiomyocytes    Vascular smooth muscle contraction    Wnt signaling pathway    Hedgehog signaling pathway    Gap junction    Circadian entrainment    Long-term potentiation    Retrograde endocannabinoid signaling    Glutamatergic synapse    Cholinergic synapse    Serotonergic synapse    GABAergic synapse    Dopaminergic synapse    Olfactory transduction    Taste transduction    Insulin signaling pathway    Insulin secretion    GnRH signaling pathway    Ovarian steroidogenesis    Progesterone-mediated oocyte maturation    Estrogen signaling pathway    Melanogenesis    Thyroid hormone synthesis    Thyroid hormone signaling pathway    Endocrine and other factor-regulated calcium reabsorption    Vasopressin-regulated water reabsorption    Salivary secretion    Gastric acid secretion    Bile secretion    Parkinson's disease    Prion diseases    Cocaine addiction    Amphetamine addiction    Morphine addiction    Alcoholism    Vibrio cholerae infection    Amoebiasis    HTLV-I infection    Epstein-Barr virus infection    Viral carcinogenesis    Proteoglycans in cancer    Dilated cardiomyopathy   
NDEx Network
Atlas of Cancer Signalling NetworkPRKACA
Wikipedia pathwaysPRKACA
Orthology - Evolution
OrthoDB5566
GeneTree (enSembl)ENSG00000072062
Phylogenetic Trees/Animal Genes : TreeFamPRKACA
Homologs : HomoloGenePRKACA
Homology/Alignments : Family Browser (UCSC)PRKACA
Gene fusions - Rearrangements
Fusion: TCGAC19orf20 PRKACA 19p13.12 BRCA
Fusion: TCGAGATAD2A 19p13.11 PRKACA 19p13.12 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerPRKACA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRKACA
dbVarPRKACA
ClinVarPRKACA
1000_GenomesPRKACA 
Exome Variant ServerPRKACA
ExAC (Exome Aggregation Consortium)PRKACA (select the gene name)
Genetic variants : HAPMAP5566
Genomic Variants (DGV)PRKACA [DGVbeta]
Mutations
ICGC Data PortalPRKACA 
TCGA Data PortalPRKACA 
Broad Tumor PortalPRKACA
OASIS PortalPRKACA [ Somatic mutations - Copy number]
Cancer Gene: CensusPRKACA 
Somatic Mutations in Cancer : COSMICPRKACA 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRKACA
DgiDB (Drug Gene Interaction Database)PRKACA
DoCM (Curated mutations)PRKACA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRKACA (select a term)
intoGenPRKACA
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)19:14202507-14219202  ENSG00000072062
CONAN: Copy Number AnalysisPRKACA 
Mutations and Diseases : HGMDPRKACA
OMIM601639    615830   
MedgenPRKACA
Genetic Testing Registry PRKACA
NextProtP17612 [Medical]
TSGene5566
GENETestsPRKACA
Huge Navigator PRKACA [HugePedia]
snp3D : Map Gene to Disease5566
BioCentury BCIQPRKACA
ClinGenPRKACA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5566
Chemical/Pharm GKB GenePA33748
Clinical trialPRKACA
Miscellaneous
canSAR (ICR)PRKACA (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRKACA
EVEXPRKACA
GoPubMedPRKACA
iHOPPRKACA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 9 19:07:41 CEST 2016

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