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PRKACA (protein kinase, cAMP-dependent, catalytic, alpha)

Identity

Other namesPKACA
HGNC (Hugo) PRKACA
LocusID (NCBI) 5566
Location 19p13.12
Location_base_pair Starts at 14202507 and ends at 14228559 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias t0817q24q22ID1494

External links

Nomenclature
HGNC (Hugo)PRKACA   9380
Cards
Entrez_Gene (NCBI)PRKACA  5566  protein kinase, cAMP-dependent, catalytic, alpha
GeneCards (Weizmann)PRKACA
Ensembl (Hinxton)ENSG00000072062 [Gene_View]  chr19:14202507-14228559 [Contig_View]  PRKACA [Vega]
ICGC DataPortalENSG00000072062
cBioPortalPRKACA
AceView (NCBI)PRKACA
Genatlas (Paris)PRKACA
WikiGenes5566
SOURCE (Princeton)NM_002730 NM_207518
Genomic and cartography
GoldenPath (UCSC)PRKACA  -  19p13.12   chr19:14202507-14228559 -  19p13.12   [Description]    (hg19-Feb_2009)
EnsemblPRKACA - 19p13.12 [CytoView]
Mapping of homologs : NCBIPRKACA [Mapview]
OMIM601639   
Gene and transcription
Genbank (Entrez)AF208004 AF224718 AF239744 AK093803 AK131561
RefSeq transcript (Entrez)NM_002730 NM_207518
RefSeq genomic (Entrez)AC_000151 NC_000019 NC_018930 NG_029699 NT_011295 NW_001838483 NW_004929414
Consensus coding sequences : CCDS (NCBI)PRKACA
Cluster EST : UnigeneHs.631630 [ NCBI ]
CGAP (NCI)Hs.631630
Alternative Splicing : Fast-db (Paris)GSHG0015564
Alternative Splicing GalleryENSG00000072062
Gene ExpressionPRKACA [ NCBI-GEO ]     PRKACA [ SEEK ]   PRKACA [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP17612 (Uniprot)
NextProtP17612  [Medical]
With graphics : InterProP17612
Splice isoforms : SwissVarP17612 (Swissvar)
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)AGC-kinase_C [organisation]   Kinase-like_dom [organisation]   Prot_kinase_dom [organisation]   Protein_kinase_ATP_BS [organisation]   Ser/Thr_dual-sp_kinase_dom [organisation]   Ser/Thr_kinase_AS [organisation]  
Related proteins : CluSTrP17612
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TK_X (SM00133)  S_TKc (SM00220)  
DMDM Disease mutations5566
Blocks (Seattle)P17612
PDB (SRS)2GU8    3AGL    3AGM    3AMA    3AMB    3L9L    3L9M    3L9N    3MVJ    3NX8    3OOG    3OVV    3OWP    3OXT    3P0M    3POO    3VQH    4AE6    4AE9   
PDB (PDBSum)2GU8    3AGL    3AGM    3AMA    3AMB    3L9L    3L9M    3L9N    3MVJ    3NX8    3OOG    3OVV    3OWP    3OXT    3P0M    3POO    3VQH    4AE6    4AE9   
PDB (IMB)2GU8    3AGL    3AGM    3AMA    3AMB    3L9L    3L9M    3L9N    3MVJ    3NX8    3OOG    3OVV    3OWP    3OXT    3P0M    3POO    3VQH    4AE6    4AE9   
PDB (RSDB)2GU8    3AGL    3AGM    3AMA    3AMB    3L9L    3L9M    3L9N    3MVJ    3NX8    3OOG    3OVV    3OWP    3OXT    3P0M    3POO    3VQH    4AE6    4AE9   
Human Protein AtlasENSG00000072062 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP17612
HPRD03382
IPIIPI00396630   IPI00217960   IPI00922246   
Protein Interaction databases
DIP (DOE-UCLA)P17612
IntAct (EBI)P17612
FunCoupENSG00000072062
BioGRIDPRKACA
InParanoidP17612
Interologous Interaction database P17612
IntegromeDBPRKACA
STRING (EMBL)PRKACA
Ontologies - Pathways
Ontology : AmiGOG2/M transition of mitotic cell cycle  mitotic cell cycle  mesoderm formation  regulation of heart rate  cAMP-dependent protein kinase activity  cAMP-dependent protein kinase activity  cAMP-dependent protein kinase activity  protein binding  ATP binding  nucleus  mitochondrion  centrosome  cytosol  plasma membrane  cilium  cAMP-dependent protein kinase complex  carbohydrate metabolic process  glucose metabolic process  gluconeogenesis  energy reserve metabolic process  protein phosphorylation  water transport  signal transduction  epidermal growth factor receptor signaling pathway  activation of phospholipase C activity  intracellular protein kinase cascade  blood coagulation  fibroblast growth factor receptor signaling pathway  regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  membrane  peptidyl-serine phosphorylation  triglyceride catabolic process  protein kinase binding  AMP-activated protein kinase complex  neuromuscular junction  ubiquitin protein ligase binding  activation of protein kinase A activity  protein kinase A regulatory subunit binding  calcium channel complex  calcium-mediated signaling using intracellular calcium source  regulation of protein binding  small molecule metabolic process  innate immune response  regulation of osteoblast differentiation  protein autophosphorylation  positive regulation of protein export from nucleus  neurotrophin TRK receptor signaling pathway  sperm capacitation  regulation of insulin secretion  regulation of synaptic transmission  cytosolic calcium ion homeostasis  transmembrane transport  regulation of cardiac muscle contraction  regulation of ryanodine-sensitive calcium-release channel activity  regulation of proteasomal protein catabolic process  positive regulation of cell cycle arrest  cellular response to glucose stimulus  cellular response to parathyroid hormone stimulus  cellular response to glucagon stimulus  cellular response to epinephrine stimulus  cell communication by electrical coupling involved in cardiac conduction  sperm midpiece  regulation of tight junction assembly  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  mitotic cell cycle  mesoderm formation  regulation of heart rate  cAMP-dependent protein kinase activity  cAMP-dependent protein kinase activity  cAMP-dependent protein kinase activity  protein binding  ATP binding  nucleus  mitochondrion  centrosome  cytosol  plasma membrane  cilium  cAMP-dependent protein kinase complex  carbohydrate metabolic process  glucose metabolic process  gluconeogenesis  energy reserve metabolic process  protein phosphorylation  water transport  signal transduction  epidermal growth factor receptor signaling pathway  activation of phospholipase C activity  intracellular protein kinase cascade  blood coagulation  fibroblast growth factor receptor signaling pathway  regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  membrane  peptidyl-serine phosphorylation  triglyceride catabolic process  protein kinase binding  AMP-activated protein kinase complex  neuromuscular junction  ubiquitin protein ligase binding  activation of protein kinase A activity  protein kinase A regulatory subunit binding  calcium channel complex  calcium-mediated signaling using intracellular calcium source  regulation of protein binding  small molecule metabolic process  innate immune response  regulation of osteoblast differentiation  protein autophosphorylation  positive regulation of protein export from nucleus  neurotrophin TRK receptor signaling pathway  sperm capacitation  regulation of insulin secretion  regulation of synaptic transmission  cytosolic calcium ion homeostasis  transmembrane transport  regulation of cardiac muscle contraction  regulation of ryanodine-sensitive calcium-release channel activity  regulation of proteasomal protein catabolic process  positive regulation of cell cycle arrest  cellular response to glucose stimulus  cellular response to parathyroid hormone stimulus  cellular response to glucagon stimulus  cellular response to epinephrine stimulus  cell communication by electrical coupling involved in cardiac conduction  sperm midpiece  regulation of tight junction assembly  
Pathways : BIOCARTAActivation of cAMP-dependent protein kinase, PKA [Genes]   
Pathways : KEGGMAPK signaling pathway    Ras signaling pathway    Calcium signaling pathway    Chemokine signaling pathway    Oocyte meiosis    Apoptosis    Adrenergic signaling in cardiomyocytes    Vascular smooth muscle contraction    Wnt signaling pathway    Hedgehog signaling pathway    Gap junction    Circadian entrainment    Long-term potentiation    Retrograde endocannabinoid signaling    Glutamatergic synapse    Cholinergic synapse    Serotonergic synapse    GABAergic synapse    Dopaminergic synapse    Olfactory transduction    Taste transduction    Insulin signaling pathway    Insulin secretion    GnRH signaling pathway    Ovarian steroidogenesis    Progesterone-mediated oocyte maturation    Estrogen signaling pathway    Melanogenesis    Thyroid hormone synthesis    Thyroid hormone signaling pathway    Endocrine and other factor-regulated calcium reabsorption    Vasopressin-regulated water reabsorption    Salivary secretion    Gastric acid secretion    Bile secretion    Parkinson's disease    Prion diseases    Cocaine addiction    Amphetamine addiction    Morphine addiction    Alcoholism    Vibrio cholerae infection    Amoebiasis    HTLV-I infection    Epstein-Barr virus infection    Viral carcinogenesis    Proteoglycans in cancer    Dilated cardiomyopathy   
Protein Interaction DatabasePRKACA
Wikipedia pathwaysPRKACA
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PRKACA
snp3D : Map Gene to Disease5566
SNP (GeneSNP Utah)PRKACA
SNP : HGBasePRKACA
Genetic variants : HAPMAPPRKACA
Exome VariantPRKACA
1000_GenomesPRKACA 
ICGC programENSG00000072062 
Somatic Mutations in Cancer : COSMICPRKACA 
CONAN: Copy Number AnalysisPRKACA 
Mutations and Diseases : HGMDPRKACA
Genomic VariantsPRKACA  PRKACA [DGVbeta]
dbVarPRKACA
ClinVarPRKACA
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM601639   
MedgenPRKACA
GENETestsPRKACA
Disease Genetic AssociationPRKACA
Huge Navigator PRKACA [HugePedia]  PRKACA [HugeCancerGEM]
General knowledge
Homologs : HomoloGenePRKACA
Homology/Alignments : Family Browser (UCSC)PRKACA
Phylogenetic Trees/Animal Genes : TreeFamPRKACA
Chemical/Protein Interactions : CTD5566
Chemical/Pharm GKB GenePA33748
Clinical trialPRKACA
Cancer Resource (Charite)ENSG00000072062
Other databases
Probes
Litterature
PubMed452 Pubmed reference(s) in Entrez
CoreMinePRKACA
iHOPPRKACA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jul 11 17:13:38 CEST 2014

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