Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PRKACB (protein kinase cAMP-activated catalytic subunit beta)

Identity

Alias_namesprotein kinase, cAMP-dependent, catalytic, beta
protein kinase, cAMP-dependent, beta catalytic subunit
Alias_symbol (synonym)PKACb
Other aliasPKA C-beta
PKACB
HGNC (Hugo) PRKACB
LocusID (NCBI) 5567
Atlas_Id 41847
Location 1p31.1  [Link to chromosome band 1p31]
Location_base_pair Starts at 84077975 and ends at 84205439 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NEUROD6 (7p14.3) / PRKACB (1p31.1)PRKACB (1p31.1) / RYR3 (15q14)SFMBT2 (10p14) / PRKACB (1p31.1)
SLC25A44 (1q22) / PRKACB (1p31.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  Lung: Translocations in Squamous Cell Carcinoma
t(1;10)(p31;p14) SFMBT2/PRKACB

External links

Nomenclature
HGNC (Hugo)PRKACB   9381
Cards
Entrez_Gene (NCBI)PRKACB  5567  protein kinase cAMP-activated catalytic subunit beta
AliasesPKA; PKACB
GeneCards (Weizmann)PRKACB
Ensembl hg19 (Hinxton)ENSG00000142875 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000142875 [Gene_View]  chr1:84077975-84205439 [Contig_View]  PRKACB [Vega]
ICGC DataPortalENSG00000142875
TCGA cBioPortalPRKACB
AceView (NCBI)PRKACB
Genatlas (Paris)PRKACB
WikiGenes5567
SOURCE (Princeton)PRKACB
Genetics Home Reference (NIH)PRKACB
Genomic and cartography
GoldenPath hg38 (UCSC)PRKACB  -     chr1:84077975-84205439 +  1p31.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRKACB  -     1p31.1   [Description]    (hg19-Feb_2009)
EnsemblPRKACB - 1p31.1 [CytoView hg19]  PRKACB - 1p31.1 [CytoView hg38]
Mapping of homologs : NCBIPRKACB [Mapview hg19]  PRKACB [Mapview hg38]
OMIM176892   
Gene and transcription
Genbank (Entrez)AA761973 AB209189 AB451239 AB451364 AI445551
RefSeq transcript (Entrez)NM_001242857 NM_001242858 NM_001242859 NM_001242860 NM_001242861 NM_001242862 NM_001300915 NM_001300916 NM_001300917 NM_002731 NM_182948 NM_207578
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PRKACB
Cluster EST : UnigeneHs.487325 [ NCBI ]
CGAP (NCI)Hs.487325
Alternative Splicing GalleryENSG00000142875
Gene ExpressionPRKACB [ NCBI-GEO ]   PRKACB [ EBI - ARRAY_EXPRESS ]   PRKACB [ SEEK ]   PRKACB [ MEM ]
Gene Expression Viewer (FireBrowse)PRKACB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5567
GTEX Portal (Tissue expression)PRKACB
Human Protein AtlasENSG00000142875-PRKACB [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP22694   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP22694  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP22694
Splice isoforms : SwissVarP22694
PhosPhoSitePlusP22694
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)AGC-kinase_C    Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TK_X (SM00133)  S_TKc (SM00220)  
Conserved Domain (NCBI)PRKACB
DMDM Disease mutations5567
Blocks (Seattle)PRKACB
SuperfamilyP22694
Human Protein Atlas [tissue]ENSG00000142875-PRKACB [tissue]
Peptide AtlasP22694
HPRD01482
IPIIPI00395654   IPI00376119   IPI00739595   IPI00739094   IPI00737155   IPI00738231   IPI00414365   IPI00645788   IPI00877619   IPI01015249   IPI00975910   IPI01018756   IPI00940146   IPI00889699   IPI00889577   IPI00643790   IPI00644248   IPI00889718   
Protein Interaction databases
DIP (DOE-UCLA)P22694
IntAct (EBI)P22694
FunCoupENSG00000142875
BioGRIDPRKACB
STRING (EMBL)PRKACB
ZODIACPRKACB
Ontologies - Pathways
QuickGOP22694
Ontology : AmiGOmagnesium ion binding  neural tube closure  stimulatory C-type lectin receptor signaling pathway  renal water homeostasis  protein serine/threonine kinase activity  protein serine/threonine kinase activity  cAMP-dependent protein kinase activity  cAMP-dependent protein kinase activity  protein binding  ATP binding  nucleoplasm  centrosome  cytosol  cytosol  plasma membrane  cAMP-dependent protein kinase complex  protein phosphorylation  signal transduction  adenylate cyclase-modulating G-protein coupled receptor signaling pathway  blood coagulation  kinase activity  ubiquitin protein ligase binding  activation of protein kinase A activity  high-density lipoprotein particle assembly  intercellular bridge  perinuclear region of cytoplasm  negative regulation of meiotic cell cycle  extracellular exosome  regulation of protein processing  cellular response to glucagon stimulus  response to clozapine  ciliary base  negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning  
Ontology : EGO-EBImagnesium ion binding  neural tube closure  stimulatory C-type lectin receptor signaling pathway  renal water homeostasis  protein serine/threonine kinase activity  protein serine/threonine kinase activity  cAMP-dependent protein kinase activity  cAMP-dependent protein kinase activity  protein binding  ATP binding  nucleoplasm  centrosome  cytosol  cytosol  plasma membrane  cAMP-dependent protein kinase complex  protein phosphorylation  signal transduction  adenylate cyclase-modulating G-protein coupled receptor signaling pathway  blood coagulation  kinase activity  ubiquitin protein ligase binding  activation of protein kinase A activity  high-density lipoprotein particle assembly  intercellular bridge  perinuclear region of cytoplasm  negative regulation of meiotic cell cycle  extracellular exosome  regulation of protein processing  cellular response to glucagon stimulus  response to clozapine  ciliary base  negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning  
Pathways : BIOCARTANFAT and Hypertrophy of the heart (Transcription in the broken heart) [Genes]    Signaling Pathway from G-Protein Families [Genes]    How Progesterone Initiates the Oocyte Maturation [Genes]    Repression of Pain Sensation by the Transcriptional Regulator DREAM [Genes]    mCalpain and friends in Cell motility [Genes]    Phospholipase C-epsilon pathway [Genes]    Stathmin and breast cancer resistance to antimicrotubule agents [Genes]    AKAP95 role in mitosis and chromosome dynamics [Genes]    Attenuation of GPCR Signaling [Genes]    Transcription factor CREB and its extracellular signals [Genes]    Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) [Genes]    Protein Kinase A at the Centrosome [Genes]    Regulation of BAD phosphorylation [Genes]    Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor [Genes]    Cystic fibrosis transmembrane conductance regulator (CFTR) and beta 2 adrenergic receptor (b2AR) pathway [Genes]    Regulation of ck1/cdk5 by type 1 glutamate receptors [Genes]    Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation [Genes]    Sonic Hedgehog (Shh) Pathway [Genes]    ChREBP regulation by carbohydrates and cAMP [Genes]    Actions of Nitric Oxide in the Heart [Genes]    Rho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation [Genes]    GATA3 participate in activating the Th2 cytokine genes expression [Genes]    Transcription Regulation by Methyltransferase of CARM1 [Genes]    Nitric Oxide Signaling Pathway [Genes]    Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells [Genes]   
Pathways : KEGGOlfactory transduction    Wnt signaling pathway    Calcium signaling pathway    MAPK signaling pathway    Insulin signaling pathway    Taste transduction    Long-term potentiation    Gap junction    Hedgehog signaling pathway    Apoptosis    GnRH signaling pathway   
NDEx NetworkPRKACB
Atlas of Cancer Signalling NetworkPRKACB
Wikipedia pathwaysPRKACB
Orthology - Evolution
OrthoDB5567
GeneTree (enSembl)ENSG00000142875
Phylogenetic Trees/Animal Genes : TreeFamPRKACB
HOVERGENP22694
HOGENOMP22694
Homologs : HomoloGenePRKACB
Homology/Alignments : Family Browser (UCSC)PRKACB
Gene fusions - Rearrangements
Fusion : MitelmanSFMBT2/PRKACB [10p14/1p31.1]  [t(1;10)(p31;p14)]  
Fusion : QuiverPRKACB
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRKACB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRKACB
dbVarPRKACB
ClinVarPRKACB
1000_GenomesPRKACB 
Exome Variant ServerPRKACB
ExAC (Exome Aggregation Consortium)ENSG00000142875
GNOMAD BrowserENSG00000142875
Genetic variants : HAPMAP5567
Genomic Variants (DGV)PRKACB [DGVbeta]
DECIPHERPRKACB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRKACB 
Mutations
ICGC Data PortalPRKACB 
TCGA Data PortalPRKACB 
Broad Tumor PortalPRKACB
OASIS PortalPRKACB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRKACB  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRKACB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRKACB
DgiDB (Drug Gene Interaction Database)PRKACB
DoCM (Curated mutations)PRKACB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRKACB (select a term)
intoGenPRKACB
Cancer3DPRKACB(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176892   
Orphanet
DisGeNETPRKACB
MedgenPRKACB
Genetic Testing Registry PRKACB
NextProtP22694 [Medical]
TSGene5567
GENETestsPRKACB
Target ValidationPRKACB
Huge Navigator PRKACB [HugePedia]
snp3D : Map Gene to Disease5567
BioCentury BCIQPRKACB
ClinGenPRKACB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5567
Chemical/Pharm GKB GenePA33749
Clinical trialPRKACB
Miscellaneous
canSAR (ICR)PRKACB (select the gene name)
Probes
Litterature
PubMed85 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRKACB
EVEXPRKACB
GoPubMedPRKACB
iHOPPRKACB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Jun 18 19:40:03 CEST 2018
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