Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PRKAG2 (protein kinase, AMP-activated, gamma 2 non-catalytic subunit)

Identity

Other namesAAKG
AAKG2
CMH6
H91620p
WPWS
HGNC (Hugo) PRKAG2
LocusID (NCBI) 51422
Atlas_Id 47132
Location 7q36.1
Location_base_pair Starts at 151253201 and ends at 151511957 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PRKAG2   9386
Cards
Entrez_Gene (NCBI)PRKAG2  51422  protein kinase, AMP-activated, gamma 2 non-catalytic subunit
GeneCards (Weizmann)PRKAG2
Ensembl hg19 (Hinxton)ENSG00000106617 [Gene_View]  chr7:151253201-151511957 [Contig_View]  PRKAG2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000106617 [Gene_View]  chr7:151253201-151511957 [Contig_View]  PRKAG2 [Vega]
ICGC DataPortalENSG00000106617
TCGA cBioPortalPRKAG2
AceView (NCBI)PRKAG2
Genatlas (Paris)PRKAG2
WikiGenes51422
SOURCE (Princeton)PRKAG2
Genomic and cartography
GoldenPath hg19 (UCSC)PRKAG2  -     chr7:151253201-151511957 -  7q36.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PRKAG2  -     7q36.1   [Description]    (hg38-Dec_2013)
EnsemblPRKAG2 - 7q36.1 [CytoView hg19]  PRKAG2 - 7q36.1 [CytoView hg38]
Mapping of homologs : NCBIPRKAG2 [Mapview hg19]  PRKAG2 [Mapview hg38]
OMIM194200   261740   600858   602743   
Gene and transcription
Genbank (Entrez)AB025580 AF087875 AI084919 AJ249976 AK001887
RefSeq transcript (Entrez)NM_001040633 NM_001304527 NM_001304531 NM_016203 NM_024429
RefSeq genomic (Entrez)NC_000007 NC_018918 NG_007486 NT_007933 NW_004929333
Consensus coding sequences : CCDS (NCBI)PRKAG2
Cluster EST : UnigeneHs.647072 [ NCBI ]
CGAP (NCI)Hs.647072
Alternative Splicing : Fast-db (Paris)GSHG0028732
Alternative Splicing GalleryENSG00000106617
Gene ExpressionPRKAG2 [ NCBI-GEO ]     PRKAG2 [ SEEK ]   PRKAG2 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UGJ0 (Uniprot)
NextProtQ9UGJ0  [Medical]  [Publications]
With graphics : InterProQ9UGJ0
Splice isoforms : SwissVarQ9UGJ0 (Swissvar)
Domaine pattern : Prosite (Expaxy)CBS (PS51371)   
Domains : Interpro (EBI)CBS_dom   
Related proteins : CluSTrQ9UGJ0
Domain families : Pfam (Sanger)CBS (PF00571)   
Domain families : Pfam (NCBI)pfam00571   
Domain families : Smart (EMBL)CBS (SM00116)  
DMDM Disease mutations51422
Blocks (Seattle)Q9UGJ0
Human Protein AtlasENSG00000106617
Peptide AtlasQ9UGJ0
HPRD04119
IPIIPI00005367   IPI00219377   IPI00646448   IPI00385995   IPI00945571   IPI00878474   IPI00946788   IPI00946456   IPI00945827   
Protein Interaction databases
DIP (DOE-UCLA)Q9UGJ0
IntAct (EBI)Q9UGJ0
FunCoupENSG00000106617
BioGRIDPRKAG2
IntegromeDBPRKAG2
STRING (EMBL)PRKAG2
Ontologies - Pathways
QuickGOQ9UGJ0
Ontology : AmiGOAMP-activated protein kinase activity  cAMP-dependent protein kinase inhibitor activity  ATP binding  extracellular space  nucleoplasm  cytosol  glycogen metabolic process  regulation of glycolytic process  energy reserve metabolic process  transcription initiation from RNA polymerase II promoter  protein phosphorylation  negative regulation of protein kinase activity  fatty acid biosynthetic process  ATP biosynthetic process  carnitine shuttle  organelle organization  mitochondrion organization  cell cycle arrest  insulin receptor signaling pathway  cAMP-dependent protein kinase regulator activity  phosphorylase kinase regulator activity  gene expression  positive regulation of peptidyl-threonine phosphorylation  sterol biosynthetic process  AMP binding  regulation of fatty acid metabolic process  protein kinase binding  protein kinase activator activity  AMP-activated protein kinase complex  intracellular signal transduction  regulation of fatty acid biosynthetic process  ADP binding  cellular lipid metabolic process  small molecule metabolic process  positive regulation of protein kinase activity  regulation of fatty acid oxidation  regulation of glucose import  membrane organization  negative regulation of protein serine/threonine kinase activity  
Ontology : EGO-EBIAMP-activated protein kinase activity  cAMP-dependent protein kinase inhibitor activity  ATP binding  extracellular space  nucleoplasm  cytosol  glycogen metabolic process  regulation of glycolytic process  energy reserve metabolic process  transcription initiation from RNA polymerase II promoter  protein phosphorylation  negative regulation of protein kinase activity  fatty acid biosynthetic process  ATP biosynthetic process  carnitine shuttle  organelle organization  mitochondrion organization  cell cycle arrest  insulin receptor signaling pathway  cAMP-dependent protein kinase regulator activity  phosphorylase kinase regulator activity  gene expression  positive regulation of peptidyl-threonine phosphorylation  sterol biosynthetic process  AMP binding  regulation of fatty acid metabolic process  protein kinase binding  protein kinase activator activity  AMP-activated protein kinase complex  intracellular signal transduction  regulation of fatty acid biosynthetic process  ADP binding  cellular lipid metabolic process  small molecule metabolic process  positive regulation of protein kinase activity  regulation of fatty acid oxidation  regulation of glucose import  membrane organization  negative regulation of protein serine/threonine kinase activity  
Pathways : BIOCARTAChREBP regulation by carbohydrates and cAMP [Genes]    Reversal of Insulin Resistance by Leptin [Genes]   
Pathways : KEGGFoxO signaling pathway    Circadian rhythm    Insulin signaling pathway    Adipocytokine signaling pathway    Non-alcoholic fatty liver disease (NAFLD)    Hypertrophic cardiomyopathy (HCM)   
Protein Interaction DatabasePRKAG2
DoCM (Curated mutations)PRKAG2
Wikipedia pathwaysPRKAG2
Gene fusion - Rearrangements
Gene fusion: TCGAPRKAG2 CA10  PRKAG2 MLL3  PRKAG2 CCDC132  PRKAG2 ADCK2  PRKAG2 ORC5  
Polymorphisms : SNP, variants
NCBI Variation ViewerPRKAG2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRKAG2
dbVarPRKAG2
ClinVarPRKAG2
1000_GenomesPRKAG2 
Exome Variant ServerPRKAG2
SNP (GeneSNP Utah)PRKAG2
SNP : HGBasePRKAG2
Genetic variants : HAPMAPPRKAG2
Genomic Variants (DGV)PRKAG2 [DGVbeta]
Mutations
ICGC Data PortalPRKAG2 
TCGA Data PortalPRKAG2 
Tumor PortalPRKAG2
Somatic Mutations in Cancer : COSMICPRKAG2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Zhejiang University Center for Genetic and Genomic Medicine (ZJU-CGGM)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)7:151253201-151511957
CONAN: Copy Number AnalysisPRKAG2 
Mutations and Diseases : HGMDPRKAG2
OMIM194200    261740    600858    602743   
MedgenPRKAG2
NextProtQ9UGJ0 [Medical]
GENETestsPRKAG2
Disease Genetic AssociationPRKAG2
Huge Navigator PRKAG2 [HugePedia]  PRKAG2 [HugeCancerGEM]
snp3D : Map Gene to Disease51422
DGIdb (Drug Gene Interaction db)PRKAG2
BioCentury BCIQPRKAG2
General knowledge
Homologs : HomoloGenePRKAG2
Homology/Alignments : Family Browser (UCSC)PRKAG2
Phylogenetic Trees/Animal Genes : TreeFamPRKAG2
Chemical/Protein Interactions : CTD51422
Chemical/Pharm GKB GenePA33752
Clinical trialPRKAG2
Cancer Resource (Charite)ENSG00000106617
Other databases
Probes
Litterature
PubMed96 Pubmed reference(s) in Entrez
CoreMinePRKAG2
GoPubMedPRKAG2
iHOPPRKAG2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jun 27 12:07:47 CEST 2015

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