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PRKAG2 (protein kinase AMP-activated non-catalytic subunit gamma 2)

Identity

Other namesAAKG
AAKG2
CMH6
H91620p
WPWS
HGNC (Hugo) PRKAG2
LocusID (NCBI) 51422
Atlas_Id 47132
Location 7q36.1  [Link to chromosome band 7q36]
Location_base_pair Starts at 151253201 and ends at 151511957 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ACOX1 (17q25.1) / PRKAG2 (7q36.1)GALNT11 (7q36.1) / PRKAG2 (7q36.1)PPP3CC (8p21.3) / PRKAG2 (7q36.1)
PRKAG2 (7q36.1) / ADCK2 (7q34)PRKAG2 (7q36.1) / CA10 (17q21.33)PRKAG2 (7q36.1) / KMT2C (7q36.1)
PRKAG2 (7q36.1) / MALAT1 (11q13.1)PRKAG2 (7q36.1) / ORC5 (7q22.1)PRKAG2 (7q36.1) / PRKAG2 (7q36.1)
PRKAG2 (7q36.1) / SMU1 (9p21.1)PRKAG2 (7q36.1) / VPS50 (7q21.3)RHEB (7q36.1) / PRKAG2 (7q36.1)
SLC2A13 (12q12) / PRKAG2 (7q36.1)ST7 (7q31.2) / PRKAG2 (7q36.1)ZNF786 (7q36.1) / PRKAG2 (7q36.1)
GALNT11 7q36.1 / PRKAG2 7q36.1PRKAG2 7q36.1 / ADCK2 7q34PRKAG2 7q36.1 / CA10 17q21.33
PRKAG2 7q36.1 CCDC132PRKAG2 7q36.1 MLL3PRKAG2 7q36.1 / ORC5 7q22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PRKAG2   9386
Cards
Entrez_Gene (NCBI)PRKAG2  51422  protein kinase AMP-activated non-catalytic subunit gamma 2
AliasesAAKG; AAKG2; CMH6; H91620p; 
WPWS
GeneCards (Weizmann)PRKAG2
Ensembl hg19 (Hinxton)ENSG00000106617 [Gene_View]  chr7:151253201-151511957 [Contig_View]  PRKAG2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000106617 [Gene_View]  chr7:151253201-151511957 [Contig_View]  PRKAG2 [Vega]
ICGC DataPortalENSG00000106617
TCGA cBioPortalPRKAG2
AceView (NCBI)PRKAG2
Genatlas (Paris)PRKAG2
WikiGenes51422
SOURCE (Princeton)PRKAG2
Genomic and cartography
GoldenPath hg19 (UCSC)PRKAG2  -     chr7:151253201-151511957 -  7q36.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PRKAG2  -     7q36.1   [Description]    (hg38-Dec_2013)
EnsemblPRKAG2 - 7q36.1 [CytoView hg19]  PRKAG2 - 7q36.1 [CytoView hg38]
Mapping of homologs : NCBIPRKAG2 [Mapview hg19]  PRKAG2 [Mapview hg38]
OMIM194200   261740   600858   602743   
Gene and transcription
Genbank (Entrez)AB025580 AF087875 AI084919 AJ249976 AK001887
RefSeq transcript (Entrez)NM_001040633 NM_001304527 NM_001304531 NM_016203 NM_024429
RefSeq genomic (Entrez)NC_000007 NC_018918 NG_007486 NT_007933 NW_004929333
Consensus coding sequences : CCDS (NCBI)PRKAG2
Cluster EST : UnigeneHs.647072 [ NCBI ]
CGAP (NCI)Hs.647072
Alternative Splicing GalleryENSG00000106617
Gene ExpressionPRKAG2 [ NCBI-GEO ]   PRKAG2 [ EBI - ARRAY_EXPRESS ]   PRKAG2 [ SEEK ]   PRKAG2 [ MEM ]
Gene Expression Viewer (FireBrowse)PRKAG2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51422
GTEX Portal (Tissue expression)PRKAG2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UGJ0 (Uniprot)
NextProtQ9UGJ0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UGJ0
Splice isoforms : SwissVarQ9UGJ0 (Swissvar)
PhosPhoSitePlusQ9UGJ0
Domaine pattern : Prosite (Expaxy)CBS (PS51371)   
Domains : Interpro (EBI)CBS_dom   
Domain families : Pfam (Sanger)CBS (PF00571)   
Domain families : Pfam (NCBI)pfam00571   
Domain families : Smart (EMBL)CBS (SM00116)  
DMDM Disease mutations51422
Blocks (Seattle)PRKAG2
SuperfamilyQ9UGJ0
Human Protein AtlasENSG00000106617
Peptide AtlasQ9UGJ0
HPRD04119
IPIIPI00005367   IPI00219377   IPI00646448   IPI00385995   IPI00945571   IPI00878474   IPI00946788   IPI00946456   IPI00945827   
Protein Interaction databases
DIP (DOE-UCLA)Q9UGJ0
IntAct (EBI)Q9UGJ0
FunCoupENSG00000106617
BioGRIDPRKAG2
STRING (EMBL)PRKAG2
ZODIACPRKAG2
Ontologies - Pathways
QuickGOQ9UGJ0
Ontology : AmiGOAMP-activated protein kinase activity  cAMP-dependent protein kinase inhibitor activity  ATP binding  extracellular space  nucleoplasm  cytosol  glycogen metabolic process  regulation of glycolytic process  protein phosphorylation  negative regulation of protein kinase activity  fatty acid biosynthetic process  ATP biosynthetic process  carnitine shuttle  cell cycle arrest  cAMP-dependent protein kinase regulator activity  phosphorylase kinase regulator activity  positive regulation of peptidyl-threonine phosphorylation  sterol biosynthetic process  AMP binding  macroautophagy  regulation of fatty acid metabolic process  protein kinase binding  protein kinase activator activity  nucleotide-activated protein kinase complex  activation of protein kinase activity  intracellular signal transduction  regulation of fatty acid biosynthetic process  ADP binding  positive regulation of protein kinase activity  regulation of fatty acid oxidation  regulation of glucose import  negative regulation of protein serine/threonine kinase activity  regulation of signal transduction by p53 class mediator  
Ontology : EGO-EBIAMP-activated protein kinase activity  cAMP-dependent protein kinase inhibitor activity  ATP binding  extracellular space  nucleoplasm  cytosol  glycogen metabolic process  regulation of glycolytic process  protein phosphorylation  negative regulation of protein kinase activity  fatty acid biosynthetic process  ATP biosynthetic process  carnitine shuttle  cell cycle arrest  cAMP-dependent protein kinase regulator activity  phosphorylase kinase regulator activity  positive regulation of peptidyl-threonine phosphorylation  sterol biosynthetic process  AMP binding  macroautophagy  regulation of fatty acid metabolic process  protein kinase binding  protein kinase activator activity  nucleotide-activated protein kinase complex  activation of protein kinase activity  intracellular signal transduction  regulation of fatty acid biosynthetic process  ADP binding  positive regulation of protein kinase activity  regulation of fatty acid oxidation  regulation of glucose import  negative regulation of protein serine/threonine kinase activity  regulation of signal transduction by p53 class mediator  
Pathways : BIOCARTAChREBP regulation by carbohydrates and cAMP [Genes]    Reversal of Insulin Resistance by Leptin [Genes]   
Pathways : KEGGFoxO signaling pathway    Circadian rhythm    Insulin signaling pathway    Adipocytokine signaling pathway    Non-alcoholic fatty liver disease (NAFLD)    Hypertrophic cardiomyopathy (HCM)   
NDEx NetworkPRKAG2
Atlas of Cancer Signalling NetworkPRKAG2
Wikipedia pathwaysPRKAG2
Orthology - Evolution
OrthoDB51422
GeneTree (enSembl)ENSG00000106617
Phylogenetic Trees/Animal Genes : TreeFamPRKAG2
Homologs : HomoloGenePRKAG2
Homology/Alignments : Family Browser (UCSC)PRKAG2
Gene fusions - Rearrangements
Fusion: TCGAGALNT11 7q36.1 PRKAG2 7q36.1 BRCA
Fusion: TCGAPRKAG2 7q36.1 ADCK2 7q34 LUAD
Fusion: TCGAPRKAG2 7q36.1 CA10 17q21.33 BRCA
Fusion: TCGAPRKAG2 7q36.1 CCDC132 BRCA
Fusion: TCGAPRKAG2 7q36.1 MLL3 BRCA PRAD
Fusion: TCGAPRKAG2 7q36.1 ORC5 7q22.1 OV
Polymorphisms : SNP, variants
NCBI Variation ViewerPRKAG2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRKAG2
dbVarPRKAG2
ClinVarPRKAG2
1000_GenomesPRKAG2 
Exome Variant ServerPRKAG2
ExAC (Exome Aggregation Consortium)PRKAG2 (select the gene name)
Genetic variants : HAPMAP51422
Genomic Variants (DGV)PRKAG2 [DGVbeta]
Mutations
ICGC Data PortalPRKAG2 
TCGA Data PortalPRKAG2 
Broad Tumor PortalPRKAG2
OASIS PortalPRKAG2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRKAG2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Zhejiang University Center for Genetic and Genomic Medicine (ZJU-CGGM)
BioMutasearch PRKAG2
DgiDB (Drug Gene Interaction Database)PRKAG2
DoCM (Curated mutations)PRKAG2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRKAG2 (select a term)
intoGenPRKAG2
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)7:151253201-151511957  ENSG00000106617
CONAN: Copy Number AnalysisPRKAG2 
Mutations and Diseases : HGMDPRKAG2
OMIM194200    261740    600858    602743   
MedgenPRKAG2
Genetic Testing Registry PRKAG2
NextProtQ9UGJ0 [Medical]
TSGene51422
GENETestsPRKAG2
Huge Navigator PRKAG2 [HugePedia]
snp3D : Map Gene to Disease51422
BioCentury BCIQPRKAG2
ClinGenPRKAG2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51422
Chemical/Pharm GKB GenePA33752
Clinical trialPRKAG2
Miscellaneous
canSAR (ICR)PRKAG2 (select the gene name)
Probes
Litterature
PubMed94 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRKAG2
EVEXPRKAG2
GoPubMedPRKAG2
iHOPPRKAG2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 19 19:08:33 CEST 2016

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