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PRKAR1B (protein kinase cAMP-dependent type I regulatory subunit beta)

Identity

Alias_namesprotein kinase, cAMP-dependent, regulatory, type I, beta
protein kinase, cAMP-dependent, regulatory subunit type I beta
Other aliasPRKAR1
HGNC (Hugo) PRKAR1B
LocusID (NCBI) 5575
Atlas_Id 41850
Location 7p22.3  [Link to chromosome band 7p22]
Location_base_pair Starts at 588834 and ends at 767313 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ADAP1 (7p22.3) / PRKAR1B (7p22.3)CTSD (11p15.5) / PRKAR1B (7p22.3)FAM20C (7p22.3) / PRKAR1B (7p22.3)
INTS1 (7p22.3) / PRKAR1B (7p22.3)MARCKSL1 (1p35.1) / PRKAR1B (7p22.3)PCMTD1 (8q11.23) / PRKAR1B (7p22.3)
PTPRN2 (7q36.3) / PRKAR1B (7p22.3)UBE2J2 (1p36.33) / PRKAR1B (7p22.3)ULK1 (12q24.33) / PRKAR1B (7p22.3)
ZFR (5p13.3) / PRKAR1B (7p22.3)ULK1 12q24.33 / PRKAR1B 7p22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PRKAR1B   9390
Cards
Entrez_Gene (NCBI)PRKAR1B  5575  protein kinase cAMP-dependent type I regulatory subunit beta
AliasesPRKAR1
GeneCards (Weizmann)PRKAR1B
Ensembl hg19 (Hinxton)ENSG00000188191 [Gene_View]  chr7:588834-767313 [Contig_View]  PRKAR1B [Vega]
Ensembl hg38 (Hinxton)ENSG00000188191 [Gene_View]  chr7:588834-767313 [Contig_View]  PRKAR1B [Vega]
ICGC DataPortalENSG00000188191
TCGA cBioPortalPRKAR1B
AceView (NCBI)PRKAR1B
Genatlas (Paris)PRKAR1B
WikiGenes5575
SOURCE (Princeton)PRKAR1B
Genetics Home Reference (NIH)PRKAR1B
Genomic and cartography
GoldenPath hg19 (UCSC)PRKAR1B  -     chr7:588834-767313 -  7p22.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PRKAR1B  -     7p22.3   [Description]    (hg38-Dec_2013)
EnsemblPRKAR1B - 7p22.3 [CytoView hg19]  PRKAR1B - 7p22.3 [CytoView hg38]
Mapping of homologs : NCBIPRKAR1B [Mapview hg19]  PRKAR1B [Mapview hg38]
OMIM176911   
Gene and transcription
Genbank (Entrez)AK098822 AK289464 AK297337 AK315951 AK315990
RefSeq transcript (Entrez)NM_001164758 NM_001164759 NM_001164760 NM_001164761 NM_001164762 NM_002735
RefSeq genomic (Entrez)NC_000007 NC_018918 NG_042811 NT_007819 NW_004929329
Consensus coding sequences : CCDS (NCBI)PRKAR1B
Cluster EST : UnigeneHs.520851 [ NCBI ]
CGAP (NCI)Hs.520851
Alternative Splicing GalleryENSG00000188191
Gene ExpressionPRKAR1B [ NCBI-GEO ]   PRKAR1B [ EBI - ARRAY_EXPRESS ]   PRKAR1B [ SEEK ]   PRKAR1B [ MEM ]
Gene Expression Viewer (FireBrowse)PRKAR1B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5575
GTEX Portal (Tissue expression)PRKAR1B
Protein : pattern, domain, 3D structure
UniProt/SwissProtP31321   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP31321  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP31321
Splice isoforms : SwissVarP31321
PhosPhoSitePlusP31321
Domaine pattern : Prosite (Expaxy)CNMP_BINDING_1 (PS00888)    CNMP_BINDING_2 (PS00889)    CNMP_BINDING_3 (PS50042)   
Domains : Interpro (EBI)cAMP_dep_PK_reg_su    cAMP_dep_PK_reg_su_I/II_a/b    cNMP-bd-like    cNMP-bd_CS    cNMP-bd_dom    RmlC-like_jellyroll   
Domain families : Pfam (Sanger)cNMP_binding (PF00027)    RIIa (PF02197)   
Domain families : Pfam (NCBI)pfam00027    pfam02197   
Domain families : Smart (EMBL)cNMP (SM00100)  RIIa (SM00394)  
Conserved Domain (NCBI)PRKAR1B
DMDM Disease mutations5575
Blocks (Seattle)PRKAR1B
PDB (SRS)4DIN    4F9K   
PDB (PDBSum)4DIN    4F9K   
PDB (IMB)4DIN    4F9K   
PDB (RSDB)4DIN    4F9K   
Structural Biology KnowledgeBase4DIN    4F9K   
SCOP (Structural Classification of Proteins)4DIN    4F9K   
CATH (Classification of proteins structures)4DIN    4F9K   
SuperfamilyP31321
Human Protein AtlasENSG00000188191
Peptide AtlasP31321
HPRD01485
IPIIPI00554488   IPI00867677   IPI00893402   IPI00893033   IPI00893162   IPI00892856   IPI00893104   
Protein Interaction databases
DIP (DOE-UCLA)P31321
IntAct (EBI)P31321
FunCoupENSG00000188191
BioGRIDPRKAR1B
STRING (EMBL)PRKAR1B
ZODIACPRKAR1B
Ontologies - Pathways
QuickGOP31321
Ontology : AmiGOrenal water homeostasis  cAMP-dependent protein kinase inhibitor activity  cytosol  plasma membrane  cAMP-dependent protein kinase complex  protein phosphorylation  blood coagulation  learning or memory  cAMP-dependent protein kinase regulator activity  cAMP-dependent protein kinase regulator activity  cAMP binding  activation of protein kinase A activity  protein kinase A catalytic subunit binding  cellular response to glucagon stimulus  ciliary base  negative regulation of cAMP-dependent protein kinase activity  
Ontology : EGO-EBIrenal water homeostasis  cAMP-dependent protein kinase inhibitor activity  cytosol  plasma membrane  cAMP-dependent protein kinase complex  protein phosphorylation  blood coagulation  learning or memory  cAMP-dependent protein kinase regulator activity  cAMP-dependent protein kinase regulator activity  cAMP binding  activation of protein kinase A activity  protein kinase A catalytic subunit binding  cellular response to glucagon stimulus  ciliary base  negative regulation of cAMP-dependent protein kinase activity  
Pathways : BIOCARTARepression of Pain Sensation by the Transcriptional Regulator DREAM [Genes]    ChREBP regulation by carbohydrates and cAMP [Genes]    GATA3 participate in activating the Th2 cytokine genes expression [Genes]    Transcription factor CREB and its extracellular signals [Genes]    Signaling Pathway from G-Protein Families [Genes]    Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation [Genes]    How Progesterone Initiates the Oocyte Maturation [Genes]    Attenuation of GPCR Signaling [Genes]    Regulation of BAD phosphorylation [Genes]    Transcription Regulation by Methyltransferase of CARM1 [Genes]    Actions of Nitric Oxide in the Heart [Genes]    Stathmin and breast cancer resistance to antimicrotubule agents [Genes]    Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor [Genes]    Regulation of ck1/cdk5 by type 1 glutamate receptors [Genes]    Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) [Genes]    Sonic Hedgehog (Shh) Pathway [Genes]    Nitric Oxide Signaling Pathway [Genes]    Cystic fibrosis transmembrane conductance regulator (CFTR) and beta 2 adrenergic receptor (b2AR) pathway [Genes]    NFAT and Hypertrophy of the heart (Transcription in the broken heart) [Genes]    Phospholipase C-epsilon pathway [Genes]    Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells [Genes]    mCalpain and friends in Cell motility [Genes]   
Pathways : KEGGApoptosis    Insulin signaling pathway   
NDEx NetworkPRKAR1B
Atlas of Cancer Signalling NetworkPRKAR1B
Wikipedia pathwaysPRKAR1B
Orthology - Evolution
OrthoDB5575
GeneTree (enSembl)ENSG00000188191
Phylogenetic Trees/Animal Genes : TreeFamPRKAR1B
HOVERGENP31321
HOGENOMP31321
Homologs : HomoloGenePRKAR1B
Homology/Alignments : Family Browser (UCSC)PRKAR1B
Gene fusions - Rearrangements
Fusion : MitelmanCTSD/PRKAR1B [11p15.5/7p22.3]  [t(7;11)(p22;p15)]  
Fusion : MitelmanINTS1/PRKAR1B [7p22.3/7p22.3]  [t(7;7)(p22;p22)]  
Fusion : MitelmanPCMTD1/PRKAR1B [8q11.23/7p22.3]  [t(7;8)(p22;q11)]  
Fusion : MitelmanULK1/PRKAR1B [12q24.33/7p22.3]  [t(7;12)(p22;q24)]  
Fusion: TCGAULK1 12q24.33 PRKAR1B 7p22.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRKAR1B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRKAR1B
dbVarPRKAR1B
ClinVarPRKAR1B
1000_GenomesPRKAR1B 
Exome Variant ServerPRKAR1B
ExAC (Exome Aggregation Consortium)PRKAR1B (select the gene name)
Genetic variants : HAPMAP5575
Genomic Variants (DGV)PRKAR1B [DGVbeta]
DECIPHER (Syndromes)7:588834-767313  ENSG00000188191
CONAN: Copy Number AnalysisPRKAR1B 
Mutations
ICGC Data PortalPRKAR1B 
TCGA Data PortalPRKAR1B 
Broad Tumor PortalPRKAR1B
OASIS PortalPRKAR1B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRKAR1B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRKAR1B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRKAR1B
DgiDB (Drug Gene Interaction Database)PRKAR1B
DoCM (Curated mutations)PRKAR1B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRKAR1B (select a term)
intoGenPRKAR1B
Cancer3DPRKAR1B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176911   
Orphanet23041   
MedgenPRKAR1B
Genetic Testing Registry PRKAR1B
NextProtP31321 [Medical]
TSGene5575
GENETestsPRKAR1B
Huge Navigator PRKAR1B [HugePedia]
snp3D : Map Gene to Disease5575
BioCentury BCIQPRKAR1B
ClinGenPRKAR1B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5575
Chemical/Pharm GKB GenePA33756
Clinical trialPRKAR1B
Miscellaneous
canSAR (ICR)PRKAR1B (select the gene name)
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRKAR1B
EVEXPRKAR1B
GoPubMedPRKAR1B
iHOPPRKAR1B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:22:55 CET 2017

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