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PRKAR2A (protein kinase cAMP-dependent type II regulatory subunit alpha)

Identity

Alias (NCBI)PKR2
PRKAR2
HGNC (Hugo) PRKAR2A
HGNC Previous namePRKAR2
HGNC Previous nameprotein kinase, cAMP-dependent, regulatory, type II, alpha
 protein kinase, cAMP-dependent, regulatory subunit type II alpha
LocusID (NCBI) 5576
Atlas_Id 45624
Location 3p21.31  [Link to chromosome band 3p21]
Location_base_pair Starts at 48746586 and ends at 48847874 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDC25A (3p21.31)::PRKAR2A (3p21.31)CTU2 (16q24.3)::PRKAR2A (3p21.31)IP6K2 (3p21.31)::PRKAR2A (3p21.31)
PRKAR2A (3p21.31)::MRPS5 (2q11.1)PRKAR2A (3p21.31)::SLC25A20 (3p21.31)PRKAR2A (3p21.31)::SPINK8 (3p21.31)
SLC26A6 (3p21.31)::PRKAR2A (3p21.31)SLC26A6 3p21.31::PRKAR2A 3p21.31CDC25A 3p21.31::PRKAR2A 3p21.31
IP6K2 3p21.31::PRKAR2A 3p21.31PRKAR2A 3p21.31::SLC25A20 3p21.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PRKAR2A   9391
Cards
Entrez_Gene (NCBI)PRKAR2A    protein kinase cAMP-dependent type II regulatory subunit alpha
AliasesPKR2; PRKAR2
GeneCards (Weizmann)PRKAR2A
Ensembl hg19 (Hinxton)ENSG00000114302 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000114302 [Gene_View]  ENSG00000114302 [Sequence]  chr3:48746586-48847874 [Contig_View]  PRKAR2A [Vega]
ICGC DataPortalENSG00000114302
TCGA cBioPortalPRKAR2A
AceView (NCBI)PRKAR2A
Genatlas (Paris)PRKAR2A
SOURCE (Princeton)PRKAR2A
Genetics Home Reference (NIH)PRKAR2A
Genomic and cartography
GoldenPath hg38 (UCSC)PRKAR2A  -     chr3:48746586-48847874 -  3p21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRKAR2A  -     3p21.31   [Description]    (hg19-Feb_2009)
GoldenPathPRKAR2A - 3p21.31 [CytoView hg19]  PRKAR2A - 3p21.31 [CytoView hg38]
ImmunoBaseENSG00000114302
Genome Data Viewer NCBIPRKAR2A [Mapview hg19]  
OMIM176910   
Gene and transcription
Genbank (Entrez)AA774111 AK023535 AK026351 AK293042 BC002763
RefSeq transcript (Entrez)NM_001321982 NM_001321983 NM_001321989 NM_004157
Consensus coding sequences : CCDS (NCBI)PRKAR2A
Gene ExpressionPRKAR2A [ NCBI-GEO ]   PRKAR2A [ EBI - ARRAY_EXPRESS ]   PRKAR2A [ SEEK ]   PRKAR2A [ MEM ]
Gene Expression Viewer (FireBrowse)PRKAR2A [ Firebrowse - Broad ]
GenevisibleExpression of PRKAR2A in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5576
GTEX Portal (Tissue expression)PRKAR2A
Human Protein AtlasENSG00000114302-PRKAR2A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP13861   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP13861  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP13861
PhosPhoSitePlusP13861
Domaine pattern : Prosite (Expaxy)CNMP_BINDING_1 (PS00888)    CNMP_BINDING_2 (PS00889)    CNMP_BINDING_3 (PS50042)   
Domains : Interpro (EBI)cAMP_dep_PK_reg_su    cAMP_dep_PK_reg_su_I/II_a/b    cNMP-bd-like    cNMP-bd_CS    cNMP-bd_dom    RmlC-like_jellyroll   
Domain families : Pfam (Sanger)cNMP_binding (PF00027)    RIIa (PF02197)   
Domain families : Pfam (NCBI)pfam00027    pfam02197   
Domain families : Smart (EMBL)cNMP (SM00100)  RIIa (SM00394)  
Conserved Domain (NCBI)PRKAR2A
PDB (RSDB)2IZX    2KYG    4ZP3    5H78    5XBY   
PDB Europe2IZX    2KYG    4ZP3    5H78    5XBY   
PDB (PDBSum)2IZX    2KYG    4ZP3    5H78    5XBY   
PDB (IMB)2IZX    2KYG    4ZP3    5H78    5XBY   
Structural Biology KnowledgeBase2IZX    2KYG    4ZP3    5H78    5XBY   
SCOP (Structural Classification of Proteins)2IZX    2KYG    4ZP3    5H78    5XBY   
CATH (Classification of proteins structures)2IZX    2KYG    4ZP3    5H78    5XBY   
SuperfamilyP13861
AlphaFold pdb e-kbP13861   
Human Protein Atlas [tissue]ENSG00000114302-PRKAR2A [tissue]
HPRD01484
Protein Interaction databases
DIP (DOE-UCLA)P13861
IntAct (EBI)P13861
BioGRIDPRKAR2A
STRING (EMBL)PRKAR2A
ZODIACPRKAR2A
Ontologies - Pathways
QuickGOP13861
Ontology : AmiGOcAMP-dependent protein kinase inhibitor activity  cAMP-dependent protein kinase inhibitor activity  protein binding  cytoplasm  cytoplasm  centrosome  cytosol  plasma membrane  focal adhesion  axoneme  cAMP-dependent protein kinase complex  cAMP-dependent protein kinase complex  cAMP-dependent protein kinase regulator activity  cAMP-dependent protein kinase regulator activity  membrane  protein domain specific binding  cAMP binding  nucleotide-activated protein kinase complex  ubiquitin protein ligase binding  protein-containing complex  protein kinase A catalytic subunit binding  protein kinase A catalytic subunit binding  intracellular signal transduction  plasma membrane raft  extracellular exosome  ciliary base  negative regulation of cAMP-dependent protein kinase activity  negative regulation of cAMP-dependent protein kinase activity  
Ontology : EGO-EBIcAMP-dependent protein kinase inhibitor activity  cAMP-dependent protein kinase inhibitor activity  protein binding  cytoplasm  cytoplasm  centrosome  cytosol  plasma membrane  focal adhesion  axoneme  cAMP-dependent protein kinase complex  cAMP-dependent protein kinase complex  cAMP-dependent protein kinase regulator activity  cAMP-dependent protein kinase regulator activity  membrane  protein domain specific binding  cAMP binding  nucleotide-activated protein kinase complex  ubiquitin protein ligase binding  protein-containing complex  protein kinase A catalytic subunit binding  protein kinase A catalytic subunit binding  intracellular signal transduction  plasma membrane raft  extracellular exosome  ciliary base  negative regulation of cAMP-dependent protein kinase activity  negative regulation of cAMP-dependent protein kinase activity  
Pathways : BIOCARTABIOCARTA_CHREBPPATHWAY    BIOCARTA_NO1PATHWAY    BIOCARTA_CSKPATHWAY    BIOCARTA_AKAP95PATHWAY    BIOCARTA_AGPCRPATHWAY    BIOCARTA_CFTRPATHWAY    BIOCARTA_GATA3PATHWAY    BIOCARTA_MPRPATHWAY    BIOCARTA_MCALPAINPATHWAY    BIOCARTA_PPARAPATHWAY    BIOCARTA_IGF1RPATHWAY    BIOCARTA_VIPPATHWAY    BIOCARTA_NFATPATHWAY    BIOCARTA_NOS1PATHWAY    BIOCARTA_PLCEPATHWAY    BIOCARTA_AKAPCENTROSOMEPATHWAY    BIOCARTA_BADPATHWAY    BIOCARTA_CK1PATHWAY    BIOCARTA_DREAMPATHWAY    BIOCARTA_AKAP13PATHWAY    BIOCARTA_GPCRPATHWAY    BIOCARTA_SHHPATHWAY    BIOCARTA_STATHMINPATHWAY    BIOCARTA_CREBPATHWAY    BIOCARTA_CARM1PATHWAY   
Pathways : KEGGKEGG_APOPTOSIS    KEGG_INSULIN_SIGNALING   
NDEx NetworkPRKAR2A
Atlas of Cancer Signalling NetworkPRKAR2A
Wikipedia pathwaysPRKAR2A
Orthology - Evolution
OrthoDB5576
GeneTree (enSembl)ENSG00000114302
Phylogenetic Trees/Animal Genes : TreeFamPRKAR2A
Homologs : HomoloGenePRKAR2A
Homology/Alignments : Family Browser (UCSC)PRKAR2A
Gene fusions - Rearrangements
Fusion : MitelmanCDC25A::PRKAR2A [3p21.31/3p21.31]  
Fusion : MitelmanIP6K2::PRKAR2A [3p21.31/3p21.31]  
Fusion : MitelmanPRKAR2A::SLC25A20 [3p21.31/3p21.31]  
Fusion : MitelmanPRKAR2A::SPINK8 [3p21.31/3p21.31]  
Fusion : MitelmanSLC26A6::PRKAR2A [3p21.31/3p21.31]  
Fusion : QuiverPRKAR2A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRKAR2A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRKAR2A
dbVarPRKAR2A
ClinVarPRKAR2A
MonarchPRKAR2A
1000_GenomesPRKAR2A 
Exome Variant ServerPRKAR2A
GNOMAD BrowserENSG00000114302
Varsome BrowserPRKAR2A
ACMGPRKAR2A variants
VarityP13861
Genomic Variants (DGV)PRKAR2A [DGVbeta]
DECIPHERPRKAR2A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRKAR2A 
Mutations
ICGC Data PortalPRKAR2A 
TCGA Data PortalPRKAR2A 
Broad Tumor PortalPRKAR2A
OASIS PortalPRKAR2A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRKAR2A  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPRKAR2A
Mutations and Diseases : HGMDPRKAR2A
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPRKAR2A
DgiDB (Drug Gene Interaction Database)PRKAR2A
DoCM (Curated mutations)PRKAR2A
CIViC (Clinical Interpretations of Variants in Cancer)PRKAR2A
Cancer3DPRKAR2A
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176910   
Orphanet
DisGeNETPRKAR2A
MedgenPRKAR2A
Genetic Testing Registry PRKAR2A
NextProtP13861 [Medical]
GENETestsPRKAR2A
Target ValidationPRKAR2A
Huge Navigator PRKAR2A [HugePedia]
ClinGenPRKAR2A
Clinical trials, drugs, therapy
MyCancerGenomePRKAR2A
Protein Interactions : CTDPRKAR2A
Pharm GKB GenePA33757
PharosP13861
Clinical trialPRKAR2A
Miscellaneous
canSAR (ICR)PRKAR2A
HarmonizomePRKAR2A
ARCHS4PRKAR2A
DataMed IndexPRKAR2A
Probes
Litterature
PubMed175 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPRKAR2A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 12:53:51 CET 2022

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