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PRKAR2A (protein kinase cAMP-dependent type II regulatory subunit alpha)

Identity

Alias_namesPRKAR2
protein kinase, cAMP-dependent, regulatory, type II, alpha
protein kinase, cAMP-dependent, regulatory subunit type II alpha
Other aliasPKR2
HGNC (Hugo) PRKAR2A
LocusID (NCBI) 5576
Atlas_Id 45624
Location 3p21.31  [Link to chromosome band 3p21]
Location_base_pair Starts at 48746579 and ends at 48847850 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CDC25A (3p21.31) / PRKAR2A (3p21.31)CTU2 (16q24.3) / PRKAR2A (3p21.31)IP6K2 (3p21.31) / PRKAR2A (3p21.31)
PRKAR2A (3p21.31) / MRPS5 (2q11.1)PRKAR2A (3p21.31) / SLC25A20 (3p21.31)PRKAR2A (3p21.31) / SPINK8 (3p21.31)
SLC26A6 (3p21.31) / PRKAR2A (3p21.31)SLC26A6 3p21.31 / PRKAR2A 3p21.31CDC25A 3p21.31 / PRKAR2A 3p21.31
IP6K2 3p21.31 / PRKAR2A 3p21.31PRKAR2A 3p21.31 / SLC25A20 3p21.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PRKAR2A   9391
Cards
Entrez_Gene (NCBI)PRKAR2A  5576  protein kinase cAMP-dependent type II regulatory subunit alpha
AliasesPKR2; PRKAR2
GeneCards (Weizmann)PRKAR2A
Ensembl hg19 (Hinxton)ENSG00000114302 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000114302 [Gene_View]  chr3:48746579-48847850 [Contig_View]  PRKAR2A [Vega]
ICGC DataPortalENSG00000114302
TCGA cBioPortalPRKAR2A
AceView (NCBI)PRKAR2A
Genatlas (Paris)PRKAR2A
WikiGenes5576
SOURCE (Princeton)PRKAR2A
Genetics Home Reference (NIH)PRKAR2A
Genomic and cartography
GoldenPath hg38 (UCSC)PRKAR2A  -     chr3:48746579-48847850 -  3p21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRKAR2A  -     3p21.31   [Description]    (hg19-Feb_2009)
EnsemblPRKAR2A - 3p21.31 [CytoView hg19]  PRKAR2A - 3p21.31 [CytoView hg38]
Mapping of homologs : NCBIPRKAR2A [Mapview hg19]  PRKAR2A [Mapview hg38]
OMIM176910   
Gene and transcription
Genbank (Entrez)AA774111 AK023535 AK026351 AK293042 BC002763
RefSeq transcript (Entrez)NM_001321982 NM_001321983 NM_001321989 NM_004157
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PRKAR2A
Cluster EST : UnigeneHs.731573 [ NCBI ]
CGAP (NCI)Hs.731573
Alternative Splicing GalleryENSG00000114302
Gene ExpressionPRKAR2A [ NCBI-GEO ]   PRKAR2A [ EBI - ARRAY_EXPRESS ]   PRKAR2A [ SEEK ]   PRKAR2A [ MEM ]
Gene Expression Viewer (FireBrowse)PRKAR2A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5576
GTEX Portal (Tissue expression)PRKAR2A
Protein : pattern, domain, 3D structure
UniProt/SwissProtP13861   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP13861  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP13861
Splice isoforms : SwissVarP13861
PhosPhoSitePlusP13861
Domaine pattern : Prosite (Expaxy)CNMP_BINDING_1 (PS00888)    CNMP_BINDING_2 (PS00889)    CNMP_BINDING_3 (PS50042)   
Domains : Interpro (EBI)cAMP_dep_PK_reg_su    cAMP_dep_PK_reg_su_I/II_a/b    cNMP-bd-like    cNMP-bd_CS    cNMP-bd_dom    RmlC-like_jellyroll   
Domain families : Pfam (Sanger)cNMP_binding (PF00027)    RIIa (PF02197)   
Domain families : Pfam (NCBI)pfam00027    pfam02197   
Domain families : Smart (EMBL)cNMP (SM00100)  RIIa (SM00394)  
Conserved Domain (NCBI)PRKAR2A
DMDM Disease mutations5576
Blocks (Seattle)PRKAR2A
PDB (SRS)2IZX    2KYG    4ZP3   
PDB (PDBSum)2IZX    2KYG    4ZP3   
PDB (IMB)2IZX    2KYG    4ZP3   
PDB (RSDB)2IZX    2KYG    4ZP3   
Structural Biology KnowledgeBase2IZX    2KYG    4ZP3   
SCOP (Structural Classification of Proteins)2IZX    2KYG    4ZP3   
CATH (Classification of proteins structures)2IZX    2KYG    4ZP3   
SuperfamilyP13861
Human Protein AtlasENSG00000114302
Peptide AtlasP13861
HPRD01484
IPIIPI00219774   IPI00063234   IPI00925126   IPI00925327   IPI00924714   IPI00924946   
Protein Interaction databases
DIP (DOE-UCLA)P13861
IntAct (EBI)P13861
FunCoupENSG00000114302
BioGRIDPRKAR2A
STRING (EMBL)PRKAR2A
ZODIACPRKAR2A
Ontologies - Pathways
QuickGOP13861
Ontology : AmiGOrenal water homeostasis  cAMP-dependent protein kinase inhibitor activity  protein binding  cytoplasm  centrosome  cytosol  plasma membrane  focal adhesion  cAMP-dependent protein kinase complex  blood coagulation  cAMP-dependent protein kinase regulator activity  cAMP-dependent protein kinase regulator activity  membrane  cAMP binding  nucleotide-activated protein kinase complex  ubiquitin protein ligase binding  activation of protein kinase A activity  protein kinase A catalytic subunit binding  intracellular signal transduction  plasma membrane raft  extracellular exosome  cellular response to glucagon stimulus  ciliary base  negative regulation of cAMP-dependent protein kinase activity  
Ontology : EGO-EBIrenal water homeostasis  cAMP-dependent protein kinase inhibitor activity  protein binding  cytoplasm  centrosome  cytosol  plasma membrane  focal adhesion  cAMP-dependent protein kinase complex  blood coagulation  cAMP-dependent protein kinase regulator activity  cAMP-dependent protein kinase regulator activity  membrane  cAMP binding  nucleotide-activated protein kinase complex  ubiquitin protein ligase binding  activation of protein kinase A activity  protein kinase A catalytic subunit binding  intracellular signal transduction  plasma membrane raft  extracellular exosome  cellular response to glucagon stimulus  ciliary base  negative regulation of cAMP-dependent protein kinase activity  
Pathways : BIOCARTA [Genes]   
Pathways : KEGGApoptosis    Insulin signaling pathway   
NDEx NetworkPRKAR2A
Atlas of Cancer Signalling NetworkPRKAR2A
Wikipedia pathwaysPRKAR2A
Orthology - Evolution
OrthoDB5576
GeneTree (enSembl)ENSG00000114302
Phylogenetic Trees/Animal Genes : TreeFamPRKAR2A
HOVERGENP13861
HOGENOMP13861
Homologs : HomoloGenePRKAR2A
Homology/Alignments : Family Browser (UCSC)PRKAR2A
Gene fusions - Rearrangements
Fusion : MitelmanCDC25A/PRKAR2A [3p21.31/3p21.31]  [t(3;3)(p21;p21)]  
Fusion : MitelmanIP6K2/PRKAR2A [3p21.31/3p21.31]  [t(3;3)(p21;p21)]  
Fusion : MitelmanPRKAR2A/SLC25A20 [3p21.31/3p21.31]  [t(3;3)(p21;p21)]  
Fusion : MitelmanPRKAR2A/SPINK8 [3p21.31/3p21.31]  [t(3;3)(p21;p21)]  
Fusion : MitelmanSLC26A6/PRKAR2A [3p21.31/3p21.31]  [del(3)(p21)]  [del(3)(p21p21)]  
Fusion: TCGACDC25A 3p21.31 PRKAR2A 3p21.31 OV
Fusion: TCGAIP6K2 3p21.31 PRKAR2A 3p21.31 BRCA
Fusion: TCGAPRKAR2A 3p21.31 SLC25A20 3p21.31 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRKAR2A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRKAR2A
dbVarPRKAR2A
ClinVarPRKAR2A
1000_GenomesPRKAR2A 
Exome Variant ServerPRKAR2A
ExAC (Exome Aggregation Consortium)PRKAR2A (select the gene name)
Genetic variants : HAPMAP5576
Genomic Variants (DGV)PRKAR2A [DGVbeta]
DECIPHERPRKAR2A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRKAR2A 
Mutations
ICGC Data PortalPRKAR2A 
TCGA Data PortalPRKAR2A 
Broad Tumor PortalPRKAR2A
OASIS PortalPRKAR2A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRKAR2A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRKAR2A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRKAR2A
DgiDB (Drug Gene Interaction Database)PRKAR2A
DoCM (Curated mutations)PRKAR2A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRKAR2A (select a term)
intoGenPRKAR2A
Cancer3DPRKAR2A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176910   
Orphanet
MedgenPRKAR2A
Genetic Testing Registry PRKAR2A
NextProtP13861 [Medical]
TSGene5576
GENETestsPRKAR2A
Target ValidationPRKAR2A
Huge Navigator PRKAR2A [HugePedia]
snp3D : Map Gene to Disease5576
BioCentury BCIQPRKAR2A
ClinGenPRKAR2A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5576
Chemical/Pharm GKB GenePA33757
Clinical trialPRKAR2A
Miscellaneous
canSAR (ICR)PRKAR2A (select the gene name)
Probes
Litterature
PubMed131 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRKAR2A
EVEXPRKAR2A
GoPubMedPRKAR2A
iHOPPRKAR2A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:26:29 CEST 2017

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