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PRKAR2B (protein kinase cAMP-dependent type II regulatory subunit beta)

Identity

Alias_namesPRKAR2
protein kinase, cAMP-dependent, regulatory, type II, beta
protein kinase, cAMP-dependent, regulatory subunit type II beta
Other aliasRII-BETA
HGNC (Hugo) PRKAR2B
LocusID (NCBI) 5577
Atlas_Id 510
Location 7q22.3  [Link to chromosome band 7q22]
Location_base_pair Starts at 107044733 and ends at 107161811 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PRKAR2B (7q22.3) / HMCN1 (1q25.3)PRKAR2B (7q22.3) / RNF121 (11q13.4)SLC35D1 (1p31.3) / PRKAR2B (7q22.3)
TRRAP (7q22.1) / PRKAR2B (7q22.3)UNC5D (8p12) / PRKAR2B (7q22.3)PRKAR2B 7q22.3 / HMCN1 1q25.3
SLC35D1 1p31.3 / PRKAR2B 7q22.3TRRAP 7q22.1 / PRKAR2B 7q22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Ovary: Sex cord-stromal tumors


External links

Nomenclature
HGNC (Hugo)PRKAR2B   9392
Cards
Entrez_Gene (NCBI)PRKAR2B  5577  protein kinase cAMP-dependent type II regulatory subunit beta
AliasesPRKAR2; RII-BETA
GeneCards (Weizmann)PRKAR2B
Ensembl hg19 (Hinxton)ENSG00000005249 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000005249 [Gene_View]  chr7:107044733-107161811 [Contig_View]  PRKAR2B [Vega]
ICGC DataPortalENSG00000005249
TCGA cBioPortalPRKAR2B
AceView (NCBI)PRKAR2B
Genatlas (Paris)PRKAR2B
WikiGenes5577
SOURCE (Princeton)PRKAR2B
Genetics Home Reference (NIH)PRKAR2B
Genomic and cartography
GoldenPath hg38 (UCSC)PRKAR2B  -     chr7:107044733-107161811 +  7q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRKAR2B  -     7q22.3   [Description]    (hg19-Feb_2009)
EnsemblPRKAR2B - 7q22.3 [CytoView hg19]  PRKAR2B - 7q22.3 [CytoView hg38]
Mapping of homologs : NCBIPRKAR2B [Mapview hg19]  PRKAR2B [Mapview hg38]
OMIM176912   
Gene and transcription
Genbank (Entrez)AK128639 AK291441 AL559918 AM392728 AM392771
RefSeq transcript (Entrez)NM_002736
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PRKAR2B
Cluster EST : UnigeneHs.433068 [ NCBI ]
CGAP (NCI)Hs.433068
Alternative Splicing GalleryENSG00000005249
Gene ExpressionPRKAR2B [ NCBI-GEO ]   PRKAR2B [ EBI - ARRAY_EXPRESS ]   PRKAR2B [ SEEK ]   PRKAR2B [ MEM ]
Gene Expression Viewer (FireBrowse)PRKAR2B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5577
GTEX Portal (Tissue expression)PRKAR2B
Protein : pattern, domain, 3D structure
UniProt/SwissProtP31323   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP31323  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP31323
Splice isoforms : SwissVarP31323
PhosPhoSitePlusP31323
Domaine pattern : Prosite (Expaxy)CNMP_BINDING_1 (PS00888)    CNMP_BINDING_2 (PS00889)    CNMP_BINDING_3 (PS50042)   
Domains : Interpro (EBI)cAMP_dep_PK_reg_su    cAMP_dep_PK_reg_su_I/II_a/b    cNMP-bd-like    cNMP-bd_CS    cNMP-bd_dom    RmlC-like_jellyroll   
Domain families : Pfam (Sanger)cNMP_binding (PF00027)    RIIa (PF02197)   
Domain families : Pfam (NCBI)pfam00027    pfam02197   
Domain families : Smart (EMBL)cNMP (SM00100)  RIIa (SM00394)  
Conserved Domain (NCBI)PRKAR2B
DMDM Disease mutations5577
Blocks (Seattle)PRKAR2B
SuperfamilyP31323
Human Protein AtlasENSG00000005249
Peptide AtlasP31323
HPRD01486
IPIIPI00554752   IPI01009627   
Protein Interaction databases
DIP (DOE-UCLA)P31323
IntAct (EBI)P31323
FunCoupENSG00000005249
BioGRIDPRKAR2B
STRING (EMBL)PRKAR2B
ZODIACPRKAR2B
Ontologies - Pathways
QuickGOP31323
Ontology : AmiGOG2/M transition of mitotic cell cycle  renal water homeostasis  cAMP-dependent protein kinase inhibitor activity  protein binding  cytoplasm  mitochondrial inner membrane  centrosome  cytosol  plasma membrane  cAMP-dependent protein kinase complex  fatty acid metabolic process  blood coagulation  learning  cAMP-dependent protein kinase regulator activity  protein domain specific binding  cAMP binding  ubiquitin protein ligase binding  activation of protein kinase A activity  protein kinase A catalytic subunit binding  intracellular signal transduction  neuronal cell body  dendritic spine  dendritic shaft  membrane raft  perinuclear region of cytoplasm  extracellular exosome  cellular response to glucagon stimulus  response to antipsychotic drug  response to clozapine  ciliary base  ciliary basal body docking  negative regulation of cAMP-dependent protein kinase activity  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  renal water homeostasis  cAMP-dependent protein kinase inhibitor activity  protein binding  cytoplasm  mitochondrial inner membrane  centrosome  cytosol  plasma membrane  cAMP-dependent protein kinase complex  fatty acid metabolic process  blood coagulation  learning  cAMP-dependent protein kinase regulator activity  protein domain specific binding  cAMP binding  ubiquitin protein ligase binding  activation of protein kinase A activity  protein kinase A catalytic subunit binding  intracellular signal transduction  neuronal cell body  dendritic spine  dendritic shaft  membrane raft  perinuclear region of cytoplasm  extracellular exosome  cellular response to glucagon stimulus  response to antipsychotic drug  response to clozapine  ciliary base  ciliary basal body docking  negative regulation of cAMP-dependent protein kinase activity  
Pathways : BIOCARTA [Genes]   
Pathways : KEGGApoptosis    Insulin signaling pathway   
NDEx NetworkPRKAR2B
Atlas of Cancer Signalling NetworkPRKAR2B
Wikipedia pathwaysPRKAR2B
Orthology - Evolution
OrthoDB5577
GeneTree (enSembl)ENSG00000005249
Phylogenetic Trees/Animal Genes : TreeFamPRKAR2B
HOVERGENP31323
HOGENOMP31323
Homologs : HomoloGenePRKAR2B
Homology/Alignments : Family Browser (UCSC)PRKAR2B
Gene fusions - Rearrangements
Fusion : MitelmanPRKAR2B/HMCN1 [7q22.3/1q25.3]  
Fusion : MitelmanSLC35D1/PRKAR2B [1p31.3/7q22.3]  [t(1;7)(p31;q22)]  
Fusion : MitelmanTRRAP/PRKAR2B [7q22.1/7q22.3]  [t(7;7)(q22;q22)]  
Fusion: TCGAPRKAR2B 7q22.3 HMCN1 1q25.3 LUSC
Fusion: TCGASLC35D1 1p31.3 PRKAR2B 7q22.3 KIRC
Fusion: TCGATRRAP 7q22.1 PRKAR2B 7q22.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRKAR2B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRKAR2B
dbVarPRKAR2B
ClinVarPRKAR2B
1000_GenomesPRKAR2B 
Exome Variant ServerPRKAR2B
ExAC (Exome Aggregation Consortium)PRKAR2B (select the gene name)
Genetic variants : HAPMAP5577
Genomic Variants (DGV)PRKAR2B [DGVbeta]
DECIPHERPRKAR2B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRKAR2B 
Mutations
ICGC Data PortalPRKAR2B 
TCGA Data PortalPRKAR2B 
Broad Tumor PortalPRKAR2B
OASIS PortalPRKAR2B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRKAR2B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRKAR2B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRKAR2B
DgiDB (Drug Gene Interaction Database)PRKAR2B
DoCM (Curated mutations)PRKAR2B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRKAR2B (select a term)
intoGenPRKAR2B
Cancer3DPRKAR2B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176912   
Orphanet
MedgenPRKAR2B
Genetic Testing Registry PRKAR2B
NextProtP31323 [Medical]
TSGene5577
GENETestsPRKAR2B
Target ValidationPRKAR2B
Huge Navigator PRKAR2B [HugePedia]
snp3D : Map Gene to Disease5577
BioCentury BCIQPRKAR2B
ClinGenPRKAR2B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5577
Chemical/Pharm GKB GenePA33758
Clinical trialPRKAR2B
Miscellaneous
canSAR (ICR)PRKAR2B (select the gene name)
Probes
Litterature
PubMed93 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRKAR2B
EVEXPRKAR2B
GoPubMedPRKAR2B
iHOPPRKAR2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:26:29 CEST 2017

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