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PRKAR2B (protein kinase cAMP-dependent type II regulatory subunit beta)

Identity

Alias (NCBI)PRKAR2
RII-BETA
HGNC (Hugo) PRKAR2B
HGNC Previous namePRKAR2
HGNC Previous nameprotein kinase, cAMP-dependent, regulatory, type II, beta
 protein kinase, cAMP-dependent, regulatory subunit type II beta
LocusID (NCBI) 5577
Atlas_Id 510
Location 7q22.3  [Link to chromosome band 7q22]
Location_base_pair Starts at 107044705 and ends at 107161811 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PRKAR2B (7q22.3)::HMCN1 (1q25.3)PRKAR2B (7q22.3)::RNF121 (11q13.4)SLC35D1 (1p31.3)::PRKAR2B (7q22.3)
TRRAP (7q22.1)::PRKAR2B (7q22.3)UNC5D (8p12)::PRKAR2B (7q22.3)PRKAR2B 7q22.3::HMCN1 1q25.3
SLC35D1 1p31.3::PRKAR2B 7q22.3TRRAP 7q22.1::PRKAR2B 7q22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PRKAR2B   9392
Cards
Entrez_Gene (NCBI)PRKAR2B    protein kinase cAMP-dependent type II regulatory subunit beta
AliasesPRKAR2; RII-BETA
GeneCards (Weizmann)PRKAR2B
Ensembl hg19 (Hinxton)ENSG00000005249 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000005249 [Gene_View]  ENSG00000005249 [Sequence]  chr7:107044705-107161811 [Contig_View]  PRKAR2B [Vega]
ICGC DataPortalENSG00000005249
TCGA cBioPortalPRKAR2B
AceView (NCBI)PRKAR2B
Genatlas (Paris)PRKAR2B
SOURCE (Princeton)PRKAR2B
Genetics Home Reference (NIH)PRKAR2B
Genomic and cartography
GoldenPath hg38 (UCSC)PRKAR2B  -     chr7:107044705-107161811 +  7q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRKAR2B  -     7q22.3   [Description]    (hg19-Feb_2009)
GoldenPathPRKAR2B - 7q22.3 [CytoView hg19]  PRKAR2B - 7q22.3 [CytoView hg38]
ImmunoBaseENSG00000005249
Genome Data Viewer NCBIPRKAR2B [Mapview hg19]  
OMIM176912   
Gene and transcription
Genbank (Entrez)AK128639 AK291441 AL559918 BC014355 BC075800
RefSeq transcript (Entrez)NM_002736
Consensus coding sequences : CCDS (NCBI)PRKAR2B
Gene ExpressionPRKAR2B [ NCBI-GEO ]   PRKAR2B [ EBI - ARRAY_EXPRESS ]   PRKAR2B [ SEEK ]   PRKAR2B [ MEM ]
Gene Expression Viewer (FireBrowse)PRKAR2B [ Firebrowse - Broad ]
GenevisibleExpression of PRKAR2B in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5577
GTEX Portal (Tissue expression)PRKAR2B
Human Protein AtlasENSG00000005249-PRKAR2B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP31323   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP31323  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP31323
PhosPhoSitePlusP31323
Domaine pattern : Prosite (Expaxy)CNMP_BINDING_1 (PS00888)    CNMP_BINDING_2 (PS00889)    CNMP_BINDING_3 (PS50042)   
Domains : Interpro (EBI)cAMP_dep_PK_reg_su    cAMP_dep_PK_reg_su_I/II_a/b    cNMP-bd-like    cNMP-bd_CS    cNMP-bd_dom    RmlC-like_jellyroll   
Domain families : Pfam (Sanger)cNMP_binding (PF00027)    RIIa (PF02197)   
Domain families : Pfam (NCBI)pfam00027    pfam02197   
Domain families : Smart (EMBL)cNMP (SM00100)  RIIa (SM00394)  
Conserved Domain (NCBI)PRKAR2B
SuperfamilyP31323
AlphaFold pdb e-kbP31323   
Human Protein Atlas [tissue]ENSG00000005249-PRKAR2B [tissue]
HPRD01486
Protein Interaction databases
DIP (DOE-UCLA)P31323
IntAct (EBI)P31323
BioGRIDPRKAR2B
STRING (EMBL)PRKAR2B
ZODIACPRKAR2B
Ontologies - Pathways
QuickGOP31323
Ontology : AmiGOcAMP-dependent protein kinase inhibitor activity  cAMP-dependent protein kinase inhibitor activity  protein binding  cytoplasm  cytoplasm  centrosome  cytosol  plasma membrane  cAMP-dependent protein kinase complex  fatty acid metabolic process  learning  cAMP-dependent protein kinase regulator activity  protein domain specific binding  cAMP binding  ubiquitin protein ligase binding  protein kinase A catalytic subunit binding  protein kinase A catalytic subunit binding  intracellular signal transduction  neuronal cell body  dendritic spine  dendritic shaft  membrane raft  perinuclear region of cytoplasm  modulation of chemical synaptic transmission  extracellular exosome  response to antipsychotic drug  response to clozapine  ciliary base  glutamatergic synapse  negative regulation of cAMP-dependent protein kinase activity  negative regulation of cAMP-dependent protein kinase activity  
Ontology : EGO-EBIcAMP-dependent protein kinase inhibitor activity  cAMP-dependent protein kinase inhibitor activity  protein binding  cytoplasm  cytoplasm  centrosome  cytosol  plasma membrane  cAMP-dependent protein kinase complex  fatty acid metabolic process  learning  cAMP-dependent protein kinase regulator activity  protein domain specific binding  cAMP binding  ubiquitin protein ligase binding  protein kinase A catalytic subunit binding  protein kinase A catalytic subunit binding  intracellular signal transduction  neuronal cell body  dendritic spine  dendritic shaft  membrane raft  perinuclear region of cytoplasm  modulation of chemical synaptic transmission  extracellular exosome  response to antipsychotic drug  response to clozapine  ciliary base  glutamatergic synapse  negative regulation of cAMP-dependent protein kinase activity  negative regulation of cAMP-dependent protein kinase activity  
Pathways : BIOCARTABIOCARTA_CHREBPPATHWAY    BIOCARTA_NO1PATHWAY    BIOCARTA_CSKPATHWAY    BIOCARTA_AKAP95PATHWAY    BIOCARTA_AGPCRPATHWAY    BIOCARTA_CFTRPATHWAY    BIOCARTA_GATA3PATHWAY    BIOCARTA_MPRPATHWAY    BIOCARTA_MCALPAINPATHWAY    BIOCARTA_PPARAPATHWAY    BIOCARTA_IGF1RPATHWAY    BIOCARTA_VIPPATHWAY    BIOCARTA_NFATPATHWAY    BIOCARTA_NOS1PATHWAY    BIOCARTA_PLCEPATHWAY    BIOCARTA_AKAPCENTROSOMEPATHWAY    BIOCARTA_BADPATHWAY    BIOCARTA_CK1PATHWAY    BIOCARTA_DREAMPATHWAY    BIOCARTA_AKAP13PATHWAY    BIOCARTA_GPCRPATHWAY    BIOCARTA_SHHPATHWAY    BIOCARTA_STATHMINPATHWAY    BIOCARTA_CREBPATHWAY    BIOCARTA_CARM1PATHWAY   
Pathways : KEGGKEGG_APOPTOSIS    KEGG_INSULIN_SIGNALING   
NDEx NetworkPRKAR2B
Atlas of Cancer Signalling NetworkPRKAR2B
Wikipedia pathwaysPRKAR2B
Orthology - Evolution
OrthoDB5577
GeneTree (enSembl)ENSG00000005249
Phylogenetic Trees/Animal Genes : TreeFamPRKAR2B
Homologs : HomoloGenePRKAR2B
Homology/Alignments : Family Browser (UCSC)PRKAR2B
Gene fusions - Rearrangements
Fusion : MitelmanPRKAR2B::HMCN1 [7q22.3/1q25.3]  
Fusion : MitelmanSLC35D1::PRKAR2B [1p31.3/7q22.3]  
Fusion : MitelmanTRRAP::PRKAR2B [7q22.1/7q22.3]  
Fusion : QuiverPRKAR2B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRKAR2B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRKAR2B
dbVarPRKAR2B
ClinVarPRKAR2B
MonarchPRKAR2B
1000_GenomesPRKAR2B 
Exome Variant ServerPRKAR2B
GNOMAD BrowserENSG00000005249
Varsome BrowserPRKAR2B
ACMGPRKAR2B variants
VarityP31323
Genomic Variants (DGV)PRKAR2B [DGVbeta]
DECIPHERPRKAR2B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRKAR2B 
Mutations
ICGC Data PortalPRKAR2B 
TCGA Data PortalPRKAR2B 
Broad Tumor PortalPRKAR2B
OASIS PortalPRKAR2B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRKAR2B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPRKAR2B
Mutations and Diseases : HGMDPRKAR2B
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPRKAR2B
DgiDB (Drug Gene Interaction Database)PRKAR2B
DoCM (Curated mutations)PRKAR2B
CIViC (Clinical Interpretations of Variants in Cancer)PRKAR2B
Cancer3DPRKAR2B
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176912   
Orphanet
DisGeNETPRKAR2B
MedgenPRKAR2B
Genetic Testing Registry PRKAR2B
NextProtP31323 [Medical]
GENETestsPRKAR2B
Target ValidationPRKAR2B
Huge Navigator PRKAR2B [HugePedia]
ClinGenPRKAR2B
Clinical trials, drugs, therapy
MyCancerGenomePRKAR2B
Protein Interactions : CTDPRKAR2B
Pharm GKB GenePA33758
PharosP31323
Clinical trialPRKAR2B
Miscellaneous
canSAR (ICR)PRKAR2B
HarmonizomePRKAR2B
ARCHS4PRKAR2B
DataMed IndexPRKAR2B
Probes
Litterature
PubMed125 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPRKAR2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 12:53:51 CET 2022

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