Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

PRKCA (protein kinase C alpha)

Identity

Alias_namesPKCA
protein kinase C
Other aliasAAG6
PKC-alpha
PRKACA
HGNC (Hugo) PRKCA
LocusID (NCBI) 5578
Atlas_Id 41851
Location 17q24.2  [Link to chromosome band 17q24]
Location_base_pair Starts at 66302808 and ends at 66810744 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ALG5 (13q13.3) / PRKCA (17q24.2)G6PD (Xq28) / PRKCA (17q24.2)IGF2BP3 (7p15.3) / PRKCA (17q24.2)
INO80 (15q15.1) / PRKCA (17q24.2)KIRREL (1q23.1) / PRKCA (17q24.2)PITPNC1 (17q24.2) / PRKCA (17q24.2)
PRKCA (17q24.2) / ATP2A2 (12q24.11)PRKCA (17q24.2) / CDH8 (16q21)PRKCA (17q24.2) / CRYBA1 (17q11.2)
PRKCA (17q24.2) / GALNT13 (2q23.3)PRKCA (17q24.2) / IGF2BP1 (17q21.32)PRKCA (17q24.2) / LYZ (12q15)
PRKCA (17q24.2) / PAFAH1B1 (17p13.3)PRKCA (17q24.2) / PBX1 (1q23.3)PRKCA (17q24.2) / PITPNC1 (17q24.2)
PRKCA (17q24.2) / SDK1 (7p22.2)PRKCA (17q24.2) / SLC45A3 (1q32.1)PRKCA (17q24.2) / ST6GALNAC2 (17q25.1)
SLC44A1 (9q31.1) / PRKCA (17q24.2)TANC2 (17q23.2) / PRKCA (17q24.2)UNK (17q25.1) / PRKCA (17q24.2)
INO80 15q15.1 / PRKCA 17q24.2PRKCA 17q24.2 / CDH8 16q21PRKCA 17q24.2 / CRYBA1 17q11.2
PRKCA 17q24.2 / IGF2BP1 17q21.32PRKCA 17q24.2 / PITPNC1 17q24.2PRKCA 17q24.2 / SDK1 7p22.2
PRKCA 17q24.2 / ST6GALNAC2 17q25.1TANC2 17q23.2 / PRKCA 17q24.2UNK 17q25.1 / PRKCA 17q24.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PRKCA   9393
Cards
Entrez_Gene (NCBI)PRKCA  5578  protein kinase C alpha
AliasesAAG6; PKC-alpha; PKCA; PRKACA
GeneCards (Weizmann)PRKCA
Ensembl hg19 (Hinxton)ENSG00000154229 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000154229 [Gene_View]  chr17:66302808-66810744 [Contig_View]  PRKCA [Vega]
ICGC DataPortalENSG00000154229
TCGA cBioPortalPRKCA
AceView (NCBI)PRKCA
Genatlas (Paris)PRKCA
WikiGenes5578
SOURCE (Princeton)PRKCA
Genetics Home Reference (NIH)PRKCA
Genomic and cartography
GoldenPath hg38 (UCSC)PRKCA  -     chr17:66302808-66810744 +  17q24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRKCA  -     17q24.2   [Description]    (hg19-Feb_2009)
EnsemblPRKCA - 17q24.2 [CytoView hg19]  PRKCA - 17q24.2 [CytoView hg38]
Mapping of homologs : NCBIPRKCA [Mapview hg19]  PRKCA [Mapview hg38]
OMIM176960   
Gene and transcription
Genbank (Entrez)###############################################################################################################################################################################################################################################################
RefSeq transcript (Entrez)NM_002737
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PRKCA
Cluster EST : UnigeneHs.708867 [ NCBI ]
CGAP (NCI)Hs.708867
Alternative Splicing GalleryENSG00000154229
Gene ExpressionPRKCA [ NCBI-GEO ]   PRKCA [ EBI - ARRAY_EXPRESS ]   PRKCA [ SEEK ]   PRKCA [ MEM ]
Gene Expression Viewer (FireBrowse)PRKCA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5578
GTEX Portal (Tissue expression)PRKCA
Protein : pattern, domain, 3D structure
UniProt/SwissProtP17252   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP17252  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP17252
Splice isoforms : SwissVarP17252
PhosPhoSitePlusP17252
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    C2 (PS50004)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    ZF_DAG_PE_1 (PS00479)    ZF_DAG_PE_2 (PS50081)   
Domains : Interpro (EBI)AGC-kinase_C    C2_dom    DAG/PE-bd    Kinase-like_dom    PE/DAG-bd    Pkinase_C    Prot_kinase_dom    Protein_kinase_ATP_BS    Protein_kinase_C_a/b/g    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)C1_1 (PF00130)    C2 (PF00168)    Pkinase (PF00069)    Pkinase_C (PF00433)   
Domain families : Pfam (NCBI)pfam00130    pfam00168    pfam00069    pfam00433   
Domain families : Smart (EMBL)C1 (SM00109)  C2 (SM00239)  S_TK_X (SM00133)  S_TKc (SM00220)  
Conserved Domain (NCBI)PRKCA
DMDM Disease mutations5578
Blocks (Seattle)PRKCA
PDB (SRS)2ELI    3IW4    4DNL    4RA4   
PDB (PDBSum)2ELI    3IW4    4DNL    4RA4   
PDB (IMB)2ELI    3IW4    4DNL    4RA4   
PDB (RSDB)2ELI    3IW4    4DNL    4RA4   
Structural Biology KnowledgeBase2ELI    3IW4    4DNL    4RA4   
SCOP (Structural Classification of Proteins)2ELI    3IW4    4DNL    4RA4   
CATH (Classification of proteins structures)2ELI    3IW4    4DNL    4RA4   
SuperfamilyP17252
Human Protein AtlasENSG00000154229
Peptide AtlasP17252
HPRD01498
IPIIPI00385449   IPI00887297   IPI01012363   IPI00748556   IPI00977298   
Protein Interaction databases
DIP (DOE-UCLA)P17252
IntAct (EBI)P17252
FunCoupENSG00000154229
BioGRIDPRKCA
STRING (EMBL)PRKCA
ZODIACPRKCA
Ontologies - Pathways
QuickGOP17252
Ontology : AmiGOangiogenesis  positive regulation of endothelial cell proliferation  desmosome assembly  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein kinase C activity  protein kinase C activity  calcium-dependent protein kinase C activity  protein binding  ATP binding  nucleoplasm  cytoplasm  mitochondrion  endoplasmic reticulum  cytosol  cytosol  plasma membrane  plasma membrane  protein phosphorylation  mitotic nuclear envelope disassembly  cell adhesion  activation of adenylate cyclase activity  negative regulation of adenylate cyclase activity  axon guidance  zinc ion binding  positive regulation of endothelial cell migration  positive regulation of cardiac muscle hypertrophy  peptidyl-serine phosphorylation  enzyme binding  platelet activation  positive regulation of cell migration  positive regulation of lipopolysaccharide-mediated signaling pathway  mitochondrial membrane  negative regulation of glial cell apoptotic process  histone kinase activity (H3-T6 specific)  histone H3-T6 phosphorylation  intracellular signal transduction  ERBB2 signaling pathway  regulation of mRNA stability  positive regulation of blood vessel endothelial cell migration  positive regulation of macrophage differentiation  positive regulation of angiogenesis  positive regulation of cell adhesion  positive regulation of mitotic cell cycle  perinuclear region of cytoplasm  regulation of insulin secretion  extracellular exosome  positive regulation of ERK1 and ERK2 cascade  response to interleukin-1  regulation of platelet aggregation  apoptotic signaling pathway  positive regulation of dense core granule biogenesis  
Ontology : EGO-EBIangiogenesis  positive regulation of endothelial cell proliferation  desmosome assembly  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein kinase C activity  protein kinase C activity  calcium-dependent protein kinase C activity  protein binding  ATP binding  nucleoplasm  cytoplasm  mitochondrion  endoplasmic reticulum  cytosol  cytosol  plasma membrane  plasma membrane  protein phosphorylation  mitotic nuclear envelope disassembly  cell adhesion  activation of adenylate cyclase activity  negative regulation of adenylate cyclase activity  axon guidance  zinc ion binding  positive regulation of endothelial cell migration  positive regulation of cardiac muscle hypertrophy  peptidyl-serine phosphorylation  enzyme binding  platelet activation  positive regulation of cell migration  positive regulation of lipopolysaccharide-mediated signaling pathway  mitochondrial membrane  negative regulation of glial cell apoptotic process  histone kinase activity (H3-T6 specific)  histone H3-T6 phosphorylation  intracellular signal transduction  ERBB2 signaling pathway  regulation of mRNA stability  positive regulation of blood vessel endothelial cell migration  positive regulation of macrophage differentiation  positive regulation of angiogenesis  positive regulation of cell adhesion  positive regulation of mitotic cell cycle  perinuclear region of cytoplasm  regulation of insulin secretion  extracellular exosome  positive regulation of ERK1 and ERK2 cascade  response to interleukin-1  regulation of platelet aggregation  apoptotic signaling pathway  positive regulation of dense core granule biogenesis  
Pathways : BIOCARTA [Genes]   
Pathways : KEGG   
NDEx NetworkPRKCA
Atlas of Cancer Signalling NetworkPRKCA
Wikipedia pathwaysPRKCA
Orthology - Evolution
OrthoDB5578
GeneTree (enSembl)ENSG00000154229
Phylogenetic Trees/Animal Genes : TreeFamPRKCA
HOVERGENP17252
HOGENOMP17252
Homologs : HomoloGenePRKCA
Homology/Alignments : Family Browser (UCSC)PRKCA
Gene fusions - Rearrangements
Fusion : MitelmanINO80/PRKCA [15q15.1/17q24.2]  [t(15;17)(q15;q24)]  
Fusion : MitelmanPRKCA/CDH8 [17q24.2/16q21]  [t(16;17)(q21;q24)]  
Fusion : MitelmanPRKCA/CRYBA1 [17q24.2/17q11.2]  [t(17;17)(q11;q24)]  
Fusion : MitelmanPRKCA/IGF2BP1 [17q24.2/17q21.32]  [t(17;17)(q21;q24)]  
Fusion : MitelmanPRKCA/PITPNC1 [17q24.2/17q24.2]  [t(17;17)(q24;q24)]  
Fusion : MitelmanPRKCA/SDK1 [17q24.2/7p22.2]  [t(7;17)(p22;q24)]  
Fusion : MitelmanPRKCA/ST6GALNAC2 [17q24.2/17q25.1]  [t(17;17)(q24;q25)]  
Fusion : MitelmanSLC44A1/PRKCA [9q31.1/17q24.2]  [t(9;17)(q31;q24)]  
Fusion : MitelmanTANC2/PRKCA [17q23.2/17q24.2]  [t(17;17)(q23;q24)]  
Fusion : MitelmanUNK/PRKCA [17q25.1/17q24.2]  [t(17;17)(q24;q25)]  
Fusion: TCGAINO80 15q15.1 PRKCA 17q24.2 BRCA
Fusion: TCGAPRKCA 17q24.2 CDH8 16q21 BRCA
Fusion: TCGAPRKCA 17q24.2 CRYBA1 17q11.2 BRCA
Fusion: TCGAPRKCA 17q24.2 IGF2BP1 17q21.32 BRCA
Fusion: TCGAPRKCA 17q24.2 PITPNC1 17q24.2 LUAD SKCM
Fusion: TCGAPRKCA 17q24.2 SDK1 7p22.2 LUSC
Fusion: TCGAPRKCA 17q24.2 ST6GALNAC2 17q25.1 BRCA
Fusion: TCGATANC2 17q23.2 PRKCA 17q24.2 LUSC
Fusion: TCGAUNK 17q25.1 PRKCA 17q24.2 KIRC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRKCA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRKCA
dbVarPRKCA
ClinVarPRKCA
1000_GenomesPRKCA 
Exome Variant ServerPRKCA
ExAC (Exome Aggregation Consortium)PRKCA (select the gene name)
Genetic variants : HAPMAP5578
Genomic Variants (DGV)PRKCA [DGVbeta]
DECIPHERPRKCA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRKCA 
Mutations
ICGC Data PortalPRKCA 
TCGA Data PortalPRKCA 
Broad Tumor PortalPRKCA
OASIS PortalPRKCA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRKCA  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRKCA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRKCA
DgiDB (Drug Gene Interaction Database)PRKCA
DoCM (Curated mutations)PRKCA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRKCA (select a term)
intoGenPRKCA
Cancer3DPRKCA(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176960   
Orphanet
MedgenPRKCA
Genetic Testing Registry PRKCA
NextProtP17252 [Medical]
TSGene5578
GENETestsPRKCA
Target ValidationPRKCA
Huge Navigator PRKCA [HugePedia]
snp3D : Map Gene to Disease5578
BioCentury BCIQPRKCA
ClinGenPRKCA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5578
Chemical/Pharm GKB GenePA33759
Clinical trialPRKCA
Miscellaneous
canSAR (ICR)PRKCA (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRKCA
EVEXPRKCA
GoPubMedPRKCA
iHOPPRKCA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 17:11:39 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.