Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PRKCB (protein kinase C, beta)

Identity

Other namesPKC-beta
PKCB
PRKCB1
PRKCB2
HGNC (Hugo) PRKCB
LocusID (NCBI) 5579
Location 16p12.2
Location_base_pair Starts at 23847300 and ends at 24231932 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PRKCB   9395
Entrez_Gene (NCBI)PRKCB  5579  protein kinase C, beta
Cards
GeneCards (Weizmann)PRKCB
Ensembl (Hinxton)ENSG00000166501 [Gene_View]  chr16:23847300-24231932 [Contig_View]  PRKCB [Vega]
AceView (NCBI)PRKCB
Genatlas (Paris)PRKCB
SOURCE (Stanford)NM_002738 NM_212535
Genomic and cartography
GoldenPath (UCSC)PRKCB  -  16p12.2   chr16:23847300-24231932 +  16p12.2   [Description]    (hg19-Feb_2009)
EnsemblPRKCB - 16p12.2 [CytoView]
Mapping of homologs : NCBIPRKCB [Mapview]
OMIM176970   
Gene and transcription
Genbank (Entrez)AA613106 AI423262 AJ002788 AK057555 AK123381
RefSeq transcript (SRS)NM_002738 NM_212535
RefSeq transcript (Entrez)NM_002738 NM_212535
RefSeq genomic (SRS)AC_000148 NC_000016 NC_018927 NG_029003 NT_010393 NW_001838401 NW_004078085
RefSeq genomic (Entrez)AC_000148 NC_000016 NC_018927 NG_029003 NT_010393 NW_001838401 NW_004078085
Consensus coding sequences : CCDS (NCBI)PRKCB
Cluster EST : UnigeneHs.460355 [ SRS ] Hs.460355 [ NCBI ]
CGAP (NCI)Hs.460355
Alternative Splicing : Fast-db (Paris)GSHG0011046
Alternative Splicing GalleryENSG00000166501
Gene ExpressionPRKCB [ NCBI-GEO ]   PRKCB [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP05771 (SRS) P05771 (Uniprot)
NextProtP05771
With graphics : InterProP05771
Splice isoforms : SwissVarP05771(Swissvar)
Domaine pattern : Prosite (SRS)AGC_KINASE_CTER (PS51285)    C2 (PS50004)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    ZF_DAG_PE_1 (PS00479)    ZF_DAG_PE_2 (PS50081)   
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    C2 (PS50004)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    ZF_DAG_PE_1 (PS00479)    ZF_DAG_PE_2 (PS50081)   
Domains : Interpro (SRS)AGC-kinase_C    C2_Ca-dep    C2_Ca/lipid-bd_dom_CaLB    C2_dom    C2_membr_targeting    DAG/PE-bd    Kinase-like_dom    Pkinase_C    Prot_Kinase_C-like_PE/DAG-bd    Prot_kinase_cat_dom    Protein_kinase_ATP_BS    Protein_kinase_C_a/b/g    Ser/Thr_dual-sp_kinase_dom    Ser/Thr_kinase_AS   
Domains : Interpro (EBI)AGC-kinase_C    C2_Ca-dep    C2_Ca/lipid-bd_dom_CaLB    C2_dom    C2_membr_targeting    DAG/PE-bd    Kinase-like_dom    Pkinase_C    Prot_Kinase_C-like_PE/DAG-bd    Prot_kinase_cat_dom    Protein_kinase_ATP_BS    Protein_kinase_C_a/b/g    Ser/Thr_dual-sp_kinase_dom    Ser/Thr_kinase_AS   
Related proteins : CluSTrP05771
Domain families : Pfam (SRS)C1_1 (PF00130)    C2 (PF00168)    Pkinase (PF00069)    Pkinase_C (PF00433)   
Domain families : Pfam (Sanger)C1_1 (PF00130)    C2 (PF00168)    Pkinase (PF00069)    Pkinase_C (PF00433)   
Domain families : Pfam (NCBI)pfam00130    pfam00168    pfam00069    pfam00433   
Domain families : Smart (EMBL)C1 (SM00109)  C2 (SM00239)  S_TK_X (SM00133)  S_TKc (SM00220)  
DMDM5579
Blocks (Seattle)P05771
PDB (SRS)2I0E   
PDB (PDBSum)2I0E   
PDB (IMB)2I0E   
PDB (RSDB)2I0E   
Human Protein AtlasENSG00000166501
HPRD01499
IPIIPI00010466   IPI00219628   
Protein Interaction databases
DIP (DOE-UCLA)P05771
IntAct (EBI)P05771
FunCoupENSG00000166501
REACTOMEPRKCB
Protein Interaction Database5579
BioGRIDPRKCB
InParanoidP05771
Interologous Interaction database P05771
IntegromeDBPRKCB
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PRKCB
SNP (GeneSNP Utah)PRKCB
SNP : HGBasePRKCB
Genetic variants : HAPMAPPRKCB
Somatic Mutations in Cancer : COSMICPRKCB 
CONAN: Copy Number AnalysisPRKCB 
Mutations and Diseases : HGMDPRKCB
OMIM176970   
GENETests176970   
Disease Genetic AssociationPRKCB
Huge Navigator PRKCB [HugePedia]  PRKCB [HugeCancerGEM]
Genomic VariantsPRKCB  PRKCB [DGVbeta]
snp3D : Map Gene to Disease5579
General knowledge
Homologs : HomoloGenePRKCB
Homology/Alignments : Family Browser (UCSC)PRKCB
Phylogenetic Trees/Animal Genes : TreeFamPRKCB
Chemical/Protein Interactions : CTD5579
Chemical/Pharm GKB GenePA33761
Clinical trialPRKCB
Cancer Resource (Charite)ENSG00000166501
Ontology : AmiGOchromatin binding  protein serine/threonine kinase activity  protein kinase C activity  protein kinase C binding  calcium channel regulator activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  plasma membrane  plasma membrane  transcription, DNA-dependent  regulation of transcription from RNA polymerase II promoter  protein phosphorylation  calcium ion transport  cellular calcium ion homeostasis  apoptotic process  signal transduction  synaptic transmission  blood coagulation  zinc ion binding  negative regulation of glucose transport  platelet activation  ligand-dependent nuclear receptor transcription coactivator activity  positive regulation of vascular endothelial growth factor receptor signaling pathway  histone kinase activity (H3-T6 specific)  histone H3-T6 phosphorylation  intracellular signal transduction  B cell activation  histone binding  lipoprotein transport  positive regulation of I-kappaB kinase/NF-kappaB cascade  positive regulation of angiogenesis  negative regulation of insulin receptor signaling pathway  metal ion binding  androgen receptor binding  B cell receptor signaling pathway  positive regulation of B cell receptor signaling pathway  positive regulation of NF-kappaB transcription factor activity  cellular response to carbohydrate stimulus  
Ontology : EGO-EBIchromatin binding  protein serine/threonine kinase activity  protein kinase C activity  protein kinase C binding  calcium channel regulator activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  plasma membrane  plasma membrane  transcription, DNA-dependent  regulation of transcription from RNA polymerase II promoter  protein phosphorylation  calcium ion transport  cellular calcium ion homeostasis  apoptotic process  signal transduction  synaptic transmission  blood coagulation  zinc ion binding  negative regulation of glucose transport  platelet activation  ligand-dependent nuclear receptor transcription coactivator activity  positive regulation of vascular endothelial growth factor receptor signaling pathway  histone kinase activity (H3-T6 specific)  histone H3-T6 phosphorylation  intracellular signal transduction  B cell activation  histone binding  lipoprotein transport  positive regulation of I-kappaB kinase/NF-kappaB cascade  positive regulation of angiogenesis  negative regulation of insulin receptor signaling pathway  metal ion binding  androgen receptor binding  B cell receptor signaling pathway  positive regulation of B cell receptor signaling pathway  positive regulation of NF-kappaB transcription factor activity  cellular response to carbohydrate stimulus  
Pathways : BIOCARTACXCR4 Signaling Pathway [Genes]    PDGF Signaling Pathway [Genes]    Activation of Src by Protein-tyrosine phosphatase alpha [Genes]    Thrombin signaling and protease-activated receptors [Genes]    Oxidative Stress Induced Gene Expression Via Nrf2 [Genes]    BCR Signaling Pathway [Genes]    CBL mediated ligand-induced downregulation of EGF receptors [Genes]    Activation of PKC through G protein coupled receptor [Genes]    Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) [Genes]    VEGF, Hypoxia, and Angiogenesis [Genes]    Keratinocyte Differentiation [Genes]    Pertussis toxin-insensitive CCR5 Signaling in Macrophage [Genes]    Effects of calcineurin in Keratinocyte Differentiation [Genes]    Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy [Genes]    g-Secretase mediated ErbB4 Signaling [Genes]    Phospholipase C Signaling Pathway [Genes]    CCR3 signaling in Eosinophils [Genes]    Attenuation of GPCR Signaling [Genes]    Signaling Pathway from G-Protein Families [Genes]    Ion Channel and Phorbal Esters Signaling Pathway [Genes]    Apoptotic Signaling in Response to DNA Damage [Genes]    Fc Epsilon Receptor I Signaling in Mast Cells [Genes]    T Cell Receptor Signaling Pathway [Genes]    TPO Signaling Pathway [Genes]    Phospholipids as signalling intermediaries [Genes]    PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase [Genes]    Cadmium induces DNA synthesis and proliferation in macrophages [Genes]    EGF Signaling Pathway [Genes]    Regulation of eIF4e and p70 S6 Kinase [Genes]    Role of MEF2D in T-cell Apoptosis [Genes]    Nitric Oxide Signaling Pathway [Genes]    Phospholipase C d1 in phospholipid associated cell signaling [Genes]    Aspirin Blocks Signaling Pathway Involved in Platelet Activation [Genes]    Trka Receptor Signaling Pathway [Genes]    Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling [Genes]    Transcription factor CREB and its extracellular signals [Genes]    Growth Hormone Signaling Pathway [Genes]    Links between Pyk2 and Map Kinases [Genes]    Bioactive Peptide Induced Signaling Pathway [Genes]   
Pathways : KEGGGnRH signaling pathwayFc epsilon RI signaling pathwayVEGF signaling pathwayWnt signaling pathwayLong-term depressionTight junctionPhosphatidylinositol signaling systemCalcium signaling pathwayLong-term potentiationB cell receptor signaling pathwayNatural killer cell mediated cytotoxicityLeukocyte transendothelial migrationGap junctionMAPK signaling pathwayFocal adhesion
Other databases
Probes
Litterature
PubMed304 Pubmed reference(s) in Entrez
PubGenePRKCB
iHOPPRKCB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:19:22 CEST 2013
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