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PRKCB (protein kinase C beta)

Identity

Alias_namesPRKCB2
PKCB
PRKCB1
protein kinase C, beta 1
protein kinase C, beta
Other aliasPKC-beta
HGNC (Hugo) PRKCB
LocusID (NCBI) 5579
Atlas_Id 50316
Location 16p12.2  [Link to chromosome band 16p12]
Location_base_pair Starts at 23835979 and ends at 24220611 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ABCC1 (16p13.11) / PRKCB (16p12.2)ADCY9 (16p13.3) / PRKCB (16p12.2)DDX5 (17q23.3) / PRKCB (16p12.2)
FAM96A (15q22.31) / PRKCB (16p12.2)GGA2 (16p12.2) / PRKCB (16p12.2)GPAM (10q25.2) / PRKCB (16p12.2)
PDPN (1p36.21) / PRKCB (16p12.2)PRKCB (16p12.2) / BCL11A (2p16.1)PRKCB (16p12.2) / CHRNA4 (20q13.33)
PRKCB (16p12.2) / LEMD2 (6p21.31)PRPS1 (Xq22.3) / PRKCB (16p12.2)PTRH2 (17q23.1) / PRKCB (16p12.2)
SPNS1 (16p11.2) / PRKCB (16p12.2)TNRC6A (16p12.1) / PRKCB (16p12.2)ABCC1 16p13.11 / PRKCB 16p12.2
ADCY9 16p13.3 / PRKCB 16p12.2GGA2 16p12.2 / PRKCB 16p12.2SPNS1 16p11.2 / PRKCB 16p12.2
TNRC6A 16p12.1 / PRKCB 16p12.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 6 ]
  t(1;16)(p36;p12) PDPN/PRKCB
t(16;16)(p11;p12) SPNS1/PRKCB
t(16;16)(p12;p12) GGA2/PRKCB
t(16;16)(p12;p12) TNRC6A/PRKCB
t(16;16)(p12;p13) ADCY9/PRKCB
t(16;16)(p12;p13) ABCC1/PRKCB


External links

Nomenclature
HGNC (Hugo)PRKCB   9395
Cards
Entrez_Gene (NCBI)PRKCB  5579  protein kinase C beta
AliasesPKC-beta; PKCB; PRKCB1; PRKCB2
GeneCards (Weizmann)PRKCB
Ensembl hg19 (Hinxton)ENSG00000166501 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166501 [Gene_View]  ENSG00000166501 [Sequence]  chr16:23835979-24220611 [Contig_View]  PRKCB [Vega]
ICGC DataPortalENSG00000166501
TCGA cBioPortalPRKCB
AceView (NCBI)PRKCB
Genatlas (Paris)PRKCB
WikiGenes5579
SOURCE (Princeton)PRKCB
Genetics Home Reference (NIH)PRKCB
Genomic and cartography
GoldenPath hg38 (UCSC)PRKCB  -     chr16:23835979-24220611 +  16p12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRKCB  -     16p12.2   [Description]    (hg19-Feb_2009)
EnsemblPRKCB - 16p12.2 [CytoView hg19]  PRKCB - 16p12.2 [CytoView hg38]
Mapping of homologs : NCBIPRKCB [Mapview hg19]  PRKCB [Mapview hg38]
OMIM176970   
Gene and transcription
Genbank (Entrez)AA613106 AI423262 AJ002788 AK057555 AK123381
RefSeq transcript (Entrez)NM_002738 NM_212535
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PRKCB
Cluster EST : UnigeneHs.460355 [ NCBI ]
CGAP (NCI)Hs.460355
Alternative Splicing GalleryENSG00000166501
Gene ExpressionPRKCB [ NCBI-GEO ]   PRKCB [ EBI - ARRAY_EXPRESS ]   PRKCB [ SEEK ]   PRKCB [ MEM ]
Gene Expression Viewer (FireBrowse)PRKCB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5579
GTEX Portal (Tissue expression)PRKCB
Human Protein AtlasENSG00000166501-PRKCB [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP05771   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP05771  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP05771
Splice isoforms : SwissVarP05771
PhosPhoSitePlusP05771
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    C2 (PS50004)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    ZF_DAG_PE_1 (PS00479)    ZF_DAG_PE_2 (PS50081)   
Domains : Interpro (EBI)AGC-kinase_C    C2_dom    DAG/PE-bd    Kinase-like_dom    PE/DAG-bd    Pkinase_C    Prot_kinase_dom    Protein_kinase_ATP_BS    Protein_kinase_C_a/b/g    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)C1_1 (PF00130)    C2 (PF00168)    Pkinase (PF00069)    Pkinase_C (PF00433)   
Domain families : Pfam (NCBI)pfam00130    pfam00168    pfam00069    pfam00433   
Domain families : Smart (EMBL)C1 (SM00109)  C2 (SM00239)  S_TK_X (SM00133)  S_TKc (SM00220)  
Conserved Domain (NCBI)PRKCB
DMDM Disease mutations5579
Blocks (Seattle)PRKCB
PDB (SRS)2I0E   
PDB (PDBSum)2I0E   
PDB (IMB)2I0E   
PDB (RSDB)2I0E   
Structural Biology KnowledgeBase2I0E   
SCOP (Structural Classification of Proteins)2I0E   
CATH (Classification of proteins structures)2I0E   
SuperfamilyP05771
Human Protein Atlas [tissue]ENSG00000166501-PRKCB [tissue]
Peptide AtlasP05771
HPRD01499
IPIIPI00010466   IPI00219628   
Protein Interaction databases
DIP (DOE-UCLA)P05771
IntAct (EBI)P05771
FunCoupENSG00000166501
BioGRIDPRKCB
STRING (EMBL)PRKCB
ZODIACPRKCB
Ontologies - Pathways
QuickGOP05771
Ontology : AmiGOresponse to hypoxia  adaptive immune response  chromatin binding  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein kinase C activity  calcium-dependent protein kinase C activity  protein kinase C binding  calcium channel regulator activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  cytosol  plasma membrane  plasma membrane  transcription, DNA-templated  regulation of transcription by RNA polymerase II  protein phosphorylation  calcium ion transport  cellular calcium ion homeostasis  apoptotic process  mitotic nuclear envelope disassembly  signal transduction  zinc ion binding  negative regulation of glucose transport  peptidyl-serine phosphorylation  platelet activation  ligand-dependent nuclear receptor transcription coactivator activity  positive regulation of vascular endothelial growth factor receptor signaling pathway  histone kinase activity (H3-T6 specific)  histone H3-T6 phosphorylation  intracellular signal transduction  B cell activation  histone binding  lipoprotein transport  positive regulation of I-kappaB kinase/NF-kappaB signaling  regulation of myeloid cell differentiation  positive regulation of angiogenesis  negative regulation of insulin receptor signaling pathway  androgen receptor binding  B cell receptor signaling pathway  positive regulation of B cell receptor signaling pathway  positive regulation of NF-kappaB transcription factor activity  extracellular exosome  cellular response to carbohydrate stimulus  
Ontology : EGO-EBIresponse to hypoxia  adaptive immune response  chromatin binding  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein kinase C activity  calcium-dependent protein kinase C activity  protein kinase C binding  calcium channel regulator activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  cytosol  plasma membrane  plasma membrane  transcription, DNA-templated  regulation of transcription by RNA polymerase II  protein phosphorylation  calcium ion transport  cellular calcium ion homeostasis  apoptotic process  mitotic nuclear envelope disassembly  signal transduction  zinc ion binding  negative regulation of glucose transport  peptidyl-serine phosphorylation  platelet activation  ligand-dependent nuclear receptor transcription coactivator activity  positive regulation of vascular endothelial growth factor receptor signaling pathway  histone kinase activity (H3-T6 specific)  histone H3-T6 phosphorylation  intracellular signal transduction  B cell activation  histone binding  lipoprotein transport  positive regulation of I-kappaB kinase/NF-kappaB signaling  regulation of myeloid cell differentiation  positive regulation of angiogenesis  negative regulation of insulin receptor signaling pathway  androgen receptor binding  B cell receptor signaling pathway  positive regulation of B cell receptor signaling pathway  positive regulation of NF-kappaB transcription factor activity  extracellular exosome  cellular response to carbohydrate stimulus  
Pathways : BIOCARTACXCR4 Signaling Pathway [Genes]    PDGF Signaling Pathway [Genes]    Activation of Src by Protein-tyrosine phosphatase alpha [Genes]    Thrombin signaling and protease-activated receptors [Genes]    Oxidative Stress Induced Gene Expression Via Nrf2 [Genes]    BCR Signaling Pathway [Genes]    CBL mediated ligand-induced downregulation of EGF receptors [Genes]    Activation of PKC through G protein coupled receptor [Genes]    Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) [Genes]    VEGF, Hypoxia, and Angiogenesis [Genes]    Keratinocyte Differentiation [Genes]    Pertussis toxin-insensitive CCR5 Signaling in Macrophage [Genes]    Effects of calcineurin in Keratinocyte Differentiation [Genes]    Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy [Genes]    g-Secretase mediated ErbB4 Signaling Pathway [Genes]    Phospholipase C Signaling Pathway [Genes]    CCR3 signaling in Eosinophils [Genes]    Attenuation of GPCR Signaling [Genes]    Signaling Pathway from G-Protein Families [Genes]    Ion Channel and Phorbal Esters Signaling Pathway [Genes]    Apoptotic Signaling in Response to DNA Damage [Genes]    Fc Epsilon Receptor I Signaling in Mast Cells [Genes]    T Cell Receptor Signaling Pathway [Genes]    TPO Signaling Pathway [Genes]    Phospholipids as signalling intermediaries [Genes]    PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase [Genes]    Cadmium induces DNA synthesis and proliferation in macrophages [Genes]    EGF Signaling Pathway [Genes]    Regulation of eIF4e and p70 S6 Kinase [Genes]    Role of MEF2D in T-cell Apoptosis [Genes]    Nitric Oxide Signaling Pathway [Genes]    Phospholipase C d1 in phospholipid associated cell signaling [Genes]    Aspirin Blocks Signaling Pathway Involved in Platelet Activation [Genes]    Trka Receptor Signaling Pathway [Genes]    Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling [Genes]    Transcription factor CREB and its extracellular signals [Genes]    Growth Hormone Signaling Pathway [Genes]    Links between Pyk2 and Map Kinases [Genes]    Bioactive Peptide Induced Signaling Pathway [Genes]   
Pathways : KEGGGnRH signaling pathway    Fc epsilon RI signaling pathway    VEGF signaling pathway    Wnt signaling pathway    Long-term depression    Tight junction    Phosphatidylinositol signaling system    Calcium signaling pathway    Long-term potentiation    B cell receptor signaling pathway    Natural killer cell mediated cytotoxicity    Leukocyte transendothelial migration    Gap junction    MAPK signaling pathway    Focal adhesion   
NDEx NetworkPRKCB
Atlas of Cancer Signalling NetworkPRKCB
Wikipedia pathwaysPRKCB
Orthology - Evolution
OrthoDB5579
GeneTree (enSembl)ENSG00000166501
Phylogenetic Trees/Animal Genes : TreeFamPRKCB
HOVERGENP05771
HOGENOMP05771
Homologs : HomoloGenePRKCB
Homology/Alignments : Family Browser (UCSC)PRKCB
Gene fusions - Rearrangements
Fusion : MitelmanABCC1/PRKCB [16p13.11/16p12.2]  [t(16;16)(p12;p13)]  
Fusion : MitelmanADCY9/PRKCB [16p13.3/16p12.2]  [t(16;16)(p12;p13)]  
Fusion : MitelmanGGA2/PRKCB [16p12.2/16p12.2]  [t(16;16)(p12;p12)]  
Fusion : MitelmanPDPN/PRKCB [1p36.21/16p12.2]  [t(1;16)(p36;p12)]  
Fusion : MitelmanSPNS1/PRKCB [16p11.2/16p12.2]  [t(16;16)(p11;p12)]  
Fusion : MitelmanTNRC6A/PRKCB [16p12.1/16p12.2]  [t(16;16)(p12;p12)]  
Fusion PortalABCC1 16p13.11 PRKCB 16p12.2 PRAD
Fusion PortalADCY9 16p13.3 PRKCB 16p12.2 LUSC
Fusion PortalGGA2 16p12.2 PRKCB 16p12.2 LGG
Fusion PortalSPNS1 16p11.2 PRKCB 16p12.2 LUAD
Fusion PortalTNRC6A 16p12.1 PRKCB 16p12.2 GBM
Fusion : QuiverPRKCB
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRKCB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRKCB
dbVarPRKCB
ClinVarPRKCB
1000_GenomesPRKCB 
Exome Variant ServerPRKCB
ExAC (Exome Aggregation Consortium)ENSG00000166501
GNOMAD BrowserENSG00000166501
Genetic variants : HAPMAP5579
Genomic Variants (DGV)PRKCB [DGVbeta]
DECIPHERPRKCB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRKCB 
Mutations
ICGC Data PortalPRKCB 
TCGA Data PortalPRKCB 
Broad Tumor PortalPRKCB
OASIS PortalPRKCB [ Somatic mutations - Copy number]
Cancer Gene: CensusPRKCB 
Somatic Mutations in Cancer : COSMICPRKCB  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRKCB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRKCB
DgiDB (Drug Gene Interaction Database)PRKCB
DoCM (Curated mutations)PRKCB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRKCB (select a term)
intoGenPRKCB
Cancer3DPRKCB(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176970   
Orphanet
DisGeNETPRKCB
MedgenPRKCB
Genetic Testing Registry PRKCB
NextProtP05771 [Medical]
TSGene5579
GENETestsPRKCB
Target ValidationPRKCB
Huge Navigator PRKCB [HugePedia]
snp3D : Map Gene to Disease5579
BioCentury BCIQPRKCB
ClinGenPRKCB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5579
Chemical/Pharm GKB GenePA33761
Clinical trialPRKCB
Miscellaneous
canSAR (ICR)PRKCB (select the gene name)
Probes
Litterature
PubMed375 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRKCB
EVEXPRKCB
GoPubMedPRKCB
iHOPPRKCB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jun 22 16:44:46 CEST 2018

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