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PRKCE (protein kinase C epsilon)

Identity

Alias_namesprotein kinase C
Other aliasPKCE
nPKC-epsilon
HGNC (Hugo) PRKCE
LocusID (NCBI) 5581
Atlas_Id 41855
Location 2p21  [Link to chromosome band 2p21]
Location_base_pair Starts at 45879043 and ends at 46415129 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ABCD4 (14q24.3) / PRKCE (2p21)BRE (2p23.2) / PRKCE (2p21)CCDC97 (19q13.2) / PRKCE (2p21)
MAP4K3 (2p22.1) / PRKCE (2p21)MBOAT2 (2p25.1) / PRKCE (2p21)PRKCE (2p21) / CAMKMT (2p21)
PRKCE (2p21) / MBOAT2 (2p25.1)PRKCE (2p21) / PRKCE (2p21)PRKCE (2p21) / SNX17 (2p23.3)
TRAPPC1 (17p13.1) / PRKCE (2p21)XRN1 (3q23) / PRKCE (2p21)ZNF609 (15q22.31) / PRKCE (2p21)
MBOAT2 2p25.1 / PRKCE 2p21BRE 2p23.2 / PRKCE 2p21PRKCE 2p21 / CAMKMT 2p21
XRN1 3q23 / PRKCE 2p21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Adenocarcinoma


External links

Nomenclature
HGNC (Hugo)PRKCE   9401
Cards
Entrez_Gene (NCBI)PRKCE  5581  protein kinase C epsilon
AliasesPKCE; nPKC-epsilon
GeneCards (Weizmann)PRKCE
Ensembl hg19 (Hinxton)ENSG00000171132 [Gene_View]  chr2:45879043-46415129 [Contig_View]  PRKCE [Vega]
Ensembl hg38 (Hinxton)ENSG00000171132 [Gene_View]  chr2:45879043-46415129 [Contig_View]  PRKCE [Vega]
ICGC DataPortalENSG00000171132
TCGA cBioPortalPRKCE
AceView (NCBI)PRKCE
Genatlas (Paris)PRKCE
WikiGenes5581
SOURCE (Princeton)PRKCE
Genetics Home Reference (NIH)PRKCE
Genomic and cartography
GoldenPath hg19 (UCSC)PRKCE  -     chr2:45879043-46415129 +  2p21   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PRKCE  -     2p21   [Description]    (hg38-Dec_2013)
EnsemblPRKCE - 2p21 [CytoView hg19]  PRKCE - 2p21 [CytoView hg38]
Mapping of homologs : NCBIPRKCE [Mapview hg19]  PRKCE [Mapview hg38]
OMIM176975   
Gene and transcription
Genbank (Entrez)AK128749 AK313842 AL832345 BC029576 BC051195
RefSeq transcript (Entrez)NM_005400
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_022184 NW_004929300
Consensus coding sequences : CCDS (NCBI)PRKCE
Cluster EST : UnigeneHs.580351 [ NCBI ]
CGAP (NCI)Hs.580351
Alternative Splicing GalleryENSG00000171132
Gene ExpressionPRKCE [ NCBI-GEO ]   PRKCE [ EBI - ARRAY_EXPRESS ]   PRKCE [ SEEK ]   PRKCE [ MEM ]
Gene Expression Viewer (FireBrowse)PRKCE [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5581
GTEX Portal (Tissue expression)PRKCE
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ02156   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ02156  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ02156
Splice isoforms : SwissVarQ02156
Catalytic activity : Enzyme2.7.11.13 [ Enzyme-Expasy ]   2.7.11.132.7.11.13 [ IntEnz-EBI ]   2.7.11.13 [ BRENDA ]   2.7.11.13 [ KEGG ]   
PhosPhoSitePlusQ02156
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    C2 (PS50004)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    ZF_DAG_PE_1 (PS00479)    ZF_DAG_PE_2 (PS50081)   
Domains : Interpro (EBI)AGC-kinase_C    C2_dom    DAG/PE-bd    Kinase-like_dom    PE/DAG-bd    PKC_epsilon    Pkinase_C    Prot_kin_PKC_delta    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)C1_1 (PF00130)    C2 (PF00168)    Pkinase (PF00069)    Pkinase_C (PF00433)   
Domain families : Pfam (NCBI)pfam00130    pfam00168    pfam00069    pfam00433   
Domain families : Smart (EMBL)C1 (SM00109)  C2 (SM00239)  S_TK_X (SM00133)  S_TKc (SM00220)  
Conserved Domain (NCBI)PRKCE
DMDM Disease mutations5581
Blocks (Seattle)PRKCE
PDB (SRS)2WH0   
PDB (PDBSum)2WH0   
PDB (IMB)2WH0   
PDB (RSDB)2WH0   
Structural Biology KnowledgeBase2WH0   
SCOP (Structural Classification of Proteins)2WH0   
CATH (Classification of proteins structures)2WH0   
SuperfamilyQ02156
Human Protein AtlasENSG00000171132
Peptide AtlasQ02156
HPRD01500
IPIIPI00024539   IPI00794086   IPI00894569   
Protein Interaction databases
DIP (DOE-UCLA)Q02156
IntAct (EBI)Q02156
FunCoupENSG00000171132
BioGRIDPRKCE
STRING (EMBL)PRKCE
ZODIACPRKCE
Ontologies - Pathways
QuickGOQ02156
Ontology : AmiGOmacrophage activation involved in immune response  actin monomer binding  protein serine/threonine kinase activity  protein kinase C activity  protein kinase C activity  calcium-independent protein kinase C activity  signal transducer activity  protein binding  ATP binding  nucleus  cytoplasm  mitochondrion  endoplasmic reticulum  Golgi apparatus  cytosol  cytosol  cytoskeleton  plasma membrane  plasma membrane  protein phosphorylation  apoptotic process  cell cycle  cell adhesion  signal transduction  activation of phospholipase C activity  enzyme activator activity  positive regulation of epithelial cell migration  positive regulation of fibroblast migration  positive regulation of cell-substrate adhesion  peptidyl-serine phosphorylation  enzyme binding  enzyme binding  platelet activation  receptor activator activity  positive regulation of actin filament polymerization  negative regulation of protein ubiquitination  lipopolysaccharide-mediated signaling pathway  positive regulation of insulin secretion  positive regulation of synaptic transmission, GABAergic  positive regulation of cytokinesis  ethanol binding  intracellular signal transduction  locomotory exploration behavior  TRAM-dependent toll-like receptor 4 signaling pathway  Fc-gamma receptor signaling pathway involved in phagocytosis  positive regulation of I-kappaB kinase/NF-kappaB signaling  response to morphine  positive regulation of MAPK cascade  metal ion binding  perinuclear region of cytoplasm  regulation of peptidyl-tyrosine phosphorylation  positive regulation of lipid catabolic process  release of sequestered calcium ion into cytosol  regulation of release of sequestered calcium ion into cytosol  cell division  regulation of insulin secretion involved in cellular response to glucose stimulus  positive regulation of mucus secretion  cellular response to ethanol  cellular response to prostaglandin E stimulus  cellular response to hypoxia  14-3-3 protein binding  cell periphery  positive regulation of wound healing  positive regulation of receptor activity  negative regulation of sodium ion transmembrane transporter activity  positive regulation of cellular glucuronidation  
Ontology : EGO-EBImacrophage activation involved in immune response  actin monomer binding  protein serine/threonine kinase activity  protein kinase C activity  protein kinase C activity  calcium-independent protein kinase C activity  signal transducer activity  protein binding  ATP binding  nucleus  cytoplasm  mitochondrion  endoplasmic reticulum  Golgi apparatus  cytosol  cytosol  cytoskeleton  plasma membrane  plasma membrane  protein phosphorylation  apoptotic process  cell cycle  cell adhesion  signal transduction  activation of phospholipase C activity  enzyme activator activity  positive regulation of epithelial cell migration  positive regulation of fibroblast migration  positive regulation of cell-substrate adhesion  peptidyl-serine phosphorylation  enzyme binding  enzyme binding  platelet activation  receptor activator activity  positive regulation of actin filament polymerization  negative regulation of protein ubiquitination  lipopolysaccharide-mediated signaling pathway  positive regulation of insulin secretion  positive regulation of synaptic transmission, GABAergic  positive regulation of cytokinesis  ethanol binding  intracellular signal transduction  locomotory exploration behavior  TRAM-dependent toll-like receptor 4 signaling pathway  Fc-gamma receptor signaling pathway involved in phagocytosis  positive regulation of I-kappaB kinase/NF-kappaB signaling  response to morphine  positive regulation of MAPK cascade  metal ion binding  perinuclear region of cytoplasm  regulation of peptidyl-tyrosine phosphorylation  positive regulation of lipid catabolic process  release of sequestered calcium ion into cytosol  regulation of release of sequestered calcium ion into cytosol  cell division  regulation of insulin secretion involved in cellular response to glucose stimulus  positive regulation of mucus secretion  cellular response to ethanol  cellular response to prostaglandin E stimulus  cellular response to hypoxia  14-3-3 protein binding  cell periphery  positive regulation of wound healing  positive regulation of receptor activity  negative regulation of sodium ion transmembrane transporter activity  positive regulation of cellular glucuronidation  
Pathways : BIOCARTACardiac Protection Against ROS [Genes]    Protein Kinase A at the Centrosome [Genes]    Keratinocyte Differentiation [Genes]    Phosphoinositides and their downstream targets. [Genes]   
Pathways : KEGGVascular smooth muscle contraction    Tight junction    Fc epsilon RI signaling pathway    Fc gamma R-mediated phagocytosis    Type II diabetes mellitus    MicroRNAs in cancer   
NDEx NetworkPRKCE
Atlas of Cancer Signalling NetworkPRKCE
Wikipedia pathwaysPRKCE
Orthology - Evolution
OrthoDB5581
GeneTree (enSembl)ENSG00000171132
Phylogenetic Trees/Animal Genes : TreeFamPRKCE
HOVERGENQ02156
HOGENOMQ02156
Homologs : HomoloGenePRKCE
Homology/Alignments : Family Browser (UCSC)PRKCE
Gene fusions - Rearrangements
Fusion : MitelmanBRE/PRKCE [2p23.2/2p21]  [t(2;2)(p21;p23)]  
Fusion : MitelmanMAP4K3/PRKCE [2p22.1/2p21]  [t(2;2)(p21;p22)]  
Fusion : MitelmanMBOAT2/PRKCE [2p25.1/2p21]  [t(2;2)(p21;p25)]  
Fusion: TCGABRE 2p23.2 PRKCE 2p21 BRCA
Fusion: TCGAPRKCE 2p21 CAMKMT 2p21 BRCA
Fusion: TCGAXRN1 3q23 PRKCE 2p21 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRKCE [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRKCE
dbVarPRKCE
ClinVarPRKCE
1000_GenomesPRKCE 
Exome Variant ServerPRKCE
ExAC (Exome Aggregation Consortium)PRKCE (select the gene name)
Genetic variants : HAPMAP5581
Genomic Variants (DGV)PRKCE [DGVbeta]
DECIPHER (Syndromes)2:45879043-46415129  ENSG00000171132
CONAN: Copy Number AnalysisPRKCE 
Mutations
ICGC Data PortalPRKCE 
TCGA Data PortalPRKCE 
Broad Tumor PortalPRKCE
OASIS PortalPRKCE [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRKCE  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRKCE
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRKCE
DgiDB (Drug Gene Interaction Database)PRKCE
DoCM (Curated mutations)PRKCE (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRKCE (select a term)
intoGenPRKCE
Cancer3DPRKCE(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176975   
Orphanet
MedgenPRKCE
Genetic Testing Registry PRKCE
NextProtQ02156 [Medical]
TSGene5581
GENETestsPRKCE
Huge Navigator PRKCE [HugePedia]
snp3D : Map Gene to Disease5581
BioCentury BCIQPRKCE
ClinGenPRKCE
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5581
Chemical/Pharm GKB GenePA33765
Clinical trialPRKCE
Miscellaneous
canSAR (ICR)PRKCE (select the gene name)
Probes
Litterature
PubMed307 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRKCE
EVEXPRKCE
GoPubMedPRKCE
iHOPPRKCE
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:15:40 CEST 2017

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