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PRKCG (protein kinase C gamma)

Identity

Alias_namesPKCG
SCA14
protein kinase C
Alias_symbol (synonym)PKCC
MGC57564
Other aliasPKC-gamma
HGNC (Hugo) PRKCG
LocusID (NCBI) 5582
Atlas_Id 41856
Location 19q13.42  [Link to chromosome band 19q13]
Location_base_pair Starts at 53882184 and ends at 53907647 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
NDUFA7 (19p13.2) / PRKCG (19q13.42)PRKCG (19q13.42) / CAV1 (7q31.2)NDUFA7 19p13.2 / PRKCG 19q13.42

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PRKCG   9402
LRG (Locus Reference Genomic)LRG_669
Cards
Entrez_Gene (NCBI)PRKCG  5582  protein kinase C gamma
AliasesPKC-gamma; PKCC; PKCG; SCA14
GeneCards (Weizmann)PRKCG
Ensembl hg19 (Hinxton)ENSG00000126583 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000126583 [Gene_View]  chr19:53882184-53907647 [Contig_View]  PRKCG [Vega]
ICGC DataPortalENSG00000126583
TCGA cBioPortalPRKCG
AceView (NCBI)PRKCG
Genatlas (Paris)PRKCG
WikiGenes5582
SOURCE (Princeton)PRKCG
Genetics Home Reference (NIH)PRKCG
Genomic and cartography
GoldenPath hg38 (UCSC)PRKCG  -     chr19:53882184-53907647 +  19q13.42   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRKCG  -     19q13.42   [Description]    (hg19-Feb_2009)
EnsemblPRKCG - 19q13.42 [CytoView hg19]  PRKCG - 19q13.42 [CytoView hg38]
Mapping of homologs : NCBIPRKCG [Mapview hg19]  PRKCG [Mapview hg38]
OMIM176980   605361   
Gene and transcription
Genbank (Entrez)AB209671 AF345987 AK296412 AK296434 AK302958
RefSeq transcript (Entrez)NM_001316329 NM_002739
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PRKCG
Cluster EST : UnigeneHs.631564 [ NCBI ]
CGAP (NCI)Hs.631564
Alternative Splicing GalleryENSG00000126583
Gene ExpressionPRKCG [ NCBI-GEO ]   PRKCG [ EBI - ARRAY_EXPRESS ]   PRKCG [ SEEK ]   PRKCG [ MEM ]
Gene Expression Viewer (FireBrowse)PRKCG [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5582
GTEX Portal (Tissue expression)PRKCG
Protein : pattern, domain, 3D structure
UniProt/SwissProtP05129   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP05129  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP05129
Splice isoforms : SwissVarP05129
PhosPhoSitePlusP05129
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    C2 (PS50004)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    ZF_DAG_PE_1 (PS00479)    ZF_DAG_PE_2 (PS50081)   
Domains : Interpro (EBI)AGC-kinase_C    C2_dom    DAG/PE-bd    Kinase-like_dom    PE/DAG-bd    Pkinase_C    Prot_kinase_dom    Protein_kinase_ATP_BS    Protein_kinase_C_a/b/g    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)C1_1 (PF00130)    C2 (PF00168)    Pkinase (PF00069)    Pkinase_C (PF00433)   
Domain families : Pfam (NCBI)pfam00130    pfam00168    pfam00069    pfam00433   
Domain families : Smart (EMBL)C1 (SM00109)  C2 (SM00239)  S_TK_X (SM00133)  S_TKc (SM00220)  
Conserved Domain (NCBI)PRKCG
DMDM Disease mutations5582
Blocks (Seattle)PRKCG
PDB (SRS)2E73    2UZP   
PDB (PDBSum)2E73    2UZP   
PDB (IMB)2E73    2UZP   
PDB (RSDB)2E73    2UZP   
Structural Biology KnowledgeBase2E73    2UZP   
SCOP (Structural Classification of Proteins)2E73    2UZP   
CATH (Classification of proteins structures)2E73    2UZP   
SuperfamilyP05129
Human Protein AtlasENSG00000126583
Peptide AtlasP05129
HPRD01502
IPIIPI01011898   IPI00007128   IPI00922927   IPI00921946   IPI00852775   
Protein Interaction databases
DIP (DOE-UCLA)P05129
IntAct (EBI)P05129
FunCoupENSG00000126583
BioGRIDPRKCG
STRING (EMBL)PRKCG
ZODIACPRKCG
Ontologies - Pathways
QuickGOP05129
Ontology : AmiGOprotein kinase activity  protein kinase C activity  calcium-dependent protein kinase C activity  protein serine/threonine/tyrosine kinase activity  ATP binding  intracellular  nucleus  cytosol  cytosol  plasma membrane  cell-cell junction  protein phosphorylation  chemical synaptic transmission  learning or memory  chemosensory behavior  zinc ion binding  postsynaptic density  phosphorylation  peptidyl-serine phosphorylation  platelet activation  dendrite  negative regulation of protein ubiquitination  regulation of response to food  positive regulation of mismatch repair  intracellular signal transduction  negative regulation of protein catabolic process  regulation of circadian rhythm  response to morphine  negative regulation of neuron apoptotic process  protein autophosphorylation  response to pain  perinuclear region of cytoplasm  rhythmic process  regulation of phagocytosis  innervation  synaptic membrane  negative regulation of proteasomal protein catabolic process  
Ontology : EGO-EBIprotein kinase activity  protein kinase C activity  calcium-dependent protein kinase C activity  protein serine/threonine/tyrosine kinase activity  ATP binding  intracellular  nucleus  cytosol  cytosol  plasma membrane  cell-cell junction  protein phosphorylation  chemical synaptic transmission  learning or memory  chemosensory behavior  zinc ion binding  postsynaptic density  phosphorylation  peptidyl-serine phosphorylation  platelet activation  dendrite  negative regulation of protein ubiquitination  regulation of response to food  positive regulation of mismatch repair  intracellular signal transduction  negative regulation of protein catabolic process  regulation of circadian rhythm  response to morphine  negative regulation of neuron apoptotic process  protein autophosphorylation  response to pain  perinuclear region of cytoplasm  rhythmic process  regulation of phagocytosis  innervation  synaptic membrane  negative regulation of proteasomal protein catabolic process  
Pathways : BIOCARTAKeratinocyte Differentiation [Genes]   
Pathways : KEGG   
NDEx NetworkPRKCG
Atlas of Cancer Signalling NetworkPRKCG
Wikipedia pathwaysPRKCG
Orthology - Evolution
OrthoDB5582
GeneTree (enSembl)ENSG00000126583
Phylogenetic Trees/Animal Genes : TreeFamPRKCG
HOVERGENP05129
HOGENOMP05129
Homologs : HomoloGenePRKCG
Homology/Alignments : Family Browser (UCSC)PRKCG
Gene fusions - Rearrangements
Fusion : MitelmanNDUFA7/PRKCG [19p13.2/19q13.42]  [t(19;19)(p13;q13)]  
Fusion: TCGANDUFA7 19p13.2 PRKCG 19q13.42 HNSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRKCG [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRKCG
dbVarPRKCG
ClinVarPRKCG
1000_GenomesPRKCG 
Exome Variant ServerPRKCG
ExAC (Exome Aggregation Consortium)PRKCG (select the gene name)
Genetic variants : HAPMAP5582
Genomic Variants (DGV)PRKCG [DGVbeta]
DECIPHERPRKCG [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRKCG 
Mutations
ICGC Data PortalPRKCG 
TCGA Data PortalPRKCG 
Broad Tumor PortalPRKCG
OASIS PortalPRKCG [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRKCG  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRKCG
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Eye diseases - LOVD
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch PRKCG
DgiDB (Drug Gene Interaction Database)PRKCG
DoCM (Curated mutations)PRKCG (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRKCG (select a term)
intoGenPRKCG
Cancer3DPRKCG(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176980    605361   
Orphanet13780   
MedgenPRKCG
Genetic Testing Registry PRKCG
NextProtP05129 [Medical]
TSGene5582
GENETestsPRKCG
Huge Navigator PRKCG [HugePedia]
snp3D : Map Gene to Disease5582
BioCentury BCIQPRKCG
ClinGenPRKCG
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5582
Chemical/Pharm GKB GenePA33766
Clinical trialPRKCG
Miscellaneous
canSAR (ICR)PRKCG (select the gene name)
Probes
Litterature
PubMed166 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRKCG
EVEXPRKCG
GoPubMedPRKCG
iHOPPRKCG
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:32:49 CEST 2017

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