Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PRKCG (protein kinase C, gamma)

Identity

Other namesPKC-gamma
PKCC
PKCG
SCA14
HGNC (Hugo) PRKCG
LocusID (NCBI) 5582
Location 19q13.42
Location_base_pair Starts at 54385467 and ends at 54410901 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PRKCG   9402
Cards
Entrez_Gene (NCBI)PRKCG  5582  protein kinase C, gamma
GeneCards (Weizmann)PRKCG
Ensembl (Hinxton)ENSG00000126583 [Gene_View]  chr19:54385467-54410901 [Contig_View]  PRKCG [Vega]
ICGC DataPortalENSG00000126583
cBioPortalPRKCG
AceView (NCBI)PRKCG
Genatlas (Paris)PRKCG
WikiGenes5582
SOURCE (Princeton)NM_002739
Genomic and cartography
GoldenPath (UCSC)PRKCG  -  19q13.42   chr19:54385467-54410901 +  19q13.42   [Description]    (hg19-Feb_2009)
EnsemblPRKCG - 19q13.42 [CytoView]
Mapping of homologs : NCBIPRKCG [Mapview]
OMIM176980   605361   
Gene and transcription
Genbank (Entrez)AB209671 AF345987 AK296412 AK296434 AK302958
RefSeq transcript (Entrez)NM_002739
RefSeq genomic (Entrez)AC_000151 NC_000019 NC_018930 NG_009114 NT_011109 NW_001838498 NW_004929415
Consensus coding sequences : CCDS (NCBI)PRKCG
Cluster EST : UnigeneHs.631564 [ NCBI ]
CGAP (NCI)Hs.631564
Alternative Splicing : Fast-db (Paris)GSHG0015170
Alternative Splicing GalleryENSG00000126583
Gene ExpressionPRKCG [ NCBI-GEO ]     PRKCG [ SEEK ]   PRKCG [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP05129 (Uniprot)
NextProtP05129  [Medical]
With graphics : InterProP05129
Splice isoforms : SwissVarP05129 (Swissvar)
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    C2 (PS50004)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    ZF_DAG_PE_1 (PS00479)    ZF_DAG_PE_2 (PS50081)   
Domains : Interpro (EBI)AGC-kinase_C [organisation]   C2_dom [organisation]   DAG/PE-bd [organisation]   Kinase-like_dom [organisation]   Pkinase_C [organisation]   Prot_Kinase_C-like_PE/DAG-bd [organisation]   Prot_kinase_dom [organisation]   Protein_kinase_ATP_BS [organisation]   Protein_kinase_C_a/b/g [organisation]   Ser/Thr_dual-sp_kinase_dom [organisation]   Ser/Thr_kinase_AS [organisation]  
Related proteins : CluSTrP05129
Domain families : Pfam (Sanger)C1_1 (PF00130)    C2 (PF00168)    Pkinase (PF00069)    Pkinase_C (PF00433)   
Domain families : Pfam (NCBI)pfam00130    pfam00168    pfam00069    pfam00433   
Domain families : Smart (EMBL)C1 (SM00109)  C2 (SM00239)  S_TK_X (SM00133)  S_TKc (SM00220)  
DMDM Disease mutations5582
Blocks (Seattle)P05129
PDB (SRS)2E73    2UZP   
PDB (PDBSum)2E73    2UZP   
PDB (IMB)2E73    2UZP   
PDB (RSDB)2E73    2UZP   
Human Protein AtlasENSG00000126583 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP05129
HPRD01502
IPIIPI01011898   IPI00007128   IPI00922927   IPI00921946   IPI00852775   
Protein Interaction databases
DIP (DOE-UCLA)P05129
IntAct (EBI)P05129
FunCoupENSG00000126583
BioGRIDPRKCG
InParanoidP05129
Interologous Interaction database P05129
IntegromeDBPRKCG
STRING (EMBL)PRKCG
Ontologies - Pathways
Ontology : AmiGOprotein kinase activity  protein kinase C activity  calcium-dependent protein kinase C activity  protein serine/threonine/tyrosine kinase activity  ATP binding  nucleus  cytosol  cytosol  plasma membrane  protein phosphorylation  signal transduction  epidermal growth factor receptor signaling pathway  activation of phospholipase C activity  synaptic transmission  blood coagulation  learning or memory  chemosensory behavior  cell death  zinc ion binding  fibroblast growth factor receptor signaling pathway  phosphorylation  cell junction  platelet activation  dendrite  negative regulation of protein ubiquitination  positive regulation of mismatch repair  intracellular signal transduction  negative regulation of protein catabolic process  response to morphine  negative regulation of neuron apoptotic process  innate immune response  protein autophosphorylation  neurotrophin TRK receptor signaling pathway  response to pain  perinuclear region of cytoplasm  innervation  synaptic membrane  
Ontology : EGO-EBIprotein kinase activity  protein kinase C activity  calcium-dependent protein kinase C activity  protein serine/threonine/tyrosine kinase activity  ATP binding  nucleus  cytosol  cytosol  plasma membrane  protein phosphorylation  signal transduction  epidermal growth factor receptor signaling pathway  activation of phospholipase C activity  synaptic transmission  blood coagulation  learning or memory  chemosensory behavior  cell death  zinc ion binding  fibroblast growth factor receptor signaling pathway  phosphorylation  cell junction  platelet activation  dendrite  negative regulation of protein ubiquitination  positive regulation of mismatch repair  intracellular signal transduction  negative regulation of protein catabolic process  response to morphine  negative regulation of neuron apoptotic process  innate immune response  protein autophosphorylation  neurotrophin TRK receptor signaling pathway  response to pain  perinuclear region of cytoplasm  innervation  synaptic membrane  
Pathways : BIOCARTAKeratinocyte Differentiation [Genes]   
Pathways : KEGGMAPK signaling pathway    ErbB signaling pathway    Ras signaling pathway    Rap1 signaling pathway    Calcium signaling pathway    HIF-1 signaling pathway    Phosphatidylinositol signaling system    mTOR signaling pathway    Vascular smooth muscle contraction    Wnt signaling pathway    VEGF signaling pathway    Focal adhesion    Tight junction    Gap junction    Natural killer cell mediated cytotoxicity    Fc gamma R-mediated phagocytosis    Leukocyte transendothelial migration    Circadian entrainment    Long-term potentiation    Retrograde endocannabinoid signaling    Glutamatergic synapse    Cholinergic synapse    Serotonergic synapse    GABAergic synapse    Dopaminergic synapse    Long-term depression    Insulin secretion    Melanogenesis    Thyroid hormone synthesis    Thyroid hormone signaling pathway    Aldosterone-regulated sodium reabsorption    Endocrine and other factor-regulated calcium reabsorption    Salivary secretion    Gastric acid secretion    Pancreatic secretion    Amphetamine addiction    Morphine addiction    Vibrio cholerae infection    African trypanosomiasis    Amoebiasis    Hepatitis B    Pathways in cancer    Proteoglycans in cancer    MicroRNAs in cancer    Glioma    Non-small cell lung cancer   
Protein Interaction DatabasePRKCG
Wikipedia pathwaysPRKCG
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PRKCG
snp3D : Map Gene to Disease5582
SNP (GeneSNP Utah)PRKCG
SNP : HGBasePRKCG
Genetic variants : HAPMAPPRKCG
Exome VariantPRKCG
1000_GenomesPRKCG 
ICGC programENSG00000126583 
Somatic Mutations in Cancer : COSMICPRKCG 
CONAN: Copy Number AnalysisPRKCG 
Mutations and Diseases : HGMDPRKCG
Genomic VariantsPRKCG  PRKCG [DGVbeta]
dbVarPRKCG
ClinVarPRKCG
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM176980    605361   
MedgenPRKCG
GENETestsPRKCG
Disease Genetic AssociationPRKCG
Huge Navigator PRKCG [HugePedia]  PRKCG [HugeCancerGEM]
General knowledge
Homologs : HomoloGenePRKCG
Homology/Alignments : Family Browser (UCSC)PRKCG
Phylogenetic Trees/Animal Genes : TreeFamPRKCG
Chemical/Protein Interactions : CTD5582
Chemical/Pharm GKB GenePA33766
Clinical trialPRKCG
Cancer Resource (Charite)ENSG00000126583
Other databases
Probes
Litterature
PubMed158 Pubmed reference(s) in Entrez
CoreMinePRKCG
iHOPPRKCG
OncoSearchPRKCG
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jul 30 14:11:16 CEST 2014

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