Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PRKCH (protein kinase C, eta)

Identity

Other namesPKC-L
PKCL
PRKCL
nPKC-eta
HGNC (Hugo) PRKCH
LocusID (NCBI) 5583
Location 14q23.1
Location_base_pair Starts at 61788515 and ends at 62017698 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PRKCH   9403
Entrez_Gene (NCBI)PRKCH  5583  protein kinase C, eta
Cards
GeneCards (Weizmann)PRKCH
Ensembl (Hinxton)ENSG00000027075 [Gene_View]  chr14:61788515-62017698 [Contig_View]  PRKCH [Vega]
AceView (NCBI)PRKCH
Genatlas (Paris)PRKCH
SOURCE (Stanford)NM_006255
Genomic and cartography
GoldenPath (UCSC)PRKCH  -  14q23.1   chr14:61788515-62017698 +  14q23.1   [Description]    (hg19-Feb_2009)
EnsemblPRKCH - 14q23.1 [CytoView]
Mapping of homologs : NCBIPRKCH [Mapview]
OMIM601367   605437   
Gene and transcription
Genbank (Entrez)AB451313 AK093241 AK290183 AK296158 AK300864
RefSeq transcript (SRS)NM_006255
RefSeq transcript (Entrez)NM_006255
RefSeq genomic (SRS)AC_000146 NC_000014 NC_018925 NG_011514 NT_026437 NW_001838111 NW_004078079
RefSeq genomic (Entrez)AC_000146 NC_000014 NC_018925 NG_011514 NT_026437 NW_001838111 NW_004078079
Consensus coding sequences : CCDS (NCBI)PRKCH
Cluster EST : UnigeneHs.333907 [ SRS ] Hs.333907 [ NCBI ]
CGAP (NCI)Hs.333907
Alternative Splicing : Fast-db (Paris)GSHG0008891
Alternative Splicing GalleryENSG00000027075
Gene ExpressionPRKCH [ NCBI-GEO ]   PRKCH [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP24723 (SRS) P24723 (Uniprot)
NextProtP24723
With graphics : InterProP24723
Splice isoforms : SwissVarP24723(Swissvar)
Domaine pattern : Prosite (SRS)AGC_KINASE_CTER (PS51285)    C2 (PS50004)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    ZF_DAG_PE_1 (PS00479)    ZF_DAG_PE_2 (PS50081)   
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    C2 (PS50004)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    ZF_DAG_PE_1 (PS00479)    ZF_DAG_PE_2 (PS50081)   
Domains : Interpro (SRS)AGC-kinase_C    C2_Ca-dep    C2_Ca/lipid-bd_dom_CaLB    C2_membr_targeting    DAG/PE-bd    Kinase-like_dom    Pkinase_C    Prot_kin_PKC_delta    Prot_Kinase_C-like_PE/DAG-bd    Prot_kinase_cat_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase_dom    Ser/Thr_kinase_AS   
Domains : Interpro (EBI)AGC-kinase_C    C2_Ca-dep    C2_Ca/lipid-bd_dom_CaLB    C2_membr_targeting    DAG/PE-bd    Kinase-like_dom    Pkinase_C    Prot_kin_PKC_delta    Prot_Kinase_C-like_PE/DAG-bd    Prot_kinase_cat_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase_dom    Ser/Thr_kinase_AS   
Related proteins : CluSTrP24723
Domain families : Pfam (SRS)C1_1 (PF00130)    C2 (PF00168)    Pkinase (PF00069)    Pkinase_C (PF00433)   
Domain families : Pfam (Sanger)C1_1 (PF00130)    C2 (PF00168)    Pkinase (PF00069)    Pkinase_C (PF00433)   
Domain families : Pfam (NCBI)pfam00130    pfam00168    pfam00069    pfam00433   
Domain families : Smart (EMBL)C1 (SM00109)  C2 (SM00239)  S_TK_X (SM00133)  S_TKc (SM00220)  
DMDM5583
Blocks (Seattle)P24723
PDB (SRS)2FK9    3TXO   
PDB (PDBSum)2FK9    3TXO   
PDB (IMB)2FK9    3TXO   
PDB (RSDB)2FK9    3TXO   
Human Protein AtlasENSG00000027075
HPRD05669
IPIIPI00184572   IPI01009472   IPI00031610   IPI01024894   IPI01026402   IPI01024744   IPI01024871   IPI01024972   IPI01025205   IPI01025313   IPI01025883   IPI01025559   IPI01025983   IPI01026100   IPI01026191   
Protein Interaction databases
DIP (DOE-UCLA)P24723
IntAct (EBI)P24723
FunCoupENSG00000027075
REACTOMEPRKCH
Protein Interaction Database5583
BioGRIDPRKCH
InParanoidP24723
Interologous Interaction database P24723
IntegromeDBPRKCH
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PRKCH
SNP (GeneSNP Utah)PRKCH
SNP : HGBasePRKCH
Genetic variants : HAPMAPPRKCH
Somatic Mutations in Cancer : COSMICPRKCH 
CONAN: Copy Number AnalysisPRKCH 
Mutations and Diseases : HGMDPRKCH
OMIM601367    605437   
GENETests601367    605437   
Disease Genetic AssociationPRKCH
Huge Navigator PRKCH [HugePedia]  PRKCH [HugeCancerGEM]
Genomic VariantsPRKCH  PRKCH [DGVbeta]
ClinVarPRKCH
snp3D : Map Gene to Disease5583
General knowledge
Homologs : HomoloGenePRKCH
Homology/Alignments : Family Browser (UCSC)PRKCH
Phylogenetic Trees/Animal Genes : TreeFamPRKCH
Catalytic activity : Enzyme2.7.11.13 [ Enzyme-Expasy ]   2.7.11.13 [ Enzyme-SRS ]   2.7.11.13 [ IntEnz-EBI ]   2.7.11.13 [ BRENDA ]   2.7.11.13 [ KEGG ]   
Chemical/Protein Interactions : CTD5583
Chemical/Pharm GKB GenePA33767
Clinical trialPRKCH
Cancer Resource (Charite)ENSG00000027075
Ontology : AmiGOprotein kinase C activity  calcium-independent protein kinase C activity  ATP binding  cytoplasm  cytosol  cytosol  plasma membrane  protein phosphorylation  signal transduction  blood coagulation  positive regulation of macrophage derived foam cell differentiation  Ral GTPase binding  enzyme binding  platelet activation  negative regulation of glial cell apoptotic process  positive regulation of keratinocyte differentiation  metal ion binding  positive regulation of B cell receptor signaling pathway  positive regulation of NF-kappaB transcription factor activity  positive regulation of glial cell proliferation  protein kinase C signaling cascade  regulation of tight junction assembly  
Ontology : EGO-EBIprotein kinase C activity  calcium-independent protein kinase C activity  ATP binding  cytoplasm  cytosol  cytosol  plasma membrane  protein phosphorylation  signal transduction  blood coagulation  positive regulation of macrophage derived foam cell differentiation  Ral GTPase binding  enzyme binding  platelet activation  negative regulation of glial cell apoptotic process  positive regulation of keratinocyte differentiation  metal ion binding  positive regulation of B cell receptor signaling pathway  positive regulation of NF-kappaB transcription factor activity  positive regulation of glial cell proliferation  protein kinase C signaling cascade  regulation of tight junction assembly  
Pathways : BIOCARTAKeratinocyte Differentiation [Genes]   
Pathways : KEGGTight junction
Other databases
Probes
Litterature
PubMed110 Pubmed reference(s) in Entrez
PubGenePRKCH
iHOPPRKCH
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 14 17:26:47 CEST 2013
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