PRKCH (protein kinase C eta)

2004-06-01  

Identity

HGNC
LOCATION
14q23.1
LOCUSID
ALIAS
PKC-L,PKCL,PRKCL,nPKC-eta
FUSION GENES

Other Information

Locus ID:

NCBI: 5583
MIM: 605437
HGNC: 9403
Ensembl: ENSG00000027075

Variants:

dbSNP: 5583
ClinVar: 5583
TCGA: ENSG00000027075
COSMIC: PRKCH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000027075ENST00000332981P24723
ENSG00000027075ENST00000553265G3V4Q9
ENSG00000027075ENST00000553726G3V4H0
ENSG00000027075ENST00000553830G3V5Y6
ENSG00000027075ENST00000553831G3V304
ENSG00000027075ENST00000555082P24723
ENSG00000027075ENST00000555185G3V4L3
ENSG00000027075ENST00000555542G3V4G6
ENSG00000027075ENST00000555906G3V3E7
ENSG00000027075ENST00000556164G3V5F8
ENSG00000027075ENST00000556778G3V4X4
ENSG00000027075ENST00000557294G3V520
ENSG00000027075ENST00000557473G3V5U5
ENSG00000027075ENST00000557585G3V4Q6
ENSG00000027075ENST00000640011A0A1W2PPU0

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
Inflammatory mediator regulation of TRP channelsKEGGhsa04750
Inflammatory mediator regulation of TRP channelsKEGGko04750
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Effects of PIP2 hydrolysisREACTOMER-HSA-114508
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (z) signalling eventsREACTOMER-HSA-418597
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128394595PLCH1GenePathwayassociated
PA134875646PLCZ1GenePathwayassociated
PA134914471PLCH2GenePathwayassociated
PA33384PLCB1GenePathwayassociated
PA33385PLCB2GenePathwayassociated
PA33386PLCB3GenePathwayassociated
PA33387PLCB4GenePathwayassociated
PA33388PLCD1GenePathwayassociated
PA33389PLCD3GenePathwayassociated
PA33390PLCD4GenePathwayassociated
PA33391PLCE1GenePathwayassociated
PA33392PLCG1GenePathwayassociated20124951
PA33393PLCG2GenePathwayassociated20124951
PA33394PLCL1GenePathwayassociated
PA33395PLCL2GenePathwayassociated
PA34183RAF1GenePathwayassociated20124951
PA39ADRB2GenePathwayassociated

References

Pubmed IDYearTitleCitations
185044232008Polymorphisms in inflammation-related genes are associated with susceptibility to major depression and antidepressant response.73
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
172061442007A nonsynonymous SNP in PRKCH (protein kinase C eta) increases the risk of cerebral infarction.56
154898972004PKC-eta mediates glioblastoma cell proliferation through the Akt and mTOR signaling pathways.32
171464452007The protein kinase C-eta isoform induces proliferation in glioblastoma cell lines through an ERK/Elk-1 pathway.26
174929412007Phospholipase C beta3 is a key component in the Gbetagamma/PKCeta/PKD-mediated regulation of trans-Golgi network to plasma membrane transport.22
195209892009The 1425G/A SNP in PRKCH is associated with ischemic stroke and cerebral hemorrhage in a Chinese population.19
195209892009The 1425G/A SNP in PRKCH is associated with ischemic stroke and cerebral hemorrhage in a Chinese population.19
196937672009Swiprosin-1 is expressed in mast cells and up-regulated through the protein kinase C beta I/eta pathway.17
162429152006PKCeta is localized in the Golgi, ER and nuclear envelope and translocates to the nuclear envelope upon PMA activation and serum-starvation: C1b domain and the pseudosubstrate containing fragment target PKCeta to the Golgi and the nuclear envelope.16

Citation

Dessen P

PRKCH (protein kinase C eta)

Atlas Genet Cytogenet Oncol Haematol. 2004-06-01

Online version: http://atlasgeneticsoncology.org/gene/42912/prkch