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PRKCH (protein kinase C eta)

Identity

Alias_namesPRKCL
protein kinase C
Alias_symbol (synonym)PKC-L
PKCL
Other aliasnPKC-eta
HGNC (Hugo) PRKCH
LocusID (NCBI) 5583
Atlas_Id 42912
Location 14q23.1  [Link to chromosome band 14q23]
Location_base_pair Starts at 61321443 and ends at 61550980 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
HIF1A (14q23.2) / PRKCH (14q23.1)MATR3 (5q31.2) / PRKCH (14q23.1)PRKCH (14q23.1) / PMPCB (7q22.1)
PRKCH (14q23.1) / PRKCH (14q23.1)PRKCH (14q23.1) / SET (9q34.11)RP11-47I22.3 () / PRKCH (14q23.1)
VASH1 (14q24.3) / PRKCH (14q23.1)HIF1A 14q23.2 / PRKCH 14q23.1RP11-47I22.3 PRKCH 14q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PRKCH   9403
Cards
Entrez_Gene (NCBI)PRKCH  5583  protein kinase C eta
AliasesPKC-L; PKCL; PRKCL; nPKC-eta
GeneCards (Weizmann)PRKCH
Ensembl hg19 (Hinxton)ENSG00000027075 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000027075 [Gene_View]  chr14:61321443-61550980 [Contig_View]  PRKCH [Vega]
ICGC DataPortalENSG00000027075
TCGA cBioPortalPRKCH
AceView (NCBI)PRKCH
Genatlas (Paris)PRKCH
WikiGenes5583
SOURCE (Princeton)PRKCH
Genetics Home Reference (NIH)PRKCH
Genomic and cartography
GoldenPath hg38 (UCSC)PRKCH  -     chr14:61321443-61550980 +  14q23.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRKCH  -     14q23.1   [Description]    (hg19-Feb_2009)
EnsemblPRKCH - 14q23.1 [CytoView hg19]  PRKCH - 14q23.1 [CytoView hg38]
Mapping of homologs : NCBIPRKCH [Mapview hg19]  PRKCH [Mapview hg38]
OMIM601367   605437   
Gene and transcription
Genbank (Entrez)AB451313 AK093241 AK290183 AK296158 AK300864
RefSeq transcript (Entrez)NM_006255
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PRKCH
Cluster EST : UnigeneHs.333907 [ NCBI ]
CGAP (NCI)Hs.333907
Alternative Splicing GalleryENSG00000027075
Gene ExpressionPRKCH [ NCBI-GEO ]   PRKCH [ EBI - ARRAY_EXPRESS ]   PRKCH [ SEEK ]   PRKCH [ MEM ]
Gene Expression Viewer (FireBrowse)PRKCH [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5583
GTEX Portal (Tissue expression)PRKCH
Protein : pattern, domain, 3D structure
UniProt/SwissProtP24723   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP24723  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP24723
Splice isoforms : SwissVarP24723
Catalytic activity : Enzyme2.7.11.13 [ Enzyme-Expasy ]   2.7.11.132.7.11.13 [ IntEnz-EBI ]   2.7.11.13 [ BRENDA ]   2.7.11.13 [ KEGG ]   
PhosPhoSitePlusP24723
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    C2 (PS50004)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    ZF_DAG_PE_1 (PS00479)    ZF_DAG_PE_2 (PS50081)   
Domains : Interpro (EBI)AGC-kinase_C    C2_dom    DAG/PE-bd    Kinase-like_dom    PE/DAG-bd    PKC_eta    Pkinase_C    Prot_kin_PKC_delta    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)C1_1 (PF00130)    C2 (PF00168)    Pkinase (PF00069)    Pkinase_C (PF00433)   
Domain families : Pfam (NCBI)pfam00130    pfam00168    pfam00069    pfam00433   
Domain families : Smart (EMBL)C1 (SM00109)  C2 (SM00239)  S_TK_X (SM00133)  S_TKc (SM00220)  
Conserved Domain (NCBI)PRKCH
DMDM Disease mutations5583
Blocks (Seattle)PRKCH
PDB (SRS)2FK9    3TXO   
PDB (PDBSum)2FK9    3TXO   
PDB (IMB)2FK9    3TXO   
PDB (RSDB)2FK9    3TXO   
Structural Biology KnowledgeBase2FK9    3TXO   
SCOP (Structural Classification of Proteins)2FK9    3TXO   
CATH (Classification of proteins structures)2FK9    3TXO   
SuperfamilyP24723
Human Protein AtlasENSG00000027075
Peptide AtlasP24723
HPRD05669
IPIIPI00184572   IPI01009472   IPI00031610   IPI01024894   IPI01026402   IPI01024744   IPI01024871   IPI01024972   IPI01025205   IPI01025313   IPI01025883   IPI01025559   IPI01025983   IPI01026100   IPI01026191   
Protein Interaction databases
DIP (DOE-UCLA)P24723
IntAct (EBI)P24723
FunCoupENSG00000027075
BioGRIDPRKCH
STRING (EMBL)PRKCH
ZODIACPRKCH
Ontologies - Pathways
QuickGOP24723
Ontology : AmiGOprotein kinase C activity  calcium-independent protein kinase C activity  ATP binding  cytoplasm  cytosol  cytosol  plasma membrane  cell-cell junction  protein phosphorylation  signal transduction  positive regulation of macrophage derived foam cell differentiation  Ral GTPase binding  peptidyl-serine phosphorylation  enzyme binding  platelet activation  negative regulation of glial cell apoptotic process  intracellular signal transduction  positive regulation of keratinocyte differentiation  metal ion binding  positive regulation of B cell receptor signaling pathway  positive regulation of NF-kappaB transcription factor activity  positive regulation of glial cell proliferation  extracellular exosome  protein kinase C signaling  positive regulation of protein localization to plasma membrane  regulation of bicellular tight junction assembly  
Ontology : EGO-EBIprotein kinase C activity  calcium-independent protein kinase C activity  ATP binding  cytoplasm  cytosol  cytosol  plasma membrane  cell-cell junction  protein phosphorylation  signal transduction  positive regulation of macrophage derived foam cell differentiation  Ral GTPase binding  peptidyl-serine phosphorylation  enzyme binding  platelet activation  negative regulation of glial cell apoptotic process  intracellular signal transduction  positive regulation of keratinocyte differentiation  metal ion binding  positive regulation of B cell receptor signaling pathway  positive regulation of NF-kappaB transcription factor activity  positive regulation of glial cell proliferation  extracellular exosome  protein kinase C signaling  positive regulation of protein localization to plasma membrane  regulation of bicellular tight junction assembly  
Pathways : BIOCARTAKeratinocyte Differentiation [Genes]   
Pathways : KEGGVascular smooth muscle contraction    Tight junction   
NDEx NetworkPRKCH
Atlas of Cancer Signalling NetworkPRKCH
Wikipedia pathwaysPRKCH
Orthology - Evolution
OrthoDB5583
GeneTree (enSembl)ENSG00000027075
Phylogenetic Trees/Animal Genes : TreeFamPRKCH
HOVERGENP24723
HOGENOMP24723
Homologs : HomoloGenePRKCH
Homology/Alignments : Family Browser (UCSC)PRKCH
Gene fusions - Rearrangements
Fusion : MitelmanHIF1A/PRKCH [14q23.2/14q23.1]  [t(14;14)(q23;q23)]  
Fusion: TCGAHIF1A 14q23.2 PRKCH 14q23.1 LUAD OV
Fusion: TCGARP11-47I22.3 PRKCH 14q23.1 BRCA KIRC LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRKCH [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRKCH
dbVarPRKCH
ClinVarPRKCH
1000_GenomesPRKCH 
Exome Variant ServerPRKCH
ExAC (Exome Aggregation Consortium)PRKCH (select the gene name)
Genetic variants : HAPMAP5583
Genomic Variants (DGV)PRKCH [DGVbeta]
DECIPHERPRKCH [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRKCH 
Mutations
ICGC Data PortalPRKCH 
TCGA Data PortalPRKCH 
Broad Tumor PortalPRKCH
OASIS PortalPRKCH [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRKCH  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRKCH
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRKCH
DgiDB (Drug Gene Interaction Database)PRKCH
DoCM (Curated mutations)PRKCH (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRKCH (select a term)
intoGenPRKCH
Cancer3DPRKCH(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601367    605437   
Orphanet
MedgenPRKCH
Genetic Testing Registry PRKCH
NextProtP24723 [Medical]
TSGene5583
GENETestsPRKCH
Target ValidationPRKCH
Huge Navigator PRKCH [HugePedia]
snp3D : Map Gene to Disease5583
BioCentury BCIQPRKCH
ClinGenPRKCH
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5583
Chemical/Pharm GKB GenePA33767
Clinical trialPRKCH
Miscellaneous
canSAR (ICR)PRKCH (select the gene name)
Probes
Litterature
PubMed125 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRKCH
EVEXPRKCH
GoPubMedPRKCH
iHOPPRKCH
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:26:30 CEST 2017

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