Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PRKCQ (protein kinase C, theta)

Identity

Other namesPRKCT
nPKC-theta
HGNC (Hugo) PRKCQ
LocusID (NCBI) 5588
Location 10p15.1
Location_base_pair Starts at 6469105 and ends at 6622263 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PRKCQ   9410
Entrez_Gene (NCBI)PRKCQ  5588  protein kinase C, theta
Cards
GeneCards (Weizmann)PRKCQ
Ensembl (Hinxton)ENSG00000065675 [Gene_View]  chr10:6469105-6622263 [Contig_View]  PRKCQ [Vega]
AceView (NCBI)PRKCQ
Genatlas (Paris)PRKCQ
SOURCE (Stanford)NM_001242413 NM_001282644 NM_001282645 NM_006257
Genomic and cartography
GoldenPath (UCSC)PRKCQ  -  10p15.1   chr10:6469105-6622263 -  10p15.1   [Description]    (hg19-Feb_2009)
EnsemblPRKCQ - 10p15.1 [CytoView]
Mapping of homologs : NCBIPRKCQ [Mapview]
OMIM600448   
Gene and transcription
Genbank (Entrez)AA234440 AI570478 AK293935 AK308099 AK312411
RefSeq transcript (SRS)NM_001242413 NM_001282644 NM_001282645 NM_006257
RefSeq transcript (Entrez)NM_001242413 NM_001282644 NM_001282645 NM_006257
RefSeq genomic (SRS)AC_000142 NC_000010 NC_018921 NT_008705 NW_001837931 NW_004929370
RefSeq genomic (Entrez)AC_000142 NC_000010 NC_018921 NT_008705 NW_001837931 NW_004929370
Consensus coding sequences : CCDS (NCBI)PRKCQ
Cluster EST : UnigeneHs.498570 [ SRS ] Hs.498570 [ NCBI ]
CGAP (NCI)Hs.498570
Alternative Splicing : Fast-db (Paris)GSHG0003849
Alternative Splicing GalleryENSG00000065675
Gene ExpressionPRKCQ [ NCBI-GEO ]   PRKCQ [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ04759 (SRS) Q04759 (Uniprot)
NextProtQ04759  [Medical]
With graphics : InterProQ04759
Splice isoforms : SwissVarQ04759(Swissvar)
Domaine pattern : Prosite (SRS)AGC_KINASE_CTER (PS51285)    C2 (PS50004)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    ZF_DAG_PE_1 (PS00479)    ZF_DAG_PE_2 (PS50081)   
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    C2 (PS50004)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    ZF_DAG_PE_1 (PS00479)    ZF_DAG_PE_2 (PS50081)   
Domains : Interpro (SRS)AGC-kinase_C    C2_dom    DAG/PE-bd    Kinase-like_dom    PKC_theta    Pkinase_C    Prot_kin_PKC_delta    Prot_Kinase_C-like_PE/DAG-bd    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase_dom    Ser/Thr_kinase_AS   
Domains : Interpro (EBI)AGC-kinase_C    C2_dom    DAG/PE-bd    Kinase-like_dom    PKC_theta    Pkinase_C    Prot_kin_PKC_delta    Prot_Kinase_C-like_PE/DAG-bd    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase_dom    Ser/Thr_kinase_AS   
Related proteins : CluSTrQ04759
Domain families : Pfam (SRS)C1_1 (PF00130)    Pkinase (PF00069)    Pkinase_C (PF00433)   
Domain families : Pfam (Sanger)C1_1 (PF00130)    Pkinase (PF00069)    Pkinase_C (PF00433)   
Domain families : Pfam (NCBI)pfam00130    pfam00069    pfam00433   
Domain families : Smart (EMBL)C1 (SM00109)  S_TK_X (SM00133)  S_TKc (SM00220)  
DMDM5588
Blocks (Seattle)Q04759
PDB (SRS)1XJD    2ENJ    2ENN    2ENZ    2JED   
PDB (PDBSum)1XJD    2ENJ    2ENN    2ENZ    2JED   
PDB (IMB)1XJD    2ENJ    2ENN    2ENZ    2JED   
PDB (RSDB)1XJD    2ENJ    2ENN    2ENZ    2JED   
Human Protein AtlasENSG00000065675
HPRD02710
IPIIPI00029196   IPI00470691   IPI01011121   IPI00552075   
Protein Interaction databases
DIP (DOE-UCLA)Q04759
IntAct (EBI)Q04759
FunCoupENSG00000065675
REACTOMEPRKCQ
Protein Interaction Database5588
BioGRIDPRKCQ
InParanoidQ04759
Interologous Interaction database Q04759
IntegromeDBPRKCQ
Gene fusion - rearrangments
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PRKCQ
SNP (GeneSNP Utah)PRKCQ
SNP : HGBasePRKCQ
Genetic variants : HAPMAPPRKCQ
Somatic Mutations in Cancer : COSMICPRKCQ 
CONAN: Copy Number AnalysisPRKCQ 
Mutations and Diseases : HGMDPRKCQ
OMIM600448   
GENETests600448   
Disease Genetic AssociationPRKCQ
Huge Navigator PRKCQ [HugePedia]  PRKCQ [HugeCancerGEM]
Genomic VariantsPRKCQ  PRKCQ [DGVbeta]
ClinVarPRKCQ
snp3D : Map Gene to Disease5588
General knowledge
Homologs : HomoloGenePRKCQ
Homology/Alignments : Family Browser (UCSC)PRKCQ
Phylogenetic Trees/Animal Genes : TreeFamPRKCQ
Catalytic activity : Enzyme2.7.11.13 [ Enzyme-Expasy ]   2.7.11.13 [ Enzyme-SRS ]   2.7.11.13 [ IntEnz-EBI ]   2.7.11.13 [ BRENDA ]   2.7.11.13 [ KEGG ]   
Chemical/Protein Interactions : CTD5588
Chemical/Pharm GKB GenePA33773
Clinical trialPRKCQ
Cancer Resource (Charite)ENSG00000065675
Ontology : AmiGOregulation of cell growth  immunological synapse  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein kinase C activity  ubiquitin-protein ligase activity  protein binding  ATP binding  intracellular  cytosol  plasma membrane  regulation of transcription, DNA-dependent  protein phosphorylation  membrane protein ectodomain proteolysis  apoptotic process  cellular component disassembly involved in execution phase of apoptosis  inflammatory response  axon guidance  blood coagulation  phototransduction, visible light  rhodopsin mediated signaling pathway  protein ubiquitination  regulation of rhodopsin mediated signaling pathway  platelet activation  positive regulation of interleukin-17 production  positive regulation of interleukin-4 production  intracellular signal transduction  Fc-epsilon receptor signaling pathway  positive regulation of T cell proliferation  positive regulation of interleukin-2 biosynthetic process  innate immune response  negative regulation of insulin receptor signaling pathway  metal ion binding  T cell receptor signaling pathway  positive regulation of T cell activation  positive regulation of NF-kappaB transcription factor activity  negative regulation of T cell apoptotic process  regulation of platelet aggregation  positive regulation of T-helper 17 type immune response  positive regulation of T-helper 2 cell activation  
Ontology : EGO-EBIregulation of cell growth  immunological synapse  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein kinase C activity  ubiquitin-protein ligase activity  protein binding  ATP binding  intracellular  cytosol  plasma membrane  regulation of transcription, DNA-dependent  protein phosphorylation  membrane protein ectodomain proteolysis  apoptotic process  cellular component disassembly involved in execution phase of apoptosis  inflammatory response  axon guidance  blood coagulation  phototransduction, visible light  rhodopsin mediated signaling pathway  protein ubiquitination  regulation of rhodopsin mediated signaling pathway  platelet activation  positive regulation of interleukin-17 production  positive regulation of interleukin-4 production  intracellular signal transduction  Fc-epsilon receptor signaling pathway  positive regulation of T cell proliferation  positive regulation of interleukin-2 biosynthetic process  innate immune response  negative regulation of insulin receptor signaling pathway  metal ion binding  T cell receptor signaling pathway  positive regulation of T cell activation  positive regulation of NF-kappaB transcription factor activity  negative regulation of T cell apoptotic process  regulation of platelet aggregation  positive regulation of T-helper 17 type immune response  positive regulation of T-helper 2 cell activation  
Pathways : BIOCARTAKeratinocyte Differentiation [Genes]   
Pathways : KEGGTight junctionT cell receptor signaling pathwayAdipocytokine signaling pathway
Other databases
Probes
Litterature
PubMed182 Pubmed reference(s) in Entrez
PubGenePRKCQ
iHOPPRKCQ
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Dec 3 19:32:43 CET 2013
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