PRKCQ (protein kinase C, theta)

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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret
Donations are also welcome

PRKCQ (protein kinase C, theta)

Identity

Other names	PRKCT
	nPKC-theta
HGNC (Hugo)	PRKCQ
LocusID (NCBI)	5588
Location	10p15.1
Location_base_pair	Starts at 6469105 and ends at 6622263 bp from pter ( according to hg19-Feb_2009)
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

DNA/RNA

External links

	Nomenclature
HGNC (Hugo)	PRKCQ 9410
	Cards
Entrez_Gene (NCBI)	PRKCQ 5588 protein kinase C, theta
GeneCards (Weizmann)	PRKCQ
Ensembl hg19 (Hinxton)	ENSG00000065675 [Gene_View] chr10:6469105-6622263 [Contig_View] PRKCQ [Vega]
Ensembl hg38 (Hinxton)	ENSG00000065675 [Gene_View] chr10:6469105-6622263 [Contig_View] PRKCQ [Vega]
ICGC DataPortal	ENSG00000065675
cBioPortal	PRKCQ
AceView (NCBI)	PRKCQ
Genatlas (Paris)	PRKCQ
WikiGenes	5588
SOURCE (Princeton)	PRKCQ
	Genomic and cartography
GoldenPath hg19 (UCSC)	PRKCQ - chr10:6469105-6622263 - 10p15.1 [Description] (hg19-Feb_2009)
GoldenPath hg38 (UCSC)	PRKCQ - 10p15.1 [Description] (hg38-Dec_2013)
Ensembl	PRKCQ - 10p15.1 [CytoView hg19] PRKCQ - 10p15.1 [CytoView hg38]
Mapping of homologs : NCBI	PRKCQ [Mapview hg19] PRKCQ [Mapview hg38]
OMIM	600448
	Gene and transcription
Genbank (Entrez)	AA234440 AI570478 AK293935 AK308099 AK312411
RefSeq transcript (Entrez)	NM_001242413 NM_001282644 NM_001282645 NM_006257
RefSeq genomic (Entrez)	AC_000142 NC_000010 NC_018921 NT_008705 NW_001837931 NW_004929370
Consensus coding sequences : CCDS (NCBI)	PRKCQ
Cluster EST : Unigene	Hs.498570 [ NCBI ]
CGAP (NCI)	Hs.498570
Alternative Splicing : Fast-db (Paris)	GSHG0003849
Alternative Splicing Gallery	ENSG00000065675
Gene Expression	PRKCQ [ NCBI-GEO ] PRKCQ [ SEEK ] PRKCQ [ MEM ]
SOURCE (Princeton)	Expression in : [Normal Tissue Atlas] [carcinoma Classsification] [NCI60]
	Protein : pattern, domain, 3D structure
UniProt/SwissProt	Q04759 (Uniprot)
NextProt	Q04759 [Medical]
With graphics : InterPro	Q04759
Splice isoforms : SwissVar	Q04759 (Swissvar)
Catalytic activity : Enzyme	2.7.11.13 [ Enzyme-Expasy ] 2.7.11.13 2.7.11.13 [ IntEnz-EBI ] 2.7.11.13 [ BRENDA ] 2.7.11.13 [ KEGG ]
Domaine pattern : Prosite (Expaxy)	AGC_KINASE_CTER (PS51285) PROTEIN_KINASE_ATP (PS00107) PROTEIN_KINASE_DOM (PS50011) PROTEIN_KINASE_ST (PS00108) ZF_DAG_PE_1 (PS00479) ZF_DAG_PE_2 (PS50081)
Domains : Interpro (EBI)	AGC-kinase_C C2_dom DAG/PE-bd Kinase-like_dom PKC_theta Pkinase_C Prot_kin_PKC_delta Prot_Kinase_C-like_PE/DAG-bd Prot_kinase_dom Protein_kinase_ATP_BS Ser/Thr_dual-sp_kinase_dom Ser/Thr_kinase_AS
Related proteins : CluSTr	Q04759
Domain families : Pfam (Sanger)	C1_1 (PF00130) Pkinase (PF00069) Pkinase_C (PF00433)
Domain families : Pfam (NCBI)	pfam00130 pfam00069 pfam00433
Domain families : Smart (EMBL)	C1 (SM00109) S_TK_X (SM00133) S_TKc (SM00220)
DMDM Disease mutations	5588
Blocks (Seattle)	Q04759
PDB (SRS)	1XJD 2ENJ 2ENN 2ENZ 2JED
PDB (PDBSum)	1XJD 2ENJ 2ENN 2ENZ 2JED
PDB (IMB)	1XJD 2ENJ 2ENN 2ENZ 2JED
PDB (RSDB)	1XJD 2ENJ 2ENN 2ENZ 2JED
Human Protein Atlas	ENSG00000065675
Peptide Atlas	Q04759
HPRD	02710
IPI	IPI00029196 IPI00470691 IPI01011121 IPI00552075
	Protein Interaction databases
DIP (DOE-UCLA)	Q04759
IntAct (EBI)	Q04759
FunCoup	ENSG00000065675
BioGRID	PRKCQ
IntegromeDB	PRKCQ
STRING (EMBL)	PRKCQ
	Ontologies - Pathways
QuickGO	Q04759
Ontology : AmiGO	regulation of cell growth immunological synapse protein serine/threonine kinase activity protein serine/threonine kinase activity protein kinase C activity ubiquitin-protein transferase activity protein binding ATP binding cytosol plasma membrane regulation of transcription, DNA-templated protein phosphorylation membrane protein ectodomain proteolysis apoptotic process cellular component disassembly involved in execution phase of apoptosis inflammatory response axon guidance blood coagulation phototransduction, visible light rhodopsin mediated signaling pathway protein ubiquitination regulation of rhodopsin mediated signaling pathway platelet activation positive regulation of interleukin-17 production positive regulation of interleukin-4 production intracellular signal transduction Fc-epsilon receptor signaling pathway positive regulation of T cell proliferation positive regulation of interleukin-2 biosynthetic process innate immune response negative regulation of insulin receptor signaling pathway metal ion binding T cell receptor signaling pathway positive regulation of T cell activation positive regulation of NF-kappaB transcription factor activity negative regulation of T cell apoptotic process regulation of platelet aggregation positive regulation of T-helper 17 type immune response positive regulation of T-helper 2 cell activation
Ontology : EGO-EBI	regulation of cell growth immunological synapse protein serine/threonine kinase activity protein serine/threonine kinase activity protein kinase C activity ubiquitin-protein transferase activity protein binding ATP binding cytosol plasma membrane regulation of transcription, DNA-templated protein phosphorylation membrane protein ectodomain proteolysis apoptotic process cellular component disassembly involved in execution phase of apoptosis inflammatory response axon guidance blood coagulation phototransduction, visible light rhodopsin mediated signaling pathway protein ubiquitination regulation of rhodopsin mediated signaling pathway platelet activation positive regulation of interleukin-17 production positive regulation of interleukin-4 production intracellular signal transduction Fc-epsilon receptor signaling pathway positive regulation of T cell proliferation positive regulation of interleukin-2 biosynthetic process innate immune response negative regulation of insulin receptor signaling pathway metal ion binding T cell receptor signaling pathway positive regulation of T cell activation positive regulation of NF-kappaB transcription factor activity negative regulation of T cell apoptotic process regulation of platelet aggregation positive regulation of T-helper 17 type immune response positive regulation of T-helper 2 cell activation
Pathways : BIOCARTA	Keratinocyte Differentiation [Genes]
Pathways : KEGG	NF-kappa B signaling pathway Vascular smooth muscle contraction Tight junction T cell receptor signaling pathway Adipocytokine signaling pathway Measles
Protein Interaction Database	PRKCQ
DoCM (Curated mutations)	PRKCQ
Wikipedia pathways	PRKCQ
	Gene fusion - rearrangements
	Polymorphisms : SNP, variants
NCBI Variation Viewer	PRKCQ [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)	PRKCQ
dbVar	PRKCQ
ClinVar	PRKCQ
1000_Genomes	PRKCQ
Exome Variant Server	PRKCQ
SNP (GeneSNP Utah)	PRKCQ
SNP : HGBase	PRKCQ
Genetic variants : HAPMAP	PRKCQ
Genomic Variants (DGV)	PRKCQ [DGVbeta]
	Mutations
ICGC Data Portal	ENSG00000065675
Somatic Mutations in Cancer : COSMIC	PRKCQ
CONAN: Copy Number Analysis	PRKCQ
LOVD (Leiden Open Variation Database)	Whole genome datasets
LOVD (Leiden Open Variation Database)	LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)	LOVD 3.0 shared installation
Impact of mutations	[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor]
	Diseases
DECIPHER (Syndromes)	10:6469105-6622263
Mutations and Diseases : HGMD	PRKCQ
OMIM	600448
Medgen	PRKCQ
NextProt	Q04759 [Medical]
GENETests	PRKCQ
Disease Genetic Association	PRKCQ
Huge Navigator	PRKCQ [HugePedia] PRKCQ [HugeCancerGEM]
snp3D : Map Gene to Disease	5588
DGIdb (Drug Gene Interaction db)	PRKCQ
	General knowledge
Homologs : HomoloGene	PRKCQ
Homology/Alignments : Family Browser (UCSC)	PRKCQ
Phylogenetic Trees/Animal Genes : TreeFam	PRKCQ
Chemical/Protein Interactions : CTD	5588
Chemical/Pharm GKB Gene	PA33773
Clinical trial	PRKCQ
Cancer Resource (Charite)	ENSG00000065675
	Other databases
	Probes
	Litterature
PubMed	186 Pubmed reference(s) in Entrez
CoreMine	PRKCQ
GoPubMed	PRKCQ
iHOP	PRKCQ

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S

Updated	12-2014	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Feb 14 18:07:41 CET 2015

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