Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PRKCQ (protein kinase C theta)

Identity

Alias_namesprotein kinase C, theta
Other aliasPRKCT
nPKC-theta
HGNC (Hugo) PRKCQ
LocusID (NCBI) 5588
Atlas_Id 41861
Location 10p15.1  [Link to chromosome band 10p15]
Location_base_pair Starts at 6427143 and ends at 6580301 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GPALPP1 (13q14.12) / PRKCQ (10p15.1)PRKCQ (10p15.1) / RSU1 (10p13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PRKCQ   9410
Cards
Entrez_Gene (NCBI)PRKCQ  5588  protein kinase C theta
AliasesPRKCT; nPKC-theta
GeneCards (Weizmann)PRKCQ
Ensembl hg19 (Hinxton)ENSG00000065675 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000065675 [Gene_View]  ENSG00000065675 [Sequence]  chr10:6427143-6580301 [Contig_View]  PRKCQ [Vega]
ICGC DataPortalENSG00000065675
TCGA cBioPortalPRKCQ
AceView (NCBI)PRKCQ
Genatlas (Paris)PRKCQ
WikiGenes5588
SOURCE (Princeton)PRKCQ
Genetics Home Reference (NIH)PRKCQ
Genomic and cartography
GoldenPath hg38 (UCSC)PRKCQ  -     chr10:6427143-6580301 -  10p15.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRKCQ  -     10p15.1   [Description]    (hg19-Feb_2009)
GoldenPathPRKCQ - 10p15.1 [CytoView hg19]  PRKCQ - 10p15.1 [CytoView hg38]
ImmunoBaseENSG00000065675
Mapping of homologs : NCBIPRKCQ [Mapview hg19]  PRKCQ [Mapview hg38]
OMIM600448   
Gene and transcription
Genbank (Entrez)AA234440 AI570478 AK293935 AK308099 AK312411
RefSeq transcript (Entrez)NM_001242413 NM_001282644 NM_001282645 NM_001323265 NM_001323266 NM_001323267 NM_006257
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PRKCQ
Cluster EST : UnigeneHs.498570 [ NCBI ]
CGAP (NCI)Hs.498570
Alternative Splicing GalleryENSG00000065675
Gene ExpressionPRKCQ [ NCBI-GEO ]   PRKCQ [ EBI - ARRAY_EXPRESS ]   PRKCQ [ SEEK ]   PRKCQ [ MEM ]
Gene Expression Viewer (FireBrowse)PRKCQ [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5588
GTEX Portal (Tissue expression)PRKCQ
Human Protein AtlasENSG00000065675-PRKCQ [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ04759   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ04759  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ04759
Splice isoforms : SwissVarQ04759
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ04759
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    ZF_DAG_PE_1 (PS00479)    ZF_DAG_PE_2 (PS50081)   
Domains : Interpro (EBI)AGC-kinase_C    C2_domain_sf    DAG/PE-bd    Kinase-like_dom_sf    nPKC_theta    PE/DAG-bd    PKC_theta    Pkinase_C    Prot_kin_PKC_delta    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)C1_1 (PF00130)    Pkinase (PF00069)    Pkinase_C (PF00433)   
Domain families : Pfam (NCBI)pfam00130    pfam00069    pfam00433   
Domain families : Smart (EMBL)C1 (SM00109)  S_TK_X (SM00133)  S_TKc (SM00220)  
Conserved Domain (NCBI)PRKCQ
DMDM Disease mutations5588
Blocks (Seattle)PRKCQ
PDB (RSDB)1XJD    2ENJ    2ENN    2ENZ    2JED    4Q9Z    4RA5    5F9E   
PDB Europe1XJD    2ENJ    2ENN    2ENZ    2JED    4Q9Z    4RA5    5F9E   
PDB (PDBSum)1XJD    2ENJ    2ENN    2ENZ    2JED    4Q9Z    4RA5    5F9E   
PDB (IMB)1XJD    2ENJ    2ENN    2ENZ    2JED    4Q9Z    4RA5    5F9E   
Structural Biology KnowledgeBase1XJD    2ENJ    2ENN    2ENZ    2JED    4Q9Z    4RA5    5F9E   
SCOP (Structural Classification of Proteins)1XJD    2ENJ    2ENN    2ENZ    2JED    4Q9Z    4RA5    5F9E   
CATH (Classification of proteins structures)1XJD    2ENJ    2ENN    2ENZ    2JED    4Q9Z    4RA5    5F9E   
SuperfamilyQ04759
Human Protein Atlas [tissue]ENSG00000065675-PRKCQ [tissue]
Peptide AtlasQ04759
HPRD02710
IPIIPI00029196   IPI00470691   IPI01011121   IPI00552075   
Protein Interaction databases
DIP (DOE-UCLA)Q04759
IntAct (EBI)Q04759
FunCoupENSG00000065675
BioGRIDPRKCQ
STRING (EMBL)PRKCQ
ZODIACPRKCQ
Ontologies - Pathways
QuickGOQ04759
Ontology : AmiGOregulation of cell growth  immunological synapse  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein kinase C activity  protein binding  ATP binding  microtubule organizing center  cytosol  plasma membrane  regulation of transcription, DNA-templated  membrane protein ectodomain proteolysis  inflammatory response  axon guidance  aggresome  peptidyl-serine phosphorylation  platelet activation  positive regulation of telomere maintenance via telomerase  positive regulation of interleukin-17 production  positive regulation of interleukin-4 production  intracellular signal transduction  intracellular signal transduction  Fc-epsilon receptor signaling pathway  positive regulation of T cell proliferation  positive regulation of interleukin-2 biosynthetic process  regulation of megakaryocyte differentiation  negative regulation of insulin receptor signaling pathway  metal ion binding  T cell receptor signaling pathway  positive regulation of T cell activation  positive regulation of NF-kappaB transcription factor activity  positive regulation of telomerase activity  cell chemotaxis  negative regulation of T cell apoptotic process  regulation of platelet aggregation  positive regulation of telomere capping  positive regulation of T-helper 17 type immune response  positive regulation of T-helper 2 cell activation  
Ontology : EGO-EBIregulation of cell growth  immunological synapse  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein kinase C activity  protein binding  ATP binding  microtubule organizing center  cytosol  plasma membrane  regulation of transcription, DNA-templated  membrane protein ectodomain proteolysis  inflammatory response  axon guidance  aggresome  peptidyl-serine phosphorylation  platelet activation  positive regulation of telomere maintenance via telomerase  positive regulation of interleukin-17 production  positive regulation of interleukin-4 production  intracellular signal transduction  intracellular signal transduction  Fc-epsilon receptor signaling pathway  positive regulation of T cell proliferation  positive regulation of interleukin-2 biosynthetic process  regulation of megakaryocyte differentiation  negative regulation of insulin receptor signaling pathway  metal ion binding  T cell receptor signaling pathway  positive regulation of T cell activation  positive regulation of NF-kappaB transcription factor activity  positive regulation of telomerase activity  cell chemotaxis  negative regulation of T cell apoptotic process  regulation of platelet aggregation  positive regulation of telomere capping  positive regulation of T-helper 17 type immune response  positive regulation of T-helper 2 cell activation  
Pathways : KEGGNF-kappa B signaling pathway    Vascular smooth muscle contraction    Tight junction    T cell receptor signaling pathway    Adipocytokine signaling pathway    Measles   
NDEx NetworkPRKCQ
Atlas of Cancer Signalling NetworkPRKCQ
Wikipedia pathwaysPRKCQ
Orthology - Evolution
OrthoDB5588
GeneTree (enSembl)ENSG00000065675
Phylogenetic Trees/Animal Genes : TreeFamPRKCQ
HOGENOMQ04759
Homologs : HomoloGenePRKCQ
Homology/Alignments : Family Browser (UCSC)PRKCQ
Gene fusions - Rearrangements
Fusion : QuiverPRKCQ
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRKCQ [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRKCQ
dbVarPRKCQ
ClinVarPRKCQ
1000_GenomesPRKCQ 
Exome Variant ServerPRKCQ
ExAC (Exome Aggregation Consortium)ENSG00000065675
GNOMAD BrowserENSG00000065675
Varsome BrowserPRKCQ
Genetic variants : HAPMAP5588
Genomic Variants (DGV)PRKCQ [DGVbeta]
DECIPHERPRKCQ [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRKCQ 
Mutations
ICGC Data PortalPRKCQ 
TCGA Data PortalPRKCQ 
Broad Tumor PortalPRKCQ
OASIS PortalPRKCQ [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRKCQ  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPRKCQ
Mutations and Diseases : HGMDPRKCQ
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRKCQ
DgiDB (Drug Gene Interaction Database)PRKCQ
DoCM (Curated mutations)PRKCQ (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRKCQ (select a term)
intoGenPRKCQ
Cancer3DPRKCQ(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600448   
Orphanet
DisGeNETPRKCQ
MedgenPRKCQ
Genetic Testing Registry PRKCQ
NextProtQ04759 [Medical]
TSGene5588
GENETestsPRKCQ
Target ValidationPRKCQ
Huge Navigator PRKCQ [HugePedia]
snp3D : Map Gene to Disease5588
BioCentury BCIQPRKCQ
ClinGenPRKCQ
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5588
Chemical/Pharm GKB GenePA33773
Clinical trialPRKCQ
Miscellaneous
canSAR (ICR)PRKCQ (select the gene name)
DataMed IndexPRKCQ
Probes
Litterature
PubMed216 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRKCQ
EVEXPRKCQ
GoPubMedPRKCQ
iHOPPRKCQ
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Aug 26 18:24:38 CEST 2019
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