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PRKCQ (protein kinase C, theta)

Identity

Other namesPRKCT
nPKC-theta
HGNC (Hugo) PRKCQ
LocusID (NCBI) 5588
Location 10p15.1
Location_base_pair Starts at 6469105 and ends at 6622263 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PRKCQ   9410
Cards
Entrez_Gene (NCBI)PRKCQ  5588  protein kinase C, theta
GeneCards (Weizmann)PRKCQ
Ensembl (Hinxton)ENSG00000065675 [Gene_View]  chr10:6469105-6622263 [Contig_View]  PRKCQ [Vega]
ICGC DataPortalENSG00000065675
cBioPortalPRKCQ
AceView (NCBI)PRKCQ
Genatlas (Paris)PRKCQ
WikiGenes5588
SOURCE (Princeton)NM_001242413 NM_001282644 NM_001282645 NM_006257
Genomic and cartography
GoldenPath (UCSC)PRKCQ  -  10p15.1   chr10:6469105-6622263 -  10p15.1   [Description]    (hg19-Feb_2009)
EnsemblPRKCQ - 10p15.1 [CytoView]
Mapping of homologs : NCBIPRKCQ [Mapview]
OMIM600448   
Gene and transcription
Genbank (Entrez)AA234440 AI570478 AK293935 AK308099 AK312411
RefSeq transcript (Entrez)NM_001242413 NM_001282644 NM_001282645 NM_006257
RefSeq genomic (Entrez)AC_000142 NC_000010 NC_018921 NT_008705 NW_001837931 NW_004929370
Consensus coding sequences : CCDS (NCBI)PRKCQ
Cluster EST : UnigeneHs.498570 [ NCBI ]
CGAP (NCI)Hs.498570
Alternative Splicing : Fast-db (Paris)GSHG0003849
Alternative Splicing GalleryENSG00000065675
Gene ExpressionPRKCQ [ NCBI-GEO ]     PRKCQ [ SEEK ]   PRKCQ [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ04759 (Uniprot)
NextProtQ04759  [Medical]
With graphics : InterProQ04759
Splice isoforms : SwissVarQ04759 (Swissvar)
Catalytic activity : Enzyme2.7.11.13 [ Enzyme-Expasy ]   2.7.11.132.7.11.13 [ IntEnz-EBI ]   2.7.11.13 [ BRENDA ]   2.7.11.13 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    ZF_DAG_PE_1 (PS00479)    ZF_DAG_PE_2 (PS50081)   
Domains : Interpro (EBI)AGC-kinase_C [organisation]   C2_dom [organisation]   DAG/PE-bd [organisation]   Kinase-like_dom [organisation]   PKC_theta [organisation]   Pkinase_C [organisation]   Prot_kin_PKC_delta [organisation]   Prot_Kinase_C-like_PE/DAG-bd [organisation]   Prot_kinase_dom [organisation]   Protein_kinase_ATP_BS [organisation]   Ser/Thr_dual-sp_kinase_dom [organisation]   Ser/Thr_kinase_AS [organisation]  
Related proteins : CluSTrQ04759
Domain families : Pfam (Sanger)C1_1 (PF00130)    Pkinase (PF00069)    Pkinase_C (PF00433)   
Domain families : Pfam (NCBI)pfam00130    pfam00069    pfam00433   
Domain families : Smart (EMBL)C1 (SM00109)  S_TK_X (SM00133)  S_TKc (SM00220)  
DMDM Disease mutations5588
Blocks (Seattle)Q04759
PDB (SRS)1XJD    2ENJ    2ENN    2ENZ    2JED   
PDB (PDBSum)1XJD    2ENJ    2ENN    2ENZ    2JED   
PDB (IMB)1XJD    2ENJ    2ENN    2ENZ    2JED   
PDB (RSDB)1XJD    2ENJ    2ENN    2ENZ    2JED   
Human Protein AtlasENSG00000065675 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasQ04759
HPRD02710
IPIIPI00029196   IPI00470691   IPI01011121   IPI00552075   
Protein Interaction databases
DIP (DOE-UCLA)Q04759
IntAct (EBI)Q04759
FunCoupENSG00000065675
BioGRIDPRKCQ
InParanoidQ04759
Interologous Interaction database Q04759
IntegromeDBPRKCQ
STRING (EMBL)PRKCQ
Ontologies - Pathways
Ontology : AmiGOregulation of cell growth  immunological synapse  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein kinase C activity  ubiquitin-protein transferase activity  protein binding  ATP binding  cytosol  plasma membrane  regulation of transcription, DNA-templated  protein phosphorylation  membrane protein ectodomain proteolysis  apoptotic process  cellular component disassembly involved in execution phase of apoptosis  inflammatory response  axon guidance  blood coagulation  phototransduction, visible light  rhodopsin mediated signaling pathway  protein ubiquitination  regulation of rhodopsin mediated signaling pathway  platelet activation  positive regulation of interleukin-17 production  positive regulation of interleukin-4 production  intracellular signal transduction  Fc-epsilon receptor signaling pathway  positive regulation of T cell proliferation  positive regulation of interleukin-2 biosynthetic process  innate immune response  negative regulation of insulin receptor signaling pathway  metal ion binding  T cell receptor signaling pathway  positive regulation of T cell activation  positive regulation of NF-kappaB transcription factor activity  negative regulation of T cell apoptotic process  regulation of platelet aggregation  positive regulation of T-helper 17 type immune response  positive regulation of T-helper 2 cell activation  
Ontology : EGO-EBIregulation of cell growth  immunological synapse  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein kinase C activity  ubiquitin-protein transferase activity  protein binding  ATP binding  cytosol  plasma membrane  regulation of transcription, DNA-templated  protein phosphorylation  membrane protein ectodomain proteolysis  apoptotic process  cellular component disassembly involved in execution phase of apoptosis  inflammatory response  axon guidance  blood coagulation  phototransduction, visible light  rhodopsin mediated signaling pathway  protein ubiquitination  regulation of rhodopsin mediated signaling pathway  platelet activation  positive regulation of interleukin-17 production  positive regulation of interleukin-4 production  intracellular signal transduction  Fc-epsilon receptor signaling pathway  positive regulation of T cell proliferation  positive regulation of interleukin-2 biosynthetic process  innate immune response  negative regulation of insulin receptor signaling pathway  metal ion binding  T cell receptor signaling pathway  positive regulation of T cell activation  positive regulation of NF-kappaB transcription factor activity  negative regulation of T cell apoptotic process  regulation of platelet aggregation  positive regulation of T-helper 17 type immune response  positive regulation of T-helper 2 cell activation  
Pathways : BIOCARTAKeratinocyte Differentiation [Genes]   
Pathways : KEGGNF-kappa B signaling pathway    Vascular smooth muscle contraction    Tight junction    T cell receptor signaling pathway    Adipocytokine signaling pathway    Measles   
Protein Interaction DatabasePRKCQ
Wikipedia pathwaysPRKCQ
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PRKCQ
snp3D : Map Gene to Disease5588
SNP (GeneSNP Utah)PRKCQ
SNP : HGBasePRKCQ
Genetic variants : HAPMAPPRKCQ
Exome VariantPRKCQ
1000_GenomesPRKCQ 
ICGC programENSG00000065675 
Somatic Mutations in Cancer : COSMICPRKCQ 
CONAN: Copy Number AnalysisPRKCQ 
Mutations and Diseases : HGMDPRKCQ
Genomic VariantsPRKCQ  PRKCQ [DGVbeta]
dbVarPRKCQ
ClinVarPRKCQ
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM600448   
MedgenPRKCQ
GENETestsPRKCQ
Disease Genetic AssociationPRKCQ
Huge Navigator PRKCQ [HugePedia]  PRKCQ [HugeCancerGEM]
General knowledge
Homologs : HomoloGenePRKCQ
Homology/Alignments : Family Browser (UCSC)PRKCQ
Phylogenetic Trees/Animal Genes : TreeFamPRKCQ
Chemical/Protein Interactions : CTD5588
Chemical/Pharm GKB GenePA33773
Clinical trialPRKCQ
Cancer Resource (Charite)ENSG00000065675
Other databases
Probes
Litterature
PubMed186 Pubmed reference(s) in Entrez
CoreMinePRKCQ
iHOPPRKCQ
OncoSearchPRKCQ
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jul 30 14:11:16 CEST 2014

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