Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PRKCZ (protein kinase C zeta)

Identity

Alias_namesprotein kinase C
Alias_symbol (synonym)PKC2
Other aliasPKC-ZETA
HGNC (Hugo) PRKCZ
LocusID (NCBI) 5590
Atlas_Id 41863
Location 1p36.33  [Link to chromosome band 1p36]
Location_base_pair Starts at 2073647 and ends at 2185395 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)		NEAT1 (11q13.1) / PRKCZ (1p36.33)PRKCZ (1p36.33) / CDC42BPG (11q13.1)PRKCZ (1p36.33) / VPS28 (8q24.3)
RPL30 (8q22.2) / PRKCZ (1p36.33)SKI (1p36.33) / PRKCZ (1p36.33)TMEM110-MUSTN1 (3p21.1) / PRKCZ (1p36.33)
WHSC1 (4p16.3) / PRKCZ (1p36.33)ZNF418 (19q13.43) / PRKCZ (1p36.33)SKI 1p36.33 / PRKCZ 1p36.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma

External links

Nomenclature
HGNC (Hugo)PRKCZ   9412
Cards
Entrez_Gene (NCBI)PRKCZ  5590  protein kinase C zeta
AliasesPKC-ZETA; PKC2
GeneCards (Weizmann)PRKCZ
Ensembl hg19 (Hinxton)ENSG00000067606 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000067606 [Gene_View]  chr1:2073647-2185395 [Contig_View]  PRKCZ [Vega]
ICGC DataPortalENSG00000067606
TCGA cBioPortalPRKCZ
AceView (NCBI)PRKCZ
Genatlas (Paris)PRKCZ
WikiGenes5590
SOURCE (Princeton)PRKCZ
Genetics Home Reference (NIH)PRKCZ
Genomic and cartography
GoldenPath hg38 (UCSC)PRKCZ  -     chr1:2073647-2185395 +  1p36.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRKCZ  -     1p36.33   [Description]    (hg19-Feb_2009)
EnsemblPRKCZ - 1p36.33 [CytoView hg19]  PRKCZ - 1p36.33 [CytoView hg38]
Mapping of homologs : NCBIPRKCZ [Mapview hg19]  PRKCZ [Mapview hg38]
OMIM176982   
Gene and transcription
Genbank (Entrez)AB007974 AI186591 AK097627 AK131526 AK290995
RefSeq transcript (Entrez)NM_001033581 NM_001033582 NM_001242874 NM_001350803 NM_001350804 NM_001350805 NM_001350806 NM_002744
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PRKCZ
Cluster EST : UnigeneHs.496255 [ NCBI ]
CGAP (NCI)Hs.496255
Alternative Splicing GalleryENSG00000067606
Gene ExpressionPRKCZ [ NCBI-GEO ]   PRKCZ [ EBI - ARRAY_EXPRESS ]   PRKCZ [ SEEK ]   PRKCZ [ MEM ]
Gene Expression Viewer (FireBrowse)PRKCZ [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5590
GTEX Portal (Tissue expression)PRKCZ
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ05513   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ05513  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ05513
Splice isoforms : SwissVarQ05513
Catalytic activity : Enzyme2.7.11.13 [ Enzyme-Expasy ]   2.7.11.132.7.11.13 [ IntEnz-EBI ]   2.7.11.13 [ BRENDA ]   2.7.11.13 [ KEGG ]   
PhosPhoSitePlusQ05513
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    PB1 (PS51745)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    ZF_DAG_PE_1 (PS00479)    ZF_DAG_PE_2 (PS50081)   
Domains : Interpro (EBI)AGC-kinase_C    DAG/PE-bd    Kinase-like_dom    PB1_dom    PE/DAG-bd    PKC    Pkinase_C    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)C1_1 (PF00130)    PB1 (PF00564)    Pkinase (PF00069)    Pkinase_C (PF00433)   
Domain families : Pfam (NCBI)pfam00130    pfam00564    pfam00069    pfam00433   
Domain families : Smart (EMBL)C1 (SM00109)  PB1 (SM00666)  S_TK_X (SM00133)  S_TKc (SM00220)  
Conserved Domain (NCBI)PRKCZ
DMDM Disease mutations5590
Blocks (Seattle)PRKCZ
SuperfamilyQ05513
Human Protein AtlasENSG00000067606
Peptide AtlasQ05513
HPRD01504
IPIIPI00013749   IPI00655886   IPI00965675   IPI00967822   IPI00965397   IPI00967181   IPI00964202   IPI00651700   IPI00966299   IPI00964557   IPI00963945   IPI00964803   IPI00965178   IPI00968107   IPI00967529   IPI00965743   IPI00964179   IPI00515054   
Protein Interaction databases
DIP (DOE-UCLA)Q05513
IntAct (EBI)Q05513
FunCoupENSG00000067606
BioGRIDPRKCZ
STRING (EMBL)PRKCZ
ZODIACPRKCZ
Ontologies - Pathways
QuickGOQ05513
Ontology : AmiGOmicrotubule cytoskeleton organization  positive regulation of cell-matrix adhesion  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein kinase C activity  protein binding  ATP binding  nuclear envelope  cytoplasm  endosome  microtubule organizing center  cytosol  cytosol  plasma membrane  cell-cell junction  bicellular tight junction  protein phosphorylation  inflammatory response  signal transduction  transforming growth factor beta receptor signaling pathway  long-term memory  positive regulation of cell proliferation  insulin receptor signaling pathway  potassium channel regulator activity  membrane  apical plasma membrane  nuclear matrix  cell migration  peptidyl-serine phosphorylation  protein kinase binding  protein domain specific binding  establishment of cell polarity  cell junction  cell leading edge  negative regulation of protein complex assembly  actin cytoskeleton reorganization  activation of phospholipase D activity  filamentous actin  vesicle  activation of protein kinase B activity  positive regulation of interleukin-4 production  myelin sheath abaxonal region  negative regulation of apoptotic process  axon hillock  phospholipase binding  insulin receptor substrate binding  membrane raft  apical cortex  positive regulation of T-helper 2 cell differentiation  positive regulation of glucose import  negative regulation of insulin receptor signaling pathway  positive regulation of insulin receptor signaling pathway  metal ion binding  vesicle transport along microtubule  perinuclear region of cytoplasm  negative regulation of peptidyl-tyrosine phosphorylation  positive regulation of NF-kappaB transcription factor activity  protein heterooligomerization  negative regulation of hydrolase activity  membrane depolarization  membrane hyperpolarization  long-term synaptic potentiation  extracellular exosome  positive regulation of ERK1 and ERK2 cascade  protein kinase C signaling  14-3-3 protein binding  protein localization to plasma membrane  neuron projection extension  positive regulation of excitatory postsynaptic potential  positive regulation of T-helper 2 cell cytokine production  positive regulation of interleukin-5 secretion  positive regulation of interleukin-13 secretion  positive regulation of interleukin-10 secretion  
Ontology : EGO-EBImicrotubule cytoskeleton organization  positive regulation of cell-matrix adhesion  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein kinase C activity  protein binding  ATP binding  nuclear envelope  cytoplasm  endosome  microtubule organizing center  cytosol  cytosol  plasma membrane  cell-cell junction  bicellular tight junction  protein phosphorylation  inflammatory response  signal transduction  transforming growth factor beta receptor signaling pathway  long-term memory  positive regulation of cell proliferation  insulin receptor signaling pathway  potassium channel regulator activity  membrane  apical plasma membrane  nuclear matrix  cell migration  peptidyl-serine phosphorylation  protein kinase binding  protein domain specific binding  establishment of cell polarity  cell junction  cell leading edge  negative regulation of protein complex assembly  actin cytoskeleton reorganization  activation of phospholipase D activity  filamentous actin  vesicle  activation of protein kinase B activity  positive regulation of interleukin-4 production  myelin sheath abaxonal region  negative regulation of apoptotic process  axon hillock  phospholipase binding  insulin receptor substrate binding  membrane raft  apical cortex  positive regulation of T-helper 2 cell differentiation  positive regulation of glucose import  negative regulation of insulin receptor signaling pathway  positive regulation of insulin receptor signaling pathway  metal ion binding  vesicle transport along microtubule  perinuclear region of cytoplasm  negative regulation of peptidyl-tyrosine phosphorylation  positive regulation of NF-kappaB transcription factor activity  protein heterooligomerization  negative regulation of hydrolase activity  membrane depolarization  membrane hyperpolarization  long-term synaptic potentiation  extracellular exosome  positive regulation of ERK1 and ERK2 cascade  protein kinase C signaling  14-3-3 protein binding  protein localization to plasma membrane  neuron projection extension  positive regulation of excitatory postsynaptic potential  positive regulation of T-helper 2 cell cytokine production  positive regulation of interleukin-5 secretion  positive regulation of interleukin-13 secretion  positive regulation of interleukin-10 secretion  
Pathways : BIOCARTAPhosphoinositides and their downstream targets. [Genes]   
Pathways : KEGGRap1 signaling pathway    Chemokine signaling pathway    Endocytosis    PI3K-Akt signaling pathway    Hippo signaling pathway    Tight junction    Insulin signaling pathway    Type II diabetes mellitus   
NDEx NetworkPRKCZ
Atlas of Cancer Signalling NetworkPRKCZ
Wikipedia pathwaysPRKCZ
Orthology - Evolution
OrthoDB5590
GeneTree (enSembl)ENSG00000067606
Phylogenetic Trees/Animal Genes : TreeFamPRKCZ
HOVERGENQ05513
HOGENOMQ05513
Homologs : HomoloGenePRKCZ
Homology/Alignments : Family Browser (UCSC)PRKCZ
Gene fusions - Rearrangements
Fusion : MitelmanSKI/PRKCZ [1p36.33/1p36.33]  [t(1;1)(p36;p36)]  
Fusion: TCGASKI 1p36.33 PRKCZ 1p36.33 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRKCZ [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRKCZ
dbVarPRKCZ
ClinVarPRKCZ
1000_GenomesPRKCZ 
Exome Variant ServerPRKCZ
ExAC (Exome Aggregation Consortium)PRKCZ (select the gene name)
Genetic variants : HAPMAP5590
Genomic Variants (DGV)PRKCZ [DGVbeta]
DECIPHERPRKCZ [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRKCZ 
Mutations
ICGC Data PortalPRKCZ 
TCGA Data PortalPRKCZ 
Broad Tumor PortalPRKCZ
OASIS PortalPRKCZ [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRKCZ  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRKCZ
intOGen PortalPRKCZ
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRKCZ
DgiDB (Drug Gene Interaction Database)PRKCZ
DoCM (Curated mutations)PRKCZ (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRKCZ (select a term)
intoGenPRKCZ
Cancer3DPRKCZ(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176982   
Orphanet
MedgenPRKCZ
Genetic Testing Registry PRKCZ
NextProtQ05513 [Medical]
TSGene5590
GENETestsPRKCZ
Target ValidationPRKCZ
Huge Navigator PRKCZ [HugePedia]
snp3D : Map Gene to Disease5590
BioCentury BCIQPRKCZ
ClinGenPRKCZ
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5590
Chemical/Pharm GKB GenePA33775
Clinical trialPRKCZ
Miscellaneous
canSAR (ICR)PRKCZ (select the gene name)
Probes
Litterature
PubMed329 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRKCZ
EVEXPRKCZ
GoPubMedPRKCZ
iHOPPRKCZ
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:51:06 CEST 2017
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