PRKCZ (protein kinase C, zeta)

Identity

Other names	PKC-ZETA
	PKC2
HGNC	PRKCZ
Location	1p36.33-p36.2
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	PRKCZ   9412
Entrez_Gene	PRKCZ  5590  protein kinase C, zeta
	Cards
GeneCards	PRKCZ
Ensembl	PRKCZ [Search_View]   ENSG00000067606 [Gene_View]
Genatlas	PRKCZ
GeneLynx	PRKCZ
eGenome	PRKCZ
euGene	5590
	Genomic and cartography
GoldenPath	PRKCZ  -     chr1:1994946-2106694 +  1p36.33   [Description]    (hg18-March_2006)
Ensembl	PRKCZ - 1p36.33 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	PRKCZ
	Gene and transcription
Genbank	AB007974 [ ENTREZ ]
Genbank	AK097627 [ ENTREZ ]
Genbank	AK131526 [ ENTREZ ]
Genbank	AK290995 [ ENTREZ ]
Genbank	AK310372 [ ENTREZ ]
RefSeq	NM_001033581 [ SRS ]    NM_001033581 [ ENTREZ ]
RefSeq	NM_001033582 [ SRS ]    NM_001033582 [ ENTREZ ]
RefSeq	NM_002744 [ SRS ]    NM_002744 [ ENTREZ ]
RefSeq	AC_000044 [ SRS ]    AC_000044 [ ENTREZ ]
RefSeq	AC_000133 [ SRS ]    AC_000133 [ ENTREZ ]
RefSeq	NC_000001 [ SRS ]    NC_000001 [ ENTREZ ]
RefSeq	NT_004350 [ SRS ]    NT_004350 [ ENTREZ ]
RefSeq	NW_001838585 [ SRS ]    NW_001838585 [ ENTREZ ]
RefSeq	NW_921350 [ SRS ]    NW_921350 [ ENTREZ ]
AceView	PRKCZ AceView - NCBI
Unigene	Hs.496255 [ SRS ]    Hs.496255 [ NCBI ]     HS496255 [ spliceNest ]
Fast-db	1393 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q05513 [ SRS]    Q05513 [ EXPASY ]     Q05513 [ INTERPRO ]     Q05513 [ UNIPROT ]
Prosite	PS51285 AGC_KINASE_CTER [ SRS ]    PS51285 AGC_KINASE_CTER [ Expasy ]
Prosite	PS00107 PROTEIN_KINASE_ATP [ SRS ]    PS00107 PROTEIN_KINASE_ATP [ Expasy ]
Prosite	PS50011 PROTEIN_KINASE_DOM [ SRS ]    PS50011 PROTEIN_KINASE_DOM [ Expasy ]
Prosite	PS00108 PROTEIN_KINASE_ST [ SRS ]    PS00108 PROTEIN_KINASE_ST [ Expasy ]
Prosite	PS00479 ZF_DAG_PE_1 [ SRS ]    PS00479 ZF_DAG_PE_1 [ Expasy ]
Prosite	PS50081 ZF_DAG_PE_2 [ SRS ]    PS50081 ZF_DAG_PE_2 [ Expasy ]
Interpro	IPR002219 DAG_PE_bd [ SRS ]    IPR002219 DAG_PE_bd [ EBI ]
Interpro	IPR000270 OPR_PB1 [ SRS ]    IPR000270 OPR_PB1 [ EBI ]
Interpro	IPR015745 PKC [ SRS ]    IPR015745 PKC [ EBI ]
Interpro	IPR012233 PKC_zeta [ SRS ]    IPR012233 PKC_zeta [ EBI ]
Interpro	IPR000961 Pkinase_C [ SRS ]    IPR000961 Pkinase_C [ EBI ]
Interpro	IPR000719 Prot_kinase_core [ SRS ]    IPR000719 Prot_kinase_core [ EBI ]
Interpro	IPR017441 Protein_kinase_ATP_bd_CS [ SRS ]    IPR017441 Protein_kinase_ATP_bd_CS [ EBI ]
Interpro	IPR017442 Se/Thr_pkinase-rel [ SRS ]    IPR017442 Se/Thr_pkinase-rel [ EBI ]
Interpro	IPR008271 Ser_thr_pkin_AS [ SRS ]    IPR008271 Ser_thr_pkin_AS [ EBI ]
Interpro	IPR002290 Ser_thr_pkinase [ SRS ]    IPR002290 Ser_thr_pkinase [ EBI ]
CluSTr	Q05513
Pfam	PF00130 C1_1 [ SRS ]    PF00130 C1_1 [ Sanger ]    pfam00130 [ NCBI-CDD ]
Pfam	PF00564 PB1 [ SRS ]    PF00564 PB1 [ Sanger ]    pfam00564 [ NCBI-CDD ]
Pfam	PF00069 Pkinase [ SRS ]    PF00069 Pkinase [ Sanger ]    pfam00069 [ NCBI-CDD ]
Pfam	PF00433 Pkinase_C [ SRS ]    PF00433 Pkinase_C [ Sanger ]    pfam00433 [ NCBI-CDD ]
Smart	SM00109 C1 [EMBL]
Smart	SM00666 PB1 [EMBL]
Smart	SM00133 S_TK_X [EMBL]
Smart	SM00220 S_TKc [EMBL]
Prodom	PD000001 Prot_kinase[INRA-Toulouse]
Prodom	Q05513 KPCZ_HUMAN [ Domain structure ]   Q05513 KPCZ_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	Q05513
HPRD	01504
	Protein Interaction databases
DIP	Q05513
IntAct	Q05513
	Polymorphism : SNP, mutations, diseases
OMIM	176982    [ map ]
GENECLINICS	176982
SNP	PRKCZ [dbSNP-NCBI]
SNP	NM_001033581 [SNP-NCI]
SNP	NM_001033582 [SNP-NCI]
SNP	NM_002744 [SNP-NCI]
SNP	PRKCZ [GeneSNPs - Utah]  PRKCZ] [HGBASE - SRS]
HAPMAP	PRKCZ [HAPMAP]
COSMIC	PRKCZ [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	PRKCZ
	General knowledge
Family Browser	PRKCZ [UCSC Family Browser]
SOURCE	NM_001033581
SOURCE	NM_001033582
SOURCE	NM_002744
SMD	Hs.496255
SAGE	Hs.496255
Enzyme	2.7.11.13 [ Enzyme-Expasy ]   2.7.11.13 [ Enzyme-SRS ]   2.7.11.13 [ IntEnz-EBI ]   2.7.11.13 [ BRENDA ]   2.7.11.13 [ KEGG ]   2.7.11.13 [ WIT ]
GO	nucleotide binding [Amigo]  nucleotide binding
GO	atypical protein kinase C activity [Amigo]  atypical protein kinase C activity
GO	protein binding [Amigo]  protein binding
GO	ATP binding [Amigo]  ATP binding
GO	membrane fraction [Amigo]  membrane fraction
GO	cytoplasm [Amigo]  cytoplasm
GO	endosome [Amigo]  endosome
GO	plasma membrane [Amigo]  plasma membrane
GO	protein amino acid phosphorylation [Amigo]  protein amino acid phosphorylation
GO	anti-apoptosis [Amigo]  anti-apoptosis
GO	intracellular signaling cascade [Amigo]  intracellular signaling cascade
GO	zinc ion binding [Amigo]  zinc ion binding
GO	transferase activity [Amigo]  transferase activity
GO	diacylglycerol binding [Amigo]  diacylglycerol binding
GO	metal ion binding [Amigo]  metal ion binding
BIOCARTA	Phosphoinositides and their downstream targets.    [Genes]
KEGG	Tight junction
KEGG	Insulin signaling pathway
KEGG	Type II diabetes mellitus
PubGene	PRKCZ
TreeFam	PRKCZ
CTD	5590 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	PRKCZ Related clones (RZPD - Berlin)
	PubMed
PubMed	188 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Sep 29 18:16:30 2008