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PRKD2 (protein kinase D2)

Identity

Alias_symbol (synonym)PKD2
HSPC187
DKFZP586E0820
Other aliasnPKC-D2
HGNC (Hugo) PRKD2
LocusID (NCBI) 25865
Atlas_Id 42916
Location 19q13.32  [Link to chromosome band 19q13]
Location_base_pair Starts at 46674316 and ends at 46717127 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DGUOK (2p13.1) / PRKD2 (19q13.32)PRKD2 (19q13.32) / CKM (19q13.32)PRKD2 (19q13.32) / PITX1 (5q31.1)
PRKD2 19q13.32 / CKM 19q13.32

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PRKD2   17293
Cards
Entrez_Gene (NCBI)PRKD2  25865  protein kinase D2
AliasesHSPC187; PKD2; nPKC-D2
GeneCards (Weizmann)PRKD2
Ensembl hg19 (Hinxton)ENSG00000105287 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105287 [Gene_View]  chr19:46674316-46717127 [Contig_View]  PRKD2 [Vega]
ICGC DataPortalENSG00000105287
TCGA cBioPortalPRKD2
AceView (NCBI)PRKD2
Genatlas (Paris)PRKD2
WikiGenes25865
SOURCE (Princeton)PRKD2
Genetics Home Reference (NIH)PRKD2
Genomic and cartography
GoldenPath hg38 (UCSC)PRKD2  -     chr19:46674316-46717127 -  19q13.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRKD2  -     19q13.32   [Description]    (hg19-Feb_2009)
EnsemblPRKD2 - 19q13.32 [CytoView hg19]  PRKD2 - 19q13.32 [CytoView hg38]
Mapping of homologs : NCBIPRKD2 [Mapview hg19]  PRKD2 [Mapview hg38]
OMIM607074   
Gene and transcription
Genbank (Entrez)AF151021 AF309082 AK074673 AK075266 AK092896
RefSeq transcript (Entrez)NM_001079880 NM_001079881 NM_001079882 NM_016457
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PRKD2
Cluster EST : UnigeneHs.466987 [ NCBI ]
CGAP (NCI)Hs.466987
Alternative Splicing GalleryENSG00000105287
Gene ExpressionPRKD2 [ NCBI-GEO ]   PRKD2 [ EBI - ARRAY_EXPRESS ]   PRKD2 [ SEEK ]   PRKD2 [ MEM ]
Gene Expression Viewer (FireBrowse)PRKD2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)25865
GTEX Portal (Tissue expression)PRKD2
Human Protein AtlasENSG00000105287-PRKD2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BZL6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BZL6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BZL6
Splice isoforms : SwissVarQ9BZL6
Catalytic activity : Enzyme2.7.11.13 [ Enzyme-Expasy ]   2.7.11.132.7.11.13 [ IntEnz-EBI ]   2.7.11.13 [ BRENDA ]   2.7.11.13 [ KEGG ]   
PhosPhoSitePlusQ9BZL6
Domaine pattern : Prosite (Expaxy)PH_DOMAIN (PS50003)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    ZF_DAG_PE_1 (PS00479)    ZF_DAG_PE_2 (PS50081)   
Domains : Interpro (EBI)DAG/PE-bd    Kinase-like_dom    PE/DAG-bd    PH_dom-like    PH_domain    Prot_kinase_dom    Protein_kinase_ATP_BS    Protein_Kinase_C_mu-related    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)C1_1 (PF00130)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00130    pfam00069   
Domain families : Smart (EMBL)C1 (SM00109)  PH (SM00233)  S_TKc (SM00220)  
Conserved Domain (NCBI)PRKD2
DMDM Disease mutations25865
Blocks (Seattle)PRKD2
PDB (SRS)2COA    3BGM    4NNX    4NNY   
PDB (PDBSum)2COA    3BGM    4NNX    4NNY   
PDB (IMB)2COA    3BGM    4NNX    4NNY   
PDB (RSDB)2COA    3BGM    4NNX    4NNY   
Structural Biology KnowledgeBase2COA    3BGM    4NNX    4NNY   
SCOP (Structural Classification of Proteins)2COA    3BGM    4NNX    4NNY   
CATH (Classification of proteins structures)2COA    3BGM    4NNX    4NNY   
SuperfamilyQ9BZL6
Human Protein Atlas [tissue]ENSG00000105287-PRKD2 [tissue]
Peptide AtlasQ9BZL6
HPRD09523
IPIIPI00941257   IPI00816171   
Protein Interaction databases
DIP (DOE-UCLA)Q9BZL6
IntAct (EBI)Q9BZL6
FunCoupENSG00000105287
BioGRIDPRKD2
STRING (EMBL)PRKD2
ZODIACPRKD2
Ontologies - Pathways
QuickGOQ9BZL6
Ontology : AmiGOangiogenesis  positive regulation of endothelial cell proliferation  positive regulation of endothelial cell proliferation  adaptive immune response  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein kinase C activity  protein binding  ATP binding  nucleus  nucleoplasm  cytoplasm  Golgi apparatus  cytosol  cytosol  plasma membrane  protein phosphorylation  protein phosphorylation  cell adhesion  cell death  positive regulation of endothelial cell migration  peptidyl-serine phosphorylation  sphingolipid biosynthetic process  positive regulation of vascular endothelial growth factor receptor signaling pathway  positive regulation of interleukin-2 production  positive regulation of interleukin-8 production  positive regulation of CREB transcription factor activity  positive regulation of peptidyl-serine phosphorylation  intracellular signal transduction  cellular response to vascular endothelial growth factor stimulus  cellular response to vascular endothelial growth factor stimulus  positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway  positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway  positive regulation of blood vessel endothelial cell migration  positive regulation of blood vessel endothelial cell migration  positive regulation of fibroblast growth factor receptor signaling pathway  positive regulation of angiogenesis  positive regulation of angiogenesis  positive regulation of cell adhesion  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  protein autophosphorylation  protein autophosphorylation  metal ion binding  vascular endothelial growth factor receptor signaling pathway  T cell receptor signaling pathway  positive regulation of T cell receptor signaling pathway  positive regulation of sequence-specific DNA binding transcription factor activity  positive regulation of NF-kappaB transcription factor activity  endothelial tube morphogenesis  positive regulation of ERK1 and ERK2 cascade  protein kinase D signaling  positive regulation of histone deacetylase activity  positive regulation of intracellular signal transduction  positive regulation of DNA biosynthetic process  positive regulation of endothelial cell chemotaxis  
Ontology : EGO-EBIangiogenesis  positive regulation of endothelial cell proliferation  positive regulation of endothelial cell proliferation  adaptive immune response  protein kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein kinase C activity  protein binding  ATP binding  nucleus  nucleoplasm  cytoplasm  Golgi apparatus  cytosol  cytosol  plasma membrane  protein phosphorylation  protein phosphorylation  cell adhesion  cell death  positive regulation of endothelial cell migration  peptidyl-serine phosphorylation  sphingolipid biosynthetic process  positive regulation of vascular endothelial growth factor receptor signaling pathway  positive regulation of interleukin-2 production  positive regulation of interleukin-8 production  positive regulation of CREB transcription factor activity  positive regulation of peptidyl-serine phosphorylation  intracellular signal transduction  cellular response to vascular endothelial growth factor stimulus  cellular response to vascular endothelial growth factor stimulus  positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway  positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway  positive regulation of blood vessel endothelial cell migration  positive regulation of blood vessel endothelial cell migration  positive regulation of fibroblast growth factor receptor signaling pathway  positive regulation of angiogenesis  positive regulation of angiogenesis  positive regulation of cell adhesion  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  protein autophosphorylation  protein autophosphorylation  metal ion binding  vascular endothelial growth factor receptor signaling pathway  T cell receptor signaling pathway  positive regulation of T cell receptor signaling pathway  positive regulation of sequence-specific DNA binding transcription factor activity  positive regulation of NF-kappaB transcription factor activity  endothelial tube morphogenesis  positive regulation of ERK1 and ERK2 cascade  protein kinase D signaling  positive regulation of histone deacetylase activity  positive regulation of intracellular signal transduction  positive regulation of DNA biosynthetic process  positive regulation of endothelial cell chemotaxis  
Pathways : KEGGRap1 signaling pathway   
NDEx NetworkPRKD2
Atlas of Cancer Signalling NetworkPRKD2
Wikipedia pathwaysPRKD2
Orthology - Evolution
OrthoDB25865
GeneTree (enSembl)ENSG00000105287
Phylogenetic Trees/Animal Genes : TreeFamPRKD2
HOVERGENQ9BZL6
HOGENOMQ9BZL6
Homologs : HomoloGenePRKD2
Homology/Alignments : Family Browser (UCSC)PRKD2
Gene fusions - Rearrangements
Fusion : MitelmanPRKD2/CKM [19q13.32/19q13.32]  
Fusion: TCGA_MDACCPRKD2 19q13.32 CKM 19q13.32 BRCA
Tumor Fusion PortalPRKD2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRKD2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRKD2
dbVarPRKD2
ClinVarPRKD2
1000_GenomesPRKD2 
Exome Variant ServerPRKD2
ExAC (Exome Aggregation Consortium)ENSG00000105287
GNOMAD BrowserENSG00000105287
Genetic variants : HAPMAP25865
Genomic Variants (DGV)PRKD2 [DGVbeta]
DECIPHERPRKD2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRKD2 
Mutations
ICGC Data PortalPRKD2 
TCGA Data PortalPRKD2 
Broad Tumor PortalPRKD2
OASIS PortalPRKD2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRKD2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRKD2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRKD2
DgiDB (Drug Gene Interaction Database)PRKD2
DoCM (Curated mutations)PRKD2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRKD2 (select a term)
intoGenPRKD2
Cancer3DPRKD2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607074   
Orphanet
DisGeNETPRKD2
MedgenPRKD2
Genetic Testing Registry PRKD2
NextProtQ9BZL6 [Medical]
TSGene25865
GENETestsPRKD2
Target ValidationPRKD2
Huge Navigator PRKD2 [HugePedia]
snp3D : Map Gene to Disease25865
BioCentury BCIQPRKD2
ClinGenPRKD2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD25865
Chemical/Pharm GKB GenePA134903505
Clinical trialPRKD2
Miscellaneous
canSAR (ICR)PRKD2 (select the gene name)
Probes
Litterature
PubMed67 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRKD2
EVEXPRKD2
GoPubMedPRKD2
iHOPPRKD2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:30:21 CET 2017

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