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PRKD3 (protein kinase D3)

Identity

Alias_namesPRKCN
protein kinase C
Alias_symbol (synonym)EPK2
Other aliasPKC-NU
PKD3
nPKC-NU
HGNC (Hugo) PRKD3
LocusID (NCBI) 23683
Atlas_Id 42900
Location 2p22.2  [Link to chromosome band 2p22]
Location_base_pair Starts at 37250503 and ends at 37317079 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EIF2AK2 (2p22.2) / PRKD3 (2p22.2)EIF2AK3 (2p11.2) / PRKD3 (2p22.2)NDUFAF7 (2p22.2) / PRKD3 (2p22.2)
PRKD3 (2p22.2) / AC016722.2 ()PRKD3 (2p22.2) / PRKD3 (2p22.2)PRKD3 (2p22.2) / QPCT (2p22.2)
PRKD3 2p22.2 AC016722.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PRKD3   9408
Cards
Entrez_Gene (NCBI)PRKD3  23683  protein kinase D3
AliasesEPK2; PKC-NU; PKD3; PRKCN; 
nPKC-NU
GeneCards (Weizmann)PRKD3
Ensembl hg19 (Hinxton)ENSG00000115825 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115825 [Gene_View]  chr2:37250503-37317079 [Contig_View]  PRKD3 [Vega]
ICGC DataPortalENSG00000115825
TCGA cBioPortalPRKD3
AceView (NCBI)PRKD3
Genatlas (Paris)PRKD3
WikiGenes23683
SOURCE (Princeton)PRKD3
Genetics Home Reference (NIH)PRKD3
Genomic and cartography
GoldenPath hg38 (UCSC)PRKD3  -     chr2:37250503-37317079 -  2p22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRKD3  -     2p22.2   [Description]    (hg19-Feb_2009)
EnsemblPRKD3 - 2p22.2 [CytoView hg19]  PRKD3 - 2p22.2 [CytoView hg38]
Mapping of homologs : NCBIPRKD3 [Mapview hg19]  PRKD3 [Mapview hg38]
OMIM607077   
Gene and transcription
Genbank (Entrez)AA631772 AB015982 AI865038 AK027585 AK122883
RefSeq transcript (Entrez)NM_005813
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PRKD3
Cluster EST : UnigeneHs.716034 [ NCBI ]
CGAP (NCI)Hs.716034
Alternative Splicing GalleryENSG00000115825
Gene ExpressionPRKD3 [ NCBI-GEO ]   PRKD3 [ EBI - ARRAY_EXPRESS ]   PRKD3 [ SEEK ]   PRKD3 [ MEM ]
Gene Expression Viewer (FireBrowse)PRKD3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23683
GTEX Portal (Tissue expression)PRKD3
Human Protein AtlasENSG00000115825-PRKD3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO94806   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO94806  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO94806
Splice isoforms : SwissVarO94806
Catalytic activity : Enzyme2.7.11.13 [ Enzyme-Expasy ]   2.7.11.132.7.11.13 [ IntEnz-EBI ]   2.7.11.13 [ BRENDA ]   2.7.11.13 [ KEGG ]   
PhosPhoSitePlusO94806
Domaine pattern : Prosite (Expaxy)PH_DOMAIN (PS50003)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    ZF_DAG_PE_1 (PS00479)    ZF_DAG_PE_2 (PS50081)   
Domains : Interpro (EBI)DAG/PE-bd    Kinase-like_dom    PE/DAG-bd    PH_dom-like    PH_domain    Prot_kinase_dom    Protein_kinase_ATP_BS    Protein_Kinase_C_mu-related    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)C1_1 (PF00130)    PH (PF00169)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00130    pfam00169    pfam00069   
Domain families : Smart (EMBL)C1 (SM00109)  PH (SM00233)  S_TKc (SM00220)  
Conserved Domain (NCBI)PRKD3
DMDM Disease mutations23683
Blocks (Seattle)PRKD3
PDB (SRS)2D9Z   
PDB (PDBSum)2D9Z   
PDB (IMB)2D9Z   
PDB (RSDB)2D9Z   
Structural Biology KnowledgeBase2D9Z   
SCOP (Structural Classification of Proteins)2D9Z   
CATH (Classification of proteins structures)2D9Z   
SuperfamilyO94806
Human Protein Atlas [tissue]ENSG00000115825-PRKD3 [tissue]
Peptide AtlasO94806
HPRD06151
IPIIPI00015538   IPI00871931   IPI00953718   IPI00893947   IPI00893805   
Protein Interaction databases
DIP (DOE-UCLA)O94806
IntAct (EBI)O94806
FunCoupENSG00000115825
BioGRIDPRKD3
STRING (EMBL)PRKD3
ZODIACPRKD3
Ontologies - Pathways
QuickGOO94806
Ontology : AmiGOprotein serine/threonine kinase activity  protein kinase C activity  protein binding  ATP binding  nucleoplasm  cytosol  cytosol  protein phosphorylation  protein kinase C-activating G-protein coupled receptor signaling pathway  membrane  kinase activity  sphingolipid biosynthetic process  metal ion binding  protein kinase D signaling  
Ontology : EGO-EBIprotein serine/threonine kinase activity  protein kinase C activity  protein binding  ATP binding  nucleoplasm  cytosol  cytosol  protein phosphorylation  protein kinase C-activating G-protein coupled receptor signaling pathway  membrane  kinase activity  sphingolipid biosynthetic process  metal ion binding  protein kinase D signaling  
Pathways : KEGGRap1 signaling pathway   
NDEx NetworkPRKD3
Atlas of Cancer Signalling NetworkPRKD3
Wikipedia pathwaysPRKD3
Orthology - Evolution
OrthoDB23683
GeneTree (enSembl)ENSG00000115825
Phylogenetic Trees/Animal Genes : TreeFamPRKD3
HOVERGENO94806
HOGENOMO94806
Homologs : HomoloGenePRKD3
Homology/Alignments : Family Browser (UCSC)PRKD3
Gene fusions - Rearrangements
Fusion : MitelmanEIF2AK3/PRKD3 [2p11.2/2p22.2]  [t(2;2)(p11;p22)]  
Fusion : MitelmanNDUFAF7/PRKD3 [2p22.2/2p22.2]  [t(2;2)(p22;p22)]  
Fusion: TCGA_MDACCPRKD3 2p22.2 AC016722.2 LUAD
Tumor Fusion PortalPRKD3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRKD3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRKD3
dbVarPRKD3
ClinVarPRKD3
1000_GenomesPRKD3 
Exome Variant ServerPRKD3
ExAC (Exome Aggregation Consortium)ENSG00000115825
GNOMAD BrowserENSG00000115825
Genetic variants : HAPMAP23683
Genomic Variants (DGV)PRKD3 [DGVbeta]
DECIPHERPRKD3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRKD3 
Mutations
ICGC Data PortalPRKD3 
TCGA Data PortalPRKD3 
Broad Tumor PortalPRKD3
OASIS PortalPRKD3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRKD3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPRKD3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PRKD3
DgiDB (Drug Gene Interaction Database)PRKD3
DoCM (Curated mutations)PRKD3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRKD3 (select a term)
intoGenPRKD3
Cancer3DPRKD3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607077   
Orphanet
DisGeNETPRKD3
MedgenPRKD3
Genetic Testing Registry PRKD3
NextProtO94806 [Medical]
TSGene23683
GENETestsPRKD3
Target ValidationPRKD3
Huge Navigator PRKD3 [HugePedia]
snp3D : Map Gene to Disease23683
BioCentury BCIQPRKD3
ClinGenPRKD3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23683
Chemical/Pharm GKB GenePA33772
Clinical trialPRKD3
Miscellaneous
canSAR (ICR)PRKD3 (select the gene name)
Probes
Litterature
PubMed55 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRKD3
EVEXPRKD3
GoPubMedPRKD3
iHOPPRKD3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:30:21 CET 2017

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